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http://dx.doi.org/10.3742/OPEM.2010.10.2.116

The improving effects of Saengmaeksan on ulcerative colitis  

Kim, Min-Cheol (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Kim, Su-Jin (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Choi, In-Young (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Ki, Ji-Ye (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Kim, Dae-Seung (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Jeon, Yong-Deok (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Bae, Go-Eun (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Choi, Sun-Kyung (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
Park, Yun-Jum (Division of Horticulture and Pet Animal-Plant Science, Wonkwang University)
Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Um, Jae-Young (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
Hong, Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude)
Publication Information
Advances in Traditional Medicine / v.10, no.2, 2010 , pp. 116-122 More about this Journal
Abstract
Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.
Keywords
Saengmaeksan; Dextran Sulfate Sodium; Ulcerative colitis; Nuclear factor-${\kappa}B$ p65; Interleukin-6;
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1 Rufo PA, Bousvaros A. (2006) Current therapy of inflammatory bowel disease in children. Paediatr. Drugs 8, 279-302.   DOI   ScienceOn
2 Sato K, Ohkura S, Kitahara Y, Ohama T, Hori M, Sato M, Kobayashi S, Sasaki Y, Hayashi T, Nasu T, Ozaki H. (2007) Involvement of CPI-17 downregula in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model. Neurogastroenterol. Motil. 19, 504-514.   DOI   ScienceOn
3 Schaecher K, Goust JM, Banik NL. (2004) The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites. Neurochem. Res. 29, 1443-1451.   DOI   ScienceOn
4 Ullman T, Croog V, Harpaz N, Sachar D, Itzkowitz S. (2003) Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis. Gastroenterology 125, 1311-1319.   DOI   ScienceOn
5 Wei YL, Li YJ, Liu X. (2001) Experimental study of protective effect of shenmai injection on endotoxin induced systemic inflammatory reaction syndrome and multiple organ dysfunction syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 21, 47-50.
6 Yadav SK, Lee SC. (2006) Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase activation. Zhong Xi Yi Jie He Xue Bao 4, 485-489.   DOI
7 Zhang YC, Chen RM, Lu BJ, Rong YZ. (2008) Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome. Chin J Integr Med 14, 107-110.   DOI   ScienceOn
8 Fan H, Qiu MY, Mei JJ, Shen GX, Liu SL, Chen R. (2005) Effects of four regulating-intestine prescriptions on pathology and ultrastructure of colon tissue in rats with ulcerative colitis. World J. Gastroenterol. 11, 4800-4806.   DOI
9 Fiocchi C. (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115, 182-205.   DOI   ScienceOn
10 Ghosh S, May MJ, Kopp EB. (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260.   DOI   ScienceOn
11 Hendrickson BA, Gokhale R, Cho JH. (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clin. Microbiol. Rev. 15, 79-94.   DOI
12 Hyams JS. (2000) Inflammatory bowel disease. Pediatr. Rev. 21, 291-295.   DOI
13 Jeong HJ, Na HJ, Hong SH, Kim HM. (2003) Inhibition of the stem cell factor-induced migration of mast cells by dexamethasone. Endocrinology 144, 4080-4086.   DOI   ScienceOn
14 Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ, van der Woude CJ. (2010) Disease-Related Expression of the IL-6/STAT3/SOCS3 Signaling Pathway in Ulcerative Colitis and Ulcerative Colitis-Related Carcinogenesis. Gut 59, 227-235.   DOI   ScienceOn
15 Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergran DJ. (1993) Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig. Dis. Sci. 38, 1722-1734.   DOI
16 Barnes PJ, Karin M. (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336, 1066-1071.   DOI   ScienceOn
17 Neurath MF, Pettersson S, Meyer zum Büschenfelde KH, Strober W. (1996) Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 2, 998-1004.   DOI   ScienceOn
18 Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98, 694-702.   DOI
19 Ardizzone S, Bianchi PG. (2005) Biologic therapy for inflammatory bowel disease. Drugs 65, 2253-2286.   DOI   ScienceOn
20 Blumberg RS, Saubermann LJ, Strober W. (1999) Animal models of mucosal inflammation and their relation to human inflammatory bowel disease.Curr. Opin. Immunol. 11, 648-656.   DOI   ScienceOn
21 Danese S, Sans M, Fiocchi C. (2004) Inflammatory bowel disease: the role of environmental factors. Autoimmun. Rev. 3, 394-400.   DOI   ScienceOn
22 Domenech E. (2006) Inflammatory bowel disease: current therapeutic options. Digestion 73, 67-76.   DOI   ScienceOn