• Korean Journal of Acupuncture
• /
• 제40권3호
• /
• pp.79-89
• /
• 2023

Objectives : The purpose of this study is to investigate various application methods of focused ultrasound and apply them to clinical use in Korean medicine. Methods : Search was performed using the search engines of electronic databases, including PubMed, ScienceDirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), China National Knowledge Infrastructure (CNKI), Wanfang Data, Japan Science Technology Information Aggregator, Electronic (J-STAGE) and Citation Information by NII (CiNii), from inception to July 2023 without language limitation. Inclusion criteria were clinical studies including randomized controlled trials (RCTs), and animal experimental studies related with focused ultrasound treatments for acupoints or meridian sinews. Results : Total 17 papers, 7 for RCT, 6 for in vivo animal studies, and other experimental studies, were finally selected. Indications used in studies were shoulder pain, back pain, chronic back pain, and degenerative knee arthritis. In experimental studies, studies on animal models of hypoxic ischemic brain damage and hyperlipidemia were also conducted. As for the acupoints, LR3, LI4, and ST36 were used in clinical studies and, in animal experimental studies, GV20, KI1, and ST36 were used. As for the dose, 4 studies below 3 W/cm² and 3 studies in the range of 0.625 to 5 W/cm² in clinical studies, and all studies did not exceed 5 W/cm². In animal experimental studies, 0.5 W/cm², 2 W/cm², 7.5 WW/cm², 15 W/cm², 10~20 W/cm² were used. In all three studies describing the penetration depth during irradiation, it was less than 1 cm. Conclusions : We suggest that focused ultrasound is an appropriate treatment tool for stimulating the acupoints to transfer heat energy. Future studies with rigorous and well-designed RCTs for various diseases will be required to ascertain the focused ultrasound stimulate acupoints or meridian sinews.

• 미래기술융합논문지
• /
• 제2권2호
• /
• pp.39-47
• /
• 2023

본 연구의 목적은 트레드밀을 이용하는 동안의 비만인과 일반인의 심혈관계 변화 차이를 알아보는 것이었다. 본 연구는 심혈관계 질환으로 병원 방문 및 치료 경험이 없는 성인 남성 32명을 대상으로 진행되었다. 대상자들은 BMI (body mass index) 25를 기준으로 비만군과 일반군으로 나누어 트레드밀 운동을 12분간 실시하였다. 심혈관계 변화의 차이를 알아보기 위해 트레드밀 전후의 SBP, DBP, HR, MAP, PP를 측정하였다. 두 그룹의 비교는 독립 t-검정을 사용하여 분석되었다. SBP, MAP, PP의 경우 군간 유의한 차이가 발견되었다(P<0.05). 그러나 DBP와 HR의 경우 두 그룹 간에 유의한 차이가 발견되지 않았다(P>0.05). 본 연구의 대상자는 건강한 20대 성인 남성으로만 구성되어 있어 짧은 시간에 수행되었다는 제한점이 있었다.

• International journal of advanced smart convergence
• /
• 제11권4호
• /
• pp.227-239
• /
• 2022

Purpose: In our study, in order to find lactic acid bacteria (LAB) with multi-drug resistance to antibiotics, we isolated 140 strains from 15 types of kimchi commercially available in Korea and 20 types of Kimchi made at home from January to December in 2016, and investigated their H₂O₂ generating ability and multi-drug resistance to antibiotics. Methods: In order to observe the H₂O₂ generation ability of LAB, we performed the experiment with methods such as Rabe, Hillier, and Kang. To test the antibacterial susceptibility of LAB, we used the disc agar diffusion method using MRS agar (Difco, USA) according to the CLSI and WHO test methods. There are 18 types of antibiotic discs used. Results: Out of the total numbers of 140 strains, 6 strains of Ent. Faecium, 25 strains of L. plantarum, 1 strain of L. rhamnosus, 3 strains of L. sakei, 1 strain of L. acidophilus, 1 strains St. thermophilus, and 7 of unidentified strains generated H₂O₂. The antibiotic susceptibility of Ent. Faecium indicated SXT, OX, NA, and E; and the antibiotic susceptibility of L. plantarum indicated NA; and the antibiotic susceptibility of St. thermophilus indicated NA, CC, RA, CTT, CM, and P ; and the antibiotic susceptibility of L. rhamnosus indicated SXT, VA, NA and CTT; and the antibiotic susceptibility of 6 strains of L. sakei indicated SXT, OX, NOR, NA, CTT and CIP, all indicating antibiotic resistance. In the case of multi-drug resistance to antibiotics for 53 strains of L. antarum, 8-drug resistance was the most common with 25 strains, followed by 7-drug-resistant strains with 18 strains, 9-drug-resistant strains with 4 strains, 6-drug-resistant strains with 3 strains, 5-drug-resistant strains with 2 strains, and 17-drug-resistant strains with 1 strain. In the case of multi-drug resistance to antibiotics for Ent. Faecium 27 strains, 9-drug resistance was most commonly identified as 9 strains, 8-drug resistance was identified as 6 strains, 7- and 11 drug resistances were identified as 4 strains each, and 4- and 6-drug resistances were identified as 1 strain each. Conclusion: Ent. Faecium, L. plantarum, L. rhamnosus, L. sakei, and St. thermophilus, shown to have anantibacterial activity in previous studies on LAB and shown to have and H₂O₂ generating ability, antibiotic resistance and multi-drug resistance in this study, are expected to be able to play an excellent role for long-term inpatients to use as an alternative to antibiotics and to cope with emerging antibiotic resistance.

• Journal of Gastric Cancer
• /
• 제23권3호
• /
• pp.499-508
• /
• 2023

Purpose: Despite scientific evidence regarding laparoscopic gastrectomy (LG) for advanced gastric cancer treatment, its application in patients receiving neoadjuvant chemotherapy remains uncertain. Materials and Methods: We used the 2019 Korean Gastric Cancer Association nationwide survey database to extract data from 489 patients with primary gastric cancer who received neoadjuvant chemotherapy. After propensity score matching analysis, we compared the surgical outcomes of 97 patients who underwent LG and 97 patients who underwent open gastrectomy (OG). We investigated the risk factors for postoperative complications using multivariate analysis. Results: The operative time was significantly shorter in the OG group. Patients in the LG group had significantly less blood loss than those in the OG group. Hospital stay and overall postoperative complications were similar between the two groups. The incidence of Clavien-Dindo grade ≥3 complications in the LG group was comparable with that in the OG group (1.03% vs. 4.12%, P=0.215). No statistically significant difference was observed in the number of harvested lymph nodes between the two groups (38.60 vs. 35.79, P=0.182). Multivariate analysis identified body mass index (odds ratio [OR], 1.824; 95% confidence interval [CI], 1.029-3.234; P=0.040) and extent of resection (OR, 3.154; 95% CI, 1.084-9.174; P=0.035) as independent risk factors for overall postoperative complications. Conclusions: Using a large nationwide multicenter survey database, we demonstrated that LG and OG had comparable short-term outcomes in patients with gastric cancer who received neoadjuvant chemotherapy.

• 한방재활의학과학회지
• /
• 제33권4호
• /
• pp.15-29
• /
• 2023

Objectives The purpose of this study is to systematically review the effects of Neuromuscular Electrical Stimulation treatment on muscle wasting in cancer patients. Methods Randomized controlled trials (RCTs) were searched from seven online databases (PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Sharing Service. The selected RCTs were evaluated for methodological quality through the Cochrane RoB. Results A total of 126 articles were identified, and 4 randomized controlled trials were selected for systematic review. In one study, it was found that there were statistically significant improvements in the Health-Related Quality of Life (FACTH&N total score, p<0.001). Additionally, significant effects were observed in measurements that represented the size of the quadriceps muscle (cross-sectional area of Vastus lateralis and Rectus femoris, p=0.004), maximum muscle strength, the twitch response of resistance muscles, and voluntary activation (p<0.001). However, no significant differences were observed between the intervention and control groups in terms of quadriceps muscle strength in two other studies (p>0.05). Lastly, while one study showed no significant differences in muscle fiber characteristics between the two groups, it did report significant improvements in measurements related to mitochondria within muscle tissue and muscle strength in the intervention group (p<0.05). Conclusions Neuromuscular electrical stimulation can be a method used to improve muscle strength in muscle wasting of cancer patients, but it is difficult to see its effects as significant compared to other treatments.

• 한방재활의학과학회지
• /
• 제34권2호
• /
• pp.29-49
• /
• 2024

Objectives The purpose of this study is to systemically review the recent studies in the Korean medicine treatments for torticollis. Methods We search the clinical studies from January 1, 2018 to December 31, 2023. The studies were searched through 10 databases (Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Sharing Service, Korean Medical Database, ScienceON, PubMed, Cochrane Library, Embase, Wanfang Data, China National Knowledge Infrastructure). Results A total of 19 studies were included in the study. 12 studies were case report studies, 5 studies were randomized controlled trials, 2 studies were non-randomized controlled trials. Of the 19 interventions, Chuna was the most used in this study and of the 28 evaluation tools, Sternocleidomastoid thickness was the most used in this study except efficiency rate. All 19 studies had improvements after treatment, and 8 studies had statistically significant improvements. As a result of the study, we found that Chuna, GB, GB20, BL10, Glycyrrhiza uralensis were commonly used Korean medicine treatments for torticollis. Conclusions We analyzed the Korean medicine treatments for torticollis. Through this study, we found that the Korean medicine was effective for torticollis. However, more research is needed to confirm the more detailed effect.

• 대한영상의학회지
• /
• 제82권4호
• /
• pp.1011-1017
• /
• 2021

골 시멘트 색전은 경피적 척추성형 후 드물지 않게 발생하는 합병증이다. 이는 보통 작은 폐동맥 색전이고 대부분 무증상이기 때문에 치료를 필요로 하지 않는다. 하지만 심장 내에 생긴 골시멘트 색전은 매우 드물며, 치명적인 결과를 야기할 수 있다. 이전 보고된 증례들은 심장 내 골시멘트 색전을 주로 개심수술을 통해 제거하였으며, 중재시술로 제거한 것은 3개 증례만 보고되어 있었다. 따라서 저자들은 경피적 척추성형 후 발생한 우심방 내 6 cm 크기의 골 시멘트 색전을 도관경유로 안전하게 제거한 1예를 보고하고자 한다. 색전이 시술 중에 두 동강나 우폐동맥으로 이동하였으나 두 개의 스네어와 하나의 필터 제거 장치를 이용하여 서로 반대 방향에서 접근시켜 우폐동맥 내의 색전 조각들을 조심스럽게 잡아 끌어낸 후 쉬스와 일렬로 만들어 제거하였으며, 시술 후 합병증은 발생하지 않았다.

• Korean Journal of Radiology
• /
• 제24권10호
• /
• pp.1006-1016
• /
• 2023

Objective: Computed tomography (CT) is an established method for the diagnosis, staging, and treatment of multiple myeloma. Here, we investigated the potential of photon-counting detector computed tomography (PCD-CT) in terms of image quality, diagnostic confidence, and radiation dose compared with energy-integrating detector CT (EID-CT). Materials and Methods: In this prospective study, patients with known multiple myeloma underwent clinically indicated whole-body PCD-CT. The image quality of PCD-CT was assessed qualitatively by three independent radiologists for overall image quality, edge sharpness, image noise, lesion conspicuity, and diagnostic confidence using a 5-point Likert scale (5 = excellent), and quantitatively for signal homogeneity using the coefficient of variation (CV) of Hounsfield Units (HU) values and modulation transfer function (MTF) via the full width at half maximum (FWHM) in the frequency space. The results were compared with those of the current clinical standard EID-CT protocols as controls. Additionally, the radiation dose (CTDIvol) was determined. Results: We enrolled 35 patients with multiple myeloma (mean age 69.8 ± 9.1 years; 18 [51%] males). Qualitative image analysis revealed superior scores (median [interquartile range]) for PCD-CT regarding overall image quality (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), edge sharpness (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), image noise (4.0 [4.0-4.0] vs. 3.0 [3.0-4.0]), lesion conspicuity (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), and diagnostic confidence (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]) compared with EID-CT (P ≤ 0.004). In quantitative image analyses, PCD-CT compared with EID-CT revealed a substantially lower FWHM (2.89 vs. 25.68 cy/pixel) and a significantly more homogeneous signal (mean CV ± standard deviation [SD], 0.99 ± 0.65 vs. 1.66 ± 0.5; P < 0.001) at a significantly lower radiation dose (mean CTDIvol ± SD, 3.33 ± 0.82 vs. 7.19 ± 3.57 mGy; P < 0.001). Conclusion: Whole-body PCD-CT provides significantly higher subjective and objective image quality at significantly reduced radiation doses than the current clinical standard EID-CT protocols, along with readily available multi-spectral data, facilitating the potential for further advanced post-processing.

• 미래기술융합논문지
• /
• 제3권2호
• /
• pp.25-31
• /
• 2024

최근 정보통신 기술로 인해 산업화되고 발달됨에 있어, 현대사회의 현대 여성들은 수많은 스트레스로 육체적, 정신적 건강에 노출되어 있다. 대중적으로 발생하는 염증들은 유산균이 감소되거나 잦은 항생제 복용 및 면역력 저하의 원인이 대표적이다. 도움이 되며 반영되는 제품 개발이 필요하다. 현재 시중에 소개되고 있는 이너케어젤은 유익균을 증가시키고 건강한 y존을 유지할수 있다. 이너 젤 속에는 하이드로젤 성분이 함유되어있다. 90%가 물로 이루어져 있고 그 외에 성분은 물을 지지하는 지지체로서의 역할을 수행하며, 고분자 사슬간의 가교결합을 통해 형성된다. HEC(hydroxyethyl cellulose)는 셀룰로오스의 하이드록시에칠에 텔이다. 사용목적은 결합제, 유화안정제, 점도증가제(수성), 피막형성제 역할을 한다. CA (crosslinker)는 가교제이며, 결합시켜주는 역할을 한다. 미용분야의 하이드로젤은 얇은 피막형성으로 피부를 부드럽게 감싸주는 피막형성제 역할을 하고, 다른 원료들이 분리되지 않도록 도움을 주는 유화안정제 역할을 한다. 또한, 화장품에 점성을 높여 점도를 개선시키는 점증제 역할을 한다. 또한, 바이오 분야에서는 포도당 감시, 간호관리, 세포이식 및 상처 치료에도 사용되어지고 있다. 현재로서는 기능성 하이드로젤을 이용한 제품은 나오지 않은 것으로 파악되어 있어 본 연구에서는 기능성 하이드로젤 항균성을 알아보기 위해 Y존 케어 하이드로젤 솔루션 제조를 수행하였으며 새로운 솔루션 개발을 목적으로 한다. 결과적으로 Y존에 적절한 Ph를 맞추었음을 확인하였고, PDB배지에 칸디다 알비칸균 배양 후 Y존 케어 하이드로젤솔루션 세가지 제품 모두 0.5~1.0mm의 항균력 효과를 보았다.

• 대한치과교정학회지
• /
• 제29권2호
• /
• pp.183-195
• /
• 1999

성장기 환자의 교정치료에서 신체의 성장 발육상태를 파악하는 것은 중요한 의미를 갖는다. 특히 부정교합에 따라 성장 발육시기가 차이를 보인다면 교정치료 시기의 선택에 있어서 이에 대한 고려가 있어야 하므로 부정교합의 양상에 따른 성장 발육상태를 평가하는 것이 필요할 것이다. 이에 본 연구에서는 부정교합 분류에 따라 골성숙도에 차이가 있는지를 조사하기 위해, 8-10세의 여자 I급 부정교합자 38명, II급 부정교합자 36명, III급 부정교합자 33명을 대상으로 약 6개월 간격으로 12-13세까지 누년적으로 촬영한 수완부골 방사선 사진을 이용하여 골성숙도를 평가한 결과 다음과 같은 결론을 얻었다. 1. 부정교합에 따른 골성숙도의 차이는 없었다. 2. 유구골의 구상돌기 (hamular process)는 $9.16{\pm}0.72$세, 두상골(pisiform bone)은 $9.13{\pm}0.71$세, 모지척측 종자골(ulnar sesamoid)은 $10.34{\pm}0.84$세에 관찰되었다. 3. 골단이 골간을 둘러싸는 시기는 셋째 수지의 원심부 지절과 중간 지절에서 각각 $10.96{\pm}0.80$세, $11.27{\pm}0.87$세였으며, 첫째 수지의 근심부 지절에서는 $11.12{\pm}0.86$세, 요골에서는 $11.21{\pm}0.82$세, 다섯째 수지의 중간 지절에서는 $11.62{\pm}0.85$세였다. 4. 두상골의 출현은 유구골 구상돌기의 출현과(r=0.91), 모지척측 종자골의 출현은 구상돌기의 진행성 화골시기와 높은 상관관계를 보였으며(r=0.86), 골단이 골간을 둘러싸는 시기는 여러 부위가 상호간에 높은 상관관계를 나타내었다(r=0.80-0.90). 5. 다섯째 수지의 중간 지절의 형태가 가장 변이가 심하였다($20.6\%$).