• Title/Summary/Keyword: Advanced Model

검색결과 6,527건 처리시간 0.04초

Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model

  • Choi, Naeun;Kim, Jong Won;Jeong, Hyeneui;Shin, Dong Gue;Seo, Jeong Hun;Kim, Jong Hoon;Lim, Chae Woong;Han, Kang Min;Kim, Bumseok
    • Journal of Ginseng Research
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    • 제43권2호
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    • pp.196-208
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    • 2019
  • Background: Nonalcoholic steatohepatitis (NASH) is one of the chronic inflammatory liver diseases and a leading cause of advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. The main purpose of this study was to clarify the effects of GBCK25 fermented by Saccharomyces servazzii GB-07 and pectinase, on NASH severity in mice. Methods: Six-wk-old male mice were fed either a normal diet (ND) or a Western diet (WD) for 12 wks to induce NASH. Each group was orally administered with vehicle or GBCK25 once daily at a dose of 10 mg/kg, 20 mg/kg, 100 mg/kg, 200 mg/kg, or 400 mg/kg during that time. The effects of GBCK25 on cellular damage and inflammation were determined by in vitro experiments. Results: Histopathologic analysis and hepatic/serum biochemical levels revealed that WD-fed mice showed severe steatosis and liver injury compared to ND-fed mice. Such lesions were significantly decreased in the livers of WD-fed mice with GBCK25 administration. Consistently, mRNA expression levels of NASH-related inflammatory-, fibrogenic-, and lipid metabolism-related genes were decreased in the livers of WD-fed mice administered with GBCK25 compared to WD-fed mice. Western blot analysis revealed decreased protein levels of cytochrome P450 2E1 (CYP2E1) with concomitantly reduced activation of c-Jun N-terminal kinase (JNK) in the livers of WD-fed mice administered with GBCK25. Also, decreased cellular damage and inflammation were observed in alpha mouse liver 12 (AML12) cells and RAW264.7 cells, respectively. Conclusion: Administration of GBCK25 ameliorates NASH severity through the modulation of CYP2E1 and its associated JNK-mediated cellular damage. GBCK25 could be a potentially effective prophylactic strategy to prevent metabolic diseases including NASH.

A proposal for the classification of Korean taste terms (한국어의 '맛 어휘' 분류 체계)

  • Kim, Hyeong Min
    • 기호학연구
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    • 제56호
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    • pp.7-44
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    • 2018
  • The objective of this paper is to propose a classification of Korean taste terms, especially Korean taste adjectives, from the perspective of cognitive science. The classification of Korean taste terms is here grounded in the definition of 'taste sense', 'flavor' and 'taste' which is usually employed in disciplines of cognitive science. There have been a large number of domestic researches in field of taste terms. Accordingly, a lot of research findings on the classification of taste terms have steadily been released showing the differences among researchers. These different classifications are largely based on the fact that researchers have applied their subjective criteria rather than their objective in order to categorize taste terms. According to previous studies, it is well-known that, in everyday usage, the term 'taste' covers a much wider range of qualities than those perceived through the taste receptor cells alone. In addition, we take it for granted that as much as 80~90% of taste comes from olfactory modality. It is also important to note that the texture and temperature of food, the color of food, the sounds of food, and atmospheric cues have an essential effect on taste perception. Many scientists have already pointed out that taste evaluations are influenced by a number of individual and sociocultural factors. Eating and tasting are important parts of our everyday life, so that linguistic approaches to taste perception seem to be of great significance. We can assume that a classification of taste terms from the perspective of cognitive sciences may shed light on the perceptive mechanism through which we perceive taste. It should be noted that this paper is an advanced work prepared for the follow-up study which will try to make a geometric model of word field 'taste terms' existing or probably existing in the mental lexicon of human beings.

An Empirical Study on the Korean Trade of International Tourism Services - Focusing on 16 nations including US, Japan and China - (한국 관광교역 현황분석을 위한 실증연구 - 미국·중국·일본 등 16개국을 중심으로 -)

  • Chung, Eun-Kyung;Kim, Chul;Choi, Young Jun
    • International Area Studies Review
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    • 제13권3호
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    • pp.413-438
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    • 2009
  • Tourism is an attractive field of industry to many countries due to its strong potentials in increasing employment rates as well as improving the national image. The positive effect of the tourism on the national economy and globalization has been recognized in Korea. A multilateral effort has been made in order to develop its tourist industry. Therefore, it is necessary to analyze the patterns of tourism demand in Korea. The present study analyzes and demonstrates the effects of a nation's characteristics on tourism demand. The study model was based on factors that affected tourism demand, especially emphasizing on the economic size, distance, national income, and language differences from the mother country. In particular, this study highlights the effects of economic relations between the countries and their exchange rate on tourism demand. In summary, this thesis demonstrates that actual national and international panel data enhance the credibility of the research and precisely determine factors that have a direct influence on tourism demand. A corresponding strategy of development and products are required as most tourists show the preference in advanced nations.

Exploring the Direction of School System Reorganization of Meister High School and Analyzing the Perceptions of Participants (마이스터고 학제 개편 방향 탐색 및 관계자 인식 분석)

  • Kim, Seoung-Nam
    • Journal of vocational education research
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    • 제37권5호
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    • pp.1-23
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    • 2018
  • The purpose of this study was to explore the direction of school system reorganization in order to strengthen the educational competitiveness of Meister high school. Specifically, the first one was to review prior research related to the school system reorganization of vocational education at the secondary level, and to propose school system reorganization plans of Meister high school. And second one was to analyze the perceptions of related parties about this reorganization plans and to derive important implications. The results of this study were as follows. First, based on the results of the analysis of precedent research, school system reorganization plans of Meister high school was composed of (1) introduction of credit system, (2) introduction of 3-semester system, and (3) expansion of school year. Second, as a result of the questionnaire survey conducted by 138 Meister high school teachers and 185 Meister high school graduates, both group seemed to agree on the necessity of school system reorganization of Meister high school. In addition, the necessity of introducing the proposed reorganization plans was more than a certain level, but the applicability was recognized as somewhat lower than the necessity of introduction. Third, the results of the FGI analysis on industrial personnel showed a positive response, especially regarding the operation of advanced course due to the expansion of school year. Based on this results, it was proposed to design a more systematic reorganization model and provide policy support, to examine the whole scale expansion through pilot application, and to collect opinions more systematically from industrial field experts on school system reorganization plans.

Predict DGPS Algorithm using Machine Learning (기계학습을 통한 예측 DGPS 항법 알고리즘)

  • Kim, HongPyo;Jang, JinHyeok;Koo, SangHoon;Ahn, Jongsun;Heo, Moon-Beom;Sung, Sangkyung;Lee, Young Jae
    • Journal of Advanced Navigation Technology
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    • 제22권6호
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    • pp.602-609
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    • 2018
  • Differential GPS (DGPS) is known as a positioning method using pseudo range correction (PRC) which is communicating between a refence receiver and moving receivers. In real world, a moving receiver loses communication with the reference receiver, resulting in loss of PRC real-time communication. In this paper, we assume that the transmission of the pseudo range correction isinterrupted in the middle of real-time positioning situations, in which calibration information is received in the DGPS method. Under the disconnected communication, we propose 'predict DGPS' that real-time virtual PRC model which is modeled by a machine learning algorithm with previously acquired PRC data from a reference receiver. To verify predict DGPS method, we compared and analyzed positioning solutions acquired from real PRC and the virtual PRC. In addition, we show that positioning using the DGPS prediction method on a real road can provide an improved positioning solution assuming a scenario in which PRC communication was cut off.

Development of V2I2V Communication-based Collision Prevention Support Service Using Artificial Neural Network (인공신경망을 활용한 V2I2V 통신 기반 차량 추돌방지 지원 서비스 개발)

  • Tak, Sehyun;Kang, Kyeongpyo;Lee, Donghoun
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • 제18권5호
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    • pp.126-141
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    • 2019
  • One of the Cooperative Intelligent Transportation System(C-ITS) priority services is collision prevention support service. Several studies have considered V2I2V communication-based collision prevention support services using Artificial Neural Networks(ANN). However, such services still show some issues due to a low penetration of C-ITS devices and large delay, particularly when loading massive traffic data into the server in the C-ITS center. This study proposes the Artificial Neural Network-based Collision Warning Service(ACWS), which allows upstream vehicle to update pre-determined weights involved in the ANN by using real-time sectional traffic information. This research evaluates the proposed service with respect to various penetration rates and delays. The evaluation result shows the performance of the ACWS increases as the penetration rate of the C-ITS devices in the vehicles increases or the delay decreases. Furthermore, it reveals a better performance is observed in more advanced ANN model-based ACWS for any given set of conditions.

A study on the establishment of Korean-Chinese language education service platform using AR/VR technology (AR/VR 기술을 활용한 한-중 어학교육 서비스 플랫폼 구축방안 연구)

  • Chun, Keung;Yoo, Gab Sang
    • Journal of Digital Convergence
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    • 제17권9호
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    • pp.23-30
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    • 2019
  • The development of content for language education using AR/VR technology is a necessary task to be pursued in line with commercialization of 5G. Research on service platform for systematic management and service is currently being carried out by global companies competitively, The unique language education service model for unique areas of culture has the right to pursue R & D jointly with Korea and China. In this study, we applied the developed "Korean language education service platform for Chinese people based on e-learning" to improve the acceptance of AR/VR contents and applied AR/VR technology to video-based language education contents. And to present a new paradigm of language education. Contents development is to develop AR-based vocabulary learning services, develop experiential learning contents for VR-based step-by-step situations, and gradually develop contents to enable beginner / intermediate / advanced language education services. The service platform enables management of learning management and learning contents, and complies with metadata attributes to complete a platform capable of accommodating large capacity AR/VR contents. In the future, systematic research will be carried out in order to develop as a portal for educational services through development of various contents using mixed reality technology.

The Distribution of Responsibility and Authority upon Public Record Appraisal : Focused on 'Citizen Participation Appraisal' (공공기록 평가의 책임과 권한의 분배 '시민참여 평가'를 중심으로)

  • Lee, Kyong Rae
    • The Korean Journal of Archival Studies
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    • 제60호
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    • pp.49-88
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    • 2019
  • Today, the civil society plays a key role not only in criticizing and monitoring the functions of the state and the market, but also as an active producer of public services by complementing the government and the public sector. Public records management is also becoming more and more popular. In the case of appraisal and selection, which is the core area of record management, discussions about citizen participation are becoming more serious than any other areas. The concept of 'proactive appraisal', which has emerged as a paradigm of citizens' participation in appraisal, reminds us that citizens themselves are the subjects of public records and are no longer alienated from the appraisal system. The problem is, while the growth of the Korean civil society about institutional participation is spreading rapidly, but citizen participation is hard to find in the field of public records. The purpose of this paper is to examine the role of citizen participation in the process of appraisal of public records, and to debunk the role of citizen participation in the appraisal processes by exploring the examples in the UK, Canada, and Australia. This paper emphasizes that the appraisal system of the national public records in crisis today could be largely restored through the domestic application of this active citizen participation cases. First of all, this study presents a conceptual appraisal model that could reflect citizen participation in the field of record management along with the analyses of the advanced cases in some western countries. Specifically, this paper focuses on presenting the models of 'appraisal documentation' and 'governance-based appraisal', reflecting the active citizen participation. This study suggests that these citizens' participatory evaluation models should be settled in Korea in the future and we should urgently discuss 'citizen participation appraisal'.

Analysis of Ka Band Satellite Link Budgets and Earth Station G/T in Korea Rainfall Environment (국내 강우 환경에서 Ka 밴드 위성 링크 버짓 및 지구국 G/T 분석)

  • Choi, Hyeong-Jae;You, Kyoung-A;Park, Dae-Kil;Koo, Kyung Heon
    • Journal of Advanced Navigation Technology
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    • 제23권2호
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    • pp.151-157
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    • 2019
  • In geostationary satellite communications, which are widely used for broadcasting and communication, there is a path loss where the signal power on the path is largely reduced. It is important to consider rain attenuation when calculating link budget because the Ka band frequency is vulnerable to rain attenuation. In this study, rainfall trends were analyzed by using rainfall data from the year 2000 in four regions of Korea (Seoul, Incheon, Busan, Jeju) and the rainfall attenuation was calculated. This was used to analyse the satellite link budget and receiving performance for the down-link of the korea satellite COMS. In this study, the calculated G/T for the rainfall intensity of 0.5% per year using the rainfall data for 18 years increased by approximately $8.5dBK^{-1}$ compared to the ITU's zone-K rain model, and decreased by approximately $1dBK^{-1}$ compared to the precipitation data for 13 years from the TTA(Korea Telecommunications Technology Association). The results of this study can be used for the design of G/T in domestic-installed satellite ground station.

Rheological Properties of Cement Paste Mixed with Aqueously Dispersed Single-Walled Carbon Nanotubes (Single-Walled 탄소나노튜브 수용액 혼입 시멘트 페이스트의 유변학적 특성)

  • Kim, Ji-Hyun;Chung, Chul-Woo
    • Journal of the Korea Institute of Building Construction
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    • 제19권2호
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    • pp.113-121
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    • 2019
  • Single walled carbon nanotube (SWCNT) has been used as a material for reinforcing various advanced materials because it has superior mechanical properties. However, pure SWCNT that does not have any functional group has a hydrophobic character, and exists as bundles due to the strong Van der Waals attraction between each SWCNT. Due to these reasons, it is very difficult to disperse SWCNTs in the water. In this work, in order to use SWCNT for production of cementitious composites, SWCNT was first dispersed in water to make an aqueous solution. Sodium deoxycholate (DOC) and Sodium dodecyl sulfate (SDS) were chosen as surfactants, and the dosage of DOC and SDS were 2wt% and 1wt%, respectively. Sonication and ultracentrifugation were applied to separate each SWCNT and impurities. Using such processed SWCNT solutions, cement paste was prepared and its shear stress vs. strain rate relationship was studied. The yield stress and plastic viscosity of cement paste were obtained using Bingham model. According to the results in this work, cement pastes made with DOC and SDS showed similar rheological behavior to that of air entrained cement paste. While cement paste made with DOC 2 wt.% SWCNT solution showed similar rheological behavior to that of plain cement paste, cement paste made with SDS 1 wt.% SWCNT solution showed different rheological behavior showing much less yield stress than plain cement paste.