• 약학회지
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• 제43권4호
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• pp.447-457
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• 1999

The purpose of this study is to prepare the adhesive type patch containing flurbiprofen, and to demonstrate the feasibility of flurbiprofen administration through the intact skin using adhesive type patch preparation. For this purpose, two pressure sensitive adhesives, Polyisobutylene(PIB) and $Gelva^{\circledR}737$, were selected from the chemical grade of polymers, and the adhesive type patches of flurbiprofen were prepared. The release rate of flurbiprofen from the PIB-based adhesive patch was higher than that from $Gelva^{\circledR}737$ based adhesive patch. The release rate of flurbiprofen from the PIB-based A-type patch with 1.0mm, 1.5mm or 2.0mm thicknesses followed the first order kinetics. In the skin permeation study, using male hairless mouse skin, a monophasic skin permeation profile was observed with 1% flurbiprofen loading dose. The inclusion of palmitic acid or SLS(0.25~0.5%) as an enhancer produced a remarkable enhancement in the skin permeation rate of flurbiprofen, and the percentile ratio of drug and enhancer appeared to be important for the effective enhancement. In the in vivo percutaneous absorption study, the plasma concentration of the optimal formulation was significantly (p<0.01) higher than that of the conventional cataplasma ($Bifen^{\circledR}$). These studies demonstrate a good feasibility of flurbiprofen administration through the intact skin using a transdermal patch, and show a possibility of the development of flurbiprofen patches.

• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.343-348
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• 1999

The purpose of this study is to prepare the controlled release adhesive patch containing naproxen. Pressuresensitive adhesive (PSA)-type patch was fabricated by casting of polyisobutylene (PIE.) and mineral oil in toluene. Membrane-controlled release (MCR)-type patch was prepared by the attachment of the controlled release membrane on the PSAtype patch. The membrane was mainly composed of Eudragit, polyethylene glycol(PEG) and glycerin. The drug release profile and skin permeation test with various patches were evaluated in vitro. The release of naproxen from PIE-based PSAtype patch with various loading doses fitted Higuchi's diffusion equation. However, the permeation of naproxen through hairless mouse skin from PSA-type patch followed zero-order kinetics. In MCR-type patch, thickness of controlled release membrane affected on the drug release rate highly. In the composition of membrane, the release rate was decreased as the ratio of Eudragit increased. The drug release from the MCR-type patch followed zero order kinetics. The permeation of naproxen through hairless mouse skin from MCR-type patch showed lag time for the intial release period and didn't fit the zero-order kinetics

• 대한의용생체공학회:의공학회지
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• 제35권6호
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• pp.203-210
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• 2014

Wearable medical device has been a resurgence of interest thanks to the development of technology and propagation of smart phone in recent years. Various types of wearable devices have been introduced and available in market. Capacitive coupled electrode which measures electrocardiogram over cloth is able to be applied wearable device. In previous approaches of capacitive electrode, they need proper pressure for stable contact of the electrode to body surface. However, wearable device that gives pressure on body surface is not suitable for long-term monitoring. In this study, we proposed adhesive polyurethane-based capacitive electrode for patch-type wearable electrocardiogram (ECG) monitoring device. Self-adhesive polyurethane make the electrode and whole system be adhered to the surface of skin without any pressure. The patch-type system is consisted of analog filter, analog-to-digital converter and wireless transmission module and designed to be attached on the body as a patch. To validate the feasibility of the developed system, we measured ECG signal in stable and active state and extracted heart rate. Therefore, we observed skin response after long-term attachment for biocompatibility of the adhesive polyurethane and adhesive strength of it. The result shows the possibility of applying the developed system for ECG monitoring in real-life.

• Fashion, Industry and Education
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• 제14권2호
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• pp.1-10
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• 2016

In the present study, the materials, sizes, and designs of blind eye patch products of skin-adhesive type and glass-attachment type currently available in the market will be analyzed and ergonomically appropriate blind eye patches will be developed. Although these skin-adhesive type eye patches were easy to use, they had shortcomings such as skin troubles due to the adhesive used on the weak and sensitive skin of children and the fact that eyebrows are pulled out and the skin is irritated when the eye patches are detached after being attached. The non-adhesive type eye patches were blind patches to be worn by putting into glasses. These products were made using diverse materials such as neoprene, non-woven fabrics, and felt and showed differences in tactile impressions and irritation to the skin depending on material characteristics. In addition, most products were efficient in blocking light with three-dimensional oval designs comprising darts. In the present study, blind eye patches were designed to reduce skin troubles by using sweat-absorbing and quick-drying functional materials with soft tactile impressions. In addition, to increase the effect to block light and the degree of tight contact with the skin when the blind eye patches are worn compared to existing eye patch designs, the sides of the wings of the blind eye patches were widened, glass frame fixing plates were added, and the darts were made to be curved thereby making an ergonomic design reflecting the shape of the face. The non-adhesive type blind eye patches developed in the present study are considered to enhance the wearing sensation with the use of the material without skin irritation but with cushioning feelings and the ergonomic design reflecting the contour of the face.

• 한국해양공학회지
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• 제22권3호
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• pp.89-95
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• 2008

Fatigue cracked components often needs to be repaired during service. Standard repair schemes involve strengthening the component by connecting reinforcing members by means of rivets or welding by reducing the crack-tip stress intensity factors. Recent technological advances in fiber reinforced composite materials and adhesive bonding have led to the development of efficient repair schemes. In this study, the influence of various shape parameters on fatigue crack growth in the CCT type uniform thickness plates and the thin-ta-thick type stiffened panels repaired with woven fabric type Kevlar-Epoxy composite patch are studied experimentally.

• 대한기계학회논문집A
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• 제25권12호
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• pp.2070-2077
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• 2001

An experimental investigation of the effect of composite patching repair was conducted to characterize the fatigue crack growth behavior in thick A16061-T6 (6mm) panels with single bonded patch by fiber reinforced composite patch. Four patch lengths and no patch plate were examined. An analytical procedure, involving three-dimensional finite element method having three layers to model cracked aluminum plate, epoxy by adhesive and composite Patch, is calculated the stress intensity factors. From the calculated stress intensity factors, the fatigue crack growth rates are obtained. At the single patching type, different fatigue crack growth ratios through the palate thickness were investigated by using the experimental and analytical results. The results demonstrated that there was a definite variation in fatigue life depending on the size of composite patch. While crack reached the patch end, retardation of crack growth was also revealed in the bonded repair.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.292-298
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• 2001

An experimental investigation of the effect of composite patching repair was conducted to characterize the fatigue crack growth behavior in thick A16061-T6 (6mm) panels with single bonded patch by fiber reinforced composite patch. Four patch lengths and no patch plate were examined. An analytical procedure, involving three-dimensional finite element method having three layers to model cracked aluminum plate, epoxy by adhesive and composite patch, is calculated the stress intensity factors. From the calculated stress intensity factors, the fatigue crack growth rates are obtained. At the single patching type, different fatigue crack growth ratios through the plate thickness were investigated by using the experimental and analytical results. The results demonstrated that there was a definite variation in fatigue life depending on the size of composite patch. While crack reached the patch end, retardation of crack growth was also revealed in the bonded repair.

• Journal of Pharmaceutical Investigation
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• 제25권4호
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• pp.339-345
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• 1995

For the effective treatment of aphthous stomatitis, the matrix type mucoadhesive patches containing triamcinolone acetonide have been formulated. The drug layer was obtained by drying the polymer gel which was prepared with carbomer 934P, ammoniomethacrylate copolymer, titanium dioxide and polyethylene glycol 400. The effects of the content of additives on physical characteristics of the polymer gel and the drug layer were evaluated. The addition of carbomer increased the yield point and the zero-shear viscosity of polymer gel as well as the thickness, the water absorption ratio, the adhesive time and $T_{50%}$ of drug layer. The adhesive time and the water absorption ratio of drug layer were also improved by the addition of ammoniomethacrylate copolymer, but the addition of titanium dioxide had decreased the zero-shear viscosity of polymer gel and the adhesive time of drug layer.

• 대한토목학회논문집
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• 제32권6A호
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• pp.411-418
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• 2012

이 연구에서는 수치해석 실험을 통하여, 원주방향 관통균열을 갖는 원통형 쉘의 패치보강 전후의 거동에 대한 평가와 다양한 변수에 따른 패치보강 효과를 분석하였다. 해석 모델의 신뢰성을 높이기 위해, h-법 및 p-법에 기초한 모델링, 두 가지 방법이 동시에 고려되었다. 또한 선형탄성파괴역학 개념에 기초하여 에너지 방출률을 산정하기 위해, 등가영역적분법 및 가상균열확장법이 고려되었다. 해석 예제로서, 먼저 연구에서 수행된 h-법 및 p-법 유한요소 모델을 검증하기 위해, 패치 보강전의 인장력을 받는 관통 균열이 있는 쉘 구조물이 해석되었으며, 해석 결과값들과 여러 참고문헌 값들이 비교되었다. 그리고 패치 보강된 원통형 쉘 시스템에서의 접착제 두께, 접착제 전단탄성계수, 패치 두께, 패치 재료, 균열 길이 등의 여러 설계 변수에 대한 민감도 해석이 수행되었다.

• 한국전산구조공학회논문집
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• 제23권2호
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• pp.191-198
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• 2010

이 연구에서는 접착패치보강의 서로 다른 형태 즉, 패치와 접착제의 재료, 크기, 두께 뿐만 아니라 일면보강 또는 양면보강에 따른 일변균열판의 응력감소에 대한 연구가 수행되었다. 수치해석 도구로는 p-수렴 부분층별 모델이 사용되었다. 이 모델의 면내 변위는 구간별 연속인 선형변화로 가정하였고, 두께방향으로의 면외 변위는 일정한 상수로 가정하여 적용하였다. 변위장의 정의는 적분형 르장드르 다항식을 적용하였고, 수치적분은 별도의 외삽법 없이 각 층별의 절점에서 발생하는 적분값을 바로 얻을 수 있는 가우스-로바토 적분법을 사용 하였다. 또, 에너지 방출률법을 사용하여 응력확대계수를 산출하였다. 수치예제를 통해 제안된 모델의 정확도는 물론이고 접착패치 보강형태에 따라 변화되는 무차원 응력확대계수와 처짐의 항으로 응력감소 효과를 분석하였다.