• Title/Summary/Keyword: Adenophora triphylla

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A Study on a Morphological Identification of Adenophora triphylla var. japonica, Codonopsis lanceolata, Adenophora remotiflora and Codonopsis pilosula (사삼(沙參), 양유근(羊乳根), 제니 및 당삼(黨參)의 형태(形態) 감별에 관한 연구)

  • Kim, Joo-Young;Lee, Young-Jong
    • The Korea Journal of Herbology
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    • v.22 no.2
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    • pp.121-126
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    • 2007
  • Objectives : A morphological classification among Adenophora triphylla var. japonica, Codonopsis lanceolata, Adenophora remotiflora and Codonopsis pilosula was made through microscopic observation. Method : The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olymphus-BHT. Result : 1. Codonopsis pilosula is like a long cone, with amole-like projected parts at the beginning of the roots. 2. Adenophora triphylla var. japonica, Codonopsis lanceolata, Adenophora remotiflora, and Codonopsis pilosula are all similar as following: 1) Cork layers are composed of a few to over 10 subsidiary cells, with individual or a group of stone cells among them. 2) Phloem is wide and has a milk tube. Conclusion : Adenophora triphylla var. japonica, Codonopsis lanceolata, Adenophora remotiflora, and Codonopsis pilosula are all similar and difficult to be distinguished through microscopic observation, so that chemical experiments should be conducted for their identification.

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Effects of Adenophora triphylla var. japonica Extract on Cognitive Function in Ovariectomized Mice (난소절제 마우스에서 잔대 추출물의 인지능 개선 효과)

  • Jang, Hwan Hee;Kim, Haeng Ran;Lee, Young Min
    • Journal of the East Asian Society of Dietary Life
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    • v.27 no.4
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    • pp.442-449
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    • 2017
  • Adenophora triphylla var. japonica extract has been reported to have estrogenic activity and beneficial effects in postmenopausal women requiring estrogen replacement therapy. This study investigated the effects of A. triphylla extract on cognitive function in ovariectomized mice. Water extracts from A. triphylla were administrated to ovariectomized mice fed a high fat diet for 6 weeks. The step through latency time in the passive avoidance test was shortened in ovariectomized mice as compared with sham-operated mice. However, administration of A. triphylla extracts had a tendency to prolong the latency time in ovariectomized mice. Moreover, A. triphylla supplementation caused a significant decrease in mean escape latency in the water maze test. These results indicate that A. triphylla could be used to improve estrogen deficiency-related learning and memory impairments in postmenopausal women.

Antioxidant and anticancer activities of Adenophora triphylla leaf and root extracts (새싹 잔대 잎과 뿌리의 항산화 및 항암 효과)

  • Seon Young Yoon;Ki Hyun Kim;Tae Kyung Hyun
    • Journal of Plant Biotechnology
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    • v.50
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    • pp.137-141
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    • 2023
  • The root of Adenophora triphylla is a highly valued medicinal resource that is used to prevent human obesity, cancer, and inflammation, whereas young leaves or sprouts of A. triphylla are used as food ingredients. In this study, we compared the antioxidant and anticancer activities of 70% ethanol extracts of A. triphylla roots and leaves. The leaf extract exhibited stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity, reducing power, and oxygen radical absorbance capacity (ORAC) than the root extract. Furthermore, the leaf extract was observed to be a potent source of anticancer compounds that were effective against A549 (lung cancer), LNcaP (prostate cancer), SKOV3 (ovarian cancer), and Caco-2 (colorectal cancer) cells. These results indicate that not only the roots but also the leaves of A. triphylla can serve as valuable sources of functional materials in the pharmaceutical industry.

Effects of Lupenone, Lupeol, and Taraxerol Derived from Adenophora triphylla on the Gene Expression and Production of Airway MUC5AC Mucin

  • Yoon, Yong Pill;Lee, Hyun Jae;Lee, Dong-Ung;Lee, Sang Kook;Hong, Jang-Hee;Lee, Choong Jae
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.3
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    • pp.210-217
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    • 2015
  • Background: Adenophora triphylla var. japonica is empirically used for controlling airway inflammatory diseases in folk medicine. We evaluated the gene expression and production of mucin from airway epithelial cells in response to lupenone, lupeol and taraxerol derived from Adenophora triphylla var. japonica. Methods: Confluent NCI-H292 cells were pretreated with lupenone, lupeol or taraxerol for 30 minutes and then stimulated with tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$) for 24 hours. The MUC5AC mucin gene expression and production were measured by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Additionally, we examined whether lupenone, lupeol or taraxerol affects MUC5AC mucin production induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA), the other 2 stimulators of airway mucin production. Results: Lupenone, lupeol, and taraxerol inhibited the gene expression and production of MUC5AC mucin induced by TNF-${\alpha}$ from NCI-H292 cells, respectively. The 3 compounds inhibited the EGF or PMA-induced production of MUC5AC mucin in NCI-H292 cells. Conclusion: These results indicated that lupenone, lupeol and taraxerol derived from Adenophora triphylla var. japonica regulates the production and gene expression of mucin, by directly acting on airway epithelial cells. In addition, the results partly explain the mechanism of of Adenophora triphylla var. japonica as a traditional remedy for diverse inflammatory pulmonary diseases.

The research for the utilization of useful microorganism for the culture of harmless medicinal herbs (Adenophora triphylla, Codonopsis pilosula) (안전한 한약재(잔대, 만삼) 재배를 위한 유용미생물 이용에 관한 연구)

  • Kim, Jae-Keun
    • Journal of environmental and Sanitary engineering
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    • v.21 no.2 s.60
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    • pp.1-10
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    • 2006
  • Codonopsis pilosula and Adenophora triphylla were cultivated by sawing seeds, but the germination rate were low. To cultivate these two wild plants was very difficult. The marketable roots of the plants had low quality. The plant pathogens were very difficulty to prevent the diseases (Rhizoctonia, Pythium, Fusarium, Erwinia, Botrytis, Phythophthora) appeared in cultural state. For the extermination of the disease needs a lot of agricultural chemicals, the effect of remain behind an insecticides was high of a hazardous rate after harvest. On this studies, for the safe prevention of the diseases and the promote of seeds germination, we used Bacillus subtilis, B. liquefaciens, Paenibacillus polymixa, Pseudomonas putida separated in our research, these results would bring us harmless products of medicinal herbs for human.

Effect of Temperature on Seed Germination and Seedling Growth in Medicinal Plants of Campanulaceae

  • Choi, Seong-Kyu
    • Plant Resources
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    • v.6 no.2
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    • pp.94-97
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    • 2003
  • The objective of this study is to investigate morphological characteristics of seeds and effects of environmental factors such as light and temperature on the germination and seedling growth of Adenophora triphylla var. japonica, Codonopsis lanceolata, Platycodon glandiflorum, Which belongs to Campanulaceae and useful for on oriental medicine materials. Seed shape of Codonopsis lanceolata is Elliptic. Platycodon glandiflorum is Oblong. Color of seed coats varied from yellow to dark brown. Seed size of Adenophora triphylla var. japonica is 1.37mm in length, 0.69mm in width. One thousand-seed weight of Adenophora triphylla var. japonica is 258mg. Seed size of Codonopsis lanceolata is 4.45mm in length, 2.11mm in width. One thousand-seed weight of Codonopsis lanoceolata is 1,278mg. Seed size of Platycodon glandiflorum is 2.31mm in length, 1.10mm in width. One thousand-seed weight of Platycodon glandiflorum is 988mg. Optimum temperatures for seed germination and seedling growth range from 20 to $25^{\circ}C$.

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Effect of Pelleting Treatment on Seed Germination in Adenophora triphylla (잔대 종자 펠렛처리가 종자 발아에 미치는 영향)

  • Im, Dong Hyeon;Nam, Joo Hee;Kim, Jong Hyuk;Lee, Min Ju;Rho, Il Rae
    • Korean Journal of Medicinal Crop Science
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    • v.28 no.2
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    • pp.128-135
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    • 2020
  • Background: Sowing seeds of Adenophora triphylla is known to be difficult owing to their small size and irregular seed shape. Therefore, this study was conducted to develop a seed pelleting technique to save labor during sowing. Methods and Results: To identify the optimal germination temperature for A. triphylla seeds, the temperature range was set from 17℃ to 32℃. Germination surveys were conducted in plastic greenhouse conditions in March, April, and May to determine the appropriate sowing time. The optimal germination temperature for A. triphylla seeds was 29℃ and May was the optimal sowing time in plastic greenhouse conditions. Covering materials for seed pelleting used talc (T), kaolin (K), calcium carbonate (C), and vermiculite (V). The pellet binder used agar (A), pectin, xanthan gum, polyvinyl alcohol (PVA), and sodium alginate (S). The best suited treatment mixture were the best suited in kaolin / calcium carbonate / vermiculite (KCV), talc / calcium carbonate / vermiculite (TCV) mixture treatment for covering material, and sodium alginate (S), agar (A) as pellet binder, respectively. The germination rate was the best in TCV mixed with S. Conclusion: The mixture of TCV (2 : 1 : 3) + 1.5% S (TCVS), was found to be the best pelleting materials for A. triphylla seeds, and seed pelleting can be labor-saving during sowing.

Anti-Inflammatory and Anti-Allergic Effects of Adenophora triphylla var. japonica Extract (잔대 추출물의 항염 및 항천식 효과)

  • Jang, Hwan Hee;Kim, Mi Ju;Cho, Su Yeon;Kim, Jung Bong;Lee, Sung Hyeon;Lee, Young Min
    • Journal of the East Asian Society of Dietary Life
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    • v.25 no.5
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    • pp.813-821
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    • 2015
  • Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The purpose of the present study was to evaluate the anti-inflammatory and anti-asthma effects of Adenophora triphylla var. japonica extracts. We investigated the molecular mechanism underlying the effects of 80% ethanol extracts (AE) of A. triphylla on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. AE treatment inhibited pro-inflammatory cytokines such as TNF-${\alpha}$ and IL-6 as well as nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. In particular, NO and pro-inflammatory cytokine production was suppressed more effectively by aerial parts (AE-A) than roots (AE-R) of A. triphylla. Quantitative RT-PCR assay showed that AE reduced mRNA levels of iNOS and COX-2. We also evaluated the anti-asthmatic effects of AE-A in an ovalbumin (OVA)-induced BALB/c mouse model. AE-A supplementation significantly reduced the amounts of airway eosinophils, IL-4 and IL-13 levels in BALF, and IgE levels in serum as compared with untreated, OVA-induced mice. These results suggest that AE-A can be considered as a therapeutic agent to potentially relieve asthma.