Journal of Plant Biotechnology

  • Volume 50
  • /
  • Pages.137-141
  • /
  • 2023
  • /
  • 1229-2818(pISSN)
  • /
  • 2384-1397(eISSN)
The Korean Society of Plant Biotechnology (한국식물생명공학회)
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Antioxidant and anticancer activities of Adenophora triphylla leaf and root extracts

새싹 잔대 잎과 뿌리의 항산화 및 항암 효과

  • Seon Young Yoon (Department of Industrial Plant Science and Technology, Chungbuk National University) ;
  • Ki Hyun Kim (Chungbuk Agricultural Research and Extension Services) ;
  • Tae Kyung Hyun (Department of Industrial Plant Science and Technology, Chungbuk National University)
  • 윤선영 (충북대학교 농업생명환경대학 특용식물학과) ;
  • 김기현 (충청북도농업기술원) ;
  • 현태경 (충북대학교 농업생명환경대학 특용식물학과)
  • Received : 2023.06.23
  • Accepted : 2023.06.27
  • Published : 2023.07.11
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Abstract

The root of Adenophora triphylla is a highly valued medicinal resource that is used to prevent human obesity, cancer, and inflammation, whereas young leaves or sprouts of A. triphylla are used as food ingredients. In this study, we compared the antioxidant and anticancer activities of 70% ethanol extracts of A. triphylla roots and leaves. The leaf extract exhibited stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity, reducing power, and oxygen radical absorbance capacity (ORAC) than the root extract. Furthermore, the leaf extract was observed to be a potent source of anticancer compounds that were effective against A549 (lung cancer), LNcaP (prostate cancer), SKOV3 (ovarian cancer), and Caco-2 (colorectal cancer) cells. These results indicate that not only the roots but also the leaves of A. triphylla can serve as valuable sources of functional materials in the pharmaceutical industry.

잔대(Adenophora triphylla var. japonica)의 뿌리는 비만, 암, 염증을 예방하는 데 사용되는 귀중한 약용 자원으로 사용되지만, 어린잎이나 순은 식재료로 사용되고 있다. 본 연구에서는 A. triphylla 뿌리와 잎에서 얻은 70% 에탄올 추출물의 항산화 및 항암 효과를 비교 평가하였다. 잎 추출물이 뿌리 추출물보다 강력한 DPPH-radical 소거 활성, 환원력 및 ORAC 값을 나타냈다. 또한, 인체 암세포주에서 잔대 추출물의 세포독성 사멸 효과를 조사한 결과, 잎 추출물이 A549 (폐암), LNcaP (전립선암), SKOV3 (난소암) 및 Caco-2 (대장암) 세포에서 강력한 항암 성분의 공급원임을 보여주었다. 이러한 결과는 뿌리뿐만 아니라 잎도 제약 산업에서 기능성 소재의 귀중한 공급원이 될 수 있음을 시사한다.

Keywords

Acknowledgement

본 연구는 농촌진흥청 공동연구사업(과제번호: PJ01704506)의 지원에 의해 이루어진 것임.

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