• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.4
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• pp.130-145
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• 2010

Purpose: The purpose of this study is to know stress and blood stasis pattern for the patients who had hysterectomy related with uterine myoma, adenomyosis, endometriosis. Methods: We got questionnaires from 55 patients among 243 patients who had hysterectomy related with uterine myoma, adenomyosis, endometriosis in the department of obstetrics and gynecology, OO medical center from April 11th 2010 to October 14th 2010, and analyzed them. We conducted correlation analysis between age, pain(VAS), duration of pain and blood stasis score, and between duration of pain, blood stasis score and the sum of Stress Response Index. We compared the sum of Stress Response Index, blood stasis score, VAS according to the result of pathology. For statistics, we used Pearson's correlation coefficient, Mann-Whitney test, oneway analysis of variances(ANOVA) and SPSS version 17.0 for windows. Results: The correlation between duration of pain and blood stasis score showed statistical significance. The correlation between sum of the Stress Response Index and blood stasis score showed statistical significance. There is no statistically correlation between age, VAS, duration of the pain and blood stasis score. There is no statistically significant difference in sum of Stress Response Index, blood stasis score, VAS according to the result of pathology. Conclusion: The result showed that Stress is related with static blood, and the longer patients suffer from pain, the easier patients' blood to be static. Further study will be needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.1
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• pp.132-143
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• 2011

Objectives: The purpose of this study is to know the correlation of transvaginal sonography findings, CA-125 and blood stasis pattern for 15 adenomyosis patients. Methods: We got questionnaires from 15 patients among 243 patients who had hysterectomy related with adenomyosis in the department of obstetrics and gynecology, OO medical center from April 11th 2010 to November 15th 2010, and analyzed them. We conducted correlation analysis between age, pain(VAS), duration of pain and blood stasis score, and between difference and sum of uterine walls, CA-125 and blood stasis score. For statistics, we used Spearman correlation coefficient and SPSS version 17.0 for windows. Results: The correlation between sum of uterine walls and CA-125 showed statistical significance. The correlation between CA-125 and blood stasis score showed statistical significance. There is no statistically correlation between age, VAS, duration of the pain and blood stasis score. There is no statistically correlation between difference of uterine walls and CA-125, and between difference and sum of uterine walls and blood stasis score. Conclusion: The result showed that sum of uterine walls is related with CA-125. We need a further study to develop blood stasis indicators with a validated questionnaire, and more subjects involved at multiple institutions.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.3
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• pp.181-184
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• 2016

The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B-C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.3
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• pp.168-174
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• 2014

Objectives: The purpose of this study is to report the effect of Gobonjibung-tang on menorrhagia diagnosed as Qi deficiency. Methods: The patients had menorrhagia caused by adenomyosis and multiple uterus myoma. We diagnosed them as Qi deficiency and treated with Gobonjibung-tang for two weeks from a week before the menstruation. And during the rest period they were treated with Bojungikgi-tang or Ikgibohyeol-tang. After three menstrual cycles, we observed whether the amount of menstruation keep reduced for two menstrual cycles. Results: Amount of menstruation were reduced during three menstrual cycles with taking herbal medicine and two menstrual cycles without taking herbal medicine. As a result of contacting with patients 4~6 months after treatment, the amount of menstruation was maintained at a reduced state. Conclusions: Gobonjibung-tang is effective in patients with menorrhagia diagnosed as Qi deficiency and the effect is continuous.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.111-122
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• 2007

Purpose: The purpose of this study is to make clear the difference of the mental state between formal menstruation group and menorragia group. Methods: The patients suffering from uterine myoma or adenomyosis answered about menstruation and did a blood test and MMPI. They were analyzed by Mann-Whitney U-test. Results: The D scale of complain of a menorrhagia group is higher than normal menstruation group. (p<0.05) According to blood test, The F scale of anemia group is higher than normal group.(p<0.05) The D scale of menorrhagia with anemia group is higher than normal menstruation without anemia group. (p<0.05) The MMPI score of complain of a menorrhagia group, anemia group, and menorrhagia with anemia group showed 1-2 profile type. The MMPI score of normal menstruation group, normal result of the blood test group, and menorrhagia with anemia group showed 1-3 profile type. Conclusion: regardless of the rxistence of anemia, the group with menorrhagia tends to show a state of depression than the control group.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.3
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• pp.78-90
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• 2016

Objectives: The purpose of these cases is to report the effects of Korean medicine on two women with recurrent miscarriage.Methods: One women who had recurrent miscarriage with myoma uteri was 39 years old. She was treated with herbal medicine and acupuncture until intrauterine pregnancy (IUP) 14 wks. the other who had recurrent miscarriage with adenomyosis was 40 years old. she was also treated with these until IUP 11 wks.Results: After treatment, one women delivered successfully by normal full term spontaneous delivery. The other succeeded in normal pregnancy and she is 15 weeks pregnant.Conclusions: Two cases show that Korean Medicine has effects on recurrent miscarriage with old age and underlying diseases.

• The Journal of Korean Medicine
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• v.34 no.2
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• pp.29-40
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• 2013

Objectives: To investigate therapeutic mechanisms of Gyejibokryeong-hwan (GJBRH) against gynaecological diseases, articles on biological assay were gathered and analyzed. Methods: The articles were classified as being from domestic or international journals, and by their year of publication. The mechanisms of the biological effects against gynaecological diseases were noted. Results: Of the 14 articles analyzed, 13 were published in China and 1 was from Japan. GJBRH showed therapeutic effect against uterine and mammary gland diseases. Uterine-related diseases such as endometriosis, hysteromyoma, adenomyosis, cancer, and inflammation can be improved by the administration of GJBRH through anti-angiogenesis, anti-inflammation, the modulation of immune cell and immunoglobulin, and the regulation of hormone secretion. GJBRH also reduced mammary hyperplasia by regulating hormone and cytokine release. Conclusions: We speculate that the inhibitory effect against uterine and mammary gland diseases could be related to the therapeutic efficacy of GJBRH in improving gynaecological diseases.

• Advances in Traditional Medicine
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• v.6 no.1
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• pp.1-11
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• 2006

Herbal medicines are widely used for centuries to treat illness and improve health in Asia and the use of these remedies has become a worldwide form of alternative therapy. However, there is very limited evidence from randomized controlled trials to support the efficacy of the vast majority of herbal products. Of the commonly used herbal medicines, systemic clinical experiences and promising experiments in animals have found potential evidence of efficacy for six herbal medicines (Unkei-to, Hachimijio-gan, Keishi-bukuryo-gan, Toki-shakuyaku-san, Shakuyaku-kanzo-to, Sairei-to) in the treatment for female reproductive dysfunction. Because herbs may contain potent bioactive substances, the physician should have an opportunity to outline more stringent regulation, similar to over-the counter drug.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5423-5425
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• 2014

Purpose: To evaluate the risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. Materials and Methods: A total of 203 patients undergoing endometrial sampling before hysterectomy were evaluated in this retrospective study. Data recorded were age, gravidity, parity, body mass index (BMI: weight(kg)/$height(m)^2$), endometrial thickness (ET), menopausal status, presence of adenomyosis and diabetes mellitus. Results: Endometrial hyperplasia and polyps were detected in 13 patients. There were statistically significant differences in terms of age, menopausal status, morbid obesity and diabetes mellitus (p<0.005). Logistic regression demonstrated that menopausal status and presence of diabetes mellitus were independent risk factors. Conclusions: According to the current study; menopause and diabetes mellitus are strong risk factors for the presence of concomitant endometrial polyps and endometrial hyperplasia.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.128-137
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• 2015

Objectives: Spontaneous pregnancy is a rare event after repeated failure of in vitro fertilization (IVF) or Intrauterine insemination (IUI) treatment. So this paper is to report the natural pregnancy of Gamiseogagjihwang-tang treatments on two infertile patients who were repeatedly failed in IVF or IUI. Methods: One patient was a 35-year-old patient diagnosed with the adenomyosis and contralateral tubal obstruction, treated with 90 cc Gamiseogagjihwang-tang two times per day for 6 weeks after second failure of IVF. The other patient was a 34-year-old patient undergone induced abortion by three times, treated with 90 cc Gamiseogagjihwang-tang two times per day for 4 weeks after second failure of IUI. Results: Through taking Gamiseogagjihwang-tang without assisted reproduction techniques, two cases got pregnant naturally. Conclusions: These cases suggest that Gamiseogagjihwang-tang is effective in treating infertile female after failure in IVF or IUI and inducing spontaneous pregnancy. Therefore, there needs to be more trial on infertile patients treated with Seogagjihwang-tang.