Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지
DOI QR코드

DOI QR Code

Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos

  • Safari, Somayyeh (Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences) ;
  • Faramarzi, Azita (Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences) ;
  • Agha-Rahimi, Azam (Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences) ;
  • Khalili, Mohammad Ali (Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences)
  • Received : 2016.05.07
  • Accepted : 2016.06.16
  • Published : 2016.09.22
Download PDF
⟨ Previous Next ⟩

Abstract

The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B-C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.

Keywords

References

  1. Das M, Holzer HE. Recurrent implantation failure: gamete and embryo factors. Fertil Steril 2012;97:1021-7. https://doi.org/10.1016/j.fertnstert.2012.02.029
  2. Timeva T, Shterev A, Kyurkchiev S. Recurrent implantation failure: the role of the endometrium. J Reprod Infertil 2014;15:173-83.
  3. Tremellen K, Russell P. Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment. Aust N Z J Obstet Gynaecol 2011;51:280-3. https://doi.org/10.1111/j.1479-828X.2010.01276.x
  4. Mauri AL, Petersen CG, Oliveira JB, Baruffi RL, Al-Hasani S, Franco JG Jr. Embryos refrozen-thawed by vitrification lead to live births: case report. Middle East Fertil Soc J 2011;16:93-97. https://doi.org/10.1016/j.mefs.2010.09.008
  5. Kumasako Y, Otsu E, Utsunomiya T, Araki Y. The efficacy of the transfer of twice frozen-thawed embryos with the vitrification method. Fertil Steril 2009;91:383-6. https://doi.org/10.1016/j.fertnstert.2007.11.079
  6. Baker A, Check JH, Lurie D, Hourani C, Hoover LM. Pregnancy achieved with pronuclear-stage embryos that were cryopreserved and thawed twice: a case report. J Assist Reprod Genet 1996;13:713-5. https://doi.org/10.1007/BF02066424
  7. Farhat M, Zentner B, Lossos F, Bdolah Y, Holtzer H, Hurwitz A. Successful pregnancy following replacement of embryos previously refrozen at blastocyst stage: case report. Hum Reprod 2001;16:337-9. https://doi.org/10.1093/humrep/16.2.337
  8. Smith LK, Roots EH, Dorsett MJ. Live birth of a normal healthy baby after a frozen embryo transfer with blastocysts that were frozen and thawed twice. Fertil Steril 2005;83:198-200. https://doi.org/10.1016/j.fertnstert.2004.07.953
  9. Takahashi T, Araki Y. Successfully healthy baby delivery from human refrozen blastocyst embryos by vitrification. J Mamm Ova Res 2004;21:162-5. https://doi.org/10.1274/jmor.21.162
  10. Hashimoto S, Murata Y, Kikkawa M, Sonoda M, Oku H, Murata T, et al. Successful delivery after the transfer of twice-vitrified embryos derived from in vitro matured oocytes: a case report. Hum Reprod 2007;22:221-3. https://doi.org/10.1093/humrep/del354
  11. Son WY, Lee SY, Chang MJ, Yoon SH, Chian RC, Lim JH. Pregnancy resulting from transfer of repeat vitrified blastocysts produced by in-vitro matured oocytes in patient with polycystic ovary syndrome. Reprod Biomed Online 2005;10:398-401. https://doi.org/10.1016/S1472-6483(10)61802-0
  12. Healy MW, Patounakis G, Connell MT, Devine K, DeCherney AH, Levy MJ, et al. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril 2016;105:93-9.e1. https://doi.org/10.1016/j.fertnstert.2015.09.015
  13. Murakami M, Egashira A, Murakami K, Araki Y, Kuramoto T. Perinatal outcome of twice-frozen-thawed embryo transfers: a clinical follow-up study. Fertil Steril 2011;95:2648-50. https://doi.org/10.1016/j.fertnstert.2010.12.038
  14. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012;97:1039-43. https://doi.org/10.1016/j.fertnstert.2012.03.010
  15. Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, et al. Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy. Hum Reprod 2010;25:642-53. https://doi.org/10.1093/humrep/dep437
  16. Tremellen KP, Russell P. The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages. J Reprod Immunol 2012;93:58-63. https://doi.org/10.1016/j.jri.2011.12.001

Cited by

  1. Pregnancy and symptomatic relief following ultrasound‐guided transvaginal radiofrequency ablation in patients with adenomyosis vol.46, pp.1, 2016, https://doi.org/10.1111/jog.14145
  2. Successful pregnancy following the transfer of re-vitrified twice-warmed embryos due to the forced cancellation of the primary FET: A case report vol.97, pp.None, 2016, https://doi.org/10.1016/j.cryobiol.2020.08.009