• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.3 s.174
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• pp.645-652
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• 2000

A method for shape design sensitivity analysis is proposed utilizing commercial software ANSYS for thermal conduction problems. While the sensitivity formula is derived analytically by introduing adjoint variable concept, sensitivity calculation in practice as well as the primal and adjoint solution of thermal conduction is performed using the ANSYS very easily. Since the formula always takes boundary integral form, sensitivity evaluation in ANSYS requires a little more addition of post-processing routine which involves evaluation of boundary variable from the obtained solution. Though the BEM has been used as a better tool for this purpose, the present study shows it can also be calculated using any kind of analysis code such as ANSYS since the formula is based on analytic nature. Therefore the present study provides a new and efficient way of optimization which was not possible before using commercial software. The usefulness of the method is illustrated via a weight minimization problem of thermal diffuser.

• The Journal of Korean Physical Therapy
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• v.19 no.1
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• pp.23-31
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• 2007

Purpose: As a preliminary study, the purpose of this study was to examine the indirect estimation of the lumbar intervertebral disc size by two anthropometric methods, in order to compare these indirect methods with the direct analysis by radiological imaging. Methods: The wrist, elbow, knee, and ankle joint (both right and left) diameters were measured in 52 volunteers, and then intervertebral disc size was calculated using two anthropometric methods (Colombini and modified Colombini). The data were analysed with independent t-test to assess clinical usefulness. Results: When using right and left joint diameter, there was no significant difference in the estimation value of the L4-5 and L5-S1 intervetebral disc sizes. However, the study has shown that male subjects have significantly larger L4-5 and L5-S1 intervertebral disc sizes, compared with those of female subjects. In addition, disc sizes calculated by Colombini's formula were significantly larger than modified Colombini's formula. Conclusion: The indirect estimation of the intervertebral disc size by anthropometric method can be considered as a clinically useful method. However, further study should be conducted to compare anthropometric values with other radiological imaging.

• Food Science and Biotechnology
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• v.16 no.4
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• pp.590-593
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• 2007

The textural properties of doughs mixed with L-ascorbic acid (AA), trypsin hydrolyzed gluten peptide (THGP), and a mixture of AA-THGP were investigated using texture analyzer under the fermentation of the full formula and the freezing process. The full formula dough (FFD) required a shorter mixing time than the flour and water formula dough (FWD). The maximum resistance (Rmax) values of both the unfrozen and frozen doughs were lower for the FFD. The effects of AA and THGP additions were not significant (p<0.01) in FFD, however, they were significant in FWD. The freezing effect was significant (p<0.0001) for FFD, indicating that yeast fermented dough was much more sensitive to damage from freezing, which subsequently affected dough strength. Additions of AA (p=0.0026) and THGP (p=0.0097) had a significant effect on the extensibility (E-value) of unfrozen FWD, where THGP increased and AA decreased the E-value. However, freezing did not significantly effect the extensibilities of FWD (p=0.64) or FFD (p=0.21). The area of FFD was lower than the area of FWD for both the unfrozen and frozen doughs. However, the frozen dough mixed with THGP alone had the largest area overall. The addition of additives did not result in significantly different (p<0.01) areas under the curve, except in the frozen FFD. Freezing caused a statistically significant difference in the area of FWD (p=0.0045).

• Toxicological Research
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• v.25 no.4
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• pp.225-230
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• 2009

The genotoxic effects of DHU001, a polyherbal formula were evaluated using the mouse micronucleus test. DHU001 was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2000, 1000 and 500 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control. The appearance of a micronucleus is used as an index for genotoxic potential. In addition, the changes on the total white blood cells and differential counts on the lymphocytes, neutrophils, eosinophils, basophils and monocytes in the prepared blood smears were also conducted to observe the possible immunosuppression. The results indicats that DHU001 showed no genotoxicity effects up to 2000 mg/kg dosing levels and did not influenced on the total white blood cells and differential counts. In addition, it is also considered that there were no problems from cytotoxicity of DHU001 tested in this study because the polychromatic erythrocyte ratio was detected as > 0.41 in all tested groups.

• Toxicological Research
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• v.24 no.3
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• pp.213-218
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• 2008

In this research, the genotoxic effects of Kong-Jin-Dan(KJD), a polyherbal formula were evaluated using the mouse micronucleus test. KJD was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2000, 1000 and 500 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control. The appearance of a micronucleus is used as an index for genotoxic potential. In addition, the changes on the total white blood cells and differential counts on the lymphocytes, neutrophils, eosinophils, basophils and monocytes in the prepared blood smears were also conducted to observe the possible immunosuppress. The results obtained indicated that KJD shows no genotoxicity effects up to 2000 mg/kg dosing levels, but KJD shows slight increased trends in the blood total leukocyte numbers as pharmacological effects of immune stimulation. In addition, it is also considered that there were no problems from cytotoxicity of KJD tested in this study because the polychromatic erythrocyte ratio was detected as > 0.42 in all tested groups.

• Herbal Formula Science
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• v.19 no.2
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• pp.93-108
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• 2011

Objectives : Angelica sinensis has been used extensively in Korean traditional medicine. Although thorough clinical trials are lacking, Various pharmacological actions for Angelica sinensis has been identified newly using animal models. In addition, it was reported that reactive intermediates, potentially causing toxic effects, was isolated from components in Angelica sinensis. In this article, it was purposed for explanation and introduction of new studies for Angelica sinensis. in terms of Pharmacological action and Toxicity. Methods : New studies for Angelica sinensis were reviewed and summarized in terms of pharmacological action and toxicity. Results and Conclusions : Angelica sinensis and its components including phthalide, phthalide dimers, polysaccharides, polyacetylenes, ligustilide와 butylidenephthalide as well as organic acid showed a variety of pharmacological actions on uterine, cardiovascular system and immune system. In addition, it was identified that three components of such as ligustilide, caffeic acid and safrole was biotransformed to reactive intermediates causing possibly toxicity.

• Herbal Formula Science
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• v.19 no.1
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• pp.219-231
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• 2011

Objectives : This study was designed to determine the effects of the GGEx18 ethyl acetate fraction(EF) on body weight gain, feeding efficiency ratio, and obesity-related factors in plasma as well as histology of liver and adipose tissues using high fat diet-fed male C57BL/6N obese mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, EF(1), EF(2) and EF(3). After mice were treated with EF for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also analysed histology of liver and adipose tissues on high fat diet-fed male C57BL/6N obese mice. Results : Compared with control, EF-treated mice had significantly lower body weight gain and feeding efficiency ratio. Consistent with the effects on body weight gain, EF significantly decreased the adipose tissue weight compared with control. Consistent with the effects on feeding efficiency ratio, EF significantly decreased plasma leptin concentrations compared with control. EF reduced the size of adipocytes as well as hepatic lipid accumulation compared with control. EF seems to be safe since not only the plasma levels of ALT and AST are within the normal range, but also EF did not show any toxic effects on organs. EF(3) was most effective among EF(1), EF(2), and EF(3) at doses of 25, 50, and 100 mg/kg, respectively. Conclusions : These results demonstrate that EF effectively reduces body weight gain, feeding efficiency ratio in high fat diet-fed obese mice, leading to the modulation of obesity. In addition, EF decreases the size of adipocytes and improves plasma lipids and controls hepatic lipid accumulation, suggesting that EF may act as a therapeutic agent for obesity.

• Journal of Cadastre & Land InformatiX
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• v.52 no.1
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• pp.5-16
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• 2022

Based on the general formula for the area error of a polygon and rectangular parcel, the constant term 0.026² × M (scale denominator) of the area error calculation formula prescribed by the Enforcement Decree was analyzed. As a result, it is found that the formula appropriately reflects the characteristics of the graphical surveying as a typical rectangular parcel model, but quantitatively allows a relatively large area error. In addition, it is found that, even if the area is the same, 50% more area error than a square parcel could be calculated depending on the shape of the parcel, and that the allowable area error should be different when dividing a parcel. Based on the analysis, furthermore, this study shows a solution that can solve the problems at once from the point of cadastral surveying. These are, the problem of reflecting the accuracy of the surveying, the problem of reflecting the size and shape of the parcel, and the problem whether a single area error formula can be used without having to distinguish between graphical and numerical surveyings. The new formula that solves these problems will bring about improvements in many related factors and promote the development of digital cadastral system.

• Journal of the Korean Geosynthetics Society
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• v.22 no.2
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• pp.71-83
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• 2023

It is very important to predict the amount of settlement in order to maintain the function of the coastal structure. Finite element analysis methods and real and model experiments are used as methods for this, but this has the disadvantage of requiring a lot of cost and time. Therefore, this study was conducted for the purpose of a simple formula proposal that can easily predict the amount of settlement of the caisson-type quay wall structure. In the research process, after calculating the PSI (Power Spectrum Intensity) of the velocity, the amount of settlement of the structure is calculated by substituting it into the simple formula of the existing gravity breakwater. By comparing and analyzing the amount of settlement of the structure obtained through numerical analysis, it was confirmed that the error between the amount of settlement of the existing simple formula and the amount of settlement of the numerical analysis was large, and it was confirmed that the background could not be considered in the case of the existing simple formula. Therefore, this study proposed a correction factor for the background of the quay wall structure, indicating a simple formula that can obtain the amount of settlement of the caisson-type quay wall structure. Compared to the numerical analysis settlement amount, it was judged that this simple formula had sufficient precision in calculating the caisson-type quay wall settlement amount. In addition, facilities vulnerable to earthquake resistance can be easily extracted in situations where time and cost are insufficient, and it is expected to be used as a screening technique.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.1
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• pp.29-37
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• 2012

This paper is concerned with the natural vibration characteristics of a rectangular plate with a rectangular hole in contact with the water. The addressed problem was solved by using the Rayleigh-Ritz method combined with the Green function method. This study presents the numerical approach, numerical results and experimental results. In addition, the validity of the approximate formula which mainly depends on the so-called non-dimensionalized added virtual mass incremental factor and the natural mode shape change due to the presence of the water were investigated. Experiments were also carried out to validate theoretical results. The theoretical results are in good agreement with the experimental results. It was found that the effect of a square hole on the natural frequencies of the square plate in contact with water is different from the effect of a square hole on the natural frequencies of the square plate in air and the approximate formula can predict lower natural frequencies in water with a good accuracy.