• Herbal Formula Science
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• v.31 no.4
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• pp.265-281
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• 2023

Objectives : Ukgan-san plus Citri Pericarpium and Pinelliae Rhizoma (UCP) is used as a traditional herbal formula in Korea and Japan for treatment of fever, fever-induced convulsions, and liver dysfunction and so on. In this study, we investigated the cytoprotective effect and underlying mechanism of UCP against oxidative stress induced by cotreatment of arachidonic acid (AA) and iron. Methods : To evaluate the hepatoprotective effects of UCP against AA + iron-induced oxidative stress in HepG2 cell, cell viability and changes on apoptosis-related proteins were assessed by MTT and immunoblot analyses. The changes in intracellular reactive oxygen species (ROS), glutathione (GSH), and mitochondrial membrane permeability (MMP) were investigated against to the oxidative stress. Furthermore, to verify underlying molecular mechanism, NF-E2-related factor 2 (Nrf2) and its downstream target genes were examined by immunoblot analysis. Results : Treatment of UCP increased the cell viability and altered the expression levels of apoptosis-related proteins such as PARP, caspase-9, caspase-3, Bcl-2. UCP also inhibited the GSH depletion, excessive ROS production and mitochondrial dysfunction induced by AA + iron. In addition, the Nrf2 and the Nrf2 target genes activation were increased by UCP. Conclusions : These results indicated that UCP has the ability to protect against oxidative stress-induced hepatocyte damage, which may be mediated with Nrf2 pathway.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.78-91
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• 2024

Double steel plate concrete composite shear wall (SCSW) has been widely utilized in nuclear power plants and high-rise structures, and its shear connectors have a substantial impact on the seismic performance of SCSW. Therefore, in this study, the mechanical properties of SCSW with angle stiffening ribs as shear connections were parametrically examined for the reactor containment structure of nuclear power plants. The axial compression ratio of the SCSW, the spacing of the angle stiffening rib arrangement and the thickness of the angle stiffening rib steel plate were selected as the study parameters. Four finite element models were constructed by using the finite element program named ABAQUS to verify the experimental results of our team, and 13 finite element models were established to investigate the selected three parameters. Thus, the shear capacity, deformation capacity, ductility and energy dissipation capacity of SCSW were determined. The research results show that: compared with studs, using stiffened ribs as shear connectors can significantly enhance the mechanical properties of SCSW; When the axial compression ratio is 0.3-0.4, the seismic performance of SCSW can be maximized; with the lowering of stiffener gap, the shear bearing capacity is greatly enhanced, and when the gap is lowered to a specific distance, the shear bearing capacity has no major affect; in addition, increasing the thickness of stiffeners can significantly increase the shear capacity, ductility and energy dissipation capacity of SCSW. With the rise in the thickness of angle stiffening ribs, the improvement rate of each mechanical property index slows down. Finally, the shear bearing capacity calculation formula of SCSW with angle stiffening ribs as shear connectors is derived. The average error between the theoretical calculation formula and the finite element calculation results is 8% demonstrating that the theoretical formula is reliable. This study can provide reference for the design of SCSW.

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.3
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• pp.102-109
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• 2001

In this paper, a new multiplication algorithm which describes the methods of constructing a multiplierover GF(p$^{m}$ ) was presented. For the multiplication of two elements in the finite field, the multiplication formula was derived. Multiplier structures which can be constructed by this formula were considered as well. For example, both GF(3) multiplication module and GF(3) addition module were realized by current-mode CMOS technology. By using these operation modules the basic cell used in GF(3$^{m}$ ) multiplier was realized and verified by SPICE simulation tool. Proposed multipliers consisted of regular interconnection of simple cells use regular cellular arrays. So they are simply expansible for the multiplication of two elements in the finite field increasing the degree m.

• Journal of Korean Traditional Oncology
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• v.16 no.2
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• pp.53-61
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• 2011

Objective : This study reports one case of urachal cancer patient treated with oriental medicine. Methods : One patient who was diagnosed with stage IVB urachal cancer was admitted and treated using different modalities of herbs, acupuncture, and pharmacopuncture. An herbal formula, Hang-Am Plus, Myun-Yuk Plus, and Nobongbiki-jung was given three times a day with daily acupuncture treatment session, in addition to Sweet bee venum pharmacopuncture injection which were administered two~three times a week. After treatment, patient's symptoms and blood test results were observed and analyzed. Results : During treatment, symptoms and laboratory findings of patient were maintained in stable condition about 4 months, and the patient survived during 22 months after operation (5.5 months after oriental medicine treatment). Conclusions : This case study shows minimum evidence of efficacy of oriental medicine for managing symptoms of urachal cancer. Considering this is only single case study, further research is needed to confirm these results.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.1
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• pp.180-187
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• 1997

A formula for estimating the elastic stiffness of TW-HDS with a uniformly tapered width from w$_{0}$ to w$_{1}$ over the length, has been analytically derived based on Euler beam theory and Castigliano's theorem. Elastic stiffnesses of the TW-HDSs designed in the same dimensional design spaces as the KOFA HDSs have been estimated from the derived formula, in addition, a sensitivity study on the elastic stiffness of the TW-HDSs has been carried out. Analysis results show that elastic stiffnesses of the TW-HDSs have been by far higher than those of the KOFA HDSs, and that, as the effects of axial and shear force on the elastic stiffness have been 0.15-0.21%, most of the elastic stiffness is attributed to the bending moment. As a result of sensitivity analysis, the elastic stiffness sensitivity at each design variable is quantified and design variables having remarkable sensitivity are identified. Among the design variables, leaf thickness is identified as that of having the most remarkable sensitivity of the elastic stiffness.

• Steel and Composite Structures
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• v.37 no.4
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• pp.481-492
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• 2020

Twenty-two corrosion-damaged columns were simulated through accelerated steel corrosion tests. Eight specimens were directly tested to failure under axial load, and the remaining specimens were tested after concrete-filled steel tube (CFST) strengthening. This study aimed to investigate the damage of RC columns after corrosion and their restoration and enhancement after strengthening. The research parameters included different corrosion degrees of RC columns, diameter-to-thickness ratio of steel tube and the strengthening concrete strength. Experimental results showed that CFST strengthening method could change the failure mode of corrosion-damaged RC columns from brittleness to ductility. In addition to the bearing capacity provided by the strengthening materials, it can also provide an extra 26.7% amplification because of the effective confinement provided by steel tubes. The influence of corrosion on reinforcement and concrete was quantitatively analysed and considered in the design formula. The proposed formula accurately predicted the bearing capacity of the strengthened columns with a maximum error of only 7.68%.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.8
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• pp.1276-1290
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• 1997

The previous elastic stiffness formulas of leaf type holddown spring assemblies(HDSs) have been corrected and extended to be able to consider the point of taper runout for the TT-HDS and all the strain energies for both the TT-HDS and the TW-HDS based on Euler beam theory and Castigliano'stheorem. The elastic stiffness sensitivity of the leaf type holddown spring assemblies was analyzed using the derived elastic stiffness formulas and their gradient vectors obtained from the mid-point formula. As a result of the sensitivity analysis, the elastic stiffness sensitivity at each design variable is quantified and design variables having remarkable sensitivity are identified. Among the design variables, leaf thickness is identified as that of having the most remarkable sensitivity of the elastic stiffness. In addition, it was found that the sensitivity of the leaf type HDS's elastic stiffness is exponentially correlated to the leaf thickness.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.3
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• pp.237-244
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• 2002

Analyzing acoustic-structural systems such as automobiles and aircraft, the FRF-based substructuring (FBS) method is one of the most powerful tools. In this paper, a general procedure for the parametric sensitivity analysis of vibro-acoustic problems has been presented using the multi-domain FRF-based substructuring formulation. For an acoustic-structural system sub-structured by multiple domains, the substructuring formulation gives the reaction farces on the interface boundaries. The design sensitivity formula is obtained from the direct differentiation of the reaction force expression with respect to the design vector. As a practical application, the proposed design sensitivity formula is applied to an engine mount system of passenger car. An objective of the problem is to identify the most effective engine mounts and bushes in minimizing the interior noise over the concerned rpm range. The comparison of the sensitivity results with those of the finite difference method shows excellent agreement. In addition, stiffness modifications of the mounts and bushes identified through the design sensitivity analysis lead to a successful decrease of the interior noise. This results show usefulness of the present method very well.

• Herbal Formula Science
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• v.11 no.2
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• pp.135-146
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• 2003

Objectives : Wolguk-whan has been used as a prescription of natural drug for the treatment of stress digestive system disease. Recently, we reported that Wolguk-whan methnol extract (WGWM) exerted a significant protective effect against oxidative damage to the liver of ICR mice. This study was purposed to investigate the effects of Wolguk-whan water extract (WGWW) on liver injury induced by oxidative stress. Methods : In order to investigate the effects of WGWW on acute liver injury, ICR mice were pretreated with WGWW for 6days, starved for 24hrs, and administerated acetamirtophen(500mg/kg, i.p.). In the liver homogenates, lipid peroxide and glutathione(GSH) levels were measured. In addition, activities of hepatic enzyme, such as catalase, glutathione peroxidase(GSH-Px), glutathione S-transferase(GST) were measured in the hepatic mitochondrial and cytosolic fractions. Results : In vivo administeration of WGWW showed effective inhibition of acetaminophen induced lipid peroxidation, and showed elevations of GSH level, catalase, GSH-Px, GST activities. Conclusions : These results suggested that WGWW might suppress the formation of oxidative metabolites, and prevent acetaminophen induced hepatotoxicity.

• Herbal Formula Science
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• v.11 no.2
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• pp.95-110
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• 2003

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. Although a variety of oriental prescriptions in study Jeonmaedan have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that A${\beta}$ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CTl05(carboxy terminal 105 amino acid peptide fragment of APP) may be an important factor causing neurotoxicity in AD. In addition, AD is one of brain degeneration disease. So we studied on herbal medicine that have a relation of brain degeneration. In Oriental Medicine, Jeonmaedan has been used for disease in relation to brain degeneration. As the result of this study, in Jeonmaedan the apoptosis in the nervous system is inhibited, the repair against the degerneration of SK-N-SH cell lines by CT105 expression is promoted. So Jeonmaedan may be beneficial for the treatment of AD.