Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지

Effect of Anti-Alzheimer's disease by Jeonmaedan in CT105-overexpressed SK-N-SH cell lines

CT105로 유도된 인간신경아세포종 세포주에서 전매단의 항치매 효과

  • Song Ho-Sang (Department of Circulatory Internal Medicine, College of Oriental Medicine, Daeguhaany University) ;
  • Park Chi-Sang (Department of Circulatory Internal Medicine, College of Oriental Medicine, Daeguhaany University) ;
  • Park Chang-Gook (Department of Circulatory Internal Medicine, College of Oriental Medicine, Daeguhaany University)
  • 송호상 (대구한의대 한의과대학 심계내과학교실) ;
  • 박치상 (대구한의대 한의과대학 심계내과학교실) ;
  • 박창국 (대구한의대 한의과대학 심계내과학교실)
  • Published : 2003.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. Although a variety of oriental prescriptions in study Jeonmaedan have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet fully elucidated. It has been widely believed that A${\beta}$ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that CTl05(carboxy terminal 105 amino acid peptide fragment of APP) may be an important factor causing neurotoxicity in AD. In addition, AD is one of brain degeneration disease. So we studied on herbal medicine that have a relation of brain degeneration. In Oriental Medicine, Jeonmaedan has been used for disease in relation to brain degeneration. As the result of this study, in Jeonmaedan the apoptosis in the nervous system is inhibited, the repair against the degerneration of SK-N-SH cell lines by CT105 expression is promoted. So Jeonmaedan may be beneficial for the treatment of AD.

Keywords

References

  1. 최신정신의학 이근후
  2. 가정의학회지 v.18 no.3 치매의 접근방법 나덕렬
  3. 신경정신의학 v.36 no.1 한국의 한 농촌 지역에 거주하는 노인에서의 치매의 유병률 우종인;이정희;유근영;홍진표;김창엽;김용익;이강욱
  4. ICD-10 정신 및 행동장애 분류 李符永(譯)
  5. 老人議學 배영철(外)
  6. 동의정신의학 김지혁;황의완
  7. 치매, 알츠하이머병 김승업
  8. J. Neurogenet. v.12 no.1 Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brain Reznik-Wolf, H.;Machado, J.;Haroutuian, V.;DeMacro, L.;Walter, G.F.;Goldman, B.;Davidson, M.;Johnson, J.A.;Lannfelt, L.;Dani, S.U.;Friedman, E.
  9. Nat. Genet. v.11 no.2 The structure of the presenilin 1(SI82) gene and identification of six novel mutation in early onset AD families Alzheimer's disease collaborative group
  10. Science v.215 no.4537 Alzheimer's disease and senile dementia;loss of neurons in the basal forebrain Whitehouse, P.J.;Price, D.L.;Struble, R.G.;Clark, A.W.;Coyle, J.T.;Delon, M.R.
  11. Exp. Gerontol. v.33 no.5 The importance of inflammatory mechanisms in Alzheimer disease Mcgeer, E.G.;McGeer, P.L.
  12. 대한신경과학회지 v.3 no.1 Alzheimer's disease의 신경화학적 변환에 관한 고찰 김진수
  13. Brain Research v.593 no.2 Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormailties Tabaton, M.;Cammarata, S.;Mandybur, T.;Richy, P.;Kawai, M.;Perry, G.;Gambetti, P.
  14. Acta Neuropathol.(Berl) v.84 no.6 Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein;iduntification of hidden and cleaved tau epitopes and a new phosphorylation site Dickson, D.W.;Ksiezak-Reding, H.;Liu, W.K.;Davis, P.;Crowe, A.;Yen, S.H.
  15. Neuroscience v.95 no.1 Suppression of an amyliod beta peptide-mediated calcium chnnel response by a secreted beta-amyloid precursor protein Li, W.Y.;Butler, J.P.;Hale, J.E.;McClure, D.B.;Little, S.P.;Czilli, D.L.;Simmons, L.K.
  16. Trends in Cell Biology v.8 no.11 The cell biology of $\beta$-amyloid precusor protein and presenilin in Alzheimer's disease Dennis J. Selkoe
  17. J. Neurochem. v.73 no.2 Secreted form of amyloid precursor protein enhances basal glucose and glutamte transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism Mattson, M.P.;Guo, Z.H.;Geiger, J.D.
  18. Brain Research v.778 no.1 Low concentrations of estradiol reduce $\beta$-amyloid(25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells Kelly E.Gridley;Pattie S. Green;James W. Simpkins
  19. Neuroreport v.11 no.15 Toxic effect of the beta-amyloid precursor protein C-terminus fragment and NA-/Ca2+ gradients Bryan-Sisneros, A.A.;Fraser, S.P.;Suh, Y.H.;Djamgoz, M.B.
  20. Nat. Med. v.6 no.4 A second cytotoxic proteolytic peptide derived from amyloid beta-protein precusor Lu, D.C.;Rabizadeh, S.;Chandra, S.;Shayya, R.F.;Ellerby, L.M.;Ye, X.(et al.)
  21. J. Neurosci. Res. v.60 no.4 APP carboxyl-terminal fragment without or with Abeta domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons Lee, J.P.;Chang, K.A.;Kim, H.S.;Kim, S.S.;Jeong, S.J.;Suh, Y.H.
  22. FASEB J. v.14 no.11 Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxity Kim, H.S.;Park, C.H.;Cha, S.H.;Lee, J.H.;Lee, S.;Kim, Y.(et al.)
  23. Biol. Psychiatry v.49 no.3 Effects of nicotine on APP secretion and A beta-or CT(105)-induced toxicity Seo, J.;Kim, S.;Kim, H.;Park, C.H.;Jeong, S.;Lee, J.(et al.)
  24. J. Neural. Transm. Suppl. v.58 no.SUP. Roles of A beta and carboxyl terminal peptide fragments of amyloid precusor protein in Alzheimer disease Suh, Y.H.;Kim, H.S.;Lee, J.P.;Park, C.H.;Jeong, S.J.;Kim, S.S.(et al.)
  25. 大韓東醫病理學會誌 v.13 no.1 치매의 病理에 대한 동서의학적 고찰 강형원;유영수;최용덕;이광규
  26. 東醫神經精神科學會誌 v.7 no.1 치매에 대한 문헌적 고찰 정인철;이상용
  27. 大韓韓方內科學會誌 v.13 no.2 노인성 치매에 대한 문헌적 고찰 김현아
  28. 景岳全書 張介賓
  29. 辨證錄 陳士鐸
  30. 辨證奇聞全書 錢鏡湖
  31. 大韓韓醫學會誌 v.13 no.2 노인성 치매에 관한 체질의학적 연구 裵旿星
  32. 大韓韓方內科學會誌 v.19 no.1 치매에 관한 최근의 연구 동향 나창수;김정상;채우석;박석천
  33. 東醫神經精神科學會誌 v.10 no.1 Vascular Dementia에 관한 한의학적 임상연구 현경철;김종우;황의완
  34. 東醫神經精神科學會誌 v.7 no.1 치매에 대한 한의학적 임상연구 황의완;김종우;이조희;엄효진;이승기
  35. 東醫生理病理學會誌 v.8 no.2 七福飮이 老化 白鼠 腦組織의 生化學的 變化에 미치는 影響 손정석;류영수
  36. 大韓韓醫學會誌 v.19 no.1 定志丸이 腦組織의 生化學的 變化와 神經細胞의 損傷에 미치는 實驗的 硏究 최용준;성강경;문병순
  37. 大韓韓方內科學會誌 v.19 no.1 四物湯이 老化白鼠 腦組織의 生化學的 變化에 미치는 影響 박종운;이기상;문병순
  38. 東醫神經精神科學會誌 v.9 no.1 蔘茸地黃湯이 腦組織의 酸化作用에 미치는 影響 김보경;이상룡
  39. 東醫神經精神科學會誌 v.8 no.2 洗心湯이 腦組織의 酸化作用에 미치는 影響 김성현;이상룡
  40. 東醫神經精神科學會誌 v.8 no.2 溫膽湯이 腦組織의 酸化作用에 미치는 影響 정인철;이상룡
  41. 東醫神經精神科學會誌 v.9 no.1 還少丹이 腦組織의 酸化作用에 미치는 影響 서원희;이상룡
  42. 東醫神經精神科學會誌 v.10 no.1 麝香蘇合元이 Alzheimer's disease모델 白鼠의 학습과 기억에 미치는 영향 황의완
  43. 東醫神經精神科學會誌 v.8 no.1 調胃升淸湯이 방사형 미로 학습과 기억에 미치는 影響 우주영;김종우;황의완;김현택;박순권
  44. 東醫神經精神科學會誌 v.9 no.1 荊方地黃湯이 Alzheimer's disease모델 白鼠의 學習과 記憶에 미치는 影響 조윤숙;황의완;김현택;박순권
  45. 東醫神經精神科學會誌 v.10 no.1 香附子八物湯이 Alzheimer's disease모델 白鼠의 학습과 기억에 미치는 영향 강현근;김종우;황의완;김현택;이홍재
  46. 東醫神經精神科學會誌 v.12 no.1 洗心湯에 의한 腦星狀細胞로부터 炎症性細胞活性物質의 分泌 抑制效果 김태헌;김준한;강형원;유영수
  47. 東醫神經精神科學會誌 v.12 no.2 생체외 알츠하이머병 실험모델에서 星香正氣散加蒲公英의 효과에 관한 연구 박진성;강형원;유영수
  48. 東醫神經精神科學會誌 v.10 no.1 遠志에 의한 腦星狀細胞로부터 炎症性 細胞活性物質 分泌의 억제 효과에 관한 연구 황시영;강형원;유영수
  49. 東醫神經精神科學會誌 v.9 no.1 天門冬에 의한 腦神經細胞로부터 炎症性 細胞活性物質 分泌의 억제 효과에 관한 연구 강형원;유영수
  50. 東醫神經精神科學會誌 v.11 no.2 益精地黃湯이 치매병태 모델에 미치는 영향 최병만;이상룡
  51. 東醫神經精神科學會誌 v.15 no.2 導痰益氣活血湯이 Alzheimer's disease 병태 모델의 생화학적 변화 및 행동에 미치는 영향 정인철
  52. 東醫神經精神科學會誌 v.12 no.1 補益淸腦湯이 치매병태 모델에 미치는 영향 고태준;이상용
  53. 東醫生理病理學會誌 v.16 no.5 釣鉤藤이 $\bata$APP 과발현 인간 신경아세포암에서의 항치매 효과에 관한 연구 김상호;강형원;유영수
  54. 東醫生理病理學會誌 v.16 no.2 山楂肉이 Alzheimer's Disease 病態 모델에 미치는 영향 정인철;이상룡
  55. 圖解腦神經外科學 郭隆璨
  56. 노인생활실태 분석 및 정책 과제 이가옥
  57. Nature v.359 no.6393 Amyloid beta-peptides is produced by cultured cells during normal metabolism Haass, C.;Schlossmacher, M.G.;Hung, A.Y.;Vigo-Pelfrey, C.;Mellon, A.;Ostaszewski, B.L.;Lieberburg, I.;Koo, E.H.;Schenk, D.;Teplow, D.B.(et al.)
  58. Eur. J. Biochem. v.225 no.3 Familial Alzheimer's disease cells abnormally accumulate beta-amyloid-harbouring peptides preferentially in cytosol but not in extracellular fluid Matsumoto, A.;Matsumoto, R.
  59. Proc. Natl. Acad. Sci. USA v.90 no.9 Altered processing of Alzheimer amyloid precusor protein in response to neuronal degeneration Iverfeldt, K.;Walaas, S.I.;Greengard, P.
  60. Proc. Natl. Acad. Sci. USA v.85 no.19 Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane-associated proteins in neural and nonneural tissues Selkoe, D.J.;Podlisny, M.B.;Joachim, C.L.;Vickers, E.A.;Lee, g.;Fritz, L.C.;Oltersdorf, T.
  61. EMBO J. v.7 no.4 Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease Dyrks, T.;Weidemann, A.;Multhaup, G.;Salbaum, J.M.;Lemaire, H.G.;Kang, J.;Muller-Hill, B.;Masters, C.L.;Beyreuther, K.
  62. Nature v.347 no.6293 Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid precursor Maruyama, K.;Terakado, K.;Usami, M.;Yoshikawa, K.
  63. Science v.281245 no.4916 Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease Yankner, B.A.;Dawes, L.R.;Fisher, S.;Villa-Komarodd, L.;Oster-Granite, M.L.;Neve, R.L.
  64. Biochem. Biophys. Res. Commun. v.182 no.1 Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity Fukuchi, K.;Kamino, K.;Deeb, S.S.;Smith, A.C.;Dang, T.;Martin, G.M.
  65. Molecular Brain Res. v.26 no.1-2 Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein Sopher, B.L.;Fukuchi, K.;Smith, A.C.;Leppig, K.A.;Furlong, C.E.;Martin, G.M.
  66. Proc. Natl. Acad. Sci. USA v.89 no.22 Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain Kammesheidt, A.;Boyce, F.M.;Spanoyannis, A.F.;Cummings, B.J.;Ortegon, M.;Cotman, C.;Vaught, J.L.;Neve, R.L.
  67. J. Neurochem. v.67 Neurotoxicity of a caroboxy terminal fragment of the Alzheimer's amyloid precursor protein Kim, S.H.;Suh, Y.H.
  68. Molecular Pharmcology v.52 Enhanced release of secreted form of Alzheimer's amyloid precursor protein($\beta$APP) in PC12 cells by nicotine Kim, S.H.;Kim, Y.K.;Jeong, S.J.;Haass, C.;Kim, Y.H.;Suh, Y.H.
  69. J. Neurochem. v.66 Membrane currents induced in Xenopus oocytes of the carboxyl terminal fragment of the amyloid precursor protein Fraser, S.;Suh, Y.H.;Chong, Y.H.;Djamgoz, M.A.
  70. Annals of N Y Acad. Sci. v.786 Molecular physiology, biochemistry and pharmacology of Alzheimer's amyloid precursor protein(APP) Suh, Y.H.;Chong, Y.H.;Kim, S.H.;Choi, W.;Kim, K.S.;Jeong, S.J.(et al.)
  71. J. Neurochemistry v.74 no.3 Effects of fragments of $\beta$-amyloid precursor protein on parallel fiber-purkinje cell synaptic transmission in rat cerebellum Hartell, N.A.;Suh, Y.H.
  72. Neuroreport v.8 no.15 Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments Cullen, W.K.;Suh, Y.H.;Anwyl, R.;Rowan, M.J.
  73. Neuroreport v.9 no.17 C-terminal fragment of amyloid precursor protein inhibits calcium uptake into rat brain microsomes by Mg2+-Ca2+ ATPase Kim, H.S.;C.H. Park;Y.H. Suh
  74. Neuroreport v.10 C-terminal fragment of Alzheimer's amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SH cell Kim, H.S.;Lee, J.H.;Suh, Y.H.
  75. 中醫雜誌 v.38 no.10 謝海洲治療腦萎縮經驗 郭字鵬;陳廷
  76. 上海中醫藥雜誌 v.3 매종담치 張覺人
  77. 臨床本草學 辛民敎
  78. 本草求眞 黃宮繡