• 전력전자학회논문지
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• 제25권3호
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• pp.188-194
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• 2020

This paper presents a high-efficiency Switch Mode Line Transformer (SMLT) composed of load-shared dual modules, which is based on the AC/AC LLC resonant converter. Given that the conventional adaptor is usually composed of two power stages, namely, the PFC and DC/DC converters, its system size can be increased according to the output power. However, given that the proposed SMLT can separate the PFC converter from the adaptor, the size reduction of the system can be achieved. Meanwhile, the SMLT with a single module has the limit of the size reduction because of a high resonant current. Thus, it can be configured with dual or multiple modules to reduce the resonant current. Then, their load sharing can be guaranteed by only the proposed transformer structure without an extra current controller. The validity of the proposed converter is proven through a 850-W prototype.

• Journal of Electrical Engineering and Technology
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• 제9권2호
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• pp.755-761
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• 2014

Heterogeneous components have different component models, which prevents such components from sharing the functionalities of other components based on the different models. As one of methods for linking heterogeneous components, this paper suggests a proxy component to construct a bridge between heterogeneous components of OPRoS (Open Platform for Robotic Service) and RTM (Robot Technology Middleware). The proxy component consists of two types of components called Adaptor and Interceptor, via which the heterogeneous components can exchange data and services easily. The proposed method enables adaptor and interceptor components to directly invoke the services of the latter and the former, respectively, in order to exchange data and services on a real-time basis. The proxy component can be implemented for OPRoS and RT (Robot Technology) component models to connect with RT and OPRoS ones, respectively. It is shown through a simple experiment that the proposed method works well for real-time control.

• 한국철도학회논문집
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• 제10권3호
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• pp.343-349
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• 2007

The flow velocity distribution at inlet and exit of a DPF was measured using a Pitot tube and 2-D positioning equipment. An adaptor which was designed for accessing the Pitot tube probe into inlet of the DPF was fabricated with inlet flange of the DPF. The Pitot tube which was mounted in the 2-D positioning machine could access to the inlet of the DPF through the rectangular window of the adaptor. Automation of the velocity measurement at the inlet and exit of the DPF was effectively achieved and measuring time was reduced drastically. The flow velocity distribution at the inlet of the DPF showed parabola shape with maximum velocity near to the center of the DPF, as expected. The velocity distribution at the exit of the DPF showed crown shape, that is, the flow velocity distribution near to the center of the DPF is lower than that at surrounded peripheral region of the DPF.

• Structural Engineering and Mechanics
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• 제77권1호
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• pp.75-87
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• 2021

The present study pertains to the introduction of two new types of grip adaptor for universal testing machines, namely Polyvinyl Chloride (PVC) and Polyoxymethylene (POM) grip adaptors, and their application to tension testing of FRP bars with different fiber and surface finish types. The tabs are connected to the FRP bar sample with the help of mechanical anchors, i.e. bolts. These new adaptors offer vital superiorities over the existing end tab designs (anchors with filling material or mechanical anchorage), including the reduction in the time and labor for production, reusability and the mild nature, i.e. low hardness of the tab material, which retards and even prevents peeling and crushing in the gripping regions of an FRP sample. The methods were successfully applied to FRP bars with different types of fiber (CFRP, GFRP and BFRP) and different types of surface texture (ribbed, wrapped, sand-coated and wound). The test results indicated that the both types of end caps prevented slip of the bar, crushing and peeling in the gripping zone. The mechanical properties from the material tests with the new caps were in perfect agreement with the ones from the material tests with steel tubular caps.

• 대한화학회지
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• 제68권1호
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• pp.25-31
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• 2024

The p97 adenosine triphosphatase is a key player in protein homeostasis, responsible for unfolding ubiquitylated substrates. It engages with various adaptor proteins through its N-terminal domain, with the p97-p47 complex attracting particular attention for its involvement in membrane remodeling. Although the structures of p97 in complex with the Ubiquitin regulatory X (UBX) domain from various adaptors have been reported, the stoichiometry is conflicting. Here, we report the crystal structure of the p97 N-D1 hexamer in complex with the p47 UBX domain at a resolution of 2.7 Å. The structure reveals a stoichiometry of 6:6 between the p97 N-D1 and the p47 UBX domain. These findings provide valuable insights into the binding stoichiometry of p97 N-D1 and p47 UBX domain, which are crucial for understanding the role of p97 and adaptor proteins in cellular processes such as the ubiquitin-proteasome pathway, membrane fusion, and cell cycle regulation.

• 생명과학회지
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• 제18권8호
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• pp.1059-1065
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• 2008

KIF21A는 kinesin superfamily에 속하는 분자 motor로서 미세소관을 따라서 분비소포를 운반한다. 최근의 연구결과 KIF21A 유전자 일부의 missense 돌연변이에 의하여 congenital fibrosis of the extraocular muscles (CFEOM) 1의 유발됨이 밝혀졌다. CFEOM1은 KIF21A의 돌연변이로 인하여 분화 발생과정에 occulo-motor신경과 neuromuscular junction 형성에 필요한 단백질을 이동시키지 못함으로써 유발된다. 본 연구에서는 효모 two-hybrid system을 사용하여 KIF21A의 WD-40 repeat domain과 결합하는 분자량이 작은 Purkinje cell protein-1 (Pcp-2), 또는 L7으로도 알려진 단백질을 분리하였다. Pcp-2는 효모 two-hybrid assay에서 KIF21A와 KIF21B의 WD-40 영역과는 결합하지만 다른 종류의 KIFs와는 결합하지 않았다. 또한 단백질간의 특이적 결합을 pull-down assay로 확인하였으며, 생쥐의 뇌 파쇄액에 Pcp-2 항체로 면역침강을 행하여 KIF21A를 확인한 결과 Pcp-2와 같이 침강하였다. 이러한 결과들은 KIF21A는 Pcp-2와 결합하며, 또한 Pcp-2는 KIF21A의 adaptor 단백질로서 세포 내 KIF21A의 수송에서 매개 단백질로 작용함을 시사한다.

• BMB Reports
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• 제34권5호
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• pp.484-488
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• 2001

STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-$\gamma$ in primary immune cells, respectively. The selective activation of STAT3 in H-ras-transformed NIH3T3 cells is associated with an increased expression of phosphoserioe STAT3 in these cells, compared to the parental cells. Notably phosphoresine-STAT3 interacts with oncogenic ras, shown by immunoprecipitation and Western blots. The results suggest the role of STAT3 in rasinduced cellular transformation as a molecular adaptor linking the Jak/STAT and Ras/MAPK pathways. In primary immune cells, IL-4 and IFN-$\gamma$ each induced (in addition to the characteristic STAT6 and STAT1 homodimers) the formation of STAT3-containing complexes that bind to GAS probes, which correspond to the $Fe{\varepsilon}$ Rll and $Fe{\gamma}$ RI promoter sequences, respectively. Since IL-4 and IFN-$\gamma$ are known to counter-regulate the expression of these genes, the ability of STAT3 to form heterodimeric complexes with STAT6 or STAT1 implies its role in the fine-tuned control of genes that are regulated by IL-4 and IFN-$\gamma$.

• Journal of Ginseng Research
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• 제41권1호
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• pp.43-51
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• 2017

Background: BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng, is widely used for cosmetic purposes in Korea. We investigated the functional mechanisms of the anti-inflammatory and antioxidative activities of BIOGF1K by discovering target enzymes through various molecular studies. Methods: We explored the inhibitory mechanisms of BIOGF1K using lipopolysaccharide-mediated inflammatory responses, reporter gene assays involving overexpression of toll-like receptor adaptor molecules, and immunoblotting analysis. We used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay to measure the antioxidative activity. We cotransfected adaptor molecules, including the myeloid differentiation primary response gene 88 (MyD88) and Toll/interleukin-receptor domain containing adaptor molecule-inducing interferon-${\beta}$ (TRIF), to measure the activation of nuclear factor (NF)-${\kappa}B$ and interferon regulatory factor 3 (IRF3). Results: BIOGF1K suppressed lipopolysaccharide-triggered NO release in macrophages as well as DPPH-induced electron-donating activity. It also blocked lipopolysaccharide-induced mRNA levels of interferon-${\beta}$ and inducible nitric oxide synthase. Moreover, BIOGF1K diminished the translocation and activation of IRF3 and NF-${\kappa}B$ (p50 and p65). This extract inhibited the upregulation of NF-${\kappa}B$-linked luciferase activity provoked by phorbal-12-myristate-13 acetate as well as MyD88, TRIF, and inhibitor of ${\kappa}B$ ($I{\kappa}B{\alpha}$) kinase ($IKK{\beta}$), and IRF3-mediated luciferase activity induced by TRIF and TANK-binding kinase 1 (TBK1). Finally, BIOGF1K downregulated the NF-${\kappa}B$ pathway by blocking $IKK{\beta}$ and the IRF3 pathway by inhibiting TBK1, according to reporter gene assays, immunoblotting analysis, and an AKT/$IKK{\beta}$/TBK1 overexpression strategy. Conclusion: Overall, our data suggest that the suppression of $IKK{\beta}$ and TBK1, which mediate transcriptional regulation of NF-${\kappa}B$ and IRF3, respectively, may contribute to the broad-spectrum inhibitory activity of BIOGF1K.

• KIEE International Transactions on Electrophysics and Applications
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• 제5C권3호
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• pp.102-110
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• 2005

Piezoelectric transformers(PT) are expected to be small, thin and highly efficient, and which are attractive as a transformer with high power density for step down voltage. For these reasons, we have attempted to develop a step-down PT for the miniaturized adaptor. We propose a PT, operating in thickness extensional vibration mode for step-down voltage. This PT consists of a multi-layered construction in the thickness direction. In order to develop the step-down PT of 10 W class and turn ratio of 0.1 with high efficiency and miniaturization, the piezoelectric ceramics and PT designs are estimated with a variety of characteristics. The basic composition of piezoelectric ceramics consists of ternary yPb(Zr$_{x}$Ti$_{1-x}$)O$_{3}$-(1-y)Pb(Mn$_{1/3}$Nb1$_{1/3}$Sb$_{1/3}$)O$_{3}$. In the piezoelectric characteristics evaluations, at y=0.95 and x=0.505, the electromechanical coupling factor(K$_{p}$) is 58$\%$, piezoelectric strain constant(d$_{33}$) is 270 pC/N, mechanical quality factor(Qr$_{m}$) is 1520, permittivity($\varepsilon$/ 0) is 1500, and Curie temperature is 350 $^{\circ}C$. At y = 0.90 and x = 0.500, kp is 56$\%$, d33 is 250 pC/N, Q$_{m}$ is 1820, $\varepsilon$$_{33}$$^{T}$/$\varepsilon$$_{0}$ is 1120, and Curie temperature is 290 $^{\circ}C$. It shows the excellent properties at morphotropic phase boundary regions. PZT-PMNS ceramic may be available for high power piezoelectric devices such as PTs. The design of step-down PTs for adaptor proposes a multi-layer structure to overcome some structural defects of conventional PTs. In order to design PTs and analyze their performances, the finite element analysis and equivalent circuit analysis method are applied. The maximum peak of gain G as a first mode for thickness extensional vibration occurs near 0.85 MHz at load resistance of 10 .The peak of second mode at 1.7 MHz is 0.12 and the efficiency is 92$\%$.

• 대한의용생체공학회:의공학회지
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• 제15권3호
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• pp.317-324
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• 1994

본 논문에서는 ISDN(Intergrated Services Digital Network) LAPD(Link Access Procedure on the D-channel)와 LAPB(Link Access Procedunre on the B-channel) 프로토콜 구현과 비 ISDN 기기 용 ISDN 접속장치인 TA(Terminal Adaptor)를 위한 새로운 방법을 제안하였다. 본 논문에서 제안한 방법은 지금까지의 방법과는 달리 실시간 운영체제의 커널부를 타켓보드(target board)에 이식하여 ISDN LAPD와 LAPB 프로토콜을 구현하는 것이다. 구현된 시스템의 특징은 첫째, 각 계층에서 발생한 프로세스들을 병렬적(Multi Tasking)으로 처리하도록 하였고, 둘째, 프로토콜 구현을 위해 필요한 타이머들이 커널부로부터 소프트웨어적으로 지원되도록 하였으며, 셋째, 운영체계의 포트 함수를 응용하여 CCITT에서 권고하는 SAP(service access point)를 구현 하였다. 제안한 방법에 따라 운영체계를 이용하여 ISDN 사용자 망 인터페이스를 위한 LAPD의 계층1(layer1), 계층2(layer2) 및 계층3(Call control) 프로토콜과 LAPB프로토콜을 구현하여 모의 망 종단 장치에 연결시켜 실험을 수행한 결과 계층2(LAPD)에서의 TEI(Terminal Equipment Identifier)할당과, 다중 프레임 전송모드의 설정 후 계층3의 메세지가 전송됨을 확인하였고, 이를 이용하여 계층3에서 호설정이 이루어지고 해제되는 것을 확인 하였다. 그리고 설정된 패스를 통해 LAPB 프로토콜을 이용하여 B 채널로 데이터의 전송이 이뤄짐을 확인하였다. 따라서, 본 논문에서는 PC로부터의 초음파 의료 영상 또는 음성 정보를 ISDN환경에서 보다 효율적으로 전송할 수 있는 ISDN망에서의 전송시스템이 구현됨으로써 향후 ISDN망에 접속하여 사용할 수 있는 가능성을 확인하였다.