• Proceedings of the Korean Information Science Society Conference
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• 2001.10a
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• pp.478-480
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• 2001

클라이언트/서버 환경, 다양만 플랫폼지원, 다양한 어플리케이션 인터페이스 통합관점에서 소프트웨어 재사용 방법은 소프트웨어 공학의 주요 이슈가 되고 있다. 최근 호환되지 않는 어플리케이션을 통합 처리하는 방법으로 EAI(Enterprise Application Integration: 전사적 어플리케이션 통합)가 대두되고 있다 EAI는 이 기종간에 어플리케이션을 통합하는 것으로서, 필요한 정보의 통합, 관리를 제공하며, 다른 환경의 어플리케이션에서 이질적인 데이터를 사용할 수 있도록 환경을 구현 한 것이다. 이러한 어플리케이션을 통합하는데 있어서 본 논문에서는 최소한의 변경만으로 통합이 가능하고, 쉽게 적용 할 수 있도록 하기 위만 방법으로 퉁합 메시지 패싱 방법을 제시 하고자 한다. 본 논문에서는 EJB(Enterprise Java Beans), JMS(Java Messaging Service)를 이용하여 통합 메시지 어댑터를 정의하고 그 방법을 제 시 한다.

• Proceedings of the Acoustical Society of Korea Conference
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• 1994.06a
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• pp.1021-1026
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• 1994

This paper proposes a filter structure suitable for speech synthesis applications. We first derive the lossy pole-zero model by employing the wave digital filter(WDF) adaptor formula, and by converting the fixed termination value - 1 into a loss factor $\mu$c$\in$(-1, 1). Then we discuss how to determine the reflection We employ the Durbin's method in estimating the numerator polynomial of the lossy pole-zero transfer function from the given speech sound, and then apply the step-down algorithm on the numerator to extract the reflection coefficients of the closed-termination tract. For determining the reflection coefficients of the other parts we employ a pre-calculated pole-estimator polynomial.

• Molecules and Cells
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• v.46 no.3
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• pp.133-141
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• 2023

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes. KEAP1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of CULLIN 3 (CUL3)-based E3 ubiquitin ligase. KEAP1 regulates the activity of NRF2 and acts as a sensor for oxidative and electrophilic stresses. NRF2 has been found to be activated in many types of cancers with poor prognosis. Therapeutic strategies to control NRF2-overeactivated cancers have been considered not only by targeting cancer cells with NRF2 inhibitors or NRF2 synthetic lethal chemicals, but also by targeting host defense with NRF2 inducers. Understanding precise molecular mechanisms how the KEAP1-NRF2 system senses and regulates the cellular response is critical to overcome intractable NRF2-activated cancers.

• Annual Conference of KIPS
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• 2008.11a
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• pp.1126-1129
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• 2008

컴퓨팅 및 네트워크의 발전은 정보가전의 기능을 다양화하고 지능화를 촉진함으로써 언제, 어디서든, 어떤 네트워크에 있는 어떤 디바이스도 사용할 수 있는 유비쿼터스 환경에 대한 관심을 증가 시키고 있다. 이러한 유비쿼터스 환경을 실현하기 위해 많은 기술들이 제시되고 있지만, 표준이 정해지지 않아 서로 다른 서비스 기술방식이나 통신 방식을 사용하고 있다. 따라서 이질적인 서비스들 사이에 상호운용을 지원할 수 있는 방법이 필요하고, 본 논문에서 이야기 하는 지니 어댑터는 웹서비스를 중간 매개체로 하여 상호운용을 지원하고자 한다. 지니 서비스를 웹서비스로 변환하여 UDDI에 등록하면 웹서비스를 호출할 수 있는 서비스는 지니서비스도 사용할 수 있게 된다. 마찬가지로 지니서비스에서 웹서비스를 호출할 수 있다면, 웹서비스와 웹서비스로 변환된 다른 서비스들을 사용함으로써 상호운용이 가능해 진다. 본 논문에서는 지니 어댑터를 통하여 지니 클라이언트가 웹서비스를 검색하고 사용하는 방법에 대하여 이야기 한다.

• Annual Conference of KIPS
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• 2008.11a
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• pp.962-965
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• 2008

유비쿼터스 환경에 산재하는 서비스 발견 미들웨어는 프로토콜, 표준, 서비스 검색 방법 및 프로그래밍 언어 등의 이질적인 특성을 가진다. 본 연구에서는 이질적인 서비스 발견 미들웨어의 상호운용을 지원하기 위해 유니버설 네트워크를 위한 웹서비스 프레임워크를 제안했다. 따라서 본 논문에서는 대표적인 미들웨어인 DPWS 와 웹서비스의 상호운용을 지원하기 위해 양방향 DPWS 어댑터에 대한 설계 및 구현을 서술한다. 또한 양방향 DPWS 어댑터의 구조, 구성 요소와 동작 과정을 설계하고, 간단한 시나리오를 구현함으로써 양방향 DPWS 어댑터가 제공하는 서비스 지향 아키텍처, 상호운용성 제공, 일반적인 웹서비스 호출, 자가 구성, 동적 서비스 검색 등의 이점을 논한다.

• Korean Journal of Poultry Science
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• v.46 no.1
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• pp.31-37
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• 2019

A chicken clathrin-associated adaptor protein $3-{\delta}$ subunit 2 (AP3S2) is a subunit of AP3, which is involved in cargo protein trafficking to target membrane with clathrin-coated vesicles. AP3S2 may play a role in virus entry into host cells through clathrin-dependent endocytosis. AP3S2 is also known to participate in metabolic disease developments of progressions, such as liver fibrosis with hepatitis C virus infection and type 2 diabetes mellitus. Chicken AP3S2 (chAP3S2) gene was originally identified as one of the differentially expressed genes (DEGs) in chicken kidney which was fed with different calcium doses. This study aims to characterize the molecular characteristics, gene expression patterns, and transcriptional regulation of chAP3S2 in response to the stimulation of Toll-like receptor 3 (TLR3) to understand the involvement of chAP3S2 in metabolic disease in chicken. As a result, the structure prediction of chAP3S2 gene revealed that the gene is highly conserved among AP3S2 orthologs from other species. Evolutionarily, it was suggested that chAP3S2 is relatively closely related to zebrafish, and fairly far from mammal AP3S2. The transcriptional profile revealed that chAP3S2 gene was highly expressed in chicken lung and spleen tissues, and under the stimulation of poly (I:C), the chAP3S2 expression was down-regulated in DF-1 cells (P<0.05). However, the presence of the transcriptional inhibitors, BAY 11-7085 (Bay) as an inhibitor for nuclear factor ${\kappa}B$ ($NF{\kappa}B$) or Tanshinone IIA (Tan-II) as an inhibitor for activated protein 1 (AP-1), did not affect the expressional level of chAP3S2, suggesting that these transcription factors might be dispensable for TLR3 mediated repression. These results suggest that chAP3S2 gene may play a significant role against viral infection and be involved in TLR3 signaling pathway. Further study about the transcriptional regulation of chAP3S2 in TLR3 pathways and the mechanism of chAP3S2 upon virus entry shall be needed.

• Journal of Life Science
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• v.33 no.11
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• pp.868-875
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• 2023

Kinesin-1 is a motor protein identified as the first member of the kinesin superfamily (KIF), which plays a role in intracellular cargo transport by acting as microtubule-dependent motor proteins within cells. Kinesin-1 consists of two heavy chains (KHCs, also known as KIF5s) and two light chains (KLCs). The 93 amino acids in the carboxyl (C)-terminal tail region of KIF5A are not homologous to the C-terminal tail region of KIF5B or the C-terminal tail region of KIF5C. In this study, we used a yeast two-hybrid screen to identify the binding proteins that interacted with the C-terminal region of KIF5A. We found an association between KIF5A and CUE domain containing 2 (CUEDC2), which is proposed to function as an adaptor protein involved in ubiquitination pathways and protein trafficking. CUEDC2 bound to the C-terminal region of KIF5A and did not interact with KIF5B (the motor of kinesin-1), KIF3A (the motor of kinesin-2), or kinesin light chain 1 (KLC1). KIF5A specifically bound to the C-terminal region of CUEDC2. Furthermore, KIF5A did not interact with another isoform: CUEDC1. In addition, glutathione S-transferase (GST) pull-downs showed that KIF5A directly bound GST-CUEDC2 but did not interact with GST-CUEDC1 and GST alone. When myc-KIF5A and EGFP-CUEDC2 were co-expressed in HEK-293T cells, CUEDC2 co-immunoprecipitated with kinesin-1, and myc-KIF5A and FLAG-CUEDC2 colocalized in the cells. These results suggest that in intracellular cargo transport by kinesin-1, CUEDC2 serves as an adaptor protein connecting kinesin-1 and cargo by binding to KIF5A.

• Journal of the Korean Society for Nondestructive Testing
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• v.36 no.5
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• pp.399-405
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• 2016

Recently, fiber optic sensors, which have many advantages are being applied in various fields by replacing conventional electric sensors. To transmit the light signals between an interrogator and a sensor head, optical components such as an optical adaptor and optical jumper cords are generally used. When signals are transmitted using an adaptor, the end surface of each jumper cord is faced together. If alien substances exist on the core surface of an optical fiber, those can cause light transmission loss and signal disappearance. For this reason, non-contact fiber jumper cords are developed to overcome the problems that require continual attention. The light transmission performance of non-contact fiber jumper cords are also evaluated. From the test results, conventional fiber jumper cords are unable to transmit the signals over 2 mm cavity between the ends of both cords. Otherwise, non-contact fiber jumper cords can transmit the signals with stability up to the cavity of 7 mm though they have more transmission loss than the conventional ones. Consequently, non-contact fiber jumper cords that have better signal stability than conventional ones in environments are highly recommended in field applications, especially if they play a role as a cable for signal transmission between fiber optic sensors.

• Journal of Advanced Navigation Technology
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• v.15 no.6
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• pp.1000-1007
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• 2011

Home Networking will be implementing the interactive network by home appliances over wireless/wireline network framwork. That is, Home appliances, which are being operated within home space configure the network through wireline/wireless network infrastructure for interworking and interacitive services by external internet access. Based on home networking, smarthome is home space where can use automatic telecommunication and interactive service by home appliances. we can call smarthome based on home networking infrastructure as the conceptual gateway for evolving future converged space like u-city. From simple home control service to home automation service over home networking infrastructure, smarthome service is evolving to up-to-date intelligent life environment in growth of IT technology. however, its service model development was based on supplier-centered based on advanced IT technology. because of this situation, smarthome service has not been acknowledged IT underprivileged people as well as IT early-adaptor. so, this research paper will consider and try to find out what will be the feasible factors to make the best service for IT underprivileged people.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.5
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• pp.459-466
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• 2016

Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of MSCs. Adaptor protein Lnk (Src homology 2B3 [SH2B3]), which belongs to a family of SH2-containing proteins, modulates the bioactivities of different stem cells, including hematopoietic stem cells and endothelial progenitor cells. In this study, we investigated whether an interaction between insulin-like growth factor-1 receptor (IGF-1R) and Lnk regulated IGF-1-induced adipogenic differentiation of MSCs. We found that wild-type MSCs showed greater adipogenic differentiation potential than $Lnk^{-/-}$ MSCs. An ex vivo adipogenic differentiation assay showed that $Lnk^{-/-}$ MSCs had decreased adipogenic differentiation potential compared with wild-type MSCs. Interestingly, we found that Lnk formed a complex with IGF-1R and that IGF-1 induced the dissociation of this complex. In addition, we observed that IGF-1-induced increase in the phosphorylation of Akt and mammalian target of rapamycin was triggered by the dissociation of the IGF-1R-Lnk complex. Expression levels of a pivotal transcription factor peroxisome proliferator-activated receptor gamma ($PPAR-{\gamma}$) and its adipogenic target genes (LPL and FABP4) significantly decreased in $Lnk^{-/-}$ MSCs. These results suggested that Lnk adaptor protein regulated the adipogenesis of MSCs through the $IGF-1/Akt/PPAR-{\gamma}$ pathway.