• 한국임상수의학회지
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• 제11권2호
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• pp.507-516
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• 1994

The purposes of this investigations were survey of the occurred bacterial diseases, development of new animal health drug, guidance to formers on the treatment and control methods of diseases. Some series of investigations have been carried out by microbiological, pathological and serological examinations. The results could be summarized as follows. 1. A total of 953 cases of outbreaked swine diseases have been diagnosed in Clinical pathology laboratories, Bayer Vet Res Institute during 8 years (from 1986 to 1993). The high incidence diseases were colibacillosis, pleuropneumonia, streptococcal infection and pasteurellosis in decreasing order. 2. Pleuropneumonia caused by Actinobacillus pleuropneumoniae was the most important respiratory diseases and pasteurellosis by Pasteurella multocide could be confirmed in several cases. 3. Actinobacillus pleuropneumoniae 50 strains were isolated and identified by biochemical and serological tests. In serotyping test, 22 isolated strains were serotype 5, 21 strains as serotype 2, each 2 strains as serotype 3 and 7 by the coagglutination test. 4. Colibacillosis and edema discase caused by Escherichia coli has been the most predominant outbreaked disease in this investigations. The 100 isolates of E coli strains were sensitive to amikacin, colistin, enrofloxacin, gentamycin and trimethoprim -sulfamethoxazole. 5. Swine erysipelas caused by Erysipelothrix rhusiopathiae was confirmed 25 cases as acute septicemic forms. Isolates of E rhusiopathiae were highly sensitive to ampicillin, cephalothin, enrofloxcin, penicillin and tetracycline. 6. The 49 cases of hemorrhagic and necrotic enteritis in piglets were observed and 13 strains of Clostridium perfringens could be isolated and confirmed by biological and serological test. Isolates of Clostridium perfringens type C were highly sensitive to ampicillin, cephalothin, enrofloxacin, penicillin and trimethoprim- sulfamethoxazole. 7. The 14 strains of Streptococcus suis type II could be isolated from meningitis of piplets. 8. Polyserositis caused by Haemophilus parasuis and salmonellosis were observed and confirmed. Also Corynebacterial infections and several parasitosis have been also observed in this investigations.

• 한국동물위생학회지
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• 제34권3호
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• pp.195-200
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• 2011

Swine influenza is an acute respiratory disease prevalent in pig-growing areas all around the world and plays the roles of an intermediate host to be transmitted to mammals including human beings through a genetic recombination with the avian influenza virus. Recognizing that people could be contracted with swine influenza, this study set out to investigate the seroprevalence of individual and multiple infections with two subtypes (H1N1 and H3N2) of the swine influenza virus in pig farms in the Gyeongnam region according to age, area, and season, as well as to provide basic data for the prevention and control of swine influenza. Used in the study were total 904 swine sera that were not vaccinated against the influenza gathered from the pig farms in the Gyeongnam region from November, 2009 to October, 2010. HerdChek SIV (H1N1, H3N2) ELISA kit (IDEXX Laboratories, USA) was used for antibody testing against swine influenza. The test results show that 370 sera (40.9%) were infected with either H1N1 or H3N2 with 37.3% (337 sera) being contracted with H1N1, 13.1% (118 sera) with H3N2, and 9.4% (85) with both H1N1 and H3N2.

• 한국시뮬레이션학회논문지
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• 제30권1호
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• pp.43-54
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• 2021

2019년 말 코로나19(중증급성 호흡기 증후군 코로나 바이러스 타입 2)가 발견된 이후로 전세계적으로 퍼져나가고 있다. 본 연구에서는 접촉자 발견 수준이 바이러스 전파에 미치는 영향을 파악하기 위해서 현재 대한민국의 코로나19 전파 상황을 반영한 에이전트 기반 시뮬레이션 모델을 소개한다. 본 연구에서는 실제적인 시뮬레이션 모델 개발을 위해 대한민국 내 관련 데이터를 수집하고 그 확률분포를 추정하였다. 감염, 격리, 회복, 사망의 전체 감염 프로세스를 도식화하였으며 사람들의 상호작용을 교통량 데이터를 기반으로 하여 모델링 하였다. 사회적 거리 두기 같은 정부 시책에 대한 사람들의 순응도를 반영하기 위해 합성 로지스틱 함수를 활용하였다. 접촉자 발견 수준에 따른 감염 양상 변화를 파악하기 위해 발견 수준을 0%에서 100%까지 변화 시켰다. 그 결과 적극적인 접촉자 추적이 바이러스 확산을 효과적으로 제한하고 제한의 효과가 접촉자 발견 수준이 증가함에 따라 기하급수적으로 증가하는 것을 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제55권1호
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• pp.19-27
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• 2022

This study estimated the direct and indirect socioeconomic costs of 238 diseases and 22 injuries from a social perspective in Korea from 2007 to 2015. The socioeconomic cost of each disease group was calculated based on the Korean Standard Disease Classification System. Direct costs were estimated using health insurance claims data provided by the National Health Insurance Service. The numbers of outpatients and inpatients with the main diagnostic codes for each disease were selected as a proxy indicator for estimating patients' medical use behavior by disease. The economic burden of disease from 2007 to 2015 showed an approximately 20% increase in total costs. From 2007 to 2015, communicable diseases (including infectious, maternal, pediatric, and nutritional diseases) accounted for 8.9-12.2% of the socioeconomic burden, while non-infectious diseases accounted for 65.7-70.7% and injuries accounted for 19.1-22.8%. The top 5 diseases in terms of the socioeconomic burden were self-harm (which took the top spot for 8 years), followed by cirrhosis of the liver, liver cancer, ischemic heart disease, and upper respiratory infections in 2007. Since 2010, the economic burden of conditions such as low back pain, falls, and acute bronchitis has been included in this ranking. This study expanded the scope of calculating the burden of disease at the national level by calculating the burden of disease in Koreans by gender and disease. These findings can be used as indicators of health equality and as useful data for establishing community-centered (or customized) health promotion policies, projects, and national health policy goals.

• Clinical and Experimental Vaccine Research
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• 제12권4호
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• pp.319-327
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• 2023

Purpose: Patients with hematological malignancies are at an increased risk of severe infection with coronavirus disease 2019 (COVID-19). However, developing an adequate immune response after vaccination is difficult, especially in patients with lymphoid neoplasms. Since the long-term effects of the BNT162b2 vaccine are unclear, the humoral immune response 5 months after the two vaccinations in patients with hematological disorders was analyzed. Materials and Methods: Samples were collected from 96 patients vaccinated twice with BNT162b2 and treated with at least one line of an antitumor or immunosuppressive drug in our hospital from November 2021 to February 2022. Serum anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) spike (S) antibody titers were analyzed. Patients were age- and sex-matched using propensity matching and compared with a healthy control group. Patients with serum anti-SARS-CoV-2 S antibodies were defined as 'responder' if >50 U/mL. The patients had B-cell non-Hodgkin lymphoma (B-NHL), multiple myeloma, chronic myeloid leukemia, etc. Results: Patients had significantly low antibody levels (median, 55.3 U/mL vs. 809.8 U/mL; p<0.001) and a significantly low response rate (p<0.001). Multivariate analysis showed that patients with B-NHL, aged >72 years, were associated with a low response to vaccination. There were no significant differences between patients with chronic myeloid leukemia and healthy controls. Conclusion: Our study shows that patients with hematological disorders are at risk of developing severe COVID-19 infections because of low responsiveness to vaccination. Moreover, the rate of antibody positivity differed between the disease groups. Further studies are warranted to determine an appropriate preventive method for these patients, especially those with B-NHL.

• Clinical and Experimental Pediatrics
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• 제49권4호
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• pp.401-409
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• 2006

목 적 : 호흡기 감염증의 주된 원인 중 하나인 hMPV가 2001년 van den Hoogen 등에 의해 네덜란드에서 처음으로 발견된 후 여러 나라에서 보고되었지만, 국내에서 hMPV의 검출에 대한 보고는 대단히 드물다. 따라서 저자들은 우리나라에서 hMPV의 역학을 연구하고자 하였다. 방 법 : 2004년 10월부터 2005년 5월까지 순천향대학교 천안 병원 소아과에 급성 하기도염으로 입원한 218명의 비인두 흡인액을 추출한 뒤 RT-PCR을 시행하고, hMPV가 검출된 환아들의 비인두 흡인물에서 nucleotide의 sequencing을 하여 네덜란드에서 보고된 예와 비교하고, phylogenetic analysis를 하여 검출된 hMPV들간에 유사성을 검토하며, 배양검사로 hMPV의 검출됨을 재확인한 뒤, hPMV가 검출된 15명의 의무기록지를 토대로 이들의 임상 양상을 조사하였다. 결 과 : 218명 중 15명의 비인두 흡인물에서 RT-PCR로 hMPV를 검출할 수 있었다(검출률 6.9%). hMPV가 검출된 15명의 비인두 흡인물 중 11명의 것으로 hMPV의 Fushion protein의 F gene에 대한 nucleotide sequencing을 하여 네덜란드의 것과 유사한 sequence임을 확인할 수 있었다. Phylogenetic analysis를 하여 본 연구에서 검출된 11개의 F gene이 두 개의 군으로 나뉘는 것을 알 수 있었다. hMPV 감염 환아의 평균연령은 2세 8개월(5개월-12세 2개월)이었고, 남녀비는 1.5 : 1이었고, 이들의 진단명은 폐렴(60.0%)이었고 모세기관지염(33.3%), 후두염(6.6%) 순으로 나타났다. 3월과 4월에만 집중적으로 검출되었고, 동시감염은 단 한 례에서 있었다. hMPV 감염 환아에서 기침이 100.0%, 콧물이 86.6%, 발열 80.0%, 호흡곤란 26.6%, 구토가 13.3%, 인후통와 설사와 두통이 각각 6.6%에서 나타났고, 발열 지속기간은 평균 4.9일(1-8일)이었으며, 입원기간은 평균 6.2일(3-14일)이었다. 신체 진찰상 나음이 80.0%에서, 호기성 천명음이 33.3%에서 청진되었고, 흉부 방사선 검사에서 33.3%에서 폐침윤이 관찰되었다. 검사실 소견상 말초혈액에서 중성구 감소증과 림프구 감소증이 각각 6.6%, 13.3%에서 나타났고, C 반응단백은 평균 19.3 mg/L(3.1-103)이었다. 결 론 : 두 개의 군에 해당되는 hMPV가 우리나라 소아에서도 동시에 유행함을 확인하였다. 연구가 기간이 짧았고, 천안 지역에 국한되었던 제한점이 있으나, hMPV 감염에 의한 급성 하기도염 환아들의 임상양상을 알아 볼 수 있었다. 우리나라에서 hMPV 감염의 정확한 역학 조사와 치료 및 예방대책을 수립하기 위해 많은 연구가 요구된다.

• 대한수의학회지
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• 제20권2호
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• pp.179-197
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• 1980

A survey was made from March 1978 through Feb. 1979 to know infection rate of parasites and incidence of diseases in 1968 cattle of 240 rearing and fattening cattle herds (1746 Korean native cattle, 186 Holstein, 34 Charolais and 2 Hereford) raising in 28 cities and counties of Gyeongbug district. The results obtained are summarized as follows: 1. The rate of nematoda infection was about 49.0% in the examined cattle. These nematodes were identified as Mecistocirrus sp., Oesophagostomum sp., Bunostomum sp., Trichostrongylus spp., Strongyloides sp. and other 3 species. Infection rate of nematoda in fattening and breeding cattle was higher than that in rearing calves, 44.3% of the positive cattle were infected with 2 to 5 species, and incidence of mixed infection was high in fattening cattle. 2. The rate of coccidal infection was 10.9%. Eimeria $z{\ddot{u}}rni$, Eimeria bovis and Eimeria bukidnonensis were mainly found in the examined cattle. The infection rates of cocidia in Holstein, breeding Korean cows, rearing Korean calves and fattening Korean cattle were 27.3%, 15.8%, 11.2% and 9.1%, respectively. 3. The rate of trematoda was 14.6% with Fasciola spp. (11.2%), Eurytrema spp. (2.0%), and Paramphistomum spp. infections (1.4%). Breeding Korean cows, fattening Korean cattle, Holstein and rearing Korean calves indicated 47.4%, 26.4%, 18.2% and 6.3% incidence of trematoda infections, respectively. of trematoda positive cattle, 76.6% were infected with Fasciola spp., 4. The rate of Theileria and Babesia infection was 62.7% in the examined cattle. Of these positive cattle 5.4% were infected with both parasites, 57.3% with Theileria, and 1.3% of rearing Korean calves and 22.6% of Holstein were found to have parasitized erythrocytes over 1.0%. 5. The incidence of diseases in 1968 cattle of 240 herds was 564 cattle (28.7%) of 154 herds (64.2%). of the diseases observed of skin occurred in 354 cattle (18.0%) of 61 herds (25.4%), diseases of respiratory system in 121 cattle (6.1%) of 34 herds (14.2%), diseases of digestive system in 38 cattle (1.9%) of 22 herds (9.2%), diseases of eye in 21 cattle (1.1%) of 13 herds (5.4%), diseases of urogenital system in 8 cattle (0.4%) of 8 herds (3.3%) and the other diseases in 24 cattle (1.2%) of 22 herds (9.2%). 6. Diseases of skin in 1968 cattle of 240 herds werds were observed in the highest incidence. Ringworm was observed in 13.3% of the examined herds, rearing Korean calves and Holstein showed high incidence. Scabies caused by Chorioptes bovis and alopecia localis along with infestation of lice (Damalinia bovis, Linognathus vituli) were observed in fattening Korean cattlein winter. 7. Diseases of respiratory system occurred frequently in rearing Korean cattle and Holstein. In the diseases of digestive system acute indigestion occurred in fattening Korean cittle, enteritis in rearing Korean calves and Holstein, and coccidiosis in rearing Korean calves maninly. 8. Infectious keratoconjunctivitis occurred in a fattening Korean cattle herd, sterility (2.0%) in breeding Korean cows, and theileriosis in Holstein calves were also occurred. In addition, poisoning and heat stroke were observed in several cattle.

• 대한한방소아과학회지
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• 제32권3호
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• pp.72-89
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• 2018

Objectives The objective of this study is to investigate the application of Sifeng point (EX-UE 10) in children and to make suggestions for domestic research and clinical application by reviewing relevant randomized controlled trials. Methods Eight electronic databases including English, Chinese, Korean databases were comprehensively searched for randomized controlled trials evaluating the effects of Sifeng point in children up to May 2, 2018. We extracted the year of publication, country, target diseases or symptoms, location of Sifeng, acupuncture method; such as acupuncture tool and depth of insertion, and frequency, number, and duration of the treatment. Results Fifty studies were included for analysis. All the included studies were conducted in China, and studies were published from 1962 to 2017. The most frequent target symptom was anorexia (46%). In addition, Sifeng point was used for digestive diseases or symptoms such as diarrhea, constipation, and mesenteric lymphadenitis, as well as respiratory diseases or symptoms such as cough, cold, acute bronchiolitis, recurrent respiratory tract infections, bronchopneumonia, and asthmatic bronchitis. Also, allergic diseases such as chronic urticaria, and other variety of symptoms such as malnutrition, fever, and iron-deficiency anemia were treated with the Sifeng point. The location of Sifeng points was inconsistent, and the most common location of the Sifeng point was the midpoint of transverse creases of the proximal interphalangeal joints of the index, middle, ring and little fingers (84.2%). The most commonly used acupuncture tool was three-edged needle (40.9%). All included studies have the method of squeezing out blood or mucus from the Sifeng points. The treatment was mostly conducted once per week (35.4%), mostly repeated for 4 times (32.6%). The most common treatment duration was 4 weeks (18.6%). Conclusions We could identify acupuncture method and various indications for the Sifeng points treatment. Based on this study, there is a need for the clinical application and related researches on the Sifeng points in children in Korea. In addition, the treatment location of Sifeng point should be standardized.

• 미생물학회지
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• 제39권2호
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• pp.89-94
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• 2003

호흡기 바이러스 분리 및 항원분석을 통하여 미래의 백신개발 및 항원 분석을 위한 역학적 자료를 제공하고자 2000~2001년 사이의 급성 호흡기 감염증 환자를 대상으로 호흡기 바이러스를 분리하여 그 특성을 조사하였다. 2000년도에 분리된 바이러스는 충 43주로서, 이 중 39주의 인플루엔자바이러스가 분리되었으며, A형이 23주, B형이 16주 관찰되었으며, 또한 아데노바이러스가 4주 관찰되었다. 그리고 2001년도에는 총 56주의 바이러스가 분리되었는데, 이는 모두 인플루엔자 바이러스로 확인되었다. 분리된 인플루엔자 바이러스의 주요항원별 특징으로는 A/Sydney/05/97(H3N2)-like, A/Beijing/262/95(H1N1)-like, 및 B/Harbin07/94-like가 2000년에, A/Panama/253/99(H3N2)-like 및 A/Newcaledonia/2007/99(H1N1)-like가 2001년에 분리되었으며, 아데노바이러스는 1, 2, 5형의 혈청형이 발견되었다. 분리된 바이러스의 성별 발생분포는 2000년에 남성환자 14명(32.56%), 여성 환자 23명(67.44%), 2001년에 남성환자 23명(41.07%), 여성환자33명(58.93%)이 발생하여 2000년과 2001년 모두 여성환자의 발생율이 비교적 높게 나타났다. 연령별 발생분포는 2000년에는 0-1세 사이에서 48.84%로 대부분을 차지하였으나, 2001년에는 l1∼20세 사이에서 33.93%로 비교적 높은 발생율을 나타내었으며, 그 외 연령별로는 비슷한 발생율을 나타내었다. 월별 발생분포는 2000년에는 1월에 한차례 높았다가 다시 4월에 다소 높은 발병율을 나타내었으며, 6월까지 낮은 비율이지만 다양한 바이러스가 출현하였다. 반면 2001년에는 2월과 3월에 집중적으로 발생하였으며 H3N2가 강력한 발병율은 나타내면서 주로 이른봄에 발생하였다.

• 한국미생물·생명공학회지
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• 제31권4호
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• pp.329-333
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• 2003

2000-2002년 사이 최근 3년간 부산지역 급성 호흡기 감염증 환자를 대상으로 인플루엔자 바이러스를 분리하여 그 특성을 조사하였다. 2000년도에 분리된 바이러스는 총 39주의 인플루엔자 바이러스이었으며, A형이 23주 그리고 B형이 16주이었다. 분리된 인플루엔자 바이러스의 항원적 특성을 관찰한 결과 A/Sydney/05/97(H3N2)-like, A/Beijing/ 262/95(H1N1)-like, 및 B/Harbin/07/94-like임을 알수 있었다. 2001년도에는 총 56주의 인플루엔자바이러스가 분리되었다. 항원적 특성을 분석한 결과 A/Panama/2007/99(H3N2)-like 및 A/Newcaledonia/20/99(H1N1)-like임을 알수 있었고, 2002년도에는 총 114주가 분리되었으며, 이 중 A/Panama/2007/99(H3N2) 유사주가 61주이고, A/Newcaledonia/20/99(H1N1) 유사주가 22주이었다. 그리고 B/Beijing/243/97, B/HonKong/22/2001, B/Sichuam/379/00 유사주가 31주 분리되었다. 분리된 바이러스의 성별 발생분포는 2000년에 남성환자 13명(33.33％), 여성환자 If면(66.67％), 2001년에 남성환자 23명(41.07％), 여성환자 33명(58.93％)이 발생하여 2000년과 2001년 모두 여성환자의 발생율이 비교적 높게 나타났다. 2002년도에는 남성환자 57명(50％), 여성환자 57명(50％)으로 남녀 발생분포가 같았다. 연령별 발생분포는 2000년에는 0-10세 사이에서 48.84％로 대부분을 차지하였으나, 2001년에는 11-20세 사이에서 33.93％로, 비교적 높은 발생율을 나타내었으며, 그 외 연령별로는 비슷한 발생율을 나타내었고, 2002년도에는 10세이하 환자가 72명으로 63.16％를 차지하였다. 월별 발생분포는 2000년에는 1월에 한차례 높았다가 다시 4월에 다소 높은 발병율을 나타내었으며, 6월까지 낮은 비율이지만 다양한 바이러스가 출현하였다. 반면 2001년에는 2월과 3월에 집중적으로 발생하였으며 H3N2가 강력한 발병율은 나타내면서 주로 이른봄에 발생하였고, 2002년도에는 3월과 11월에 두 번이나 높은 발생율을 나타내었다. 이상의 결과는 급성호흡기증후군이 세계적으로 유행하고 있는 현 시점에서 인플루엔자 백신 개발 및 유행예측을 위한 역학자료로 유용하게 이용될 것으로 사료된다.