• 제목/요약/키워드: Acute toxicity

검색결과 1,229건 처리시간 0.038초

Acute and subacute toxicity studies of GX-12, a DNA vaccine for the treatment of HIV infection, in SD rats

  • Park, Seul-Min;Kang, Kyung-Koo;Sohn, Yong-Sung;Kim, Mi-Ju;Baik, Dae-Hyun;Ahn, Byung-Ok;Kim, Won-Bae
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.157-157
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    • 2002
  • The toxicity of GX-12, a naked DNA vaccine developed by research team of Dong-A Pharmaceutical Company, Green Cross Company and Genexine for the treatment of HIV infection, was investigated in Sprague-Dawley rats. In single-dose intramuscular/oral acute toxicity studies, animals were treated 0, 250, 1000 or 4000 $\mu\textrm{g}$/kg/$m\ell$ in sodium phosphate buffer.(omitted)

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딸기용 농약의 꿀벌에 대한 급성독성 및 엽상잔류독성 (Honeybee Acute and Residual Toxicity of Pesticides Registered for Strawberry)

  • 김병석;박연기;이용훈;정미혜;유아선;양유정;김진배;권오경;안용준
    • 농약과학회지
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    • 제12권3호
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    • pp.229-235
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    • 2008
  • 시설재배 딸기에 사용하는 농약이 화분매개를 위해 투입된 꿀벌(Apis mellifera L.)에 미치는 영향을 조사하기 위해 꿀벌에 노출될 가능성이 있는 21종의 농약을 선정하여 꿀벌 급성독성시험과 엽상잔류독성시험을 실시하였다. 표준살포농도로 분무처리한 급성접촉독성시험에서는 24시간 후에 꿀벌치사율이 대조군과 유한 차이를 보인 농약은 dichlofluanid WP 등 6종이었고, 48시간 후에는 fenpropathrin EC 등 7종이었다. 급성 섭식독성시험에서는 fenpropathrin EC만이 꿀벌에 독성을 보여주었으며 milbemectin EC는 배량처리군에서 대조군과 비교하여 유의한 치사율 차이를 보여주었다. 또한 엽상잔류독성시험에서는 fenpropathrin EC만이 10일 이상 장기간 잔류독성을 보였다. 이상의 결과를 종합하여 21종 제품농약에 대한 살포 후 꿀벌안전방사기간을 제안하였다.

비글개에 대한 Paecilomyces sinclairii의 급성 경구독성에 관한 연구 (Acute Oral Toxicity of Paecilomyces sinclairii in Beagle Dogs)

  • 안미영;강세찬;정나진;구현정;곽승준;유은정;정진아;고진경;류강선
    • Toxicological Research
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    • 제19권3호
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    • pp.241-245
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    • 2003
  • The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/biochemical examinations for 14 days after administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the $LD_{50}$ was greater than 10 g/kg in beagle dogs.

연교(連翹)추출물의 일반(一般) 약리작용(藥理作用) (Pharmacological Studies on Forsythiae Fructus)

  • 이은방;금혜정
    • 생약학회지
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    • 제19권4호
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    • pp.262-269
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    • 1988
  • The Forsythiae fructus is described to be used as an antiinflammatory drug, diuretics, antidotes and antibacterials in oriental literatures. In order to investigate the efficacy of Forsythiae viridissima (Oleaceae), the methanol extract and its fraction have been evaluated for the acute toxicity, antiinflammatory, analgesic and spasmolytic action in animals. The methanol extract of Forsythiae fructus was found to have significant antiinflammatory activity in the acute and subacute antiinflammatory model in rats, but have no analgesic action. Furthermore, through fractionation procedure, it was found that the active compounds were easily soluble in chloroform and butanol. It is also noted that the extracts had spasmolytic activities in the rat fundus and uterus and had low acute toxicity in mice.

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랫드에서 인체 재조합 적혈구 조혈인자, rHu-EPO의 급성정맥독성시험 (Acute Toxicity Study of Recombinant Human Erythropoietin(rHu-EPO) in Rats)

  • 곽승준;김형식;임소영;천선아;홍채영;박현선;김원배;김병문;안병옥
    • Biomolecules & Therapeutics
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    • 제4권4호
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    • pp.330-333
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    • 1996
  • Acute intravenous toxicities of rHu-EPO (recombinant human erythropoietin) were investigated in Sprague-Dawley rats. Seven days after administration of rHu-EPO, we examined the clinical signs, mortalities, body weight and etc. No clinical signs and mortalities of toxicity were observed in animals. Also, a significant change of body weights was not observed. These results suggest that LD$_{50}$ value was >25,000 unit/ kg in Sprague-Dawley rats and the acute intravenous toxicities of rHu-EPO were not significant.t.

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마우스에서 황토국화 추출물의 급성독성 연구 (Acute Toxicity Study on Mud chrysanthemum Indicum in Mice)

  • 마진열;박화용;최한;지옥표;이재훈
    • 대한본초학회지
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    • 제23권2호
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    • pp.81-85
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    • 2008
  • Objectives : The aim of this study is to collect data for toxicity and safety of Mud chrysanthemum indicum. Methods : In this study, we investigated the acute toxicity for buthanol-extracted Mud schrysanthemum indicum, 25 male and 25 female mice were observed for 14days after one day oral administration of Mud chrysanthemum indicum at the respective doses of 0(control group), 1024, 1280, 1600 and 2000mg/kg. Results : We observed survival rates, general toxicity, change of body weight and autopsy. No abnormality was found for all cases. Conclusions : The data confirmed that Mud chrysanthemum indicum is free from, the toxicity and safety problems. Compared with the control group, we could not find any toxic alteration in all treated groups (1024, 1280, 1600 and 2000mg/kg), In conclusion, LD50 of Mud chrysanthemum indicum was over 2000 mg/kg and it is very safe to mice.

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Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai

  • Choi, Seona;Kim, Soyoun;Bae, Yeon-Jae;Park, June-Woo;Jung, Jinho
    • Environmental Analysis Health and Toxicology
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    • 제30권
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    • pp.3.1-3.6
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    • 2015
  • Objectives This study aims to evaluate the size-dependent toxicity of spherical silver nanoparticles (Ag NPs) to an endemic benthic organism, Glyptotendipes tokunagai. Methods Ag nanoparticles of three nominal sizes (50, 100, and 150 nm) capped with polyvinyl pyrrolidone (PVP-Ag NPs) were used. Their physicochemical properties, acute toxicity (48 hours), and bioaccumulation were measured using third instar larvae of G. tokunagai. Results The aggregation and dissolution of PVP-Ag NPs increased with exposure time and concentration, respectively, particularly for 50 nm PVP-Ag NPs. However, the dissolved concentration of Ag ions was not significant compared with the median lethal concentration value for $AgNO_3$ (3.51 mg/L). The acute toxicity of PVP-Ag NPs was highest for the smallest particles (50 nm), whereas bioaccumulation was greatest for the largest particles (150 nm). However, larger PVP-Ag NPs were absorbed and excreted rapidly, resulting in shorter stays in G. tokunagai than the smaller ones. Conclusions The size of PVP-Ag NPs significantly affects their acute toxicity to G. tokunagai. In particular, smaller PVP-Ag NPs have a higher solubility and stay longer in the body of G. tokunagai, resulting in higher toxicity than larger PVP-Ag NPs.

국내 유통되는 농약 유효성분에 대한 안전보건정보 데이터베이스 구축 (A Study on Developing Safety and Health Information Database of Pesticide Ingredients Used in Korea)

  • 임경채;최상준
    • 대한안전경영과학회지
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    • 제12권3호
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    • pp.27-35
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    • 2010
  • In this study, we have developed the database of safety and health information for pesticide active ingredients used in Korea. There were 1,283 pesticide items among which 296 were found to be out of use in current. A total of 349 pesticide ingredients were being used in Korea. The database consists of 32 types of information including chemical characteristics, acute toxicity, chronic toxicity (carcinogenic and reproductive toxicity), specific symptoms by exposure route and first aid. When pesticide ingredients were assessed in terms of key properties such as color, odor, acute toxicity, carcinogenic and reproductive toxicity, they were white, colorless and odorless, in general. When ingredients were classified by category of acute toxicity, 'Non-hazardous' represented 29%, followed by 'Slightly hazardous' at 16%, 'Moderately hazardous' at 14%, 'Highly hazardous' at 5%, and 'Extremely hazardous' at 2%. 85 out of 349, or 24% of ingredients were found to be possibly carcinogenic to human. This database is expected to provide an easy access for farmers, agriculture supervisors, researchers and consumers, and it can ultimately be used as basic data on farmer's safety and health.

Daphnia magna를 이용한 과불화화합물의 독성평가 (Toxicity Evaluation of Perfluorinated Compounds Using Daphnia magna)

  • 김경태;조재구;윤준헌;이철우;최경희;김현미;류지성
    • Environmental Analysis Health and Toxicology
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    • 제25권2호
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    • pp.153-159
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    • 2010
  • Perfluorooctane sulfonic acid (PFOS) and Perfluorooctanoic acid (PFOA) are the principal chemicals known as perfluoroalkyl acids (PFAs). Despite the widespread use of these compounds, relatively little is known about their fate and effects. The purpose of this study was to determine the toxic effects of PFOS and PFOA on Daphnia magna. In the acute toxicity test, D. magna were exposed for 48 hours at concentrations of 0, 30, 45, 67.5, 101.25 and 151.88 mg/L PFOS, and 0, 100, 160, 225, 337.5 and 506.25 mg/L PFOA, respectively. In the case of chronic toxicity test, D. magna were exposed through water for 21 days at concentrations of 0, 0.375, 0.75, 1.5, 3 and 6 mg/L PFOS, and 0, 1.25, 2.5, 5, 10 and 20 mg/L PFOA, respectively. Acute toxicity was assessed on the basis of immobility, while chronic toxicity was assessed on the basis of fecundity. The acute toxicity test on PFOS and PFOA showed that the values of $EC_{50}$ were 50.90 mg/L and 253.47 mg/L, respectively. In the chronic test, fecundity was reduced significantly at 1.5 mg/L of PFOS and 10 mg/L of PFOA, respectively. These results indicated that PFOS is more toxic to zooplankton than PFOA, and both chemicals have some hazard demonstrates risk for acute or chronic toxicity to freshwater organism.

Ceriodaphnia dubia의 온도조절에 근거한 단기급성독성 조사법 (Rapid Bioassay Technique Based on Temperature Control of Ceriodaphnia dubia)

  • 박종호;이상일;조영옥;이원호;연익준;조규석
    • 한국수산과학회지
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    • 제37권3호
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    • pp.209-214
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    • 2004
  • A method for rapid acute toxicity test based on temperature control of Ceriodaphnia dubia has been developed and evaluated. A new toxicity test based on temperature control (TTBTC) which are based on temperature control, was developed and compared for the adsorption of the better methodology for short-term toxicity screening. Initially, daphnid larval are exposed to toxicants and at the same time the temperature of the water bath containing media is increased to high temperature $(35.5^{\circ}C).$ After 1.25 hrs of contact time, the number of the daphnids, either living (no toxic effect) or dead (toxic effect), is counted by the naked eyes. Effect of exposure time on test sensitivity was not significantly different between 1 to 1.5 hr. Comparison of the rapid 1.25 hr acute toxicity test developed in this study and the standard 48 hr acute toxicity test using heavy metals, cyanide and pentachlorophenol indicated that the 1.25 hour test provides an acceptable level of sensitivity in toxicity test for C. dubia.