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Acute Oral Toxicity of Paecilomyces sinclairii in Beagle Dogs  

안미영 (농업과학기술원 잠사곤충부)
강세찬 (성균관대학교 약학대학 독성학교실)
정나진 (성균관대학교 약학대학 독성학교실)
구현정 (성균관대학교 약학대학 독성학교실)
곽승준 (성균관대학교 약학대학 독성학교실)
유은정 (성균관대학교 약학대학 독성학교실)
정진아 (성균관대학교 약학대학 독성학교실)
고진경 (성균관대학교 약학대학 독성학교실)
류강선 (농업과학기술원 잠사곤충부)
Publication Information
Toxicological Research / v.19, no.3, 2003 , pp. 241-245 More about this Journal
Abstract
The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/biochemical examinations for 14 days after administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the $LD_{50}$ was greater than 10 g/kg in beagle dogs.
Keywords
Acute toxicity; Paecilomyces sinclairii; Beagle dogs.;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
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