• 동의신경정신과학회지
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• 제27권3호
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• pp.197-206
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• 2016

Objectives: This study was performed to review the research trends in the treatment of posttraumatic stress disorder in traditional Chinese medicine.Methods: We searched articles in the China National Knowledge Infrastructure (CNKI) using keywords, “ Posttraumatic stress disorder” , and “ PTSD” in Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs and Combination of Traditional Chinese Medicine and the Western Medicine field. We selected 16 studies after excluding non-clinical or unrelated studies.Results: Four pre-post comparison studies and 12 controlled clinical trials were performed in patients with PTSD in China. Herbal medicine, acupuncture, and moxibustion therapy were used for the treatment of PTSD. Most of the studies showed positive results, and they reported that the treatment groups had fewer side effects than the control group. However, the quality of these clinical studies was low.Conclusions: According to this study, TCM for PTSD would be an effective and safe intervention. Therefore, based on this study, more clinical research on the treatment of PTSD should be performed in Korean medicine in the near future.

• 동의신경정신과학회지
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• 제27권4호
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• pp.223-234
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• 2016

Objectives: This study was carried out to develop a standard tool of pattern identifications for insomnia in Korean Medicine. Methods: The advisory committee for this study was organized by 17 Korean Medicine neuropsychiatry professors who were faculty members of different Korean Medicine colleges. The pattern identifications and symptoms for this tool were extracted from published Korean and Chinese literature. The Instrument on Pattern Identifications for Insomnia was developed following discussions among internal experts and after consultations with members of the advisory committee. Results: 1) Five pattern identifications were set for the tool. 2) The mean weights which represent the importance of each symptom and scored on a hundred-point scale were obtained. 3) The Instrument on Pattern Identifications for insomnia was designed in the self-reporting format composed of 47 questions. Conclusions: An Instrument on Pattern Identifications for Insomnia was created in this study. However, owing to any clinical trials has not been set yet. Therefore its validity and reliability were not confirmed. To make up for this limitation, the further clinical study would be performed in the near future.

• 동의신경정신과학회지
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• 제27권4호
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• pp.235-248
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• 2016

Objectives: The aim of this review was to investigate whether evidence of complementary and alternative medicine (CAM) was reflected in clinical practice guidelines (CPGs) for insomnia based on relevant clinical trials. Methods: We conducted a systematic search on domestic and international CPG databases and medical databases. In addition, we conducted manual searches of relevant articles. Three authors independently searched and selected relevant studies; any disagreement was resolved by discussion. We extracted and analyzed the following data: published language, country, development group, participants, interventions, presence or absence of recommendations for CAM, level of evidence, grade of recommendation for CAM, and methods of development. Results: We identified 8,241 records from domestic and international databases, and 22 CPGs were included. Eleven of the 22 CPGs mentioned CAM interventions including herbal medicine, relaxation, acupuncture moxibustion, Tai Chi, meditation, hypnosis, biofeedback, Tuina, and external herbal medicine. However, most of the CPGs indicated 'no recommendation' or 'weak recommendation' for CAM interventions. Only Valeriana dageletiana Nakai and relaxation were considered to have experimental evidence. Valeriana dageletiana Nakai was recommended for improvement of sleep latency, sleep maintenance, total sleeping time, and sleep cycle. Relaxation was recommended as effective intervention for relieving physical and psychological arousal. Conclusions: Despite systematic reviews and randomized controlled trials on CAM for insomnia, most of the CPGs for insomnia did not reflect the evidence obtained. Further CPGs for insomnia should be developed by considering the current advanced studies in the field of CAM.

• 동의생리병리학회지
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• 제29권4호
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• pp.337-346
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• 2015

Sprain is the injury of meridian-muscle, and is caused by qi and blood obstruction or regional stagnation of qi and blood. So we take the channel points where pain flows. If we take the locations that feel pain, those locations are treatments points and ashi points. So we searched over the ashi points appearing on the patients with wrist sprain. Ashi points appeared on LI5, TE4, SI5 around wrist joints, LI10, LI11, LU6 around elbow joints, LI14, LU3, LU4, PC2 around upper arm. Also, ashi points appeared much on ST17, KI23, PC1, SP18, ST18 around thoracic region, and, on BL15, BL44, BL13 around anterior and thoracodorsal region, in order stated. Ashi points of the highest frequency appeared on LI14 around upper arm, and on LI5, TE4 around wrist joint, and SI5, ST17, KI12, PC1, SP18 appeared with second highest frequency. And ashi points on elbow points and thoracodorsal region appeared with the same frequency. Therefore, it is possible for us to know that the pain location appears in order of upper arm, anterior thoracic region, elbow joint region, and, thoracodorsal region, in treating wrist joints. There was a tendency that pain and movement disturbance recovered more quickly, depending on the pain reduction, as we found out the ashi points closely from stagnated qi and blood caused by wrist arthritis, and relaxed the stiff location. Rubbing treatments in treating pain ashi points is considered to play an important role to reduce pain effectively, so it is necessary to make a further study.

• 대한약침학회지
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• 제19권2호
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• pp.155-162
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• 2016

Objectives: Bufonis venonum (BV) is toad venom and is the dried, white secretions of the auricular and the skin glands of toads. This study was performed to evaluate the toxicity of intravenous injection of Bufonis venonum pharmacopuncture (BVP) through a single-dose test with sprague-dawley (SD) rats. Methods: Twenty male and 20 female 6-week-old SD rats were injected intravenously in the caudal vein with BVP or normal saline. The animals were divided into four groups with five female and five male rats per group: the control group injected with normal saline, the low-dosage group injected with 0.1 mL/animal of BVP, the medium-dosage group injected with 0.5 mL/animal of BVP and the high-dosage group injected with 1.0 mL/animal of BVP. We performed clinical observations every day and body weight measurements on days 3, 7 and 14 after the injection. We also conducted hematology, serum biochemistry, and histological observations immediately after the observation period. Results: No mortalities were observed in any experimental group. Paleness occurred in the medium- and the high-dosage groups, and congestion on tails was observed in females in the medium- and the high-dosage groups. No significant changes in weight, hematology, serum biochemistry, and histological observations that could be attributed to the intravenous injection of BVP were observed in any experimental group. Conclusion: The lethal dose of intravenously-administered BVP in SD rats is over 1.0 mL/animal.

• 대한약침학회지
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• 제12권4호
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• pp.97-110
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• 2009

Objective : The purpose of this study is to determine the effect of Hominis Placenta Pharmacopuncture(HPP) on lower limb spasticity control in stroke patients. Methods : Twenty stroke patients with Leg spasticity were randomly divided into two groups, a Distilled water Pharmacopuncture(group I) and a HPP(group II). The number of Pharmacopuncture was 5 times a week and acupuncture treatment was 3 times a week for 3 weeks. Modified Ashworth Scale(MAS), H-reflex/M-response ratio(H/M ratio), Berg Balance Scale(BBS) and Time Up & Go(TUG) were used for evaluation of spasticity control before experiment, after 1 week, 2 weeks, 3 weeks. Results : Group I showed significant improvement(p$<$.05) in BBS but no significant improvement in MAS, H/M ratio, and TUG. Group II showed significant improvement(p$<$.05) in MAS, BBS, and TUG, but no significant improvement in H/M ratio. The results showed significant difference in TUG, but no significant difference in MAS, H/M ratio and BBS between 2 groups. Conclusion : These results showed that HPP might decrease lower limb spasticity and increase leg motor function in stroke patients. Further studies will be required to examine more cases in the long period for the effect on lower limb in spasticity by HPP.

• 대한약침학회지
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• 제13권3호
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• pp.5-13
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• 2010

Reactive Oxygen Species(ROS) are continuously produced at a high rate as a by-product of aerobic metabolism. Since tissue damage by free radical increases with age, the reactive oxygen species(ROS) such as hydrogen peroxide($H_2O_2$), nitric oxide(NO). Several lines of evidence provided that ROS appears to cause to develop aging-related various diseases such as cancer, arthritis, cardiovascular disease. Our reserch objective was to examine the in vitro biological activity of Scolopendrid Pharmacopuncture, including the total poly-phenol content, DPPH radical scavenging, ABTS radical scavenging, Superoxide dismutase(SOD)-like activity, Nitrite scavenging ability. The total poly-phenol contents of Scolopendrid Pharmacopuncture was 35.859mg/L. Elctron donation ability on DPPH was 36.82%. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 84.7%. The superoxide dismutase (SOD)-like activities of Scolopendrid Pharmacopuncture was 44.33%. The nitrite scavenging effects were pH dependent, and were highest at pH 1.5(45.2%) and lowest at pH 6.0(11.3%). We conclude that Scolopendrid Pharmacopuncture may be useful as potential sources of antioxidant.

• 대한약침학회지
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• 제13권3호
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• pp.81-90
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• 2010

Objectives: This investigation was conducted to evaluate current education status of pharmacopuncture in Korean traditional medicine schools and suggest improvement in the structure of pharmacopuncture education. Methods: Among the eleven Korean traditional medicine schools in the country, six schools participated in the survey. 252 students in fifth and sixth year whom have finished pharmacopuncture studies completed were given questionnaire developed for the purpose and survey results were analyzed. Results : 1. For the question pertaining to the text used for the pharmacopuncture lecture, a significant difference was witnessed suggesting that few schools were not utilizing common textbooks. 2. For the item pertaining to the lecture progression, each school showed significant difference and student satisfaction rate differed vastly between schools. 3. Lecture hours and lecture materials were also significantly different between schools and overall satisfaction rate was low. 4. All of students participated in the survey had high expectation in the clinical applications of pharmacopuncture treatment. Conclusions: Above findings indicate that students at Korean traditional medicine schools throughout the nation have high expectation for pharmacopuncture, but lack of standardized education system and materials and qualified instructors calls for immediate modification in the education of pharmacopuncture studies.

• 기술혁신학회지
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• 제17권2호
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• pp.334-354
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• 2014

본 논문에서는 KCI(한국학술지인용색인) 데이터를 기반으로 네트워크 분석 기법을 활용하여 한의학 분야 연구동향 분석을 실시하였다. 먼저 기술통계분석 결과에 의하면, 한의학분야 논문은 증가하다가 2008년을 정점으로 감소 추세이며 논문 저자수도 이와 같은 추세를 보여 주었다. 동의생리병리학회지가 가장 많은 논문을 생산하고 있고, 핵심어의 경우 acupunture가 월등한 빈도수 차이로 1위를 차지하였다. 다음으로 네트워크 분석을 통해 네트워크의 형태와 중심성 수치를 통해 네트워크의 중심과 핵심 그룹을 파악하였고, 연도별 비교를 통해서 네트워크의 모습과 중심이 어떻게 변화했는지 알 수 있었다. 학술지 네트워크의 경우 동의생리병리학회지, 대한한의학회지 등이 핵심적인 그룹을 형성하였고, 그 중 한의학연구원논문집이 최근에 중심적 위치를 차지한 것으로 나타났다. 연구기관 네트워크에서는 경희대학교가 가장 중심에 있으며, 최근 한의학연구원의 중심성이 커졌다. 핵심어 네트워크를 통해 한의학 연구가 질환의 기전과 치료로 양분되어 수행되는 것을 확인할 수 있었다. 이러한 사회연결망분석의 결과를 통해 심층적인 연구동향을 파악할 수 있어서 연구동향 분석에서 전문가 식견에 의한 동향분석 방법과 서로 연계되는 유용한 방법임을 확인 할 수 있었다.

• 대한한의학회지
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• 제21권4호
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• pp.216-226
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• 2000

Objectives : The aim of this clinical experiment was to investigate the effect of KamiWooseul-tang on low back pain and kidney function. Methods: We investigated 64 low back pain patients. We treated the patients with acupuncture, bed rest, herbal medicine, physical therapy. The patients were divided into two groups as follows, 32 patients (with normal renal function) were treated with only KamiWooseul-tang. Another 32 patients were treated with a commonly used herbal medicine. Results : The obtained results are summarized as follows. The patients were 43.8% male and 56.2% female. Their age were 20s 15.6%, 30s 25%, 40s 17.2%, 50s 9.3%, 60s 18.8% 70s 12.5% and 80s1.6%. Duration is most common in the most acute stage (< 1 week), next was chronic stage ( >6 months ), acute stage (1 week ~ 1 month) and subacute stage(l months ~ 6 months) in turn. Cure rate increased step by step after herb-medicine administration. Duration of patients had no relation with cure rate(P>0.05). The KamiWooseul-tang was more effective than the commonly used herbal medicine after 3 weeks therapy (P<0.05). Serum BUN and Creatinine level in KamiWooseul-tang group changed from $14.69{\pm}4.0,{\;}0.76{\pm}0.19(mg/dl)$ before adminstration to $13.64{\pm}3.92{\;}0.77{\pm}0.19,{\;}13.48{\pm}3.00{\;}0.82{\pm}0.21,{\;}13.26{\pm}3.73{\;}0.87{\pm}0.21(mg/dl)$ at 7th, 14th, and 21st days of administration respectively. Urinalysis showed no specific change in the KamiWooseul-tang group. During medication serum-electrolyte was within normal range. Conclusion : Therefore KamiWooseul-tang was more effective than the commonly used herbal medicine and there was no clinically remarkable difference in the serum BUN, Creatinine level, urinalysis and serum electrolyte between pre-medication and post-medication in the KamiWooseul-tang group.