• Journal of Ginseng Research
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• v.4 no.1
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• pp.31-39
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• 1980

This study was prepared to observe some enzyme activities in the liver of mice treated with extracts of Ginseng anticancer compound, separated from the petroleum ether extracts by silicic acid chromatography, has the cytotoxic activity against cancer cells. Swiss mice, 72 heads were used (or this experiment and they were divdied into control, test group I and test group If, that test group I was injected crude extract and test group II was injected anticancer compound, while the control group was injected 0.9% NaCl solution. The injections were carried out 1,2,4 and 8 times once a day for 1-8 day, respectively. The liver was removed carefully from the mice at 24 hours after drugs injected, and homogenized at 4$^{\circ}C$ for enzyme study. The activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase(GPT) were determined by Reitmen and Frankel method and lactic acid dehydrogenase activity was determined by Wroblewski methods in vitro. The results obtained are summarized as follows; 1. The GOT activity was increased 26%, crude extract and 16%, anticancer compound than those of control at 1st injected groups and decreased gradually according to increase of injection time, at 8th injected groups, the GOT activity was decresed by 16%, crude extract and 12%, anticancer compound. 2. The GPT activity was not changed significantly at 1st and 2nd injected groups, but, at 4th injected groups, the GPT activity was decreased 20%, crude extract and 14%, anticancer compound. While the GPT activity was recovered to normal value at 8th injected groups. 3. At 1st injected groups, the LDH activity was increased 17%, anticancer compound, while those of crude extract was shown normal value. At 2nd injected groups, the LDH activity increased 35yo:, crude extract while those of anticancer compound was showed normal value. And the LOH activity was recovered gradually at 4th and 8th injected groups.

• Journal of Digital Convergence
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• v.14 no.5
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• pp.459-471
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• 2016

This study presents a comparative study for differences in efficacy and ingredient of white ginseng(WG), red ginseng(RG), and black ginseng(BG) using anti-oxidative activity test and anti-inflammatory activity test. In the results of cytotoxicity test for WG, RG, and BG, the survival rate of all cells was more than 95%. In the total polyphenol analysis, DPPH, ABTS radical scavenging test, and ROS production test, BG showed higher anti-oxidant activity than WG and RG. RG and WG showed higher inhibition activity of NO production and $PGE_2$ production, respectively. As results of the test for the effect on reduction of inflammatory cytokine production, WG and RG were effective on reduction of IL-$1{\beta}$ production, and BG was effective on reduction of IL-6. In the case of TNF-${\alpha}$ production, there was no difference among samples. This study could be useful basic data for the development of functional food and the fabrication of safe cosmetic.

• Advances in Traditional Medicine
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• v.9 no.2
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• pp.142-148
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• 2009

Anxiety disorders are one of the serious problems which need proper therapy devoid of side effects of presently available medicines. The present study evaluates the anxiolytic and sedative activity of leaf galls of Piper nigrum Linn. in Swiss Albino mice. The pet. ether, chloroform, ethyl acetate and ethanol extracts of leaf galls of Piper nigrum Linn were obtained by continuous soxhlet extraction. The prepared extracts were found to be safe up to 2000 mg/kg body weight of mice in the acute toxicity study. Each extract was assessed for anxiolytic activity in Swiss Albino mice by elevated plus Maze, open field test, rota rod test and phenobarbitone induced sleeping time test. In the Elevated Plus Maze test, the pet.ether extract and chloroform extract at a dose of 50 mg/kg b.w. orally, significantly (P < 0.01) increased the number of entries and time spent in open arm comparable with standard diazepam at the dose of 10 mg/kg. b.w. p.o. In the open field test, pet. ether extract (50 mg/kg b.w. p.o.) showed significant increase (P < 0.01) in ambulation and activity in the center. Chloroform extract (50 mg/kg b.w p.o.) was significant (P < 0.05) for both ambulation and center activity. Pet. ether extract (50 mg/kg b.w. p.o) also showed significant activity (P < 0.01) in rota rod test. All the results are comparable with standard diazepam at the dose of 1 mg /kg b.w, p.o. Moreover all the extracts showed significant (P < 0.01) increase in the phenobarbitone induced sleeping time among which pet.ether showed more prominent activity (36%) comparable with control. The results revealed that, the active pet.ether extract and chloroform extract of leaf galls of Piper nigrum Linn is worthwhile to develop the bioactive principle for anxiolytic activity.

• The Journal of Korean Physical Therapy
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• v.36 no.1
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• pp.1-8
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• 2024

Purpose: The purpose of this study was to determine the effect of proprioceptive neuromuscular facilitation (PNF) abdominal muscle strengthening exercise on the activity, posture, and body function of clients with abdominal muscle weakness after cesarean section. Methods: PNF abdominal muscle strengthening exercise was applied to one patient with abdominal muscle weakness after cesarean section. PNF abdominal muscle strengthening exercise was applied five times a week for four weeks. The 5-time supine-to-long sitting test (5-TSLST) and supine-to-stand test (SST) were used to measure activity, and the pelvis tilt angle test (PTAT) and anterior head translation test (AHTT) were used to measure posture. Body function was assessed using the transverse abdominis muscle strength test (TAMST), the internal oblique and external oblique muscle strength test (IOEOMST), and the rectus abdominis muscle strength test (RAMST). Results: Activity, posture, and body function were improved post-intervention. Conclusion: The study verified that PNF abdominal muscle strengthening exercises are effective when applied to patients with abdominal muscle weakness after cesarean section. The findings of this study provide useful data for future interventions in patients with abdominal muscle weakness after cesarean section.

• The Journal of Dong Guk Oriental Medicine
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• v.5
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• pp.167-186
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• 1996

This study aimed to evaluate the protective effect of the MeoH extract of Ikhwangsan against galactosamine-induced hepatotoxicity. In the experiments, after treated with Ikhwangsan methanol extract to the rats for 15days and then induced hepatotoxicity with galactosamine for 2days. Then content of glutathione, level of lipid peroxide and activity of GOT GPT in the hepatic tissue, activity of GOT GPT ${\gamma}$-GTP ALP and ratio albumin/globulin in serum were measured. The results were obtained as followed : 1. The content of hepatic glutathione was significantly reduced by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably increased. 2. The level of hepatic lipid peroxide was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 3. The activity of GOT GPT in the hepatic tissue was significantly constrained by galactisamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably increased. 4. The activity of GOT GPT in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 5. The activity of ${\gamma}$-GTP in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was reduced. 6. The activity of ALP in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 7. The ratio albumin/globulin in serum was reduced by galactosamine. The test group which have been pre-treated by Ikhwangsan was increased.

• Physical Therapy Korea
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• v.22 no.1
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• pp.49-57
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• 2015

The purpose of this study was to investigate the dynamic balance and activity of internal oblique muscle, multifidus muscle, gluteus maximus muscle, biceps femoris muscle during the Y balance test following the wearing of pelvic compression belt. Forty healthy adults were recruited for this test. The dynamic balance score was estimated as the following: (anterior+posteromdial+posterolateral)/($3{\times}leg$ length)${\times}100$. The electromyography signals were measured through %reference voluntary contraction, which was normalized by reference voluntary contraction of Y balance test without wearing the pelvic compression belt. The paired t-test was carried out to compare the dynamic balance score and the activity of the trunk and hip extensor with and without the wearing of pelvic compression belt. The dynamic balance score of the Y balance test when wearing pelvic compression belt was significantly than when measured without wearing the pelvic compression belt (p<.05). The muscle activity of the internal oblique and the multifidus was significantly decreased when wearing pelvic compression belt (p<.05). The muscle activity of the gluteus maximus was significantly increased when wearing pelvic compression belt (p<.05). However, there was no significant difference in hamstring muscle activity, with or without wearing the belt (p>.05). In conclusion, this study shows that the wearing of pelvic compression belt affects trunk muscle and hip extensor muscle activity related to the pelvic mobility and stability and increases dynamic balance and also contributes to the stabilization of the external pelvic stabilization.

• Journal of the Korean Society of Physical Medicine
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• v.13 no.2
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• pp.1-9
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• 2018

PURPOSE: This study investigated the relationship between the daily physical activity level and fall-proof-related fitness in older female adults. METHODS: This study promoted and sampled the subjects who participated in the study for 2 weeks, and developed a basic information questionnaire to select the subjects to be excluded from the research. The amount of energy expenditure through daily physical activity was examined, and the elderly physical fitness, and balance test were analyzed. The subjects were divided into group A (${\geq}1,500kcal/week$), group B (<$1,500-{\geq}1,000kcal/week$), and group C (<1,000 kcal/week) according to their daily physical activity level. RESULTS: A significant difference in the daily physical activity level (energy expenditure), Chair Stand Test (lower body strength), 8-Foot Up-and Go Test (dynamic balance), and CTSIB-M (modified Clinical Test of Sensory Interaction in Balance) was observed among groups A, B, and C (p<.5), but there was no significant difference in the Chair Sit-and-Reach Test (lower body flexibility) (p>.5). CONCLUSION: The increase in physical activity is an essential factor for preventing falls and it provides many health benefits for the elderly. On the other hand, considering that elderly people cannot access exercise programs easily in Korea, it can be predicted that increasing elderly people's physical activity in daily life rather than specific exercises may help prevent falls.

• Restorative Dentistry and Endodontics
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• v.26 no.2
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• pp.141-152
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• 2001

Eliminating the infecting bacteria of the root canal system and preventing reinfection must be the main objectives of all endodontic works. None of commercially available root canal sealers have the properties of desirable tissue compatibility and strong antibacterial activity. The purpose of this study is to develope an ideal root canal sealer using commercially available polyphosphate (polyP), Calgon, which is known to be antibacterial and safe. For the study. resin type AH26, zinc oxide eugenol type Tubli Seal. Ca(OH)$_2$ type Apexit as base sealers for polyP (0~3%) and para formaldehyde containing N2 as a control base were selected. Specimens (3$\times$4mm) of the sealers were prepared in a 37$^{\circ}C$ incubator for 3 and 10 days and their antibacterial activity against streptococci and black pigmented anaerobic rods was observed using an agar diffusion method. The result were as follows: 1. Among 3 day old root canal sealers. N2 as a positive control showed the strongest antibacterial effect. followed by AH26. Tubli Seal and. Apexit which barely showed antibacterial activity against the test bacteria. In contrast. 10 day old AH26 showed a greater antibacterial activity than 10 day old N2. 2. All sealer specimens showed a greater antibacterial activity against black pigmented anaerobic rods than streptococci. Three day old ones appeared to be more antibacterial than 10 day old ones except for Apexit. 3. As compared to N2, 3 day old AH26 demonstrated a similar antibacterial activity against black pig mented anaerobic rods but to a lesser extent to streptococci. Ten day old AH26 showed a greater antibacterial activity against black pigmented anaerobic rods than 10 day old N2. 4. As compared to AH26. Tubli Seal generally revealed a lower antibacterial activity but it showed a greater antibacterial activity aginst S. gordonii Challis. 5. Enhancement of antibacterial activity by polyP was more clearly observed when it was added to Ca(OH)$^{\circ}C$ based root canal sealers. Tubli Seal and N2. 6. The addition of polyP enhanced the antibacterial activity of 3 day old AH26 against S. gordonii G9B (16%) and Challis (29%), and P. gingivalis 2561 (24%) only. Moreover, polyP failed to increase antibacterial activity of 10 day old AH26 against the test strains but P. gingivalis A7A1 28(13%). 7. The addition of polyP increased the antibacterial effect of 3 day old Tubli Seal on several test bacteria including s. mutans GS 5 (50%). s. gordonii G9B (47%) and Challis (122%). and all the test strains of P. gingivalis (13~35%) except for 9 14K 1. The addition of polyP to 10 day old Tubli Seal increased antibacterial activity of the root canal sealer against most test strains. 8. 3 day old Apexit failed to show antibacterial activity. if any very little against S. mutans GS 5 and Pr. intermedia ATCC 49046. However. polyP increased its antibacterial activity by 50 and 69%, respectively. Increase of antibacterial activity of 10 day old Apexit by polyP was more clearly observed than that of 3 day old one.

• Korean Journal of Veterinary Research
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• v.53 no.4
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• pp.231-237
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• 2013

This study aimed to assess the attraction effect against Lycorma delicatula and antioxidant activity of hexane, chloroform, butanol and water fraction obtained from Ailanthus altissima methanol extract. The attraction effect of chloroform fraction showed the highest activity (47%) as compared to that of other fractions. In the DPPH radical scavenging activity, methanol and butanol fraction showed higher antioxidant activity than other solvent fractions. From the above results, the potential chloroform fraction was further performed by local irritation test in New Zealand white rabbits. In eye irritation test, chloroform fraction showed moderate irritant at high concentration 0.5 g/site/mL, but there was no eye irritation at low concentration (0.05 g/site/mL). In accordance with the Draize evaluation of skin irritation, the primary irritation index was calculated to 3.3 and 0.68 at high (0.5 g/site/mL) and low concentration (0.05 g/site/mL) causing moderate and mild irritation, respectively. On the basis of this study, Ailanthus altissima chloroform fraction could be safely considered to be a candidate of attractant against Lycorma delicatula.

• The Journal of Korean Physical Therapy
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• v.21 no.1
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• pp.49-55
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• 2009

Purpose: The purpose of this study was to evaluate influence of contract-relax exercise on functional leg length inequality (FLLI) and muscle activity. Methods: The subjects were consisted of 40 healthy adults who had FLLI of which degree was at least 10mm. All subjects were randomly assigned to two groups : Contract-Relax Exercise (CRE) group (n=20), control group (n=20). The experimental group underwent CRE for 3 times a week for 4 weeks. Myosystem 1200 was used to measure the activity of rectus femoris and hamstring muscle. The tape measure method was used to measure FLLI. Statistical analysis was used repeated ANOVA know comparison of period, independent T-est know comparison of experiment group and control group. Results: All measurements for each subject took the following test : pre-test, post-test in 2 weeks, post-test in 4 weeks. The FLLI of the experimental group was significantly reduced according to within intervention period (p<0.05). Rectus femoris and hamstring muscle activity of the experimental group was significantly increased (p<0.05). Conclusion: The CRE can reduce FLLI and increase rectus femoris and hamstring muscle activity. Various contract-relax exercise for reduced of FLLI and the methods should be customized for the patients.