• 생약학회지
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• 제24권3호
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• pp.231-234
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• 1993

Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권7호
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• pp.2476-2495
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• 2021

Model-based software architecture verification and test scenarios generation are becoming more and more important in the software industry. Based on the existing temporal graph grammar, this paper proposes a new formalization method of the context-sensitive graph grammar for aiming at UML activity diagrams, which is called the UML Activity Graph Grammar, or UAGG. In the UAGG, there are new definitions and parsing algorithms. The proposed mechanisms are able to not only check the structural correctness of the UML activity diagram but also automatically generate the test scenario according to user constraints. Finally, a case study is discussed to illustrate how the UAGG and its algorithms work.

• 치위생과학회지
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• 제12권2호
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• pp.93-102
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• 2012

보건의료분야의 제반환경의 개선에도 불구하고 국민들의 구강건강상태는 아직도 OECD국가 중에서 매우 열악한 상태이다. 국민들의 구강건강을 효율적으로 증진유지하기 위해서는 중대구강병인 치아우식증을 예방하고 조기에 치료할 수 있는 구강보건진료가 이루어져야 한다. 특히 평생구강건강유지에 중요한 연령층인 초등학교학생들을 대상으로 정기적인 계속구강건강관리제도가 시급히 필요하나 초등학생 대상 계속구강건강관리방식의 치아우식예방관리법의 효과에 관한 사례가 부족한 실정이다. 따라서 광주광역시 소재의 S 치과에 2005년 12월부터 2006년 2월에 내원한 만6세에서 13세 환자 중 환자보호자의 동의를 받은 총 39명을 대상으로 실험군과 대조군으로 분류하여 치아우식활성도와 치아우식경험도를 조사하여 지역사회 치과의원에서 기초자료로 활용할 목적으로 시행한바 다음과 같은 결과를 얻었다. 1. 계속구강건강관리군의 기간별 Alban's test 및 Lactobacillius test 점수는 6개월경과 후 초진시의 1.4배에서 1.5배 감소되었고, 12개월경과 후 초진시의 1.5배에서 1.6배 감소되었다(p<0.001). 2. 계속구강건강관리군의 기간별 간이구강위생지수는 6개월과 12개월경과 후 초진시의 1.6배 감소되었다(p<0.05). 3. 12개월경과 후 우식경험영구치지수는 계속관리군(1.88개)에서 대조군(2.72개)보다 1.4배 감소되었으며, 우식영구치지수는 계속관리군(0.07개)에서 대조군(0.85개)보다 12배 감소되었다(p<0.05). 4. 12개월경과 후 제1대구치건강도는 계속관리군(98.04%)에서 대조군(95.97%)보다 1.02배 높게 나타났다(p<0.05). 이상과 같은 결과에 의하여 지역사회 치과의원에서 지속적인 계속구강건강관리제도를 시행하여 아동의 평생구강건강상태를 유지시켜야 한다고 사료되었다.

• The Journal of Korean Physical Therapy
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• 제26권1호
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• pp.33-40
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• 2014

Purpose: The aim of this study was to identify the effects of the lower trunk stabilization exercise using neurodevelopmental technique (NDT) on muscle activity in lumbar region and balance in the patients with hemiplegia. Methods: Fifteen participants were allocated in two groups: NDT group (n=8) or control group (n=7). NDT group performed NDT exercise program, while control group conducted walking exercise. Both interventions were given for 30 minutes a day, 3 times a week, for 5 weeks. To measure the muscle activity in rectus abdominis (RA), external oblique (EO) and internal oblique (IO), electromyography (EMG) was used. And, Timed-Up and Go (TUG) test and Berg-Balance Scale (BBS) were performed to assess balance before and after intervention. Results: NDT group showed a significant improvement of muscle activity in RA and EO, while control group did not show significant changes in three muscles. Also, there was a significant difference in muscle activity of RA and EO between two groups. In BBS and TUG test, participants in two groups showed significant improvements after intervention. Especially, significant difference was observed in TUG test between two groups (p<.05). Conclusion: This study demonstrated that NDT exercise is an effective intervention to improve the muscle activity in trunk region and to increase balance in patients with stroke. Thus, we suggested that NDT exercise program would be a treatment intervention in stroke rehabilitation.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.349-354
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• 2006

In the present study, three Malaysian Channa spp. fish Channa striatus, Channa micropeltes and Channa lucius were assessed for their analgesic activity. Distilled water and mixture of chloroform: methanol were used for extraction. The analgesic or antinociceptive activity was investigated by abdominal writhing and hot plate test. The water extract of Channa striatus and the chloroform: methanol extract Channa lucius produced potent antinociceptive effect when assessed with the abdominal writhing test. The activity was compared to morphine where the activity of the extracts was less potent than the opioid. In the hote plate test, water extract of Channa striatus revealed significant activity and chloroform:methanol extract of Channa micropeltes had moderate activity. However, these activities were statistically lower than morphine. Collectively, this study also showed that Channa striatus extract was more potent analgesic agent when compared to the other closely related snakehead Channa micropeltes and Channa lucius.

• 동의생리병리학회지
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• 제29권5호
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• pp.409-415
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• 2015

This study compared the heart rate variability tests of healthy college students and chronic fatigue patients for 2 years. Study subjects were idiopathic chronic fatigue patients who carried out the HRV tests and students conducted HRV test when health screening test. Study subjects were 250 people, 104 people and men (41.6%), women were 146 patients (58.4%). In patient group, the autonomic nervous system activity was decreased, the activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced compared to the control group(Patient:84.17±16.27, Control:98.33±17.28). Regardless of gender, patient group's autonomic nervous system activity was decreased, the activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced, compared to the control group(Patient Female:84.17±16.27, Patient Male:84.07±14.96/Control Female:98.33±17.28, Control Male:96.45±16.92). Even though same ages, patient group's autonomic nervous activity was reduced compared to control group(Patient:89.36±12.43, Control:97.39±16.91). Fatigue patients' activity of the sympathetic nerve and the parasympathetic nerve were significantly reduced, regardless of the fact that activity of the sympathetic nerve is increased and the parasympathetic nerve is decreased in stress state like an impassioned injury(七情傷). Therefore HRV test is useful to diagnose Fatigue from this study.

• 한방재활의학과학회지
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• 제30권1호
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• pp.31-45
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• 2020

Objectives In this study, we investigated the antimicrobial activity of a 70% ethanol extract of Maneung-hwan (MEH), which is prescribed by practitioners of oriental medicine for use against methicillin-resistant Staphylococcus aureus (MRSA). Methods The antibacterial activity of MEH against MRSA strains was evaluated using the disc diffusion method, broth microdilution method (minimal inhibitory concentration, MIC), checkerboard dilution test, and time-kill test. The mechanism of action of MEH was investigated by bacteriolysis using detergents or ATPase inhibitors Additionally, mRNA and protein expression were investigated by quantitative reverse transcription-polymerase chain reaction and western blot assay, respectively. Results The MIC of MEH was 25~1,600 ㎍/mL against all the tested bacterial strains. We showed that MEH extract exerts strong antibacterial activity. In the checkerboard dilution test, the fractional inhibitory concentration index of MEH in combination with antibiotics indicated synergism or partial synergism against S. aureus. The time-kill study indicated that the growth of the tested bacteria was considerably inhibited after a 24-h treatment with MEH and selected antibiotics. To measure the cell membrane permeability, MEH (3.9 ㎍/mL) was combined with Triton X-100 (TX) at various concentrations N,N-dicyclohexylcarbodimide (DCCD) was also tested as an ATPase inhibitor. TX and DCCD cooperation against S. aureus exhibited synergistic action. Accordingly, the antimicrobial activity of MEH in the context of cell membrane rupture and ATPase inhibition was assessed. Additionally, the expression of genes and proteins associated with resistance was reduced after exposing MRSA to MEH. Conclusions These results suggest that MEH possesses antibacterial activity and acts as a potential natural antibiotic against MRSA.

• 생약학회지
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• 제53권2호
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• pp.87-95
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• 2022

Methicillin resistance Staphylococcus aureus (MRSA) is a gram-positive bacterium, the most commonly isolated bacterial human pathogen. JiYu-san is one of the natural products used to treat diseases in the folk recipe. In this study, we investigated the antimicrobial activity of EtOH 70% extracts of JiYu-san (JYS) against MRSA. The antibacterial activity of JYS against MRSA strain was evaluated using minimum inhibitory concentration (MIC), checkerboard dilution test, and time-kill assay. The effect of JYS on the immune mechanism of MRSA was confirmed through cell membrane permeability tests and energy metabolism tests, and the antibacterial activity mechanism was performed using qRT-PCR and western blot. As a result, in the antibacterial test of JYS, the MIC was measured to be 1.9~1000 ㎍/mL, and synergistic or showed a partial synergistic effect. In addition, JYS showed antibacterial activity in a combination test with DCCD or TX-100. In a study on the mechanism of action of antibacterial activity, it was found that JYS suppressed MRSA resistance genes and proteins. These results suggest that JYS has antibacterial activity and provides great potential as a natural antibiotic by modulating the immune mechanism against MRSA.

• 대한물리의학회지
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• 제18권4호
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• pp.89-96
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• 2023

PURPOSE: To investigate the effects of the underwater Ai-Chi exercise on the joint range of motion, balance and posture. METHODS: Thirty-six college students (30 men, 6 women) were divided into a 'low physical activity' groups (Group I). and an 'appropriate physical activity' groups (Group II). The Ai-Chi underwater exercise was conducted three times a week for two weeks for both groups. A goniometer was used to measure the range of motion of the hip joint, and Y-Balance and the posture screen mobile were used to measure the stability of the lower extremities. RESULTS: An evaluation of the range of motion of the hip joint before and after the Ai-Chi exercise showed significant results in the low physical activity group. However, the flexural range showed a significant increase after exercise, but not significant result. In the comparison of the mean increase between groups, only the right hip joint showed a significant difference in both groups. Also, in the comparison of the Y balance test and posture screen test before and after exercise, both groups showed significant. CONCLUSION: The Ai-Chi underwater exercise helped improve the range of motion of the hip joint and the ability to balance. Also It helped improve posture alignment. In addition, although the increase in all physical activity groups lower than the appropriate physical activity groups was greater in all figures, the increase in the number of samples, the extension of the experimental period, and various variables could be obtained.

• 대한통합의학회지
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• 제7권4호
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• pp.161-170
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• 2019

Purpose : This study aimed to investigate the effects of a thoracic flexibility exercise program on pain, heart rate variability (HRV), and depression in patients with chronic low back pain. Methods : Fifty patients with chronic low back pain participated in this study. Each participant performed a pre-test and post-test. The outcome measures evaluated were a visual analog scale, HRV test results (automatic activity, standard deviation normal to normal [SDNN], low frequency [LF], high frequency [HF], and LF/HF ratio), and the Beck Depression Inventory. Patients underwent conventional physiotherapy for 35 minutes per session. In addition, a thoracic flexibility exercise program (trunk rotation exercise, McKenzie exercise, and supine thoracic extension exercise) were performed 3 times per week for 4 weeks. Results : After the training period, the visual analog scale results showed a significant decrease in the post-test compared to the pre-test. Automatic activity, SDNN, LF, HF, and LF/HF ratio significantly increased in the post-test compared to the pre-test. The Beck depression inventory results significantly decreased in the post-test compared to the pre-test. Conclusion : This study demonstrated that a thoracic flexibility exercise program improves a visual analog scale, HRV (automatic activity, SDNN, LF, HF, and LF/HF ratio), and the Beck Depression Inventory in patients with chronic low back pain.