• Journal of rehabilitation welfare engineering & assistive technology
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• v.5 no.1
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• pp.117-124
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• 2011

The purpose of this study was to identity the types of leisure and to examine the quality of life according to them and suggest the basic resources about leisure on elderly chronic stroke. The subject of this study was elderly chronic strokes(n=80) in Gwang Ju. A total of 80 questionnaires from subjects were analyzed. The social leisure activity shows more clear and positive purpose and more higher quality of life than private leisure. But it also has limited time and require more money. Elderly chronic stroke presents passive and limited leisure activity and shows low satisfaction about leisure. But the leisures that needed more physical movements show higher quality of life. So leisure activity program which is able to support and assist the limited body function will be helpful to increase the quality of life of elderly chronic stroke.

• Journal of Korean Academy of Nursing Administration
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• v.9 no.1
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• pp.129-139
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• 2003

Purpose : The purpose of this study is to investigate the actual condition and recognition about social service activity(SSA) of nurses. Methods : This is a descriptive study. The data were collected by a structured questionare from July 15 to 31, 2002. The questionares were sent to 711 nurses of 38 hospitals, and 664 cases were returned. The answer rate is 93.4%. The data were analyzed by SPSS 11.0. Results : 1. 71.0% nurses had a SSA experience during university, but only 14.2% nurses are participated in SSA now. 2. In the case of having an experience, 56.0% nurses participated in SSA under 1 year, 69.5% nurses didn't support the service costs. 3. In the case of not having experience, the main reason why they didn't participate in is to lack of opportunity. 4. 91.1% nurses recognize the necessity of SSA and 99.5% nurses agree with the necessity of operation system. 82.9% nurses approve the cooperation system among the regions. 87.2% nurses have an intension to participate in SSA when the cooperation system is set up. Conclusion : It need to set up the social service operating system among the regions, and encourage nurse to participate in the SSA.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2719-2724
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• 2015

Objective: The aim of this study was to investigate the clinical significance of annexin a1 (ANXA1) and provide molecular evidence to support that decreased ANXA1 expression could enhance cancer migration and invasion in pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: Immunohistochemistry of a tissue microarray with 162 surgically resected PDAC specimens was performed to examine the expression of ANXA1. We also investigated the relationship between ANXA1 expression and clinicopathological factors and prognosis of PDAC patients. We further studied the role of ANXA1 in PDAC cell proliferation, migration and invasion by cell proliferation assay, migration assay and matrigel invasion assay with reduced ANXA1 expression by RNAi. Western blotting was used to detect matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) expression. We also detected MMP-9 enzyme activity by gelatin zymography. Results: Decreased expression of ANXA1 was significantly associated with poor differentiation, lymph node metastasis and advanced TNM stage of PDAC patients (p<0.05). Moreover, decreased expression of ANXA1 was correlated with poor survival (p<0.05). Furthermore, we found that ANXA1 knockdown inhibited cell proliferation, induced G1 phase cell cycle arrest, increased PDAC cell migration and invasion capacity compared with controls. In addition, Western blotting showed that ANXA1 knockdown increased the MMP-9 protein level and decreased TIMP-1 expression. Gelatin zymography showed that MMP-9 enzyme activity was also elevated. Conclusions: Negative ANXA1 expression is a most unfavorable prognostic factor for PDAC patients. ANXA1 knockdown inhibits cell proliferation by inducing G1 phase cell cycle arrest and increases migration and invasion of PDAC cells through up-regulating MMP-9 expression and activity, implying that ANXA1 may serve as a promising prognostic biomarker and therapeutic target for PDAC.

• Journal of Environmental Science International
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• v.16 no.12
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• pp.1431-1437
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• 2007

Cobalt titanates($CoTiO_x$), such as $CoTiO_3$ and $Co_2TiO_4$, have been synthesized via a solid-state reaction and characterized using X-ray diffraction(XRD) and X-ray photoelectron spectroscopic(XPS) measurement techniques, prior to being used for continuous wet trichloroethylene(TCE) oxidation at $36^{\circ}C$, to support our earlier chemical structure model for Co species in 5 wt% $CoO_x/TiO_2$(fresh) and(spent) catalysts. Each XRD pattern for the synthesized $CoTiO_3$ and $Co_2TiO_4$ was very close to those obtained from the respective standard XRD data files. The two $CoTiO_x$ samples gave Co 2p XPS spectra consisting of very strong main peaks for Co $2p_{3/2}$ and $2p_{1/2}$ with corresponding satellite structures at higher binding energies. The Co $2p_{3/2}$ main structure appeared at 781.3 eV for the $CoTiO_3$, and it was indicated at 781.1 eV with the $Co_2TiO_4$. Not only could these binding energy values be very similar to that exhibited for the 5 wt% $CoO_x/TiO_2$(fresh), but the spin-orbit splitting(${\Delta}E$) had also no noticeable difference between the cobalt titanates and a sample of the fresh catalyst. Neither of all the $CoTiO_x$ samples were active for the wet TCE oxidation, as expected, but a sample of pure $Co_3O_4$ had a good activity for this reaction. The earlier proposed model for the surface $CoO_x$ species existing with the fresh and spent catalysts is very consistent with the XPS characterization and activity measurements for the cobalt titanates.

• Journal of Families and Better Life
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• v.31 no.5
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• pp.97-108
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• 2013

The purpose of this study was to investigate what variables have a significant effect on child care center teachers' mathematics teaching efficacy among teachers' individual variables, mathematics activity variables, and teachers' awareness variables, and also whether these results are different for teachers of 0 to 2-year-olds when compared to teachers of 3 to 5-year-olds. The subjects consisted of 438 teachers from child care centers located in D city and K province of Korea. The results of this study were as follows: First, mathematics activity variables had a significant effect on the mathematics teaching efficacy of both teacher groups. Second, teachers' awareness of the environment of mathematics education had a significant influence on the mathematics teaching efficacy of both teacher groups, and for teachers of 0 to 2-year-olds, that influence was the greatest among all of the variables. Third, teachers' awareness of the purpose of mathematics education had a significant effect on the mathematics teaching efficacy of only teachers of 0 to 2-year-olds. Lastly. teachers' awareness of the mathematics education curriculum had a significant influence on the mathematics teaching efficacy of only teachers of 3 to 5-year-olds, and that influence was the greatest. These results were discussed in terms of different types of support for each teacher group to improve the quality of mathematics education.

• Physical Therapy Korea
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• v.27 no.4
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• pp.250-256
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• 2020

Background: Unstable surface-based core training can significantly enhance core strength, but no studies have compared the effects of balance pad- and sling-assisted exercises. Objects: To study the effects of unstable surface-based balance pad- and sling-assisted core strength exercises on muscle activity. Methods: Twenty male students aged 20-25 years participated in this study. The effects of three types of core strength exercises, performed with a sling or balance pad, on the activities of three muscles, i.e., the right musculus obliquus externus abdominis (EO), right erector spinae (ES), and right gluteus maximus (GM), were examined. Results: 1) In the glute bridge exercise, the percentage of maximum voluntary contraction of the EO, ES, and GM were significantly different between the balance pad- and sling-assisted exercises. The relative contribution of the ES and GM activities to all muscle activity were not significantly different between the two training types, whereas that for EO showed a significant difference. 2) There was no significant difference in the percentage value of maximum voluntary contraction (%MVC) among the EO, ES, and GM during the "leg-lifting with flat support" exercise, and there were no significant difference in the relative contributions between the two training types. 3) In the "side bridge leg separation exercise", the %MVC of the ES, EO, and GM were significantly different between the two training types. Conclusion: Sling training for core muscles was generally better than balance pad assist training. The majority of physiotherapy patients require core training. Our results could guide physiotherapists in the choice of targeted exercises for these patients.

• Korean Journal of Health Education and Promotion
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• v.33 no.1
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• pp.49-60
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• 2016

Objectives: This study aims to assess the relationships between individual, social and physical environmental correlates and physical activity (PA) and sedentary behavior (SB) in Korean children. Methods: A total of 1,134 elementary school students (512 boys, $5^{th}$ and $6^{th}$ graders) in Seoul participated in the survey including self-reported moderate and vigorous intensity PA and SB as well as demographic and psychological correlates. These data were matched them with school- and community-level environmental data from the government sources. The relationships of the multilevel correlates with PA and SE were analyzed using gender-specific hierarchical regression analysis. Results: Boys were more active than girls, but there was no gender difference in SB. Students with higher levels of self-efficacy were more likely to participate in moderate and vigorous PA. There were gender-specific associations between social and physical environments correlates and PA. Boys with higher levels of self-esteem and self-efficacy were less likely to involve in SB. Girls in the $6^{th}$ grade were more likely to involve in SB. Conclusions: In order to encourage PA and discourage SB in children, school- and community-level environmental support should be considered along with programs to improve self-efficacy and self-esteem.

• Korean Journal of Pharmacognosy
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• v.36 no.4 s.143
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• pp.324-331
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• 2005

The roots of Rosa rugosa have been used to treat diabetes mellitus in the folkloric society of Korea. To demonstrate the active component for the rat obesity induced by high fat diet for 6 weeks, the phytochemical fractionation and the pharmacological activity test were performed on this crude drug. It was shown that the methanolic extract and its EtOAc fraction inhibited the weight increase of the rat body, abdominal fat pad and hyperlipidemia at 200 mg/kg dose. Further, the triterpenoids, euscaphic acid and tormentic acid, isolated from R. rugosa roots were active at 30 mg/kg in the same assay. The two components shifted serum total-, HDL, and LDL-cholesterol levels toward the values of the unteated group, suggesting that the active compounds has hypolipidemic effects. The rats fad euscaphic acid and tormentic acid also reduced thiobarbituric acid-reactive substance (TBARS) and hydroxyl radical in the rat blood and increased superoxide dismutase activity compared to the control. TBARS values and carbonyl contest of the hepatic protein were reduced by treatment with the two triterpenoids. Antioxidative enzyme (SOD, glutathione peroxidase, and catalase) activities in hepatic were increased by treatment of rats with the triterpenoids, which suggests that triterpenoids inhibited the reduction of hepatic antioxidative activity caused by high fat diet. Taken together, these results support that euscaphic acid and tormentic acid improve a high fat diet-induced hyperlipidemia via the activation of antioxidative mechanism.

• Molecules and Cells
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• v.28 no.4
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• pp.331-339
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• 2009

Capsaicin is a very important secondary metabolite that is unique to Capsicum. Capsaicin biosynthesis is regulated developmentally and environmentally in the placenta of hot pepper. To investigate regulation of capsaicin biosynthesis, the promoter (1,537 bp) of pepper capsaicin synthase (CS) was fused to GUS and introduced into Arabidopsis thaliana (Col-0) via Agrobacterium tumefaciens to produce CSPRO::GUS transgenic plants. The CS was specifically expressed in the placenta tissue of immature green fruit. However, the transgenic Arabidopsis showed ectopic GUS expressions in the leaves, flowers and roots, but not in the stems. The CSPRO activity was relatively high under light conditions and was induced by both heat shock and wounding, as CS transcripts were increased by wounding. Exogenous capsaicin caused strong suppression of the CSPRO activity in transgenic Arabidopsis, as demonstrated by suppression of CS expression in the placenta after capsaicin treatment. Furthermore, the differential expression levels of Kas, Pal and pAmt, which are associated with the capsaicinoid biosynthetic pathway, were also suppressed in the placenta by capsaicin treatment. These results support that capsaicin, a feedback inhibitor, plays a pivotal role in regulating gene expression which is involved in the biosynthesis of capsaicinoids.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.772-778
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• 2005

The chloromethyl-2-dihydroxyphosphinyl-6,7-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (CDDT) is a newly synthesized derivative from 1,2,3,4-Tetra- hydroisoquinoline (THIQ). The THIQs include potent cytotoxic agents that display a range of antitumor activities, antimicrobial activity, and other biological properties. In this study, we investigated the effect of CDDT on the cytotoxicity, induction of apoptosis in human promyelocytic leukemia cells (HL-60 cells). CDDT showed a significant cytotoxic activity in HL-60 cells ($IC_{50}$ = approximately $37\;{\mu}g/ml$) at a 24 hr incubation. Treatment of HL-60 cells with CDDT displayed several features of apoptosis, including formation of DNA ladders in agarose gel electrophoresis, morphological changes of HL-60 cells with DAPI stain. Here we observed that CDDT caused activation of caspase-3, caspase-8, and caspase-9. The most efficacious time on the activation of caspases-3 was achieved at 12 hr. Further molecular analysis demonstrated that CDDT led to cleavage of poly(ADP-ribose) polymerase (PARP), increase of hypodiploid (Sub-G1) population in the flow cytometric analysis. In conclusion, these above results indicate that CDDT dramatically suppresses HL-60 cell growth by activation of caspase-3 with caspase-8, -9 activity. These data may support a pivotal mechanism for the use of CDDT in the prevention and treatment of leukemia.