• Journal of the Korean Institute of Rural Architecture
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• v.7 no.1
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• pp.39-50
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• 2005

This study is result of interview and investigation into three rural communities progressing Rural activity, and points to be considered before promoting policy 1) Resident participation taking a lot of time, need to sustainable education and chance of personal experience, as well as stage of working plan and performance must be a serious consideration about resident opinions. 2) Until placing operation and management on the right track, experts and administrators will be help aspects of software and finance. 3) It is necessary to periodically train rural activity experts, and educate business persons. 4) Through checking a process, each community improve, supplement, will work out the next support system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.115-120
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• 1997

Environmental Product Life Cycle Management is an activity for defining and describing the product, process or activity environmentally. Especially, the main responsibility for the environmental impact of products lies in the design phase of product. Designers cany a heavy responsibility to determine technical, economic and ecological properties of the product. So in order to help designers, structured understanding and application of treating large amount of data and infonnation should be considered. This paper presents a methodological approach for decision supporting to build Product Life Cycle Management system and show a set of database modeling. Additionally, a key issue for databases is the quality of the provided information.

• Journal of the Optical Society of Korea
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• v.13 no.2
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• pp.272-278
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• 2009

Recently, there has been a growing interest in optical imaging of neural activity because the optical neuroimaging has considerable advantages over conventional imaging. Birefringence of the axon has been reported to change during neural activation, but the neurophysiological origin of the change is still unresolved. This study hypothesizes that the birefringence signal is at least partially attributed to the transient cellular volume change associated with nerve excitation. To examine this hypothesis, we investigated how the intensity of cross-polarized light transmitting through the axon would change as the size of the axon changes. For this purpose, a two-dimensional finite-difference time-domain program was developed with the improvement of the total-field/scattered-field method which reduces numerical noise. The results support our hypothesis in that the computed cross-polarized signals exhibit some agreement with previously-reported birefringence signals.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.891-894
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• 2013

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.

• Toxicological Research
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• v.13 no.4
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• pp.349-352
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• 1997

Scopoliae rhizoma is a perennial herb which has a similar effect with atropine on the cardiovascular system. It is also known to have a seditive and anticonvulsant activity on the central nerve system. In order to evaluate an acute toxicity of Scopoliae rhizoma, the present study was performed after administration the Scopoliae rhizoma prepared by both decoctional and frozen dried extract through three different routes (oral; 5,000 mg/kg, intraperitoneal; 2,000 mg/kg, subcutaneous; 5,000 mg/kg) to the female ICR mice. In the group treated intraperitoneally with a frozen dried extract, abnormal clinical signs such as decreased activity, crouch, potosis and abnormal walking were observed for 40 rain after administration. With regard to WBC, decreased number of lymphocyte and increased number of monocyte and granulocyte were also observed in the animals received intraperitoneally with Scopoliae rhizoma extract. Taken together, what toxicity of Scopoliae rhizoma was shown differently depending on its type for administration may be resulted in the differency of administered dose. The results provided here support a pharmacological and toxicological consideration for its clinical use in the regard of oriental medicine.

• Fire Science and Engineering
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• v.17 no.4
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• pp.92-97
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• 2003

It is necessary to build countermeasure for the reduction of flood damage, such as the analysis of shelter activities of local residents and the publishment of flood informations. The control factors for mental refuge activity by the questionnaire survey were classified and estimated into two categories: internal and external ones. Furthermore, the optimal time for refuse activities related to flood risk was derived by hydraulic simulation. The shelter activities considering inundation depth will serve citizen's consensus by exercise, it would aid to support the activities to minimize flood victims.

• Proceedings of the Korea Contents Association Conference
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• 2016.05a
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• pp.247-248
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• 2016

To investigate activities in the evacuated situation of people, the measurement system is newly constructed, that composed of a wearable sensor device of heart beats rates and mobile devices like an Android smartphone with a bluetooth low energy (BLE) connection. Smartphone not only displays the heart beats variation (HBR) and the current location of evacuation person by Global Positioning System (GPS), but also exports the CSV formatted file that would be used for further analyzing the activity of person in detail. As an example of the application of this system, we show the case of evacuation routes for elderly person in Hizen-Hamashuku Area, Saga Prefecture. Using the proposed measuring system, the activities of evacuates can be clearly shown on the map of Geospatial Information System (GIS).

• Proceedings of the Korea Association of Information Systems Conference
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• 2000.11a
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• pp.12-15
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• 2000

An SADT-based methodology is presented for systematically analyzing the container working process in container terminal, as well as an object-oriented design method for an integrated information system for container terminal resource planning and management. Our design architecture is composed of four levels, activity interface, activity PDCA control, human resource management, and facility resource management. Especially, the consideration of the human resource management level makes it possible to support cooperative tasks, to make the authority and responsibility on a task clear, and to extremely promote the balance between human and facility resources. Finally, The system architecture is suggested for Virtual Container Terminal, in which a planned container working process is simulated for previous feasibility check, work orders are transferred to control real devices, and to manage the entire process and related data.

• Journal of the Korea Institute of Military Science and Technology
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• v.3 no.2
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• pp.156-165
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• 2000

This paper describes modeling and simulation of automotive forward collision warning and avoidance system using CASE(Computer-Aided Systems Engineering) tool. The system is composed or many sensors, a controller, warning devices, brakes and etc. The system was modeled by one activity chart, fourteen state charts and one module chart. Rear-end collision scenarios was generated by Simulink and used to support Stalemate model. The resulting model was used to evaluate the correctness of function and behavior of the system. A simulator for the system has been designed and used to validate the model under realistic operating conditions in the laboratory. To model and simulate the system's functionality and behavior brings clarity to system design early in the system development.

• BMB Reports
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• v.42 no.8
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• pp.467-474
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• 2009

The modification of proteins by reversible phosphorylation is a key mechanism in the regulation of various physiological functions. Abnormal protein kinase or phosphatase activity can cause disease by altering the phosphorylation of critical proteins in normal cellular and disease processes. Alzheimer' disease (AD), typically occurring in the elderly, is an irreversible, progressive brain disorder characterized by memory loss and cognitive decline. Accumulating evidence suggests that protein kinase and phosphatase activity are altered in the brain tissue of AD patients. Tau is a highly recognized phosphoprotein that undergoes hyperphosphorylation to form neurofibrillary tangles, a neuropathlogical hallmark with amyloid plaques in AD brains. This study is a brief overview of the altered protein phosphorylation pathways found in AD. Understanding the molecular mechanisms by which the activities of protein kinases and phosphatases are altered as well as the phosphorylation events in AD can potentially reveal novel insights into the role aberrant phosphorylation plays in the pathogenesis of AD, providing support for protein phosphorylation as a potential treatment strategy for AD.