• Reproductive and Developmental Biology
• /
• v.30 no.2
• /
• pp.75-79
• /
• 2006

The developmental regulation of the preimplantation mammalian embryos is a fundamental step for preparing the implantation and it may be regulated by several autocrine and paracrine factors including platelet-activating factor. PAF improved the embryonic survival and implantation but its role during blastocyst development is still largely unknown. In this study, the effects and the possible pathway of PAF on developmental regulation of blastocyst to hatching stage were investigated. Developmental pattern in hatching embryo was a concentration-response curve showing maximal activity at 1 nM PAF, with decreasing activity at higher concentrations. $50{\mu}M$ 1-(5-isoquinolimnesulfonyl)-2-methylpiperazinme dihydrochloride (H-7), a PKC inhibitor, inhibited the progression of blastocyst to hatching embryo. In addition H-7 blocked the PAF effects on the blastocyst development. Besides tetradecanoylphorbol acetate (TPA), a PKC activator stimulated development of blastocyst to the hatching stage. These finding revealed that PAF support the blastocyst development to the hatching embryo. Also it is suggested that PAF action pathways in hatching supporting include the PKC signaling pathway.

• Journal of Information Technology Services
• /
• v.8 no.2
• /
• pp.71-87
• /
• 2009

In this paper, the technology innovation for software firms are discussed. Through the literature study, the concepts about this issue and the environment and activity of software firm's the technology innovation related are described. The survey paper was developed for searching the obstacles, policy considerations, and performance of this issue etc. Also questionnaire sheet was made for identifying the relations on technology innovation activities and performance. The degree of understanding about the need of technology innovation were very high according to the analysis result from the response based on the 103 software firms. Among this survey the other results are described as follows; the motivation of technology innovation, the necessity and implementation, the duration acquired for innovation result, the favorite support program as for innovation policy, obstacles for innovation implementation, the reason for innovation collaboration etc. Finally, it is verified statistically that the performance of technology innovation be affected by the employment of external professional technician, research and development, the technical education.

• Journal of muscle and joint health
• /
• v.11 no.2
• /
• pp.176-186
• /
• 2004

Purpose: The purpose this research was to provide with basic data in the control of the sleep disorder found in the patients with fibromyalgia by analysing the main factors that affect that. Method: At two university medical center, appointed 171 out-patients diagnosed of fibromyalgia according to the conditions by American College of Rheumatology(1990). The research instruments used in this study were VAS Scale(Anxiety, fatigue, pain, joint stiffness and depression), physical activity family support, the number of tender points and Self-efficacy scale. In data analysis, SPSS 11.0 program was utilized and data were analyzed using descriptive statistics, Pearson's correlation coefficient and multiple regression. Result: The main factors that affect the sleep disorder of patients with fibromyalgia were fatigue, physical activity, and depressions which explained 46.2% of the sleep disorder. Conclusion: It has been confirmed that the regression equation model of this research may serve as a sleep disorder prediction factors in patients with fibromyalgia.

• Journal of the Korean Chemical Society
• /
• v.48 no.2
• /
• pp.177-181
• /
• 2004

1,2,4-Triazoles, pyrazolones and 1,3,4-oxadiazoles have been synthesized from substituted hydrazide using various solid supports under microwave irradiation (MWI). The results obtained highlight the versatility of the solid supports. All synthesized compounds were screened for their antifungal activity against A. niger and A. flavus and were found to possess good activity.

• Journal of Construction Engineering and Project Management
• /
• v.5 no.4
• /
• pp.12-15
• /
• 2015

Size of building has a direct relationship with building cost, energy use and space maintenance cost. Therefore, minimizing building size during a project development is of paramount importance against such wastes. However, incautious reduction of building size may result in crowded space, and therefore harms the functionality despite the fact that building is supposed to satisfactorily support users' activity. A well-balanced design solution is, therefore, needed at an optimum level that minimizes building size in tandem with providing sufficient space to maintain functionality. For such design, architects and engineers need to be informed accurate and reliable space-use information. We present in this paper a conceptual framework of an agent-based space-use prediction simulation system that provides individual level space-use information over time in a building in consideration of project specific user information and activity schedules, space preference, ad beavioural rules. The information will accordingly assist architects and engineers to optimize space of the building as appropriate.

• Journal of the Korean Home Economics Association
• /
• v.39 no.8
• /
• pp.53-66
• /
• 2001

The primary objectives of this research is to identify the unmarried mother's (1) socio-demographic characteristics and (2) factors that correlates their stress and (3) factors that predicts their stress. This study uses the data based on interviews with 136 unmarried mothers selected purposive sampling from the 5 unmarried mothers protective institutions in Seoul, Pyungtak, Chunchon, Taegu, and Gwanju. The major findings were as follows. First of all, the age of the first sexual activity of the late-teens among the unmarried mothers are over the half. The portions over the one time abortion are 33.3%. Second, the social support part in the coping sub-category had positive correlation with the stress of unmarried mothers. And the age of the first sexual activity and my thought on the adolescent sex had negative correlation with the stress of unmarried mothers. Third, the age of the first sexual activity predicted the stress of unmarried mothers. Therefore, the comprehensive and systematic intervention programs should be required to ensure that they intervene the stress of unmarried mothers.

• Journal of the Korea Safety Management & Science
• /
• v.1 no.1
• /
• pp.259-272
• /
• 1999

In order to enhance the selectivity, productivity and yield of methyl fructoside, which was synthesized by enzymatic glycosylation of sucrose and methanol solution, controlling of surface property of solid support using different immobilization procedures optimized microenvironment of immobilized invertase. Silanization and polyethylene imine coating methods were adopted to give a hydrophobic and hydrophilic environment of immobilized invertase. As a result, polyethyleneimine coating method gave higher loading of enzyme, effective activity, and relative activity than silanization method, because it brought on increasing the functional density of amino group and enhancing the conservation of activity by regulating of hydrophilicity. And then, hydrophilic environment was possible to restraint the assessing of methyl fructoside molecule, which was more hydrophobic than sucrose, fructose, and glucose molecule in the reaction mixture, into .the active site of immobilizedinvertase. Consequently, hydrophilic microenvironment of immobilized invertase by polyethyleneimine coating obtained higher yield and productivity with increasing conversion than silanized and native invertase. Thus, this procedure optimized the microenvironment of immobilized invertase suitable for the enzymatic synthesis of methyl fructoside.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.3
• /
• pp.899-904
• /
• 2011

A series of 5-indolylpyrimido[4,5-d]pyrimidinones (4a-h) were obtained by multi-component reaction of 3-formylindole (1), thiobarbituric acid/barbituric acid (2) and thiourea/urea (3) under microwave irradiation in dry media. Secondly, grinding together neat reactants also gave the titled compounds in good yields. All the synthesized compounds have been characterized on the basis of elemental analyses and spectral data (IR, $^1H$ NMR and Mass). Representative compounds were also evaluated for their antimicrobial activity against Rhizopus stolonifer, Fusarium oxysporum, Escherichia coli, and Pseudomonas aeruginosa at different concentrations. Some of the compounds showed promising activity.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.20 no.4
• /
• pp.569-576
• /
• 2014

Purpose: This study investigates the factors affecting spirituality in nursing students. Method: A total of 247 nursing students participated in the study. Data were analyzed by frequencies, t-tests, ANOVA, Pearson correlation coefficients and multiple stepwise regression via SPSS WIN 18.0. Results: The mean scores for hope, gratitude, and spirituality were above-average. However, there were significant mean differences in spirituality according to religion, religious activity, voluntary service, satisfaction with the nursing field, and motivation for entering a college of nursing. Spirituality positively correlated with hope and gratitude. Significant predictors of spirituality included hope, gratitude, voluntary service and religious activity. The regression model explained 51.3% of perceived spirituality. Conclusion: To improve spirituality among nursing students, nursing educators should develop educational intervention programs to promote hope and gratitude, and support participation in voluntary service and religious activity.

• Journal of Plant Biology
• /
• v.29 no.2
• /
• pp.85-94
• /
• 1986

Canavanine content of the cotyledons of Canavalia lineata decreased gradually during germination and growth of seedlings but continued to increase in roots and leaves. After abscission of cotyledons, canavanine content of leaves depleted competely. The activity of canavanase could be detected in leaves and roots, but not in cotyledons. High arginase activity was observed in the cotyledons of seeds at the earlyimbibition period. During the growth of seedlings, cotyledonary canavanine appeared to be transported to the growing of seedlings where it could be utilized through nitrogen metabolic pathways. In crude cell-free extracts of leaves, maximum activities of canavanase or arginase appeared in 30mM Tris-HCl buffer (pH 9.0) or 30mM NaHCO3 buffer (pH 10.0), respectively. The activities of these two enzymes differed from each other when treated with Co2+ or Mn2+. These results support the idea that canavanase and arginase might be different enzymes.