• Journal of Korea Port Economic Association
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• v.24 no.4
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• pp.257-281
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• 2008

This study aims to draw meaningful points from the Chang Po Go period in which Chang Po Go, who established an integrated logistics system while operating on the seas of three nations including Japan, China, and Shilla by taking Chunghaejin, Shilla, as a base of operations in the 9th century, and to discover the need for the construction of the logistics system in northeast Asia. Also, the study intends to propose strategies for contemporary application of the logistics system used during the Chang Po Go period, based on the modern logistics concept. As a result of specifically reviewing the lesson from the Chang Po Go period, which created a paradigm for a new cooperation in logistics, the leadership of the CEO, who is prepared with the long-term vision of Chang Po Go, the implementation of an integrated system for logistics activity, and the political support of the government for private companies, will initiate a bright outlook for the construction of the logistics system in northeast Asia, amid the growing need for cooperation in logistics among the three northeast Asian countries. In this era in which northeast Asia is emerging as the center of the world economy, the cooperative model in the logistics field, which transcended the border of Chang Po Go, who built a maritime logistics network in the 9th century, will help implement a cooperative logistics system in the northeast Asian region.

• Journal of Life Science
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• v.14 no.3
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• pp.478-483
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• 2004

In a model reaction using lysyl oxidase purified partilally from bovine aorta, effect of L-ascorbic acid AsA on the oxidative reaction of lysine in collagen was investigated. Addition of Ash to the reaction mixture under aerobic conditions resulted in the decrease of enzymatic activity. In order to examine the specificity of AsA in the oxidative reaction of lysine, other reductants including A derivatives instead of AsA were added to the reaction mixture. Thiol such as glutathione had no effect on the activities of lysyl oxidase. on the other hand, it was observed that erythorbic acid, which was a stereoisomer of AsA, had the same inhibitory effect on this oxidative reaction as AsA. Moreover, by the addition of 3,4-dihydroxybenzoate, which was structural analog of AsA, the activities decreased in a similar manner to that of AsA. These results indicate that the regulatory effect of AsA on lysyl oxidase is attributed to characteristics of the structure. From the determination of Ash remained in the reaction mixture, it is shown that AsA concentration remarkably decreased by lysyl oxidase of the reaction mixture. It is hypothesized that endiol groups reduces the enzyme-bound $Cu^{+2}$ required for further progress of the reaction, and suggests that AsA regulates specifically the reduction of $Cu^{+2}$ required to oxidize lysyl oxidase. This findings support that AsA has an important regulatory role on the oxidative reaction of lysine and on changes of collagen cross-links with aging.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.2
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• pp.161-173
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• 2015

The guarantee of transportation for elderly and handicapped people is increasingly necessary owing to their growing social and economic activity. In March of 2013, a partial amendment to the law for transportation of the vulnerable was made by the government, to make more convenient transport a legal requirement. The amendment describes standards for the installation of transport facilities, and its support available. However, the adjustment of low-floor bus routes is not included. Therefore, low-floor buses are operating without consideration for the handicapped. This study evaluates the current low-floor bus system user experience by considering the residential distribution of vulnerable customers and analyzing their reasons for using public transport. As a result of this work, adjustments to current bus routes are proposed. The residential distribution of vulnerable people has been assessed using the supporting materials of the urban renewal project in Busan City, and their reasons for using public transport have been collected by a survey of the target user groups. The results show that group A, which has good accessibility, was in high demand, but provided the most limited service. Whereas group C, which also has good accessibility but was in low demand, provided its service most frequently. The data show the supply and demand inconsistencies of low-floor buses, and the inefficiency of bus route allocation. Therefore, this study proposes improvements to current methods for the effective operation of low-floor buses.

• Journal of The Korean Association For Science Education
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• v.34 no.5
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• pp.479-490
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• 2014

The purpose of this study is to develop an argument-based modeling strategy, utilizing writing and argumentation for communication in science education. We need to support students and teachers who have difficulty in modeling in science education, this strategy focuses on development of four kinds of factors as follows: First, awareness of problems, recognizing in association with problems by observing several problematic situations. Second is science concept structuralization suggesting enough science concepts by organization for scientific explanation. The third is claim-evidence appropriateness that suggests appropriate representation as evidence for assertions. Last, the use of various representations and multimodal representations that converts and integrates these representations in evidence suggestion. For the development of these four factors, this study organized three stages. 'Recognition process' for understanding of multimodal representations, and 'Interpretation process' for understanding of activity according to multimodal representations, 'Application process' for understanding of modeling through argumentation. This application process has been done with eight stages of 'Asking questions or problems - Planning experiment - Investigation through observation on experiment - Analyzing and interpreting data - Constructing pre-model - Presenting model - Expressing model using multimodal representations - Evaluating model - Revising model'. After this application process, students could have opportunity to form scientific knowledge by making their own model as scientific explanation system for the phenomenon of the natural world they observed during a series of courses of modeling.

• Journal of Dental Anesthesia and Pain Medicine
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• v.16 no.4
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• pp.295-302
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• 2016

Background: Reactive oxygen species play critical roles in homeostasis and cell signaling. Dexmedetomidine, a specific agonist of the ${\alpha}2$-adrenoceptor, has been commonly used for sedation, and it has been reported to have a protective effect against oxidative stress. In this study, we investigated whether dexmedetomidine has a protective effect against $H_2O_2$-induced oxidative stress and the mechanism of $H_2O_2$-induced cell death in normal human fetal osteoblast (hFOB) cells. Methods: Cells were divided into three groups: control group-cells were incubated in normoxia without dexmedetomidine, hydrogen peroxide ($H_2O_2$) group-cells were exposed to $H_2O_2$ ($200{\mu}M$) for 2 h, and Dex/$H_2O_2$ group-cells were pretreated with dexmedetomidine ($5{\mu}M$) for 2 h then exposed to $H_2O_2$ ($200{\mu}M$) for 2 h. Cell viability and apoptosis were evaluated. Osteoblast maturation was determined by assaying bone nodular mineralization. Expression levels of bone-related proteins were determined by western blot. Results: Cell viability was significantly decreased in the $H_2O_2$ group compared with the control group, and this effect was improved by dexmedetomidine. The Hoechst 33342 and Annexin-V FITC/PI staining revealed that dexmedetomidine effectively decreased $H_2O_2$-induced hFOB cell apoptosis. Dexmedetomidine enhanced the mineralization of hFOB cells when compared to the $H_2O_2$ group. In western blot analysis, bone-related protein was increased in the Dex/$H_2O_2$ group. Conclusions: We demonstrated the potential therapeutic value of dexmedetomidine in $H_2O_2$-induced oxidative stress by inhibiting apoptosis and enhancing osteoblast activity. Additionally, the current investigation could be evidence to support the antioxidant potential of dexmedetomidine in vitro.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.4
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• pp.508-514
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• 2010

This study was conducted to evaluate the effects of dietary arachidonic acid (AA, 20:4n-6) levels on growth performance and body composition in juvenile eel, Anguilla japonica. Six semi-purified experimental diets were formulated to be isonitrogenous and iso-caloric containing 55.0% crude protein and 15% crude lipid (18.3 kJ of available energy $g^{-1}$). Six different levels of AA were added to the basal diet, with 0, 0.2, 0.4, 0.6, 0.8 or 1.2% on a dry matter (DM) basis, respectively ($AA_{0.07},\;AA_{0.22},\;AA_{0.43},\;AA_{0.57},\;AA_{0.78}\;or\;AA_{1.23}$). After a conditioning period, fish initially averaging 27${\pm}$0.5 g (mean${\pm}$SD) were randomly distributed into each aquarium as triplicate groups of 20 fish each. One of six experimental diets was fed on a DM basis to fish in three randomly selected aquaria at a rate of 2-3% of total body weight twice a day. At the end of the 12-week feeding trial, weight gain (WG) and feed efficiency (FE) of fish fed $AA_{0.78}$ and $AA_{1.23}$ diets were significantly higher than of fish fed $AA_{0.07},\;AA_{0.22},\;AA_{0.43}$ diets (p<0.05). Specific growth rate (SGR) of fish fed the $AA_{0.78}$ diet was significantly higher than of fish fed $AA_{0.07},\;AA_{0.22},\;AA_{0.43}$ diets (p<0.05). However, there were no significant differences in WG, SGR and FE among fish fed $AA_{0.57},\;AA_{0.78}\;or\;AA_{1.23}$ diets (p>0.05). Whole body AA deposition of fish fed the $AA_{1.23}$ diet was significantly higher than for the other diets (p<0.05). Broken-line model analysis on the basis of WG and SGR indicated that the dietary AA requirement could be greater than 0.69% but less than 0.71% of the diet in juvenile eel. The growth-promoting activity of AA observed in the present study provides strong support for the contention that dietary AA is essential for juvenile eel.

• Korean Journal of Health Education and Promotion
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• v.22 no.2
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• pp.19-32
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• 2005

Objectives: The purpose of this study was to examine teachers' safety education activities to determine the significant educational diagnosis variables and to identify their needs of safety education in early-child care centers based on the PRECEDE model. Methods: A total of 304 teachers in early-child care centers participated in this study selected by a multi-stage stratified sampling method considering 11 regions in Seoul, Korea. Self-report type questionnaires were posted to all teachers in 220 early-child care centers by ground mailing service and the 304 teachers completed the questionnaires. The participants' responses were anonymously coded into and analyzed in SPSS program. Results: 'Scratch or bite' was the most frequent accident type(78.3%) and the frequent accident places were 'classroom(88.8%)' and 'playground(67.8%)'. The most frequently conducted safety education activities were 'reminding children their safe behaviors at the beginning and the end of daily class' and the next was 'saving a special time for safety education.' For educational diagnosis factors, related to safety education activities, teachers' safety education activity was more frequent when teachers' safety knowledge was high(p<.001), when teachers had good application skills of their knowledge to their teaching activities(p<.001), when they had strong needs on safety training opportunities(p<.05), and their interests on safety education(p<.001). For enabling factors, class preparation by safety education guide-book review(p<.001), by development of educational materials(p<.001), and by search for the related reference (p<.001), and by participation to safety education training programs for teachers(p<.01) were the significant enabling factors on teachers' safety class activities. For the reinforcing factors, the center-wide support of safety education brochures to children (p<.001), the concerns of centers utilizing safety education specialists(p<.001), and the concerns about safety information collection out of centers(p<.001) were significant factors related with teachers' safety education activities. Conclusions: The significant educational and institutional factors on teachers' safety education activities were teachers' concerns on safety education, their interests on safety knowledge, and the strong concerns on child safety education from the centers.

• Economic and Environmental Geology
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• v.53 no.5
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• pp.585-596
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• 2020

The 2017 Pohang Earthquakes occurred near a drill site in the Pohang Enhanced Geothermal System. Water injected for well stimulation was believed to have reactivated the buried near-critically stressed Miocene faults by the accumulation of the Quaternary tectonic strain. However, surface expressions of the Quaternary tectonic activity had not been reported near the epicenter of the earthquakes before the site construction. Unusual, large-scale water-escaped structures were identified 4 km away from the epicenter during a post-seismic investigation. The water-escaped structures comprise Miocene mudstones injected into overlying Pleistocene coastal sediments that formed during Marine Isotope Stage 5. This indicates the vulnerable state of the mudstones long after deposition, resulted from the combined effects of rapid tectonic uplift (before significant diagenesis) and the development of an aquifer at their unconformable interface of the mudstone. Based on the detailed field analysis and consideration of all possible endogenic triggers, we interpreted the structures to have been formed by elevated pore pressures in the mudstones (thixotropy), triggered by cyclic ground motion during the earthquakes. This interpretation is strengthened by the presence of faults 400 m from the study area, which cut unconsolidated coastal sediment deposited after Marine Isotope Stage 5. Geological context, including high rates of tectonic uplift in SE Korea, paleo-seismological research on Quaternary faults near the study area, and historical records of paleoearthquakes in SE Korea, also support the interpretation. Thus, epicenter and surrounding areas of the 2017 Pohang Earthquake are considered as a paleoseismologically active area, and the causative fault of the 2017 Pohang Earthquakes was expected to be nearly critical state.

• Journal of Life Science
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• v.27 no.8
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• pp.951-957
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• 2017

To understand the cytotoxic activity of Machilus thunbergii, which has been used as a traditional oriental medicine, the mechanism underlying the cytotoxic effect of its extract on human acute Jurkat T cells was investigated. The methanol extract of roots (3 kg) of M. thunbergii was evaporated, dissolved in, and then extracted by water. The water-extracted active substance was designated MTWE. When Jurkat T cells were treated with MTWE at concentrations of 0, 25, 50, and $100{\mu}g/ml$, the apoptotic phenomenon of cells accompanying several subsequent biochemical reactions, such as mitochondrial cytochrome c release, activation of caspase-3, and ICAD degradation, was detected in the Jurkat T cells. Moverover. the expression of Bcl-xL, which is a suppressor for mitochondrial cytochrome c release pathway, was reduced in the Jurkat T cells. As DUSP6, a growth suppressor of cancer cells, ranged from 0, 25, 50, $100{\mu}g/ml$ of MTWE, the expression level was elevated in the Jurkat T cells. The apoptotic morphological change of the nuclei was observed by DAPI staining. Although the potential involvement of the other factors and DUSP6 is currently being investigated in more detail, these findings support the notion that MTWE is able to achieve the apoptosis of Jurkat T cells, and it seems that MTWE is useful as a method of evaluating a chemotherapeutic agent or tonic materials for human acute leukemia.

• Journal of KIISE:Software and Applications
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• v.26 no.12
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• pp.1393-1403
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• 1999

공간 데이타베이스 시스템을 통하여 공유되는 공간 데이타는 무결성이 적절하게 유지되지 않는 한 전체 응용 시스템의 행위를 예측할 수 없게 되므로 데이타의 무결성 확인 및 유지는 필수적이다. 특히 공공 GIS에 저장된 공간 데이타는 토지 이용도 평가, 도시 계획, 자원 관리, 시설물 관리, 안전 관리, 국방 등 국가 전체 및 지역의 중요한 정책 결정을 위한 다양한 응용 시스템들에 의해 이용되므로 적절한 공간 객체의 무결성 확인이 더욱 더 필요하다. 본 논문에서는 능동(active) DBMS의 능동 규칙(active rule) 기법을 이용하여 공간 객체의 무결성 확인을 지원하기 위한 규칙 관리 시스템을 제시한다. 능동 규칙을 이용한 공간 객체의 무결성 확인은 응용 프로그래머를 무결성 확인에 대한 부담으로부터 자유롭게 할 수 있다. 본 시스템은 특정 DBMS에 종속되지 않는 독립적인 외부 시스템으로 존재하며, 능동 규칙 관리기, 규칙 베이스, 그리고 활성규칙 생성기의 3 부분으로 구성된다. 사용자가 공간 데이타베이스 응용 프로그램을 통해 공간 객체를 조작하고자 할 때, 본 시스템은 데이타베이스 트랜잭션을 단위로 조작되는 모든 공간 객체의 무결성 확인을 위해 응용 프로그램에 삽입될 무결성 제약조건 규칙들을 효율적으로 관리하는 역할을 한다.Abstract It is necessary that the integrity of spatial data shared through the spatial database system is validated and appropriately maintained, otherwise the activity of whole application system is unpredictable. Specially, the integrity of spatial data stored in public GIS has to be validated, because those data are used by various applications which make a decision on an important policy of the region and/or whole nation such as evaluation of land use, city planning, resource management, facility management, risk management/safety supervision, national defense. In this paper, we propose rule management system to support validating the integrity of spatial object, using the technique of active rule technique from active DBMS. Validating data integrity using active rules allows database application programmer to be free from a burden on validation of the data integrity. This system is an independent, external system that is not subject to specific DBMS and consists of three parts, which are the active rule manager, the rule base, and the triggered rule generator. When an user tries to manipulate spatial objects through a spatial database application program, this system serves to efficiently manage integrity rules to be inserted into the application program to validate the integrity constraints of all the spatial objects manipulated by database transactions.