• Natural Product Sciences
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• v.25 no.2
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• pp.115-121
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• 2019

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl($1{\rightarrow}6$)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-$15{\beta}$-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at $100{\mu}M$. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and ${\pi}-{\pi}$ stacking interactions which could explain the compound potency to inhibit AChE and BChE.

• Mass Spectrometry Letters
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• v.13 no.4
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• pp.152-157
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• 2022

Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3A-inhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature's Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature's Way, which exhibited the strongest inhibition against CYP3A, had the highest contents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.

• Bulletin of the Korean Chemical Society
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• v.29 no.4
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• pp.817-821
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• 2008

We have investigated the influence of the crystal structure on the chemical bonding nature and photocatalytic activity of cubic and hexagonal perovskite A[$Cr_{1/2}Ta_{1/2}$]O3 (A = Sr, Ba) compounds. According to neutron diffraction and field emission-scanning electron microscopy, the crystal structure and particle size of these compounds are strongly dependent on the nature of A-site cations. Also, it was found that the face-shared octahedra in the hexagonal phase are exclusively occupied by chromium ions, suggesting the presence of metallic (Cr-Cr) bonds. X-ray absorption and diffuse UV-vis spectroscopic analyses clearly demonstrated that, in comparison with cubic Sr[$Cr_{1/2}Ta_{1/2}$]$O_3$ phase, hexagonal Ba[$Cr_{1/2}Ta_{1/2}$]$O_3$ phase shows a decrease of Cr oxidation state as well as remarkable changes in interband Cr d-d transitions, which can be interpreted as a result of metallic (Cr-Cr) interactions. According to the test of photocatalytic activity, the present semiconducting materials have a distinct activity against the photodegradation of 4-chlorophenol. Also the Srbased compound was found to show a higher photocatalytic activity than the Ba-based one, which is attributable to its smaller particle size and its stronger absorption in visible light region.

• Proceedings of the Zoological Society Korea Conference
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• 1995.10b
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• pp.83-83
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• 1995

The three chitin synthetases of Saccharomyces cerevisiae, Chs1, Chs2, and Chs3, participate in septum and cell wall formation of vegetative cells and in wall morphogenesis of conjugating cells and spores. Because of the differences in the nature and in the time of execution of their functions, the synthetases must be specifically and individually regulated. The nature of that regulation has been investigated by measuring changes in the levels of the three synthetases and of the messages of the three corresponding gnes, CDSI, CHS2, and CAL1/CSD2/DITl0l(referred to below as CAL1), during the budding cycles. For Chs1 and Chs3, posttranslational regulation, probably by activation of latent forms, appears to be predominant. Since Chs2, like Chs1, is found in the cell in the zymogenic form, a posttranslational activation step appears to be necessary for this synthetase also. The regulation mechanism was investigated to search the relationship of CAL1, CAL2 and CALJ which is involved in Chs3 activity us ing different assay methods other than previous one. Treatment of Chs3-containing membranes with detergents drastically reduced the enzymatic activity. Activity could, however, be restored by subsequent incubation with trypsin or other pro teases in the presence of UDPGlcNAc. Experiments wi th mutants in the three genes invoIved in Chs3 activity-CAL1, CAL2, and CALJ-showed that only CAL1 and CALJ are required for the proteaseelicited (zymogenic) activity. It is concluded that Chs3 IS a zymogen and that the CAL2 product funct ions as its activator.ivator.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.9
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• pp.1506-1518
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• 2009

This study identifies the relationships among demographic variables, well-being health consciousness, sports/leisure activity, and the perceived premium price for high functional sports/leisure wear. An empirical study was conducted with the data collected by questionnaires distributed to male and female respondents aged 15 and over. Descriptive statistics, factor analysis, MANOVA, two-way ANOVA, and regressions were used to analyze 244 answers. As a result, 3 factors were determined for well-being health consciousness: nature-friendly life, premium consumption for health, and health care. The older group pursued a nature-friendly life more than the younger group, the female group pursued premium consumption for health more than male group, and older women and younger men pursued health care more than their counterparts. Sports/leisure activity was relatively intensive in the male group and in the younger group. Sports/leisure activity was explained by male characteristic and health care factors. Sports/leisure activity was the only element for predicting the perceived premium price ratio for high functional sports/leisure wear.

• The Journal of the Korea Contents Association
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• v.11 no.11
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• pp.296-312
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• 2011

Korea has been suffering from financial hardship with low birth rate and rapid growing of advanced aged people because low economic growth and low interest rate have continued after IMF foreign-exchange crisis. Under these circumstances, it is necessary for the middle-aged people to have well-prepared retirement plan in the sense of physical, psychological, social and economical preparedness. The study intends to find out how the occupation and activity characteristics affect the physical, psychological, social and economical preparation for their remaining old age. For the purpose, questionnaires were collected from 344 middle-aged people working in private companies, public offices and small-business owners in metropolitan and Chungcheong province. The findings are as follows: First, they were physically well-prepared, as they thought their leisure activity was more important, their occupational role was more stable and they were old and healthy. Second, Women had notion about their occupation if they kept a good relationship with their colleagues. And they were psychologically prepared well as they valued their leisure activities. Third, if they perceived their occupations as stable and had more social and leisure activities, they were socially well-prepared. Fourth, Although the level of economical preparation depends on their wealth, the occupation and activity characteristics had no effect on the economical preparation. These findings imply that the retirement preparation as a recent social issue has been influenced by the nature of occupation and activity and suggest that the definite policy and program will be required for the retirement preparation of the middle-aged people from various aspects.

• Journal of Environmental Science International
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• v.19 no.11
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• pp.1437-1444
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• 2010

This research was to find out the effectiveness of the horticultural therapy program based on the therapeutic factors and the most meaningful experiences of the clients. For this purpose "Green harmony" program focused on harmony through horticulture was implemented. It is based on the preposition that holistic health is promoted with harmonious relationships with oneself, other people, community and nature. The program has three-fold structure: In innermost it deals with the task of the late adolescent, i.e., self identity, secondly the experience of communication and solidarity in the group, and finally extension of interest to the community. For the therapeutic intervention, questions using the metaphor of the activity were given to the clients for the establishment of self-identity, while group activity and the donation of the works let the second and third purpose accomplished. Outdoor activity, 'Tire garden project', has provided the clients with chances of the contact with nature, cooperation with other group members, and a contest to provoke enthusiasm. Also recycling and greening of the community were possible by utilizing old tires for the containers and by donating the final works to the community. For the evaluation of the result, the effect of the program on the stress of the college students was tested, and the most meaningful experiences during the participation to the program were asked to identify the therapeutic factors acknowledged by clients. "Green harmony" program has brought positive effects on the stress of the clients in spite of relatively short period of five weeks. The clients has acknowledged plant/nature contact and interactions between group members for the most meaningful experiences. This research suggests "Green harmony" horticultural therapy program based on the therapeutic factors is highly applicable for the general populations.

• Hwankyungkyoyuk
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• v.23 no.3
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• pp.97-114
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• 2010

The aims of this study are to develop and apply a Nature Game program for the ecological experience learning in Jeju Gotjawal forest and analyze the environmental sensitivity change of the students. The results obtained in 4th graders of A elementary school of Seogwipo-city are as follows: It was found that attention, susceptibility and practice will of environment protection for forest environment of the experimental class were significantly higher than those of the comparison class. And it was found that interest and curiosity into forest environment were also elevated in the results of the qualitative evaluation, suggesting that we could get the effect of developed Nature Game program on ecological experience learning. If various ecological experience learning programs considering the regional-specific characteristics are developed to cause students' interest and curiosity, students would come to participate in the protection activity of environment aggressively a little more.

• Korean Journal of Applied Biomechanics
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• v.20 no.4
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• pp.407-414
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• 2010

The purpose of this study was to evaluate the effect of taping-tape with or without using spiral taping on vertical jump. The subjects for this study were about 20 years old healthy male college students without muscloskeletal diseases. Data for EMG activity and Ground Reaction Force(GRF) were estimated at three knee angles(i.e., 45, 90 & full degree). As a result, there was no statistical significance in max GRF at 90 and full degree regardless of spiral taping-tape. On the other hand, statistical significance was found when vertically jumping at 45 degree knee angle(p<.05). All the data for EMG activity at the three knee angles were not statistically significant, but there was a trend for a decrease in average EMG activity in elector spinae & Medial gastrocnemius at 90 degree knee angle. Based on these data, initial flexor action of knee was stabilized with spiral taping-tape when vertically jumping, resulting in improved muscular activity in Medial gastrocnemius. In conclusion, taping technique for jumping ability associated muscles like quadriceps is also required to develop.

• Hwankyungkyoyuk
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• v.18 no.2 s.27
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• pp.90-100
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• 2005

This study was intended to investigate effects of building school forests on elementary school students, including changes in mental image of school, attitude toward nature and forest, and awareness of their relationship with school forest. The total number of 770 drawings and 1,124 writings were collected to be analyzed from three elementary schools. The results showed that there were significant differences between two student groups, respectively forest school group versus non-forest school group, in their mental image of school. For instance, more often observed in the drawings of forest school group students than their counterparts were natural and human elements, activities associated with nature, and natural or human elements located at central area. Also, more frequently found in the writings of forest school group students than their counterparts were letter-style sentences, stories about school forests, inherent values on nature and forest, and curiosity regarding the nature. These results seem to indicate that in order to materialize educational value of school forests, practical workshops for teachers need to be held as soon as possible and new activity models for students should be developed. In addition to that, long-term research on effectiveness of school forest have to be conducted to a number of schools.