• 산업공학
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• 제16권2호
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• pp.258-267
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• 2003

Recently, virtual reality technologies have been rapidly developed and realtime virtual simulation methods have been extensively employed for several application areas such as game, sports, manufacturing, military, and so on. A 3D database in realtime virtual simulation plays a key role because it makes users feel reality in virtual space. In a application view of 3D database, a systematic construction approach is required to reduce its construction time and increase its quality. However, many researches have been mostly focused on realtime graphic issues and its key technologies. In virtual simulation of transportation equipments, this paper proposes a systematic construction process of 3D database consisting of four stages as follows: 1) determine the activity space of a equipment, 2) collect data related to 3D database construction, 3) make a 3-dimensional modeling strategy, and 4) generate and evaluate a 3D model. This paper also introduces a new procedure of 3D environment modeling, which summarizes and expands our modeling experiences, to be used as a modeling guide.

• 약학회지
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• 제59권4호
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• pp.151-157
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• 2015

The purpose of this study is to demonstrate how lead compounds are best optimized with the application of in silico QSAR and PBPK modeling at the early drug discovery stage. Several predictive QSAR models such as $IC_{50}$ potency model, intrinsic clearance model and brain penetration model were built and applied to a set of virtually synthesized library of the BACE1 inhibitors. Selected candidate compounds were also applied to the PBPK modeling for comparison between the predicted animal pharmacokinetic parameters and the observed ones in vivo. This novel lead optimization strategy using QSAR and PBPK modelings could be helpful to expedite the drug discovery process.

• 디지털산업정보학회논문지
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• 제7권1호
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• pp.173-183
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• 2011

Global logistics including Korea had developed at various fields through the developed IT technology. In addition, in changing into Internet based digital economy times, economic and logistics activities became extending into worldwide over the cross-border. Logistics activity performed by off-line rapidly changed in real environment. But, unfortunately business process modeling about the whole logistics was not happened, even though process modeling had done by transport stages or logistics entities. Therefore, it is difficult to grasp the whole logistics. Additional cost and time was requested due to no association between logistics entities and invisibility. So, this paper has to be process modeling for logistics industry domain. For objective modeling, work area shall be divided and it extracts general work process per each area. And then it defines subprocess of general work process. Cargo tracking in logistics industry domain means to grasp the status and present states at transportation or storage stage. This paper defines business process and data model for electronic processed work area using the UN/CEFACT standard modeling methodology.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제15권2호
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• pp.181-196
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• 2011

In mathematical modeling tasks, where students are exposed to model-eliciting for real and open problems, students are supposed to formulate and use a variety of mathematical skills and tools at hand to achieve feasible and meaningful solutions using appropriate problem solving strategies. In contrast to problem solving activities in conventional math classes, math modeling tasks call for varieties of mathematical ability including mathematical creativity. Mathematical creativity encompasses complex and compound traits. Many researchers suggest the exhaustive list of criterions of mathematical creativity. With regard to the research considering the possibility of enhancing creativity via math modeling instruction, a quantitative scheme to scale and calibrate the creativity was investigated and the assessment of math modeling activity was suggested for practical purposes.

• Bulletin of the Korean Chemical Society
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• 제34권3호
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• pp.837-850
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• 2013

Bovine viral diarrhea virus (BVDV), a major pathogen of cattle, is a well-characterized pestivirus which has been used as a good model virus for HCV. The RNA-dependent RNA polymerase (RdRp) plays a key role in the RNA replication process, thus it has been targeted for antivirus drugs. We employed two-dimensional quantitative structure-activity relationship (2D-QSAR) and molecular field analysis (MFA) to identify the molecular substructure requirements, and the particular characteristics resulted in increased inhibitory activity for the known series of compounds to act as effective BVDV inhibitors. The 2D-QSAR study provided the rationale concept for changes in the structure to have more potent analogs focused on the class of arylazoenamines, benzimidazoles, and acridine derivatives with an optimal subset of descriptors, which have significantly contributed to overall anti-BVDV activity. MFA represented the molecular patterns responsible for the actions of antiviral compound at their receptors. We conclude that the polarity and the polarizability of a molecule play a main role in the inhibitory activity of BVDV inhibitors in the QSAR modeling.

• 대한토목학회논문집
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• 제33권2호
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• pp.719-727
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• 2013

교통수요 예측 모델에서 통행을 기본 단위로 사용하는 4-단계 통행기반 모형은 오랜 시간동안 광범위하게 사용되어 왔으나, 최근 교통수요예측의 결과가 차량 개통 후 실제 교통량과 차이가 크게 발생되어, 예측 결과에 대한 불신이 증가되고 있다. 이러한 교통량 예측의 차이는 인간의 자연스러운 통행활동을 모형 개발 단계에서 고려하지 않기 때문이다. 그러나 미국에서는 교통수요예측의 정확성과 현실성을 높이기 위해 활동기반 모형을 1990년대 부터 활발하게 연구 및 개발하여 점진적으로 기존 4-단계 통행기반 모형을 대체하고 있는 상황이다. 본 논문은 통행기반 모형과 활동기반 모형을 분석단위, 분석절차, 문제점 등을 상호 비교 검토하는데 목적을 두었다. 기존의 교통수요예측 방법론의 문제점을 진단하기 위해, 미국을 중심으로 대표적인 세 가지 활동기반 모형 시스템(DaySim, CT-Ramp, CEMDAP)을 사용하였다. 통행기반 모형은 인간의 다차원적인 통행의사 결정 과정을 효율적으로 쉽게 설명할 수 있으며, 이는 교통수요 예측의 정확성을 한층 더 높일 수 있을 것으로 판단된다. 따라서, 우리나라도 수요예측의 현실성과 정확도를 높이기 위해 인간의 활동을 기반으로 보완, 개선된 수요예측방법론이 검토되어야 한다.

• 대한수학교육학회지:학교수학
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• 제16권3호
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• pp.409-444
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• 2014

수학교육 연구 공동체에서는 모델링 활동을 통한 수학 학습에 대한 논의들이 지속되어 왔다. 모델링 활동은 대안적인 수학 교수 학습 방법으로 논의되어 왔으나, 모델링 활동을 통하여 이루어지는 수학 학습은 어떠한 성격을 갖는지, 그리고 이는 어떠한 과제 설계와 수업 실행을 통하여 달성할 수 있는지에 대한 합의점은 도출되지 못한 실정이다. 모델링 활동을 통한 수학 학습을 시도해 온 선행 연구들의 논의로부터, 본 연구에서는 모델링 활동이 메타수준의 수학적 담론 생성과 메타규칙의 변화를 포함하는 메타수준 학습을 촉진할 수 있을 것으로 판단하였다. 이에 본 연구에서는 메타수준 학습을 촉진할 수 있는 모델링 과제 설계와 수업 실행 방안을 도출하고, 이를 실행하여 수학 교수 학습에서 모델링 활동의 잠재력을 확인하는 데 목적을 둔다.

• 한국수학교육학회지시리즈A:수학교육
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• 제57권4호
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• pp.371-391
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• 2018

The purpose of this study is to analyze manifestation examples and effects of group creativity in mathematical modeling and to discuss teaching and learning methods for group creativity. The following two points were examined from the theoretical background. First, we examined the possibility of group activity in mathematical modeling. Second, we examined the meaning and characteristics of group creativity. Six students in the second grade of high school participated in this study in two groups of three each. Mathematical modeling task was "What are your own strategies to prevent or cope with blackouts?". Unit of analysis was the observed types of interaction at each stage of mathematical modeling. Especially, it was confirmed that group creativity can be developed through repetitive occurrences of mutually complementary, conflict-based, metacognitive interactions. The conclusion is as follows. First, examples of mutually complementary interaction, conflict-based interaction, and metacognitive interaction were observed in the real-world inquiry and the factor-finding stage, the simplification stage, and the mathematical model derivation stage, respectively. And the positive effect of group creativity on mathematical modeling were confirmed. Second, example of non interaction was observed, and it was confirmed that there were limitations on students' interaction object and interaction participation, and teacher's failure on appropriate intervention. Third, as teaching learning methods for group creativity, we proposed students' role play and teachers' questioning in the direction of promoting interaction.

• BMB Reports
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• 제35권5호
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• pp.498-507
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• 2002

A gene that encodes a thermostable protease, coined thermicin, has been isolated from Thermoanaerobacter yonseiensis that is expressed and characterized in E. coli.. In order to elucidate the molecular characteristics on thermostability of the enzyme, molecular modeling and mutagenesis technology were applied. In the modeling structure, the structural core, including the active site, was well conserved; whereas, the two loop regions were unique when compared to thermitase. The mutant enzyme with the small loop deleted (D190-I196), based on modeling structural information, showed identical enzyme activity. However, when the large loop was deleted (P233-P244), a little lower $K_m$ and even a lower kcat was found. This indicates that the large loop could influence catalytic activity. However, the unfolding temperature ($T_m$), which was determined by a differential-scanning calorimetry for the mutant enzyme deleted the small loop, was $96^{\circ}C$. This is $14^{\circ}C$ lower than that for the parent thermicin. These results suggest that the small loop may play a role in maintaining the proper folding of the enzyme at high temperatures, whereas the large loop might be related to catalysis.

• 한국전자거래학회지
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• 제14권1호
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• pp.35-56
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• 2009

프로세스 설계에는 Petri-net, EPC, UML Activity Diagram 등 다양한 모델 기법이 사용되고 있다. 업무 프로세스 내에 복잡한 업무 규칙이 다수 결합되어 있거나, 유비쿼터스 컴퓨팅과 같이 분산 환경에서 복합한 상호운용 규칙이 산재되어 있는 경우에는 정형적인 프로세스 모델링 기법이 비효율적이므로 규칙 기반의 분산 프로세스 설계를 사용할 수 있다. 본 연구는 유비쿼터스 환경에서의 규칙 기반 프로세스 설계 방법을 분석한다. 특히, 이벤트-조건-액션(ECA) 형태의 능동형 규칙을 이용한 프로세스 설계를 대상으로 분석하며, ECA 스키마는 웹 서비스 기술을 위해 개발된 WS-ECA 언어를 사용한다. ECA 규칙을 이용한 여러가지 프로세스 통제 흐름 표현 방법을 분석하기 위하여 워크플로우 패턴을 활용하였다. 워크플로우 패턴에 따라 ECA 규칙 기반 프로세스 표현법을 제공함으로써 규칙 기반 프로세스를 설계하기 위한 가이드라인을 제시하였다는 데 연구의 의의가 있다.