• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.277-282
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• 2007

Construction process works in sequence order and there are many different software for managing project and activity. So, there are many limitations such as in the stage of activity data loss can occur, in each stage concurrent cannot operate in construction industry. In order to solve these problem, agents have to cooperate each other and they need to share of data. Therefore, the purpose of this paper is to develop a process model and the process model will be use in the future to make Construction Project Life-Cycle Management based on concept of PLM(Product Life cycle Management) in the manufacturing industry, CE(Concurrent Engineering) and BlM(Building Information Modeling)

• Informatization Policy
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• v.29 no.4
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• pp.43-66
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• 2022

With the development of artificial intelligence technology, competition for artificial intelligence technology patents around the world is intensifying. During the period 2000 ~ 2021, artificial intelligence technology patent applications at the US Patent and Trademark Office have been steadily increasing, and the growth rate has been steeper since the 2010s. As a result of analyzing Korea's artificial intelligence technology competitiveness through patent indices, it is evaluated that patent activity, impact, and marketability are superior in areas such as auditory intelligence and visual intelligence. However, compared to other countries, overall Korea's artificial intelligence technology patents are good in terms of activity and marketability, but somewhat inferior in technological impact. While noise canceling and voice recognition have recently decreased as topics for artificial intelligence, growth is expected in areas such as model learning optimization, smart sensors, and autonomous driving. In the case of Korea, efforts are required as there is a slight lack of patent applications in areas such as fraud detection/security and medical vision learning.

• Journal of Ginseng Research
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• v.48 no.1
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• pp.89-97
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• 2024

Background: Ginsenoside F2 (GF2), the protopanaxadiol-type constituent in Panax ginseng, has been reported to attenuate metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanism of action is not fully understood. Here, this study investigates the molecular mechanism by which GF2 regulates MASLD progression through liver X receptor (LXR). Methods: To demonstrate the effect of GF2 on LXR activity, computational modeling of protein-ligand binding, Time-resolved fluorescence resonance energy transfer (TR-FRET) assay for LXR cofactor recruitment, and luciferase reporter assay were performed. LXR agonist T0901317 was used for LXR activation in hepatocytes and macrophages. MASLD was induced by high-fat diet (HFD) feeding with or without GF2 administration in WT and LXRα^-/- mice. Results: Computational modeling showed that GF2 had a high affinity with LXRα. LXRE-luciferase reporter assay with amino acid substitution at the predicted ligand binding site revealed that the S264 residue of LXRα was the crucial interaction site of GF2. TR-FRET assay demonstrated that GF2 suppressed LXRα activity by favoring the binding of corepressors to LXRα while inhibiting the accessibility of coactivators. In vitro, GF2 treatments reduced T0901317-induced fat accumulation and pro-inflammatory cytokine expression in hepatocytes and macrophages, respectively. Consistently, GF2 administration ameliorated hepatic steatohepatitis and improved glucose or insulin tolerance in WT but not in LXRα^-/- mice. Conclusion: GF2 alters the binding affinities of LXRα coregulators, thereby interrupting hepatic steatosis and inflammation in macrophages. Therefore, we propose that GF2 might be a potential therapeutic agent for the intervention in patients with MASLD.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.565-573
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• 2004

In this paper, we proposed a heart activity control model for simulation of the aortic sinus baroreceptor, which was the most representative baroreceptor sensing the variance of pressure in the cardiovascular system. And then, the heart activity control model composed electric circuit model of the cardiovascular system with baroreflex control and time delay sub-model to observe the effect of time delay in heart period and stroke volume under the regulation of baroreflex in the aortic sinus. The mechanism of time delay in the heart activity baroreflex control model is as follows. A control function is conduct sensing pressure information in the aortic sinus baroreceptor to transmit the efferent nerve through central nervous system. As simulation results of the proposed model, we observed three patterns of the cardiovascular system variability by the time delay. First of all, if the time delay over 2.5 second, aortic pressure and stroke volume and heart rate was observed non-periodically and irregularly. However, if the time delay from 0.1 second to 0.25 second, the regular oscillation was observed. And then, if time delay under 0.1 second, then heart rate and aortic pressure-heart rate trajectory were maintained in stable state.

• Korean Journal of Social Welfare Studies
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• v.48 no.4
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• pp.91-120
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• 2017

This study aimed (a) to examine the association between chronic illness and multidimensional disability(i.e., psychological/emotional functions, activity capacity, and participation frequency) among older adults with disabilities, (b) to investigate the effect of formal and informal supports on multidimensional disability, and (c) to analyze the moderating effects of formal and informal supports on the association between chronic illness and multidimensional disability. This study used 2014 Korea Welfare Panel Study(the 9th wave) data and 450 older adults with disabilities aged 50 and over were selected as the study target. The research model was analyzed by structural equation modeling using IBM AMOS 22.0. Based on the ICF framework developed by WHO, health condition was measured by the level of chronic illness; psychological/emotional functions were measured by health satisfaction, self-esteem, and depression; activity capacity was measured by ADLs and IADLs; participation frequency was measured by the total number of social activities joined; formal support was measured by the total number of formal welfare services for people with disabilities utilized; informal support was measured by perceived social support. The findings showed that the level of chronic illness was negatively associated with psychological/emotional functions among the older adults with disabilities. The informal support positively affected psychological/emotional functions and activity capacity, whereas the formal support showed the opposite result. That is, the formal support negatively influenced activity capacity and showed a moderating effect on the association between the level of chronic illness and the psychological/emotional functions in a reverse way. Based on the results, practice and policy implications for alleviating disability level among the older adults with disabilities were discussed.

• Therapeutic Science for Rehabilitation
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• v.12 no.4
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• pp.39-51
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• 2023

Objective : This study seeks to unveil the intellectual framework of research surrounding children's occupations by utilizing social network analysis of keywords from studies focused on childhood. Methods : From August 2003 to August 2023, we analyzed 3,364 keywords extracted from 270 research articles in the Korean Citation Index with the keyword "Child and Occupation" using the NetMiner program. Results : Research on children's work has increased quantitatively over the past decade. Keywords exhibiting a high degree of centrality in the realm of child occupation research included Task (0.055), Group therapy (0.040), Working memory (0.037), Intervention (0.033), Performance (0.030), Language (0.026), Ability (0.026), Skill (0.024), and Program (0.023). Notably, the weighted terms in the Word Network included Evaluation-Tool (30), School-Student (15), and Activity-Participation (15). The primary keywords from each topic in topic modeling were Activity (0.295), Disability (0.604), Education (0.356), Skill (0.478), School (0.317), Function (0.462), Disorder (0.324), Language (0.310), Comprehension (0.412), and Training (0.511). Conclusion : This study describes the trends in the domestic field of pediatric occupational research. These efforts provided valuable insights into pediatric occupational therapy in South Korea.

• The Journal of the Korea Contents Association
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• v.11 no.7
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• pp.478-488
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• 2011

The aims of this research are to form a research model for negotiations against leisure constraints, serious leisure activity, and the specialization of sports activity, verify the fitness of this model and define the relationship between the variables in the model. This research was taken on a population of 235 people in the commercial sports center in Seoul city in 2010, taking the members by voluntary, and analyzed them with purposive sampling. The research used AMOS 18.0 program to carry out a covariance structure analysis. The conclusions are as follows. First, serious leisure can be experienced when one puts effort in negotiating against the leisure constraints. Second, when one puts effort in negotiating against leisure constraints, progress is made in specialization of sports activity. Lastly, sports activity becomes more professionalized when one experiences serious leisure.

• BMB Reports
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• v.34 no.2
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• pp.109-113
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• 2001

The Serratia marcescens metalloprotease inhibitor (SmaPI) is a proteinase inhibitor toward Serratia marcescens metalloprotease (SMP). The three-dimensional structure of SmaPI was calculated by computer modeling using the structure complex between SMP and the Erwinia chrysanthemi inhibitor as a template. Based on this model structure, the substitution of the amino acid residues, Ala4, Leu-5, Pro-6, and Thr-7, were located at the hinge region of the N-terminal segment by site-directed mutagenesis. Although the A4R and T7A mutant SmaPIs showed a nearly full inhibitory activity, the inhibitory activity of SmaPI decreased significantly when the Leu-5 was converted to Ala, Gly, Ile, or Val. Surprisingly, the L5I and L5V mutant SmaPIs showed less inhibitory activities than the L5A mutant. From these results, we suggested that the orientations and positions of respective aliphatic groups in the side-chain of position 5 mainly affected the inhibitory activity of SmaPI. The overall side-chain hydrophobicity was only slightly affected. The side-chain of the Leu-5 residue contributed approximately 0.79 kcal/mol out of 8.44 kcal/mol to the binding of SmaPI with SMP The inhibitory activities of P6A and F6G were also severely decreased. The Pro-6 may have a critical role in maintaining the strict conformation of the N-terminal portion that may be important in the inhibitory activity of SmaPI. In conclusion, Leu-5 and Pro-6 have crucial roles in the inhibitory function of SmaPI toward SMP.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.734-743
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• 2007

The KTX station is one of special generators that produce a lot of trips caused by special land use such as university, airport, and super shopping mall. Special generators need special attention in developing travel demand models since the standard trip generation and distribution model in the conventional four-step approach do not provide reliable estimates of their travel patterns. New modeling approach, activity-based model, considering travel behavior of person, seem to be more appropriate for those special generators. Thus, this study introduces a spatial-temporal activity-based approach and how activity-based approach can be applied to estimation of travel demand at KTX stations.

• Journal of Microbiology and Biotechnology
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• v.25 no.1
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• pp.89-97
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• 2015

Bacillus subtilis HK176 with high fibrinolytic activity was isolated from cheonggukjang, a Korean fermented soyfood. A gene, aprE176, encoding the major fibrinolytic enzyme was cloned from B. subtilis HK176 and overexpressed in E. coli BL21(DE3) using plasmid pET26b(+). The specific activity of purified AprE176 was 216.8 ± 5.4 plasmin unit/mg protein and the optimum pH and temperature were pH 8.0 and 40℃, respectively. Error-prone PCR was performed for aprE176, and the PCR products were introduced into E. coli BL21(DE3) after ligation with pET26b(+). Mutants showing enhanced fibrinolytic activities were screened first using skim-milk plates and then fibrin plates. Among the mutants, M179 showed the highest activity on a fibrin plate and it had one amino acid substitution (A176T). The specific activity of M179 was 2.2-fold higher than that of the wild-type enzyme, but the catalytic efficiency (k_cat/K_m) of M179 was not different from the wild-type enzyme owing to reduced substrate affinity. Interestingly, M179 showed increased thermostability. M179 retained 36% of activity after 5 h at 45℃, whereas AprE176 retained only 11%. Molecular modeling analysis suggested that the 176^th residue of M179, threonine, was located near the cation-binding site compared with the wild type. This probably caused tight binding of M179 with Ca²⁺, whichincreased the thermostability of M179.