• Biomedical Science Letters
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• v.20 no.3
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• pp.162-167
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• 2014

Tuberculosis (TB) is one of the major global health problems and it has been estimated that in 5~10% of Mycobacterium tuberculosis (MTB)-infected individuals, the infection progresses to an active disease. Numerous cytokines and chemokines regulate immunological responses at cellular level including stimulation and recruitment of wide range of cells in immunity and inflammation. In the present study, the mRNA expression levels of eight host immune markers containing of IFN-${\gamma}$, TNF-${\alpha}$, IL-2R, IL-4, IL-10, CXCL9, CXCL10, and CXCL11 in whole blood cells from active pulmonary TB patients were measured after T-cell mitogen (PHA) and MTB specific antigens (ESAT-6, CFP-10, and TB7.7). Among the TH1-type factors, IFN-${\gamma}$ mRNA expression was peaked at 4 h, TNF-${\alpha}$ and IL-2R mRNA expression was significantly high at the late time points (24 h) in active TB patients, TH2-type cytokine (IL4 and IL10) mRNA expression levels in both active TB and healthy controls samples did not changed significantly, and the mRNA expression of the three IFN-${\gamma}$-induced chemokines (CXCL9, CXCL10, and CXCL11) were peaked at the late time points (24 h) in active TB patients after MTB specific antigen stimulation. In conclusion, the mRNA expression patterns of the TB-related immune markers in response to the T-cell mitogen (PHA) differed from those in response to MTB specific antigens and these findings may helpful for understanding the relationship between MTB infection and host immune markers in a transcripts level.

• Structural Engineering and Mechanics
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• v.17 no.3_4
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• pp.573-591
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• 2004

A hybrid control system is presented for seismic-resistant building structures with and without soil-structure interaction (SSI). The hybrid control is a damper-actuator-bracing control system composed of passive and active controllers. An intelligent algorithm is developed for the hybrid system, in which the passive damper is designed for minor and moderate earthquakes and the active control is designed to activate when the structural response is greater than a given threshold quantity. Thus, the external energy for active controller can be optimally utilized. In the control of a multistory building, the controller placement is determined by evaluating the optimal location index (OLI) calculated from six earthquake sources. In the study, the soil-structure interaction is considered both in frequency domain and time domain analyses. It is found that the interaction can significantly affect the control effectiveness. In the hybrid control algorithm with intelligent strategy, the working stages of passive and active controllers can be different for a building with and without considering SSI. Thus SSI is essential to be included in predicting the response history of a controlled structure.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.10a
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• pp.476-483
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• 2004

This paper presents a hybrid system combining lead rubber bearings and hydraulic actuators controlled by a μ-synthesis method for seismic response control of a cable-stayed bridge. A hybrid system could alleviate some of restrictions and limitations that exist when each system is acting alone because multiple control devices are operating. Therefore, the overall control performance of a hybrid system may be improved compared to each system, however the overall system robustness may be negatively impacted by active device in the hybrid system or active controller may cause instability due to small margins. Therefore, a f-synthesis method that guarantees the robust performance is considered to enhance the possibility of real applications of the control system. The control performances of the proposed control system are compared with those of passive, active, semiactive control systems and hybrid system controlled by LQG algorithm and an extensive robust analysis with respect to stiffness and mass matrices perturbation and time delay of actuator is performed. Numerical simulation results show that the control performance of the proposed control system is superior to that of the passive system and slightly better than that of the active and semiactive systems and two hybrid systems show similar control performances. Furthermore, the hybrid system controlled by a μ-synthesis method shows the good robustness without loss of control performances. Therefore, the proposed control system could effectively be used to seismically excited cable-stayed bridge which contains many uncertainties.

• Structural Engineering and Mechanics
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• v.58 no.6
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• pp.1127-1143
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• 2016

The pounding phenomenon in adjacent structures happens in severing earthquakes that can cause great damages. Connecting neighboring structures with active and semi-active control devices is an effective method to avoid mutual colliding between neighboring buildings. One of the most important issues in control systems is applying online control force. There will be a time delay if the prose of producing control force does not perform on time. This paper proposed a time-delay compensation method in coupled structures control, with semi-active Magnetorheological (MR) damper. This method based on Newmark's integration is adopted to mitigate the time-delay effect. In this study, Lyapunov's direct approach is employed to compute demanded voltage for MR dampers. Using Lyapunov's direct algorithm guarantees the system stability to design a controller based on feedback. Because of the strong nonlinearity of MR dampers, the equation of motion of coupled structures becomes an involved equation, and it is impossible to solve it with the common time step methods. In present paper modified Newmark-Beta integration based on the instantaneous optimal control algorithm, used to solve the involved equation. In this method, the response of a coupled system estimated base on optimal control force. Two MDOF structures with different degrees of freedom are finally considered as a numeric example. The numerical results show, the Newmark compensation is an efficient method to decrease the negative effect of time delay in coupled systems; furthermore, instantaneous optimal control algorithm can estimate the response of structures suitable.

• Architectural research
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• v.14 no.3
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• pp.99-108
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• 2012

An innovative multi-story Semi-Active Tuned Mass Damper (SATMD) building system is proposed to control seismic response of existing structures. The application of adding new stories as large tuned mass and semi-active (SA) resettable actuators as central features of the control scheme is derived. For the effective control of the structures, the optimal tuning parameters are considered for the large mass ratio, for which a previously proposed equation is used and the practical optimal stiffness is allocated to the actuator stiffness and rubber bearing stiffness. A two-degree-of freedom (2-DOF) model is adopted to verify the principal efficiency of the suggested structural control concept. The simulations for this study utilizes the three ground motions, from SAC project, having probability of exceedance of 50% in 50 years, 10% in 50 years, and 2% in 50 years for the Los Angeles region. 12-story moment resisting frames, which are modified as '12+2' and '12+4' story structures, are investigated to assess the viability and effectiveness of the system that aims to reduce the response of the buildings to earthquakes. The control ability of the SATMD scheme is compared to that of an uncontrolled and an ideal Passive Tuned Mass Damper (PTMD) building system. From the performance results of suggested '12+2' and '12+4' story retrofitting case studies, SATMD systems shows significant promise for application of structural control where extra stories might be added.

• Transactions of the Korean Society of Automotive Engineers
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• v.2 no.4
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• pp.27-38
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• 1994

In this paper, a simplified model of a hydraulic actuator system for a low-band type active suspension system is derived. To reduce the order of model, time constants of each chamber in hydraulic system are neglected except that of an accumulator. And the dynamics of a spool in the pressure control valve is regarded as a first-order system. The step response and the frequency response of the simplified second-order simulation model exhibit a good agreement with those of the actual system as well as those of the tenth-order simulation model. It is possible to simplify the tenth-order model to the second-order one. The low-band type active suspension model is built up by combining of a quarter car model test rig to testify the validity of the simplified model. The experimental results of suspension characteristics show that the simplified second-order hydraulic actuator model is reasonable to describe the dynamics of the actual hydraulic actuator system for a low-band type active suspension system.

• Smart Structures and Systems
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• v.20 no.6
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• pp.657-668
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• 2017

In this research, an active vibration suppression of a smart beam having piezoelectric sensor and actuators is investigated by designing separate controllers comprising a linear quadratic regulator and a neural network. Firstly, design of a smart beam which consists of a cantilever aluminum beam with surface bonded piezoelectric patches and a designed mechanism having a micro servomotor with a mass attached arm for obtaining variations in the frequency response function are presented. Secondly, the frequency response functions of the smart beam are investigated experimentally by using different piezoelectric patch combinations and the analytical models of the smart beam around its first resonance frequency region for various servomotor arm angle configurations are obtained. Then, a linear quadratic regulator controller is designed and used to simulate the suppression of free and forced vibrations which are performed both in time and frequency domain. In parallel to simulations, experiments are conducted to observe the closed loop behavior of the smart beam and the results are compared as well. Finally, active vibration suppression of the smart beam is investigated by using a linear controller with a neural network based adaptive element which is designed for the purpose of overcoming the undesired consequences due to variations in the real system.

• Journal of Power Electronics
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• v.15 no.1
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• pp.202-215
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• 2015

This paper investigates the stability and performance of model predictive controlled active-front-end (AFE) rectifiers for energy storage systems, which has been increasingly applied in power distribution sectors and in renewable energy sources to ensure an uninterruptable power supply. The model predictive control (MPC) algorithm utilizes the discrete behavior of power converters to determine appropriate switching states by defining a cost function. The stability of the MPC algorithm is analyzed with the discrete z-domain response and the nonlinear simulation model. The results confirms that the control method of the active-front-end (AFE) rectifier is stable, and that is operates with an infinite gain margin and a very fast dynamic response. Moreover, the performance of the MPC controlled AFE rectifier is verified with a 3.0 kW experimental system. This shows that the MPC controlled AFE rectifier operates with a unity power factor, an acceptable THD (4.0 %) level for the input current and a very low DC voltage ripple. Finally, an efficiency comparison is performed between the MPC and the VOC-based PWM controllers for AFE rectifiers. This comparison demonstrates the effectiveness of the MPC controller.

• Smart Structures and Systems
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• v.13 no.2
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• pp.305-318
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• 2014

This paper numerically investigates the feasibility of an active mass damper (AMD) system using the time delay control (TDC) algorithm, which is one of the robust and adaptive control algorithms, for effectively suppressing the excessive vibration of a building structure under wind loading. Because of its several attractive features such as the simplicity and the excellent robustness to unknown system dynamics and disturbance, the TDC algorithm has the potential to be an effective control system for mitigating the vibration of civil engineering structures such as buildings and bridges. However, it has not been used for structural response reduction yet. In this study, therefore, the active control method combining an AMD system with the TDC algorithm is first proposed in order to reduce the wind-induced vibration of a building structure and its effectiveness is numerically examined. To this end, its stability analysis is first performed; and then, a series of numerical simulations are conducted. It is demonstrated that the proposed active structural control system can effectively reduce the acceleration response of the building structure.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.1155-1160
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• 1993

The control-ability of vehicle active suspension is strongly affected by the performance of pressure control valve especially in the view of dynamic response and energy consumption. Important design parameters in the valve are selected and the effect of variation of those is analized experimentally to enhance the performance of pressure control valve used in Active Suspension.