• Korean Journal of Food Science and Technology
• /
• v.35 no.3
• /
• pp.483-487
• /
• 2003

The antimicrobial activity of the omija extract shown at pH 6.5, which was observed in the previous research, suggested that there could be active substances other than citric acid and malic acid in the Omija extract. Therefore, attempts were made to identify antimicrobial compounds in the essential oils extracted from Omija. The results of silica gel column chromatography and GC-MS revealed that terpineol and citronellol in the essential oil were the active compounds.

• Natural Product Sciences
• /
• v.28 no.3
• /
• pp.153-160
• /
• 2022

Neuroinflammation is known to be associated with brain injury in Alzheimer's disease (AD), and the inhibition of microglial activation, a key player in inflammatory response, is considerd as important target for AD. In this study, the ethanol extract of aerial parts of Forsythia velutina Nakai, a Korean native species, significantly inhibited nitric oxide (NO) production in LPS-stimulated BV2 microglial cells. Thus, the active principles in F. velutina aerial parts were isolated based on activity-guided isolation method. As a result, six compounds were isolated and their structures were elucidated based on NMR data and the comparison with the relevant references as arctigenin (1), matairesinol (2), rengyolone (3), ursolic acid (4), secoisolariciresinol (5), and arctiin (6). Among them, four compounds including arctigenin (1), matairesinol (2), secoisolariciresinol (5), and arctiin (6) significantly inhibited NO production in a dose-dependent manner. In particular, matairesinol (2) and secoisolariciresinol (5) reduced 60% of NO production compared to LPS-treated group. This inhibitory effects of matairesinol (2) and secoisolariciresinol (5) were accompanied with the reduced expression levels of iNOS and COX-2. These results suggest that the extract of F. velutina and its active compounds could be beneficial for neuroinflammatory diseases including AD.

• Preventive Nutrition and Food Science
• /
• v.3 no.4
• /
• pp.334-338
• /
• 1998

Kale(Brassica oleracea var. acephala) is one of Cruciferous vegetables that is closely related to the wild ancestral form of cabbabe. The ethanol extract of kale which contains the active compoundsss under Salmonella assay system was fractionated with chloroform to collect the nonpolar solvent soluble compounds, and then further fractionation was carried out by silica gel column chromatography. Among kale extracts separated by silical gel column chromatography, the fractions of 4, 5 and 6 exhibited strong antimutagenic activities. The major active compounds from the fraction were identified as chlorophyll derivatives by the analysis with HPLC-fritp-MS. The molecular weights of each chlorophyll derivatives in the sample were acquired from the peaks of positive ion atomosphere pressure chemical ionization (APCI) mas spectrometry.

• Bulletin of the Korean Chemical Society
• /
• v.33 no.5
• /
• pp.1597-1602
• /
• 2012

In this study, we determined the 3D-structure of Arabidopsis thaliana KAPAS by homology modeling. We then investigated the binding mode of compounds obtained from in-house library using computational docking methods. From the flexible docking study, we achieved high dock scores for the active compounds denoted in this study as compound $\mathbf{3}$ and compound $\mathbf{4}$. Thus, we highlight the flexibility of specific residues, Lys 312 and Phe 172, when used in active sites.

• Journal of the Korean institute of surface engineering
• /
• v.37 no.2
• /
• pp.128-136
• /
• 2004

Effects of alloying elements on the surface characteristics of Fe-38Al intermetallic compounds were investigated using potentiostat. The specimens were casted by the vacuum arc melting. The subsequent homogenization and the stabilization led to the homogeneous DO$_3$ structure of the specimen. After the corrosion tests, the surface of the tested specimen was observed by the optical microscopy and scanning electron microscopy(SEM). For Fe-38 at.% Al intermetallic compound, the addition of Cr and Mo proved to be beneficial in decreasing the grain boundary attack by decreasing the active current density. Addition of Band Nb resulted in a higher active current density and also a higher passive current density. These results indicated the role of Cr and Mo in improving the pitting corrosion resistance of Fe-38 at.%Al intermetallic compound. Band Nb addition to Fe-38 at.%Al accelerated the granular corrosion. Fe-38 at.%Al containing Cr and Mo showed remarkably improved pitting corrosion resistance in comparison with Band Nb addition to Fe-38 at. %Al.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.2
• /
• pp.262-266
• /
• 2018

Phytochemicals have been considered as alternatives for synthetic fungicides because of their biodegradability and low toxicity. In this study, we found that the methanolic extract of Corydalis ternata suppressed the development of plant diseases caused by Puccinia triticina and Colletotrichum coccodes. As the antifungal substance, three isoquinoline alkaloids (dehydrocorydaline, stylopine, and corydaline) were isolated from C. ternata. These active compounds also exhibited in vivo antifungal activity against P. triticina and C. coccodes. Taken together, our results suggest that C. ternata and its active compounds can be used to control plant diseases.

• Journal of Microbiology and Biotechnology
• /
• v.21 no.10
• /
• pp.1043-1048
• /
• 2011

A methanol extract of Cassia tora seeds was successively partitioned with diethyl ether, chloroform, ethyl acetate, and water, and the antitumor-promoting activity of the solvent fractions was determined by inhibition of Epstein-Barr virus early antigen (EBV-EA) activation induced by teleocidin B-4 in Raji cells. The diethyl ether (68.7%) and chloroform (91.2%) fractions and the hydrolysate (94.3%) of the ethyl acetate fraction had strong inhibitory activities. The chloroform and ethyl acetate fractions were chromatographed on silica gel and further purified by HPLC. Three active compounds, obtusifolin-2-glucoside (75.0%), chryso-obtusin-6-glucoside (56.8%), and norrubrofusarin-6-glucoside (39.4%), were obtained from the ethyl acetate fraction, and two active compounds, questin (97.9%) and chryso-obtusin (53.8%), were isolated from the chloroform fraction.

• Journal of the Korean Applied Science and Technology
• /
• v.4 no.1
• /
• pp.45-52
• /
• 1987

Surface chemical properties including surface tension, Ross-Miles foaming power, foam stabilities, emulsifying properties, emulsion stabilities, effectiveness of dispersion, dispersion stabilites of the quaternary ammonium salt type deoxyaminoimositol derivatives such as sixteen kinds of dimethylafkyl-deoxyscyllo-inosityl- dimethylalkyl-2-deoxy-2-myo-inosityl-, dimethylakyl-2-deoxy-2-epi-inosityl- and dimethylalkyl-4-deoxy-4-myo-inosityl ammonium chlorides are tested. And critical micelle concentration of these compounds are estimated from the curves of surface tension and concentration. The experimental results show that the members of this class of compounds have necessary surface active properties to make them effective surfactants.

• Journal of Medicine and Life Science
• /
• v.15 no.1
• /
• pp.6-11
• /
• 2018

Previous studies have suggested that Citrus fruits might suppress the proliferation of various cancer cells. However, little is known about any specific ingredients in the extract of Citrus fruits to exert its anti-proliferative activity in cancer cells. The present study aimed to identify the active ingredients in Citrus fruits to suppress the proliferation of rat hepatocellular carcinoma cells. Among tested compounds, two polymethoxylated flavones (nobiletin and tangeritin) showed significant anti-proliferative activity whereas other compounds (synephrine, rutin, hesperidin) did not. Interestingly, nobiletin as well as tangeritin also decreased the protein amount of gluconeogenic enzymes, PEPCK and G6Pase. The possible involvement of gluconeogenic activity in the proliferation of hepatocellulacarcinoma cells are further to be investigated.

• Korean Journal of Weed Science
• /
• v.17 no.2
• /
• pp.135-138
• /
• 1997

Sulfonylureas are highly active herbicides which can be applied at very low rate(10-50g/ha) to control broadleaf weeds. The nature of this category of compound is, however, very unstable toward hydrolysis. Therefore, the preparation of these compounds as liquid formulation was not possible. Most of the current formulations of sulfonylurea are in dry forms such as water dispersible granule or wettable powder. Even in these dry forms, the active ingredients also encounter significant chemical decomposition. This study involves the preparation of the sulfonylurea salts by reacting the parent compound with base such as sodium hydroxide. The salt becomes stable toward hydrolysis and it turns soluble when diluted with water. This discovery makes the preparation for liquid formulation or soluble granule of sulfonylurea possible. The stoichiometry of base added to the neutral sulfonylurea is controlled quite precisely. The base has to be added enough to quench the acidic impurities in the technical material and to convert the active ingredient into salt. However, the base should not be overused to cause further saponification of the sulfonylurea salts. The chemical nature of these compounds is presented and the chemical reaction is described. New soluble liquid formulation and solid granule formulation of sulfonylurea are suggested.