• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.630-644
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• 2003

A human Cu, Zn-superoxide dismutase (Cu, Zn-SOD) was fused with a Tat PTD of HIV-1 to produce a novel anti-aging ingredient, Tat-SOD for cosmeceuticals. Test of stability and evaluation of transduction efficacy and enzymatic activity suggest Tat-SOD is an effective active ingredient for anti-aging treatment.

• 대한간호학회지
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• 제45권2호
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• pp.231-239
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• 2015

Purpose: This study was conducted to examine the prevalence of successful aging and factors influencing successful aging. Methods: This was a secondary analysis study. Data were analyzed from 10,462 elderly people who participated in the 2011 National Elderly Survey. According to the use of community senior facilities, participants were divided into 4 groups: those who used senior centers (group A, n=580), village senior clubs (group B, n=3,240), both of the 2 facilities (group C, n=339), and neither of the 2 facilities (group D, n=6,303). Cross-tabulation and logistic regression were performed. Results: The prevalence of successful aging was highest in group C (20.94%) and lowest in group D (10.41%). The physical & mental function and active engagement domains were highest in group C, while they were lowest in group D. The disease & risk factors domain were highest in group A, while lowest in group B. An educational level of middle-school or higher and income level in the third or higher quintile were significant factors for predicting successful aging in all groups. Conclusion: These results provide a basis for designing prevention and management programs as interventions to increase the prevalence of successful aging in Korean older adults.

• 한국노년학
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• 제41권1호
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• pp.85-105
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• 2021

본 연구는 활동적 노화의 관점을 적용하여 장기요양시설에서의 돌봄 유형에 관한 다양한 인식유형을 분석하는 데 목적을 둔다. 이를 위해 Q방법론을 적용하였다. WHO의 활동적 노화를 위한 건강, 안전, 참여 세 영역에서 장기요양시설의 돌봄에 관한 다양한 생각을 파악하기 위해 심층면접을 진행하였다. 면접조사에는 장기요양시설 거주 노인, 거주 노인의 성인자녀, 지역사회 거주 노인, 서비스 제공자, 장기요양 전문가 등 35명이 참여하였다. 451개의 Q모집단 중 63개의 Q표본을 추출하였으며, 최종 자료분석에는 43개의 P표본 자료가 활용되었다. QUANL 프로그램을 활용하여 자료를 분석한 결과, 3개의 요인구조(4개 유형)가 적합하며 이는 전체 변량의 30.15%를 설명하는 것으로 나타났다. 현재 장기요양시설의 돌봄은 보호 중심 돌봄(1유형), 참여 중심 돌봄(2유형), 의료연계 중심 돌봄(3유형), 인간 중심 돌봄(4유형)으로 유형화할 수 있다. 본 연구결과를 바탕으로 장기요양시설에서 돌봄의 질적 변화를 위한 제도적, 실천적 함의를 제시하였다.

• Journal of Electrical Engineering and Technology
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• 제12권1호
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• pp.29-38
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• 2017

This paper presents a study on the state-of-charge (SOC) reference based active cell balancing in real-time. The optimal references of SOC are determined by using the proposed active cell balancing system with the bidirectional DC/DC converters via the dual active bridge (DAB) type. Then, the energies between cells can be balanced by the power flow control of DAB based bidirectional DC/DC converters. That is, it provides the effective management of battery by transferring energy from the strong cell to the weak one until the cell voltages are equalized to the same level and therefore improving the additional charging capacity of battery. In particular, the cell aging of battery and power loss caused from energy transfer are considered. The performances of proposed active cell balancing system are evaluated by an electromagnetic transient program (EMTP) simulation. Then, the experimental prototype is implemented in hardware to verify the usefulness of proposed system.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.590-600
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• 2003

The matrix metalloproteinases (MMPs) are a family of enzymes responsible for degrading connective tissue. MMPs catalyze the breakdown of collagen from the extracellular matrix, leading to wrinkle formation and accelerated skin aging. Furthermore, ultraviolet irradiation causes increased expression of certain MMPs. In the extracellular matrix turnover, MMPs are interacting with endogenous regulators named tissue inhibitors of metalloproteinases (TIMPs). Using peptide substrate assays, it has been demonstrated that TIMP-MMP complexes interact highly specifically with $K_{i}$ values of 10$^{-9}$ -10$^{-16}$ M. Therefore applications for TIMP as inhibitor of collagen degradation are suggested for cosmetic anti-aging products to prevent wrinkle formation and loss of elasticity. To date four TIMP proteins (TIMP-1, TIMP-2, TIMP-3 and TIMP-4) have been identified which show a high degree in sequence similarity. The production of human TIMP-2, a 194-residue nonglycosylated protein, was performed by fed-batch culture of Escherichia coli. TIMP-2 accumulated in the bacterial cells in an insoluble form as inclusion bodies. The inclusion bodies were solubilized and the protein refolded to yield the native TIMP-2 in the active form. The integrity of the protein was confirmed by mass analysis, Edman sequencing and gel shift experiments with authentic samples. The inhibitory activity of the refolded and purified TIMP-2 was demonstrated with MMP-1 and MMP-2 assays using synthetic fluorogenic peptide substrates.s.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.117-138
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• 2003

Reactive oxygen species are capable of damaging biomolecules such as lipids, proteins, and DNA, which can not only lead to various diseases, but also oxidative damage resulting aging. In our previous study, Cercis chinensis (Leguminosae) showed a potent antioxidant activity. Nineteen compounds were isolated through antioxidant activity-guided fractionation. The C. chinensis extract and some of the constituents exhibited a potent antioxidant activity on the free radicals and lipid peroxidation and a notable protective effect on the t-BuOOH induced oxidative damage. In vivo test of skin damage induced by UVB irradiation, the extract of C. chinensis and a constituent, piceatannol, exhibited a significant protective effect. The life-span of the HEK-N/F cells were extended by 1.21-2.12 fold as a result of the continuous administration of 3 $\mu\textrm{g}$/ml of the C. chinensis extract and the active constituents compared to that of the control. These observations were attributed to the inhibitory effect of the C. chinensis extract and its constituents on the age-dependent shortening of the telomere. Thus, C. chinensis was demonstrated to protect the skin cells against oxidative stress and inhibit thereby the cellular aging, followed by expectation as antiaging cosmetic ingredient.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.659-659
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• 2003

In this study, we have investigated the potent anti-aging effect of DA-3711, a cosmetic ingredient derived from artificial skin culture. The artificial skin was originally developed as a skin replacement for the treatment of chronic skin wounds. To produce DA-3711, neonatal human fibroblasts were seeded into biocompatible collagen/chitosan/glycosaminoglycan (GAG) scaffolds and cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with fetal bovine serum and nonessential amino acids. Analysis of the culture broth (DA-3711) showed that growth factors such as VEGF, TGF-$\beta$, KGF were present at significantly higher levels that in the culture broth of fibroblasts cultured in monolayer. The biological activity of DA-3711 was assessed by measuring in vitro cell proliferation and collagen synthesis of normal human fibroblasts. Fibroblasts treated with 10％ DA-3711 showed a 2-fold higher proliferation and 2 to 4-fold higher collagen synthesis than untreated cells. DA-3711 also exhibited anti-oxidative effects, since cells under peroxide-induced oxidative stress showed a 30％ higher viability in DA-3711-containing medium than in medium without DA-3711 addition. The results suggest that DA-3711 may have anti-aging effects by stimulating skin regeneration and protecting against oxidative stress.

• 한국전자파학회논문지
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• 제11권2호
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• pp.268-277
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• 2000

이동통선 서비스가 확장됨에 따라 인접 기지국간의 간섭이 증가하고 그에 따른 IMD(Intermodulation Distortion) 문제도 증가하여 Active IMD뿐만 아니라 Passive IMD(Passive Intermodulation Distortion)에 대한 문 제도 함께 부상하고 었다. 따라서 본 고에서는 대표적인 RF 소자 중 동축선에서의 PIMD의 발생기구의 분석을 위하여 다양한 도금 두께와 도금 재질을 갖는 어랩터를 설계 및 제작하였다. 제작된 어댐터 측정결과 1M 발생 수준이 도금 재질의 전도율, 소자의 구조, 도금 재질의 두께. Aging현상 등에 의존함을 확인하였으며, 도금 두께의 변화와 재질의 변화를 통해 PIMD 발생기구를 분석하였고, PIMD의 제어기술 방안을 검토하였다.

• 보건의료산업학회지
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• 제13권1호
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• pp.55-65
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• 2019

Objectives: The purpose of this study is to analyze basic data on socio - demographic characteristics, occupational careers, and desire for employment of job seekers in their Fifties and Sixties using a portal site. Methods: For this research, secondary data were collected by the researcher from 704 job seekers and were statistically analyzed using the SPSS package. Results: The results of the analysis are as follows: Most job seekers want a job that suits their competence and career trajectory, but the reality is that as their age increases, jobs suitable for those in their fifties and sixties are hard to find; thus these job seekers accept simple labor or functional jobs. Conclusions: Differences were found in work conditions such as occupation level, job position, total career years, desired employment type, and expected salary depending on socio - demographic variables. Consequently, improvements should be made for various job searching paths for older adults as well as increasing the accessibility of job searching information.

• International Journal of Internet, Broadcasting and Communication
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• 제13권1호
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• pp.37-46
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• 2021

Recently, social technologies have been created to solve problems from businesses for the establishment of generational solidarity ecosystem in terms of employment, residential space, network and social capital, age, cognitive and environmental aspects. This is senior-friendly healthcare business system aimed at meeting the senior needs for health life to enjoy active consumption culture life even after retirement, becoming a catalyst for minimizing generational conflicts, preventing the cognitive and physical deterioration of seniority in the areas of life healthcare, fitness and well-aging, and expanding into systems necessary for seniority self-reliance. We would like to draw up the development and requirements of the concept of the service platform for the study of collective characteristics for generation solidarity with senior class and the establishment of a customized senior health life system for generation solidarity. This system is characterized by a platform that can prevent the decline of seniors' cognitive and physical functions and enhance emotional stability. It is significant in providing feedback on the risk perception index, fall index, and prevention training index information to the child through the analysis and extraction of the senior health index for risk perception, fall probability, and fall prevention.