• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.161-169
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• 2019

Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether FC has anti-adipogenic effects in 3T3-L1 adipocytes and whether it ameliorates lipid accumulation in high-fat diet (HFD)-induced obese mice. FC notably increased the levels of glycerol in the culture supernatants and markedly reduced lipid accumulation in 3T3-L1 adipocytes. FC differentially inhibited the expressions of adipogenesis-related genes, including the peroxisome proliferator-activated receptor proteins, CCAAT/enhancer-binding proteins, and sterol regulatory element-binding proteins. FC markedly reduced the expressions of lipid synthesis-related genes, such as the fatty acid binding protein, lipoprotein lipase, and fatty acid synthase. Furthermore, FC significantly increased the expressions of lipolysis-related genes, such as the hormone-sensitive lipase, Aquaporin-7, and adipose triglyceride lipase. In HFD-induced obese mice, intraperitoneal injections of FC decreased both the body weight and visceral adipose tissue weight. FC administration significantly reduced lipid accumulation. Moreover, FC could dose-dependently and differentially regulate the expressions of lipid metabolism-related transcription factors. All these data indicated that FC exhibited anti-obesity effects through modulating adipogenesis and lipolysis.

• 디지털융복합연구
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• 제17권4호
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• pp.75-85
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• 2019

휴대폰을 구매하는 과정에서, 소비자들의 선택 기준은 다양한 요인으로 구성된다. 이동 통신의 중요성이 증대된다는 점을 고려하여, 이 연구는 구조 방정식 모델을 통해 소비자 만족 행동에 영향을 미치는 요소들을 조사하고자 했다. 이 연구는 소비자 만족을 결정하는 여섯 가지 주요 요인을 제안하며, 인구통계학적 요인들의 조절 효과를 검증했다. 386 명의 적극적인 이용자로부터 수집한 설문 데이터를 분석했다. 연구 결과는 브랜드 명칭, 사회적 영향력, 그리고 애프터 서비스가 소비자 만족의 세 가지 중요한 결정 요인임을 보여준다. 또한 연구 결과는 인구통계학적 속성이 고객 만족에 영향을 미친다는 점을 제안한다. 이 연구는 휴대폰 소비자의 만족을 신흥 시장의 관점에서 조망함으로써, 이론적 이해를 확대하고 실무적 함의를 제공한다.

• 대한예방한의학회지
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• 제23권1호
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• pp.1-13
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• 2019

Backgrounds : The market of Complementary Alternative Medicine(CAM) in the United State(U.S.) accounts for a large proportion of the global CAM market and has a high growth rate. The recent introduction of Obama Care has brought the change in the health insurance system for CAM, and we need to analyze it for its implication to Korean system. Objectives : The purpose of this study is to investigate the current status of acupuncture and chiropractic health insurance in the U.S., and to draw implications for expanding the health insurance coverage for Korean traditional medicine through the comparison between the U.S. and Korean health insurance systems. Methods : We examined the data through the literature search and from the websites of both U.S. government departments and related organizations for the health insurance policy. Based on the collected data, we analyzed its CAM health insurance system in Korea. Results : The acupuncture covered by public health insurance in the U.S. has a limit in the number of treatments and a range of applied diseases compared with Korea. In addition, the practice of acupuncture is not subdivided. However, the chiropractic in the U.S. which also has a limited number of coverage and only three categories of practices are similar to that of Korea. Conclusions : Although the use of CAM by public health insurance is not active in the U.S., but the organizations such as Veterans Health Administration in Vermont is already discussing the use of acupuncture to solve the problem of opioid overuse. Thus Korea also needs to discuss to promote the expansion of the insurance system for CAM.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.1011-1021
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• 2021

The root bark of Ulmus davidiana var. japonica (Japanese elm) is used in Korea and other East Asian countries as a traditional herbal remedy to treat a variety of inflammatory diseases and ailments such as edema, gastric cancer and mastitis. For this study, we investigated the lipid metabolism and anti-obesity efficacy of ethyl alcohol extract of Ulmus davidiana var. japonica root bark (UDE). First, HPLC was performed to quantify the level of (+)-catechin, the active ingredient of UDE. In the following experiments, cultured 3T3-L1 pre-adipocytes and high-fat diet (HFD)-fed murine model were studied for anti-obesity efficacy by testing the lipid metabolism effects of UDE and (+)-catechin. In the test using 3T3-L1 pre-adipocytes, treatment with UDE inhibited adipocyte differentiation and significantly reduced the production of adipogenic genes and transcription factors PPARγ, C/EBPα and SREBP-1c. HFD-fed, obese mice were administered with UDE (200 mg/kg per day) and (+)-catechin (30 mg/kg per day) by oral gavage for 4 weeks. Weight gain, epididymal and abdominal adipose tissue mass were significantly reduced, and a change in adipocyte size was observed in the UDE and (+)-catechin treatment groups compared to the untreated control group (^***p < 0.001). Significantly lower total cholesterol and triglyceride levels were detected in UDE-treated HFD mice compared to the control, revealing the efficacy of UDE. In addition, it was found that lipid accumulation in hepatocytes was also significantly reduced after administration of UDE. These results suggest that UDE has significant anti-obesity and lipid metabolism effects through inhibition of adipocyte differentiation and adipogenesis.

• 대한두개안면성형외과학회지
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• 제20권5호
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• pp.289-296
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• 2019

Background: Topical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions, inflammation, and infections that can interfere with the wound healing process. Therefore, we should select hemostatic agents after considering their effects on wound healing. Here, we compared the effects of hemostatic agents on wound healing in a rectus abdominis muscle defect in rats. Methods: Twelve Sprague Dawley rats were subjected to creation of a $6{\times}6mm$ defect in the rectus abdominis muscle and divided into four groups: control group; group A, Tachosil fibrin sealant patch; group B, Surgicel Fibrillar oxidized regenerated cellulose; and group C, Surgicel Snow oxidized regenerated cellulose. For the histologic analysis, biopsies were performed on the 3rd, 7th, and 27th days. Results: The foreign body reaction was the weakest in group A and most significant in group C. The inflammatory cell infiltration was the weakest in group A and similar in groups B and C. Muscle regeneration differed among periods. The rats in group A were the most active initially, while those in group C showed prolonged activity. Conclusion: Tachosil and Surgicel administration increased inflammation via foreign body reactions, but the overall wound healing process was not significantly affected. The increased inflammation in the Surgicel groups was due to a low pH. We recommend using Tachosil, because it results in less intense foreign body reactions than Surgicel and faster wound healing due to the fibrin action.

• 보건의료산업학회지
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• 제12권4호
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• pp.1-15
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• 2018

Objectives: We analyzed the importance and performance of hospital social responsibility (HSR) according to the characteristics of hospitals, and presented strategies for HSR activities. Methods: An online HSR questionnaire was sent to hospitals nationwide from October 12 to 26, 2018. The 206 responses received were analyzed in accordance with the IPA to assess the performance and importance of HSR. Results: There was a statistically significant difference between the employees and hospitals regarding the importance and performance of HSR activities. In the area of "sustained maintenance", items related to consumer issues such as "compliance with personal information processing policy", "patient confidentiality", "fair information provision", and "system for patient safety and infection prevention" were derived. In the area of "'high priority for improvement", there were three common items between hospitals and general hospitals: "regular donations and support from local communities", "active cooperation with related institutions", and "compliance with process-related laws and regulations". In the area of "low priority", four items were derived: "support for employee participation in community activities", "efforts to hire local residents", "education and cultural programs for local communities", and "transparent support for political activities". In the area of "sublation of excessive efforts", two items of "employee welfare efforts" and "efforts to improve labor relations", were commonly found in hospitals and general hospitals. Conclusions: It is necessary to improve the management efficiency of hospitals by the systematic allocation of manpower and resources through the establishment of four regional strategies based on the results of IPA analysis.

• 국제지역연구
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• 제13권2호
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• pp.712-739
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• 2009

본 연구는 예술경영의 한 영역으로 다루어졌던 미술경영의 범위에 대한 다양한 견해를 경영학적 시각에서 문헌고찰과 통계자료를 근거로 정리하였다. 공연예술 분야의 예술경영은 경영학적인 조직관리, 인력관리, 마케팅, 재무관리 등을 접목할 수 있는 영역이다. 그러나 미술경영은 경영이론의 파생적 관점에서 접근할 수 있는 분야가 있는 반면 미술이라는 특수한 학문영역에 대한 접근이라는 관점에서 새로운 시각이 요청되는 분야이다. 미술은 미술작품의 미학적 관점과 미학사적인 해석이 필요한 전문영역이 포함되기 때문이다. 이와 함께 지난 10여년 사이에 미술시장의 개방과 활발한 국제교류가 이루어지고 있어 미국과 유럽, 중국 등의 주요 국제미술시장에 대한 경영전략적인 접근이 필요하다. 이러한 국제미술시장은 국제경매시장, 국제비엔날레, 국제아트페어, 화랑의 해외진출 등과 관련하여 첫째, 국내 작가의 스타작가 양성과 같은 전략적 접근이 필요하다. 둘째, 비엔날레와 아트페어를 비롯하여 세계 유명 박물관이나 미술관의 작품에 대한 대규모 블록버스터 전시기획력이 요청된다. 국제미술시장에 대한 경영전략적인 접근은 바로 국가의 문화경쟁력을 높여주며 국가이미지 제고와 다른 산업에까지 영향을 미칠 것이기 때문이다.

• Journal of Information Science Theory and Practice
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• 제8권4호
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• pp.40-54
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• 2020

This proposed work aims to understand the Korean Academic Circle (KAC)'s research trend on the "One Belt One Road" (OBOR) by employing a quantitative analysis of the recent research articles published by the KAC. To do so, this proposed research has used the well-known network analysis software, Ucinet 6, by which the papers on related topics are collected and filtered from Korea Citation Index. To perform the analytical selection, the proposed work has chosen 'keywords' as the core research object and performed analysis from transverse to longitudinal aspects, and from holistic to individual aspects, respectively; and from this, the KAC's research trend on OBOR is derived. The present work has established that the KAC's attention is continuously increasing on OBOR and has sustainability. Centered on the OBOR, Korean researchers have spread their studies in various dimensions ranging from the issues like China's political economy to Sino-Korea economic and trade exchanges, and so on. The KAC has even combined OBOR with Korea's international development initiatives, which can help Korea benefit from active and sustainable cooperation with China. Moreover, the proposed work has found that Korean researchers have also actively expressed their growing attention, highlighted Korea's interest, and showed concern about China hegemony and Sinocentrism in their recent documented research works.

• 산업융합연구
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• 제18권6호
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• pp.1-7
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• 2020

본 연구에서는 자기효능감이나 불확실성에 대한 태도와 같은 창업자의 심리적 특성에 따라 창업지원서비스에 대한 니즈(needs)가 달라질 수 있다는 가설을 세우고 실증분석을 통해 이를 검증하였다. 서울과 대전 지역 창업보육센터에 입주한 86개 기업의 창업자를 대상으로 설문조사를 실시하고 그 데이터를 기반으로 실증분석을 수행하였다. 그 결과, 창업자의 자기효능감이 높을수록 대학 외부 번화가에 창업존을 제공하려는 창업지원서비스에 대해 적극적인 수용의사를 밝힌 반면, 과거 창업에서 실패경험을 가진 창업자는 대학 외부에 위치한 고객 유치에 대해 긍정적인 반응을 보였다. 또한, 창업기업의 성과가 좋지 않을수록, 그리고 여성 보다는 남성 창업자가 창업지원에 대한 니즈(needs)가 더 큰 것으로 나타났다. 연구결과는 창업지원에 대한 정책을 결정할 때에는 업종이나 성장단계와 같은 창업기업 차원의 특성 뿐 아니라 창업자의 심리적 상태 역시 중요한 고려대상에 포함시켜 차별화된 창업지원서비스를 설계해야 함을 시사한다.

• 동의생리병리학회지
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• 제34권4호
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• pp.177-183
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• 2020

The Hippo-YAP signaling pathway is critical for cell proliferation, survival, and self-renewal in both Drosophila and mammals. Disorder of Hippo-YAP pathway leads to tumor development, progression and poor prognosis in various cancers. YAP/TAZ are the key downstream effectors of the Hippo pathway and they can be inhibited through LATS1/2, core kinases in the Hippo pathway, mediated phosphorylation. In this study, we investigated the effect of Angelica gigas Nakai extract (AGNE) on Hippo-YAP/TAZ pathway. First, ANGE induced YAP/TAZ phosphorylation and dissociation of the YAP/TAZ-TEAD transcription complex. By qRT-PCR, we found that ANGE inhibits the expression of YAP/TAZ-TEAD target gene, CTGF and CYR61. In addition, the transcriptional activity of YAP/TAZ was not suppressed significantly in LATS1/2 double-knockout (DKO) cells by ANGE compared to LATS1/2 wild-type (WT) cells, which means AGNE inhibits YAP/TAZ signaling through direct action on LATS1/2. Further, it was confirmed that AGNE-induced activation of LATS1/2 inhibited the migration potential of the vector-expressing cells by suppressing YAP/TAZ activity. The reduced migration potential was restored in active YAP-TEAD expressing cells. Taken together, the results of this study indicate that ANGE downregulates YAP/TAZ signaling in cells through the activation of LATS1/2.