• Archives of Pharmacal Research
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• 제24권3호
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• pp.234-239
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• 2001

Three types of learning and memory tests (Morris water maze, active and passive avoidance) were performed in rats following intracerebroventricular infusion of ethylcholine aziridium (AF64A). In Morris water maze, AF64A-treated rats showed the delayed latencies to find the platform iron 6th day after the infusion. In pretrained rats, AF64A caused the significant delay of latency at 7th days but not 8th day. In the active avoidance for the pretrained rats, the escape latency was significantly delayed in AF64A-treatment. The percentages of avoidance in AF64A-treated rats were less increased than those in the control. Especially, the percentage of no response in the AF64A-treated rats was markedly increased in the first half trials. In the passive avoidance, AF64A-treated rats shortened the latency 1.5 h after the electronic shock, but not 24 h. AF64A also caused the pretrained rats to shorten the latency 7th day after the infusion, but not 8th day. These results indicate that AF64A might impair the learning and memory. However, these results indicate that the disturbed memory by AF64A might rapidly recover after the first retrain. Furthermore, these results suggest that AF64A may be a useful agent for the animal model of learning for Spatial cognition .

• YAKHAK HOEJI
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• 제37권1호
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• pp.41-48
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• 1993

The effect of captopril on the lung angiotensin converting enzyme (ACE) was investigated after 3 weeks oral administration (120~160 mg/kg/day) through drinking water in SpragueDawley rats. On the $^{125}$I-351A, an ACE inhibitor, binding assay in the isolated perpused lungs, the number of ACE molecules at the intrapulmonary endothelial cell surface was significantly decreased (p<0.001), and recovered to the normal level 7 days after discontinuation of captopril treatment. Intrapulmonary conversion ratio of Al to All was also significantly decreased (p<0.05) in the isolated perpused lungs. Bolus intravenous injection of angiotensin I did not showed pressor response in the both of systemic and pulmonary blood pressure of the anesthetized rats. ACE activity of the lung homogenates was also significantly reduced. These data consistently indicate the decrease of functionally active ACE molecule at the pulmonary artery after chronic captopril treatment. However, serum ACE activity was increased three fold in captopril treated rats compared to the normal rats. So, these results suggest that the functionally active ACE molecule at the pulmonary artery was still inhibited, which is directly associated with the antihypertensive effects, even if the total angiotensn converting enzyme induction was resulted after chronic captopril treatment.

• The Journal of Korean Society for School & Community Health Education
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• 제23권4호
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• pp.1-15
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• 2022

Objectives: The purpose of this study was to examine the mediating effect of Stress coping method in the relationship between Covid-19 stress and academic burnout of university students in the long-lasting Covid-19 situation. Methods: The subjects of this study were 323 college students and data were collected by on-line questionnaire survey. The collected data was analyzed using SPSS 23.0 and t-test, ANOVA, multiple linear regression analysis were conducted. Also mediation analysis was performed according to the Baron & Kenny method. Results: The results were as follows. First, students with high Covid-19 stress had high academic burnout by regression analysis. Second, in the stress coping method, the active coping method lowered academic burnout, and the passive coping method increased academic burnout. Third, the active coping method showed a partial mediating effect in the relationship between Covid-19 stress and the academic burnout(p<.01). Conclusions: In order to help college students cope with academic burnout caused by Covid-19 stress, it is recommended to guide students to use active coping method through counseling and education. Ultimately, it is necessary to support students to use various coping methods according to their situation appropriately.

• Journal of Ginseng Research
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• 제48권3호
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• pp.253-265
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• 2024

Orally administered ginsenosides, the major active components of ginseng, have been shown to be biotransformed into a number of metabolites by gastric juice, digestive and bacterial enzymes in the gastrointestinal tract and also in the liver. Attention is brought to pharmacokinetic studies of ginseng that need further clarification to better understand the safety and possible active mechanism for clinical application. Experimental results demonstrated that ginsenoside metabolites play an important role in the pharmacokinetic properties such as drug metabolizing enzymes and drug transporters, thereby can be applied as a metabolic modulator. Very few are known on the possibility of the consistency of detected ginsenosides with real active metabolites if taken the recommended dose of ginseng, but they have been found to act on the pharmacokinetic key factors in any clinical trial, affecting oral bioavailability. Since ginseng is increasingly being taken in a manner more often associated with prescription medicines, ginseng and drug interactions have been also reviewed. Considering the extensive oral administration of ginseng, the aim of this review is to provide a comprehensive overview and perspectives of recent studies on the pharmacokinetic properties of ginsenosides such as deglycosylation, absorption, metabolizing enzymes and transporters, together with ginsenoside and drug interactions.

• 한국경영정보학회:학술대회논문집
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• 한국경영정보학회 2007년도 International Conference
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• pp.409-414
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• 2007

Over the past three decades, the impact of IT investments on firm performance has been the subject Q{active research. Although many studies have shown positive and significant benefits derived from IT investment, the findings of almost all these studies are based on data collected in developed countries. This study tries to investigate the effects of IT investment on firm financial performance in the Chinese electronics industry, a typical developing country, and compare it with the United States. Findings show that there is a positive impact of IT investment on firm performance in China. Moreover, the impact in China is not different from what occurred in the United States in the direction and the size against the assertion of previous studies and expectation.

• Journal of Pharmaceutical Investigation
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• 제33권1호
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• pp.67-71
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• 2003

Drug excipients are material used in the formulation of pharmacologically active drugs. They have a variety of roles including dilutents/fillers/bulking agents, binders/adhesives, propellant, disintegrants, lubricants/dlidants, colors, flavors, coating agents, polising agents, fragrance, sweeteening agent, polymers and waxes. Excipient should be inert or inactive and does not interfere with the test. Nowadays within industry there has been a recent surge of interest in novel excipient for novel dosage forms. The purpose of the review is to introduce the administration systems of drug excipient about kinds, matters to be attended to change of excipients.

• The Journal of Fisheries Business Administration
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• 제39권1호
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• pp.1-16
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• 2008

For the last few years, the wholesale market system in Japan has been experiencing a lot of changes in the related sectors. The greatest changes in the environments surrounding the wholesale market were enlargement of the producers' cooperatives, increase of fisheries products marketed in the outside of the wholesale market system, and management aggravation of the related businessmen, These changes resulted in the revision of the wholesale Market Law in 1999 to cope with the social needs successfully. Recently, fisheries wholesale markets in Japan have a few problems like declining of earning power, weakening of management constitution, etc. Consequently, Japanese government presents policy for enforcing the competition power through reform laws related with fisheries wholesale markets. Also the fisheries wholesale markets have been trying variety and active countermeasures like undertaking, merger, coalition, etc. to overcome the crisis.

• The Korean Journal of Pharmacology
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• 제1권1호
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• pp.7-16
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• 1965

Glycyrrhizin, an active constituent of Glycyrrhiza, was chemically extracted and its hypocholesterolemic activities were studied in rats. Following were the results: 1. The Sprague Dowley rats fed with the standard diet were divided into 4 groups, $50{\sim}60$ in each, and glycyrrhizin was given in doses of 0 (control), 0.5, 1.0 and 2.0mg per 100gm body weight daily for 10, 20, 30, and 60 days. Glycyrrhizin showed more or less the hypocholesterolemic activities in all animals. All of the animal groups to which 1. 0mg and 2.0mg of glycyrrhizin were given died before 60 days, while no mortality cases was noted in the group to which 0.5mg of glycyrrhizin was given. 2. Cholesterol administration induced hypercholesterolemia in all experimental animals, however, simultaneous administration of cholesterol with 0.5mg of glycyrrhizin suppressed the rise of the total serum cholesterol levels. The former group did not survive until 56 days, while the latter did. 3. Glycyrrhizin also Suppressed the cholesterol biosynthesis and incorporation of cholesterol in the liver tissues. 4. Glycyrrhizin induced the increase of the fecal excretion of the sterol compounds.

• International Commerce and Information Review
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• 제7권3호
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• pp.213-228
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• 2005

China is our second largest trade partner and the biggest country of our investment. For this reason, the Korea active strategy for coping with China's changes is very critical at the current point in time due to the economic structure of Korea dependent on exports. This essay is aimed at studying the Foreign Trade Administration System of China and selecting Korea's prospective exports-imports to China. The purpose of this, essay is to help Korean trading corporation to understand the difference between Korea and China in foreign trade administration in order to promote bilateral trade between Korea and China.

• Journal of Korean Academy of Nursing Administration
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• 제14권1호
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• pp.63-71
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• 2008

Purpose: This study was conducted to identify nurses' self-leadership, organizational commitment and their nursing performance, and examine the relationship among them. Method: A total of 330 clinical nurses with more than one year nursing experiences were recruited from 10 hospitals in G city and J province in Korea. Data were collected using questionnaires from March, 12 to April 21, 2007. For data analyzed using SPSS 12.0 for windows program, Results: There were significant positive correlations between self-leadership, organizational commitment, and independent, dependent, and interpersonal nursing performances. In addition, the organizational commitment had significant positive correlations with independent, dependent, and interpersonal nursing performances. Conclusion: These findings suggest that nurses' organizational commitment and nursing performance ability will be enhanced by hospitals' active supports such as empowering individual nurses' self-leadership through enlarging their autonomy and strengthening their ability to control themselves.