• Journal of Institute of Control, Robotics and Systems
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• v.16 no.10
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• pp.927-932
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• 2010

Estimation methods of motion intention from bio-signal present challenges in man machine interaction(MMI) to offer user's command to machine without control of any devices. Measurements of meaningful bio-signals that contain the motion intention and motion estimation methods from bio-signal are important issues for accurate and safe interaction. This paper proposes a novel motion estimation sensor based on a geometrical muscle changes, and a motion estimation method using the sensor. For estimation of the motion, we measure the circumference change of the muscle which is proportional to muscle activation level using a flexible piezoelectric cable (pMAS, piezo muscle activation sensor), designed in band type. The pMAS measures variations of the cable band that originate from circumference changes of muscle bundles. Moreover, we estimate the elbow motion by applying the sensor to upper limb with least square method. The proposed sensor and prediction method are simple to use so that they can be used to motion prediction device and methods in rehabilitation and sports fields.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.6
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• pp.579-589
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• 2016

This research focuses on accomplishing analysis problems and issues by examining the policies and systems related to geo-spatial big data which have recently arisen, and suggests political and systemic improvement plan for service activation. To do this, problems and probable issues concerning geo-spatial big data service activation should be analyzed through the examination of precedent studies, policies and planning, pilot projects, the current legislative situation regarding geo-spatial big data, both domestic and abroad. Therefore, eight political and systematical improvement plan proposals are suggested for geo-spatial big data service activation: legislative-related issues regarding geo-spatial big data, establishing an exclusive organization in charge of geospatial big data, setting up systems for cooperative governance, establishing subsequent systems, preparing non-identifying standards for personal information, providing measures for activating civil information, data standardization on geo-spatial big data analysis, developing analysis techniques for geo-spatial big data, etc. Consistent governmental problem-solving approaches should be required to make these suggestions effectively proceed.

• Biomolecules & Therapeutics
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• v.32 no.5
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• pp.568-576
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• 2024

Colorectal cancer (CRC) continues to demonstrate high incidence and mortality rates, emphasizing that implementing strategic measures for prevention and treatment is crucial. Recently, the dopamine receptor D2 (DRD2), a G protein-coupled receptor, has been reported to play multiple roles in growth of tumor cells. This study investigated the anticancer potential of domperidone, a dopamine receptor D2 antagonist, in HCT116 human CRC cells. Domperidone demonstrated concentration- and time-dependent reductions in cell viability, thereby inducing apoptosis. The molecular mechanism revealed that domperidone modulated the mitochondrial pathway, decreasing mitochondrial Bcl-2 levels, elevating cytosolic cytochrome C expression, and triggering caspase-3, -7, and -9 cleavage. Domperidone decreased in formation of β-arrestin2/MEK complex, which contributing to inhibition of ERK activation. Additionally, treatment with domperidone diminished JAK2 and STAT3 activation. Treatment of U0126, the MEK inhibitor, resulted in reduced phosphorylation of MEK, ERK, and STAT3 without alteration of JAK2 activation, indicating that domperidone targeted both MEK-ERK-STAT3 and JAK2-STAT3 signaling pathways. Immunoblot analysis revealed that domperidone also downregulated DRD2 expression. Domperidone-induced reactive oxygen species (ROS) generation and N-acetylcysteine treatment mitigated ROS levels and restored cell viability. An in vivo xenograft study verified the significant antitumor effects of domperidone. These results emphasize the multifaceted anticancer effects of domperidone, highlighting its potential as a promising therapeutic agent for human CRC.

• Physical Therapy Korea
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• v.11 no.3
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• pp.43-50
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• 2004

This study was designed to determine the effects of different widths in the base of support (BOS) on trunk and lower extremity muscle activation during upper extremity exercise. Twenty-seven healthy male subjects volunteered for this study. Exercises were performed for a total of 10 trials with a load of 10 repetitions maximum (10 RM) for each of the various widths of BOS (10 cm, 32 cm, 45 cm). The width of a BOS is the distance between each medial malleoli when a subject was in a comfortable standing position. Electromyography was used to determine muscle activation. Surface bipolar electrodes were applied over the tibialis anterior, medial gastrocnemius, biceps femoris, rectus femoris, gluteus maximus, upper rectus abdominis, and elector spinae muscle. Electromyographic (EMG) root mean square (RMS) signal intensity was normalized to 5 seconds of EMG obtained with a maximal voluntary isometric contraction (MVIC). The data were analyzed by atwo-factor analysis of variance (ANOVA) with repeated-measures ($3{\times}7$) and Bonferroni post hoc test. The results were as follows: (1) There were significant differences in the width of the BOS (p=.006). (2) The post hoc test showed significant differences with the BOS between 10 cm and 32 cm, between 10 cm and 45 cm and between 32 cm and 35 cm (p=.008, p=.003, p=.011). (3) There was no interaction with the BOS and muscle. (p=.438) There were no significant differences in the muscle activation (p=.215).

• Physical Therapy Korea
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• v.24 no.4
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• pp.11-19
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• 2017

Background: Methods for exercising serratus anterior (SA) and upper trapezius (UT) muscles are important for the recovery of patients with various shoulder disorders, yet the efficacy of closed or open kinetic chain exercises have not yet been evaluated. Objects: The purpose of this study was to compare the activation of the SA and UT muscles during scapular protraction considering both closed and open kinetic chain exercises. Methods: Thirty subjects were randomly divided into experimental groups (closed kinetic chain exercise) and control groups (open kinetic chain exercise) in which scapular protraction was performed at $90^{\circ}$ or $125^{\circ}$ shoulder flexion. Electromyographic activity data were collected from the SA and UT muscles per position and exercise method. Results: Separate mixed 2-way analysis of variance showed significant differences in the activation of the SA (F1,28=6.447, p=.017) and the UT (F1,28=35.450, p=.001) muscles between the groups at $90^{\circ}$ and $125^{\circ}$ shoulder flexion. Also, the SA/UT ratio measures at $90^{\circ}$ and $125^{\circ}$ shoulder flexion significantly differed between the groups (F1,28=15.457, p=.001). That is, the closed chain exercise was more effective than open chain exercise for strengthening the SA muscle and controlling the UT muscle, $125^{\circ}$ of shoulder joint was more effective than $90^{\circ}$. Conclusion: The findings suggest that scapular protraction with shoulder $125^{\circ}$ flexion at the closed kinetic chain exercise may be more effective in increasing SA muscle activation and decreasing UT muscle activation as well as increasing the SA/UT ratio than open kinetic chain exercise.

• The Journal of Korean Physical Therapy
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• v.21 no.1
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• pp.1-7
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• 2009

Purpose: The aim of this study was to determine the effect of proprioceptive neuromuscular facilitation (PNF) leg patterns on muscle activation of paretic and nonparetic arm in post-stroke hemiparetic subjects. Methods: Eighteen hemiparetic patients participated in this study. Each subject was asked to perform four PNF leg patterns against maximal manual resistance on nonparetic leg. EMG data were collected from biceps and triceps on the paretic and nonparetic side. The measured EMG data was digitized and processed to root mean square (RMS) and expressed as percentage maximal voluntary isometric contraction (％MVIC). The data were analyzed using paired t-test and one-way analysis of variance (ANOVA) with repeated measures to determine the statistical significance. Results: The results of this study were summarized as follows: Firstly, during four PNF patterns application, all of the ％MVIC values of biceps and triceps in paretic and nonparetic arms increased significantly compared with resting condition (p<0.05). Secondly, there was a significant difference in ％MVIC of paretic biceps between PNF leg pattern 1 and 4 (p<0.05). Conclusion: In conclusion, regardless of the kinematic components of PNF leg patterns, all of the muscle activation of biceps and triceps in paretic and nonparetic arm was significantly increased. The finding of this study indicates that irradiation effect caused by PNF leg patterns is beneficial for increased muscle activation of both paretic and nonparetic arms in post-stroke patients.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.1
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• pp.11-25
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• 2021

The objective of this study was to analyze the impact of activation functions on flood forecasting model based on Artificial neural networks (ANNs). The traditional activation functions, the sigmoid and tanh functions, were compared with the functions which have been recently recommended for deep neural networks; the ReLU, leaky ReLU, and ELU functions. The flood forecasting model based on ANNs was designed to predict real-time runoff for 1 to 6-h lead time using the rainfall and runoff data of the past nine hours. The statistical measures such as R2, Nash-Sutcliffe Efficiency (NSE), Root Mean Squared Error (RMSE), the error of peak time (ETp), and the error of peak discharge (EQp) were used to evaluate the model accuracy. The tanh and ELU functions were most accurate with R2=0.97 and RMSE=30.1 (㎥/s) for 1-h lead time and R2=0.56 and RMSE=124.6~124.8 (㎥/s) for 6-h lead time. We also evaluated the learning speed by using the number of epochs that minimizes errors. The sigmoid function had the slowest learning speed due to the 'vanishing gradient problem' and the limited direction of weight update. The learning speed of the ELU function was 1.2 times faster than the tanh function. As a result, the ELU function most effectively improved the accuracy and speed of the ANNs model, so it was determined to be the best activation function for ANNs-based flood forecasting.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.49
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• pp.409-434
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• 2011

SWIFT has designed Trade Services Utility(TSU) to meet the new paradigm of electronic trade. The Trade Services Utility is a matching and workflow application that sits on the SWIFT network. The TSU is designed to help banks offer advanced supply chain services to their corporate customers who are involved in open account trading. Nowadays, the Bank payment obligation(BPO) can optionally be included in a baseline by mutual consent. The BPO is an irrevocable and conditional obligation of an obligor bank(buyers bank) to pay a specified amount to seller's bank according to an established baseline of a single TSU transaction. Therefore, SWIFT enables its customers to automate and standardise financial transactions, thereby lowering costs, reducing operational risk and eliminating inefficiencies from their operations. Whereas, Banks can use the core functionality of the Trade Services Utility to offer competitive services that complement existing services. But SWIFT need to come up with the measures of activating the TSU BPO. So, this paper is to introduce TSU BPO and check the measures for the activation of the TSU BPO under the electronic trade environment.

• Journal of Navigation and Port Research
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• v.31 no.7
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• pp.623-628
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• 2007

By employing primarily the Kendall's Concordance Test, the paper attempted to conduct an experts' evaluation on the interaction among the agents in Busan marine tourism cluster and recommend some measures for policy consideration for the cluster's activation. For this purpose, a conceptual framework was developed to guide the assessment by using inter-agent cooperation and network approaches regarding the nature of the marine tourism cluster. Such factors as cooperation, competition, relationship marketing, and networking were identified as critical. Findings of the study imply that Busan marine tourism cluster is at its embryonic stage and needs desperate measures for improvement in the inter-organizational cooperation and networking, the major regional characteristics that determine the competitiveness of marine tourism.

• Korea Journal of Hospital Management
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• v.13 no.1
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• pp.24-41
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• 2008

This research is aimed at analyzing and understanding the perception and attitudes of inpatients in a general hospital in Seoul towards the activation of private health insurance. Survey was conducted against 231 inpatients, results of which were analyzed in the methods of frequency analysis, chi square test, and logistic regression. The results are summarized as follows; First, better-educated population who finished college education at least, higher-income population, and people who had more knowledge about private health insurance showed more perception about activation of private health insurance. Second, better-educated population who finished college education at least, higher-income population, those who are insured in existing private insurance, oncological patients, and people who had more knowledge about private health insurance showed more positive attitude towards private health insurance paying for actual damages, long-term care insurance, and income security insurance. Third, age and education were the factors affecting perception about activation of private health insurance. The older the age is, perception was 1.035 times positive towards activation of private health insurance, and those who finished college education or above showed 3.148 times positive perception towards the same. Forth, surgical patients showed 1.087 times more positive attitude towards private health insurance paying for actual damages than internal medicine patients, while oncological patients showed 2.314 times more positive attitude than internal medicine patients. Further, understanding on the activation of private health insurance was 6.014 times higher in the higher understanding group than in the lower understanding group. Intention to use long-term care insurance was 2.692 times stronger in the male group than in the female group, and 3.616 times stronger in the oncological patients group than in internal medicine patients group. Further, understanding on the activation of private health insurance was 3.881 times deeper in the higher understanding group than in the lower understanding group. Intention to use income security insurance was 3.185 times stronger in those who have academic background of under the high school than those over the college, and 4.175 times higher in the group those whose monthly average income is over 4 million won than those under 4 million won. Also, intention to use income security insurance was 4.323 times higher in the group those who are insured by existing private insurances than those who are not insured by those insurances and it was 5.234 times higher in the group of oncological patients than in the group of internal medicine patients. Further, intention to use income security insurance was 3.559 times higher in the group those who thought that out-of-pocket money of the National Health Insurance is too much to bear than those it is quite endurable. Understanding on the activation of private health insurance was 4.875 times deeper in the higher understanding group than in the lower understanding group. There were some suggestions could be made based on the results of this research. First, reinforced publicity and education is needed for the low-educated or low-income group, as there are gaps in the understanding on the activation of private health insurance depending on the degree of education and income. Second, government should prepare administrative complementary measures to solve the problem of adverse selection by the consumer which is foreseen when private health insurances are activated. Third, government should suggest the desirable course of development of private health insurance items to ensure efficient use of enormous fund of private insurance market for health security of the people. Further, institutional complementary measures are needed to convert existing cancer insurances or specific disease insurances to private health insurances paying for actual damages guaranteeing against every kind of disease. Forth, it judged that, not only private health insurances paying for actual damages, but also long-term care insurances and income security insurances are prospective as fields to create fresh demand for insurance industry.