• 한국엔터테인먼트산업학회논문지
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• 제15권1호
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• pp.75-85
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• 2021

무용학원 이용자들이 무용학원 이용 및 선택 시 중요도와 만족도를 알아보고 이를 기초자료로 활용하여 무용학원 활성화방안에 도움을 주고자 G광역시의 12개 무용학원을 이용하는 213명을 대상으로 IPA 통계적 방법을 이용하여 설문조사를 실시한 후 다음과 같은 결론을 얻었다. IPA분석별 무용학원 중요도는 지도자 전문성, 무용이용 장비의 청결성, 교통접근성, 무용학원 이용비용, 지도자 친절성 등의 순위로 나타났고, 만족도는 지도자 전문성, 무용프로그램 다양성, 지도자 작품구성능력, 지도자 친절성, 교통접근성 등의 순위로 나타났다. 이상 연구결과 무용학원 선택 시 이용자들이 중요하게 느끼는 요인은 직접적인 레슨을 실시하는 지도자의 전문성과 친절 및 학원이용비용, 코로나 19시대를 경험하면서 학원장비의 청결성을 중요하다 하였고, 이용에 따른 만족도는 지도자와 관련된 요인과 학원 교통접근성에서 높은 만족도를 보였다. 이에 무용학원활성화를 위하여 전문적이고, 친절성을 겸비한 지도자와 청결하고 위생적인 환경으로 학원을 관리한다면 무용학원의 활성화가 이루어질 것으로 생각된다. 또한 무용학원 외 학원들에게도 이와 같은 방법을 적용하여 연구가 진행된다면 사설학원들의 활성화에도 도움이 될 것이다.

• Journal of Ginseng Research
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• 제48권5호
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• pp.464-473
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• 2024

Background: The effects of individual panaxadiol saponin and panaxatriol saponin on rodent models of Parkinson's disease (PD) have been recognized. However, it is not clear whether purified total ginsenosides as an entirety has effect against PD in rat model. This study compared the protective effects of a purified panaxadiol saponin fraction (PDSF), a purified panaxatriol saponin fraction (PTSF), and their mixtures against the rotenone (ROT)-induced PD in rats. Methods: Potential effects of PDSF, PTSF, and their mixtures against motor dysfunction and impairments of nigrostriatal dopaminergic neurons (DN), blood-brain barrier (BBB), cerebrovascular endothelial cells (CEC), and glial cells were measured in the models of ROT-induced PD rats and cell damage. Pro-inflammatory NF-kB p65 (p65) activation was localized in DN and other cells in the striatum. Results: PDSF and PTSF had a dose-dependent effect against motor dysfunction with a larger effective dose range for PDSF. PDSF protected CEC, glial cells, and DN in models of PD rats and cell damage, while PTSF had no such protections. Chronic ROT exposure potently activated p65 in CEC with enhanced pro-inflammatory and decreased anti-inflammatory factors and impaired BBB in the striatum, PDSF almost completely blocked the ROT-induced p65 activation and maintained both anti- and pro-inflammatory factors at normal levels and BBB integrity, but PTSF aggravated the p65 activation with impaired BBB. Furthermore, PTSF nullified all the effects of PDSF when they were co-administrated. Conclusion: PDSF had significant protective effect against the ROT-induced PD in rats by protecting CEC, glial cells, and DN, likely through inhibiting NF-κB p65 in CEC from triggering neuroinflammation, and also directly protecting glial cells and neurons against ROT-induced toxicity. PDSF has great potential for preventing and treating PD.

• 여성건강간호학회지
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• 제13권4호
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• pp.310-319
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• 2007

Purpose: The descriptive correlational study was designed to examine the relationship of eating behavior to depression, trait anger, anger expression, Behavior Activation System(BAS) and Behavior Inhibition System(BIS) in adolescent women. Method: 437 women aged 15 to 18 years were recruited from two high schools located in Seoul, Korea. The instruments used were SCL's depression scale, Spielberger's state trait anger expression inventory-Korean version for trait anger and anger expression, the Korean-BAS/BIS scale for behavior activation system and behavior inhibition system, and Eating Attitude Test(EAT-26) for eating behavior. Results: The score of EAT significantly correlated with depression, trait anger, anger expression, BAS and BIS. The EAT score also had a significant relationship with anger-in and anger-out. Depression only correlated with the dieting among factors of EAT, Trait anger, anger-in and anger-out showed a significant correlation with EAT factors such as dieting and oral control. BAS significantly correlated with dieting; whereas, BIS revealed a relationship with bulimia/food preoccupation. Conclusion: Based on this results, various variables need to be included for a nursing intervention program leading to healthy diet behaviors of adolescent women.

• 한국실내디자인학회논문집
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• 제22권3호
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• pp.205-216
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• 2013

Korean cities need sustainable urban regeneration based on the effective application of space and resource. Especially a sustainable urban regeneration needs the activation of community in the urban underground space as urban development center. The purpose of this study is to propose elements and factors of spatial planning of community in urban underground space for sustainable urban regeneration and to propose the characteristics of spatial planning of community in urban underground space according to strategies of sustainable urban regeneration. The research methods of this study used to conduct research include precedent study reviews and survey. The conclusions of this study are as following; The application of various factors related to spatial planning aspect of communication, supportive cultural facilities, accessibility and nature is needed for creating a sustainable urban regeneration. Especially, in urban underground space, the application of spatial planning for community activation considered strategies of sustainable urban regeneration should be necessary. And introduction of cultural facilities, multi-dimensional pedestrian network for accessibility and natural elements for activating community in urban underground space are needed for making sustainable urban regeneration.

• Clinical and Experimental Pediatrics
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• 제57권12호
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• pp.505-513
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• 2014

While the survival of extremely premature infants with respiratory distress syndrome has increased due to advanced respiratory care in recent years, necrotizing enterocolitis (NEC) remains the leading cause of neonatal mortality and morbidity. NEC is more prevalent in lower gestational age and lower birth weight groups. It is characterized by various degrees of mucosal or transmural necrosis of the intestine. Its exact pathogenesis remains unclear, but prematurity, enteral feeding, bacterial products, and intestinal ischemia have all been shown to cause activation of the inflammatory cascade, which is known as the final common pathway of intestinal injury. Awareness of the risk factors for NEC; practices to reduce the risk, including early trophic feeding with breast milk and following the established feeding guidelines; and administration of probiotics have been shown to reduce the incidence of NEC. Despite advancements in the knowledge and understanding of the pathophysiology of NEC, there is currently no universal prevention measure for this serious and often fatal disease. Therefore, new potential techniques to detect early biomarkers or factors specific to intestinal inflammation, as well as further strategies to prevent the activation of the inflammatory cascade, which is important for disease progression, should be investigated.

• 대한의생명과학회지
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• 제15권3호
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• pp.179-185
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• 2009

In our previous report, we showed that $PPAR{\gamma}$ does not influence adipogenesis in females with functioning ovaries, indicating that $PPAR{\gamma}$ activity on adipogenesis is associated with sex-related factors. Among the sex-related factors, estrogen has been recognized as a major factor in inhibiting adiposgenesis in females. Thus, we hypothensized that $17{\beta}$-estradiol (E) inhibits 3T3-L1 cell adipogenesis by preventing $PPAR{\gamma}$ activity. E decreased triglyceirde accumulation in differentiated 3T3-L1 cells compared with control group. E also decreased the expression of $PPAR{\gamma}$ mRNA as well as $PPAR{\gamma}$ dependent adipocyte-specific genes, such as adipocyte fatty acid binding protein and tumor necrosis factor $\alpha$. In addition, E not only decreased luciferase reporter activity by $PPAR{\gamma}$, but also transfection of estrogen receptor $\alpha$ ($ER{\alpha}$) or $ER{\beta}$ led to decreases in $PPAR{\gamma}$ reporter gene activation. Moreover, E-activated ERs significantly decreased the luciferase reporter gene activation induced by $PPAR{\gamma}$ transfection, suggesting that estrogen-activated ERs inhibit $PPAR{\gamma}$-dependent transactivation. Accordingly, our results demonstrate that E inhibits the action of $PPAR{\gamma}$ on adipogenesis through E activated ER, providing evidence that lack of estrogen may potentiate $PPAR{\gamma}$ action on adipogenesis.

• 동아시아경상학회지
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• 제7권1호
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• pp.1-16
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• 2019

Purpose - For the development of fresh food shopping malls, consumers should continue to experience loyalty and favorability for the company's products or brands, and this should lead directly to purchase so that active word-ofmouth and recommendation should be encouraged. Therefore, the purpose of this study is to investigate the effect of e-service quality and e-ERM on e-loyalty with customer satisfaction and commitment as mediators. Research design, data, and methodology - This study was conducted by sample survey method on 320 online customers who have experience in using major online fresh food shopping malls for more than one year. Data analysis methods were frequency analysis, confirmatory factor analysis, reliability analysis, correlation analysis, and structural equation model analysis. Result - Hypothesis 1 through Hypothesis 7 were all supported. The results of this study suggest that e-service quality and e-CRM of online fresh food shopping malls have a significant effect on satisfaction and commitment. Therefore, the conclusion has been derived that the focus of this study, that such satisfaction and commitment have a significant effect on e-customer loyalty. has been supported theoretically and empirically. Conclusion - This study suggests that studies on customer loyalty based on activation commerce factors related to fresh food in online shopping malls will be an index that can reflect on customer's needs corresponding with future trends of not only online shopping malls but also offline shopping malls.

• Journal of Microbiology
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• 제39권4호
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• pp.314-320
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• 2001

Macrophages stimulated by lipopolysaccharide(LPS) from gram negative bacteria undergo activation of a group of immediate early genes including Rantes. The mouse Rantes gene promoter region contains an LPS rsponsive element(LPE) We detected 3 specific bands termed B1, B2 and 3 formed by the interaction of the LPE and proteins found in LPS-stimulated RAW 367.7 cells. An additional band B4 was determined to be an Ap-1 binding protein. The B1 band appears within 1 hour of LPS nuclear extracts from LPS-stimulation, and this protein kinase enhances B1 and formation. The B1 band can be converted to band B2/B3 by adding specific heparin column fraction purified Ser/Thr specific protein phosphatases PP-1 and PP-2A can stimulate the same conversion to about the same extent. Thus, the formation of the LRE sequence binding complex appears to be regulated by Ser/Thr protein kinase and one or more Ser/Thr specific phosphatases. At least four proteins are involved in the trgulation of the LRE-dependent Rants experssion: two binding factors that bind directly to the target sequences. and two factors that control their binding. The future purification and characterization of these binding pro-teins will reveal in detail the mechanism of Rantes gene activation after LPS stimulation.

• International Journal of Oral Biology
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• 제38권2호
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• pp.67-72
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• 2013

This study examined the anti-osteoclastogenic effects of baicalin on receptor activator of NF-${\kappa}$B ligand (RANKL)-induced RAW264.7 cells. Baicalin is a flavonoid that is produced by Scutellaria baicalensis and is known to have multiple biological properties, including antibacterial, anti-inflammatory and analgesic effects. The effects of baicalin on osteoclasts were examined by measuring 1) cell viability; 2) the formation of tartrate-resistant acid phosphatase (TRAP) (+) multinucleated cells; 3) RANK/RANKL signaling pathways and 4) mRNA levels of osteoclast-associated genes. Baicalin inhibited the formation of RANKL-stimulated TRAP (+) multinucleated cells and also suppressed the RANKL-stimulated activation of p-38, ERK, cSrc and AKT signaling. Baicalin also inhibited the RANKL-stimulated degradation of $I{\kappa}B$ in RAW264.7 cells. In addition, the RANKL-stimulated induction of NFATc1 transcription factors was found to be abrogated by this flavonoid. Baicalin was further found to decrease the mRNA expression of osteoclast-associated genes, including carbonic anhydrase II, TRAP and cathepsin K in the RAW264.7 cells. Our data thus demonstrate that baicalin inhibits osteoclastogenesis by inhibiting the RANKL-induced activation of signaling molecules and transcription factors in osteoclast precursors.

• 대기
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• 제31권1호
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• pp.73-83
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• 2021

Numerical weather prediction (NWP) models play an essential role in predicting weather factors, but using them is challenging due to various factors. To overcome the difficulties of NWP models, deep learning models have been deployed in weather forecasting by several recent studies. This study adapts long short-term memory (LSTM), which demonstrates remarkable performance in time-series prediction. The combination of LSTM model input of meteorological features and activation functions have a significant impact on the performance therefore, the results from 5 combinations of input features and 4 activation functions are analyzed in 9 Automated Surface Observing System (ASOS) stations corresponding to cities/islands/mountains. The optimized LSTM model produces better performance within eight forecast hours than Local Data Assimilation and Prediction System (LDAPS) operated by Korean meteorological administration. Therefore, this study illustrates that this LSTM model can be usefully applied to very short-term weather forecasting, and further studies about CNN-LSTM model with 2-D spatial convolution neural network (CNN) coupled in LSTM are required for improvement.