• 한국재료학회지
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• 제11권6호
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• pp.508-511
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• 2001

사파이어 단결정의 취성-연성전이에 대한 실험을 행하였다. 사파이어 단결정의 취성-연성전이온도는 변형율 3.3$\times$ $10^{-5}$/sec에서 $1000\pm$$25^{\circ}C$ 그리고 변형률 3.3$\times$$10^{-5}$/sec에서는 1100$\pm$26$^{\circ}C$이었다. 취성-연성전이모델을 이용하여 Prism Plane slip {1120} <1100> 전위속도의 활성화에너지를 계산하였으며, 그 결과 활성화에너지는 4.6$\pm$2.3eV의 범위를 가졌다. 이 활성화에너지는 에치-퍼트법을 이용하여 전위속도측정으로부터 구한 결과치 3.8eV와 유사하였다.

• Membrane and Water Treatment
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• 제14권1호
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• pp.1-10
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• 2023

This study explored the feasibility of calcium-rich food waste, Mactra veneriformis shells (MVS), as an adsorbent for phosphate removal, and its removal efficiency was enhanced by the thermal activation process. The CaCO3 in MVS was converted to CaO by thermal activation (>800 ℃), which is more favorable for adsorbing phosphate. Thermal activation did not noticeably influence the specific surface area of MVS. The MVS thermally activated at 800 ℃ (MVS-800), showed the highest phosphate adsorption capacity, was used for further adsorption experiments, including kinetics, equilibrium isotherms, and thermodynamic adsorption. The effects of environmental factors, including pH, competing anions, and adsorbent dosage, were also studied. Phosphate adsorption by MVS-800 reached equilibrium within 48h, and the kinetic adsorption data were well explained by the pseudo-first-order model. The Langmuir model was a better fit for phosphate adsorption by MVS-800 than the Freundlich model, and the maximum adsorption capacity of MVS-800 obtained via the Langmuir model was 188.86 mg/g. Phosphate adsorption is an endothermic and involuntary process. As the pH increased, the phosphate adsorption decreased, and a sharp decrease was observed between pH 7 and 9. The presence of anions had a negative impact on phosphate removal, and their impact followed the decreasing order CO₃^2- > SO₄²- > NO₃^- > Cl^-. The increase in adsorbent dosage increased phosphate removal percentage, and 6.67 g/L of MVS-800 dose achieved 99.9% of phosphate removal. It can be concluded that the thermally treated MVS-800 can be used as an effective adsorbent for removing phosphate.

• The Korean Journal of Physiology and Pharmacology
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• 제8권5호
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• pp.237-243
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• 2004

Glial cells are activated in neuropathy and play a key role in hyperalgesia and allodynia. This study was performed to determine whether minocycline could attenuate heat hyperalgesia and mechanical allodynia, and how glial cell activation and nuclear factor kappa B (NF-kappaB) were regulated by minocycline in a model of chronic constriction of sciatic nerve (CCl). When minocycline (50 mg/kg, oral) was daily administered from 1 day before to 9 days after ligation, heat hyperalgesia and mechanical allodynia were attenuated. Furthermore, when minocycline treatment was initiated 1 or 3 days after ligation, attenuation of the hypersensitive behavior was still robust. However, the effect of attenuation was less when minocycline was started from day 5. In order to elucidate the mechanism of pain attenuation by minocycline, we examined the changes of glia and NF-kappaB, and found that attenuated hyperalgesia and allodynia by minocycline was accompanied by reduced microglial activation. Furthermore, the number of NF-kappaB immunoreactive cells increased after CCI treatment and this increase was attenuated by minocycline. We also observed translocation of NF-kappaB into the nuclei of activated glial cells. These results suggest that minocycline inhibits activation of glial cells and NF-kappaB, thereby attenuating the development of behavioral hypersensitivity to stimuli.

• 한국항공우주학회지
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• 제31권4호
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• pp.35-43
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• 2003

본 논문에서는 새로 제안된 절점 활성화 기법을 실제 구현하기 위한 효율적 계산법을 소개하고 각종 수치실험을 수행한다. 포아송 방정식, 2차원 탄성문제, 3차원 탄성문제에 대하여 다양하게 수행된 수치실험을 통하여 절점활성화 이론의 타당성, 수렴성, 및 효율성을 고찰한다. 수렴성, 패치 테스트 등이 포함된 각종 수치실험 결과로부터 절점활성화 기법을 이용하면 정확도의 큰 손실 없이도 많은 수의 유한요소 절점 중 관심이 있는 일부 절점만을 선택, 활성화시켜 이들만을 미지수로 이용하여 효율적으로 문제를 해석할 수 있음을 입증한다.

• The Korean Journal of Physiology and Pharmacology
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• 제10권3호
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• pp.123-129
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• 2006

In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical ap-plication. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether estrogen protected CAI neurons and affected activation of Akt (pAkt) in CAI region under OGD. Thus, rat hippocampal slices on day 7 of culture were treated with $17-{\beta}$ estradiol (E, 1 nM) for 7 days before 30 min OGD, and cell death of CAI neurons was quantified by propidium iodide (PI) staining and expression of pAkt was studied by Western blot and immunofluorescence. PI intensity in slices treated with E was significantly reduced 72 hour after OGD compared to that of non-treated slices (p < 0.05). E pretreatment also increased the expression of pAkt 72 hour after OGD compared to that of no treatment (p<0.01). These data suggest that estrogen pretreatment may rescue neurons from ischemic insults through the activation of Akt and also indicate that our model would be a useful alternative method to study the mechanisms and effects of estrogen replacement treatment for neuroprotection.

• 공업화학
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• 제4권1호
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• pp.113-124
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• 1993

Polyacrylonitrile계 섬유를 전구체로 하여 비등온 과정에 의한 활성화를 승온속도를 달리한 TGA(thermogravimetric analysis) 방법으로 연구하였다. 탄소섬유 -$H_2O$(30%)-$N_2$계 비등온 활성화 과정에서 유도된 속도식 $f=1-\exp(-a{\Delta}T)^b$는 실험값과 잘 일치하였다. 전환율에 따른 세공 용적은 pore volume model에 의한 이론값과 비교적 잘 일치하였고, 이때의 세공 구조는 승온속도, 활성화 온도와 내부 및 외부 전환율과의 복합적인 작용에 의하여 결정되었다.

• 약학회지
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• 제53권3호
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• pp.119-124
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• 2009

Cell-cell adhesion managed by various adhesion molecules plays an important role in regulating functional activation of cells. This event mediates attachment of inflammatory cells to endothelial cells, interaction of antigen-presenting cells with T cells and metastatic adherence of cancer cells to epithelial tissue cells. Therefore, this cellular response is considered as one of therapeutic target to treat various cancers and inflammatory diseases. To develop proper model for evaluation of functional activation of adhesion molecules, the ability of U937 and Jurkat T cells responsive to various adhesion inducers such as phorbal-12-myristate-13-acetate (PMA), staurosporin and monoclonal antibodies to CD29, CD43 and CD98 was investigated using quantitative cell-cell adhesion assay. U937 cells made more cell-cell clusters by the treatment of antibodies to CD29 and CD43 than Jurkat T cells, while Jurkat T cells exhibited increased cell-cell adhesion ability in CD98 antibody treatment. In agreement, the surface levels of CD29 and CD98 were highly observed in U937 and Jurkat T cells, respectively. Therefore, our data suggest that Jurkat T and U937 cells can be used for model system to evaluate functional activation of adhesion molecules such as CD29 and CD98.

• 한국지역지리학회지
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• 제22권1호
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• pp.102-119
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• 2016

본 연구는 영국 런던지역의 한인 이주민 사례를 통해, 한인 이주민의 정착과정에서 한인네트워크 역할을 살펴보고, 한인네트워크의 활성화 방안을 모색하는 것을 목적으로 한다. 분석결과를 요약하면 다음과 같다. 첫째로, 영국으로의 최초 이주과정에서 대다수의 응답자들은 한인네트워크를 활용한 것으로 나타난다. 둘째로, 한인네트워크의 역할과 관련하여 응답자들은 종교활동, 쇼핑활동, 교육활동 분야에서 많이 활용하는 것으로 나타난다. 셋째로, 대다수의 응답자들은 한인네트워크의 활성화 필요성을 인지하고 있으며, 한인네트워크의 활성화 방안으로는 한국정부의 지원방안들에 대한 선호도가 높게 나타난다. 넷째로, 한인네트워크의 활성화 방안으로, 한인네트워크의 성숙단계에 따른 차별화되고 종합적인 한인네트워크의 활성화 모형을 제시하였다.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1571-1584
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• 2023

In this study, a numerical analysis was performed as part of an international joint research project to reproduce a real cable tray fire that occurred in the heater bay area of the turbine building of a nuclear power plant. A sensitivity analysis was performed on various input parameters to derive results consistent with the sprinkler activation time obtained from the fire event analysis. For all sensitive parameters, the normalized sprinkler activation time correlated well with the power function of the normalized sprinkler height. A correlation equation was developed to identify the sprinkler activation time at any location when determining the slope or fire growth rate under the conditions assuming a linear or t-squared heat release rate (HRR) time curve. Various cable fire growth assumptions were used to determine which assumption was better to provide the prediction coincident with the information given from the fire event analysis in terms of the sprinkler activation time and total energy generated from cables damaged by fire. In the comprehensive analysis of all the sensitive parameters, the standard deviation of the input parameters increased as the sprinkler height decreased. Within the range of the sensitivity parameter values given in this study, when considering all sprinkler heights, the standard deviation of the cable model change was the largest and that of the overhang position change was the smallest.

• 공업화학
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• 제29권6호
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• pp.789-798
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• 2018

고분자전해질 연료전지(PEMFC)의 성능을 예측할 수 있는 empirical equation의 역할이 중요하게 대두되고 있다. 본 연구에서는 polarization curve에서 activation loss, ohmic loss, mass transfer loss 영역을 분리하였고, 현재까지 개발된 model 중 Kim의 model과 Hao의 model을 선정하여 각 영역의 fitting을 시행하였다. 온도, 압력, 산소 농도 및 막 두께를 운전변수로 설정하여 조건 변화에 대한 각 loss의 변화를 비교하였다. 기존 model은 전반적으로 좋은 fitting 정확도를 보였지만, 분리된 loss 영역에서는 부정확한 fitting 결과를 보이기도 하였다. 연료전지 성능 예측의 정확도를 개선하기 위하여 converge coefficient를 도입한 새로운 model을 제안하였다. 본 연구에서 제안한 model을 연료전지 성능 예측에 적용한 경우에 신뢰도 평가에서 개선된 결과를 얻을 수 있었다.