• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2014년도 춘계학술대회 논문집
• /
• pp.728-729
• /
• 2014

• 한국초전도학회:학술대회논문집
• /
• 한국초전도학회 2008년도 High Temperature Superconductivity Vol.XVIII
• /
• pp.34-34
• /
• 2008

• Korean Journal of Acupuncture
• /
• 제29권3호
• /
• pp.396-405
• /
• 2012

Objectives : To confirm whether acupuncture can suppress the degree of seizure and the activation of astrocytes in hippocampi using kainic acid(KA)-induced epilepsy mouse model. Methods : 8 weeks C57BL/6 mice(20~25 g) were given acupuncture once a day at acupoint HT8(Shaofu) bilaterally during 2 days before KA injection. After an intraperitoneal injection of 30 mg/kg KA, acupuncture treatment was subsequently administered once more(total 3 times), and the degree of seizure was observed for 120 min. The neuronal cell death, pERK expression, and astrocyte activation confirmed 1 hour and 24 hours after KA injection. Results : Acupuncture treatment at HT8 suppressed KA-induced epileptic seizure. One hour after KA injection, the pERK expression was increased, which was reduced by the acupuncture treatment. Twenty four hours after injection, the treatment decreased the KA-induced neuronal cell death, the interleukin-$1{\beta}$ expression and the astrocyte activation in the CA3 region of the mouse hippocampus. Conclusions : Acupuncture treatment at HT8 decreases the KA-induced epileptic seizure, the neural cell inflammation and death.

• 한국가스학회지
• /
• 제24권3호
• /
• pp.40-46
• /
• 2020

텨셔리부틸퍼옥시말레이트(Tertbutylperoxymaleate : TBPM)는 인조대리석 제조에 사용되는 개시제 조성물의 원료로 유기과산화물의 일종이다. 본 연구에서는 시차주사열량계(DSC)를 이용하여 공기 및 질소 분위기에서 TBPM의 열분해특성을 평가하였다. TBPM은 반응 분위기와 관계없이 130 ℃ 이하에서 급격한 분해에 의한 발열을 나타냈다. 그리고 동적방법을 이용한 속도론적 평가에서 방법에 따라서 203~217 kJ/mol의 활성화에너지를 보였으며, Model-free 방법에 의한 분석에서는 118~232 kJ/mol의 활성화에너지를 갖는 것으로 평가되었다. 그리고 도출된 활성화에너지를 이용하여 24시간 이내에 최대발열속도에 도달하는 온도인 ADT₂₄는 (80~95) ℃로 평가되었다.

• Korean Journal of Acupuncture
• /
• 제30권1호
• /
• pp.73-80
• /
• 2013

Objectives : LI11 has been known to suppress epileptic seizure. Using an mouse epilepsy model, we investigated whether acupuncture stimulation at LI11 can suppress kainic acid(KA)-induced epileptic seizure and apoptosis in the mouse hippocampus. Methods : Eight-week-old male C57/BL6 mice(20~25 g) were given acupuncture at LI11 or ST36 once a day for 3 days. After the last acupuncture stimulations, KA(30 mg/kg) was injected intraperitoneally and the degree of seizure was observed for 90 minutes. Twenty-four hours after KA administration, mice were sacrificed and the neural cell death, astrocyte activation and caspase-3 expression in their hippocampi were investigated. Results : Acupuncture stimulation at LI11 suppressed KA-induced epileptic seizure, neuronal cell death, astrocyte activation and caspase-3 expression. Conclusions : Acupuncture stimulation at LI11 decreases the KA-induced epileptic seizure and protects hippocampal cell death via regulating astrocyte activation and caspase-3 expression.

• 대한기계학회논문집B
• /
• 제33권1호
• /
• pp.38-45
• /
• 2009

Oxy-fuel combustion of pulverized coal is one of the promising new technologies to reduce $CO_2$ and NOx from coal combustion. However, the stability of pulverized coal flame is reduced in the oxy-fuel combustion. This flame stability is concerned with the flame propagation that is affected by surrounding gas and coal characteristics, such as gas temperature, gas composition, coal volatile, coal activation energy and coal size. In this paper, a study on the influence of surrounding gas and coal characteristics on the flame propagation velocity in oxy-fuel combustion of pulverized coal was preformed. One dimensional model was used to calculate the flame propagation velocity of pulverized coal clouds. In this model, the radiation is considered to be the main source of heat exchange, and Monte Carlo method was adopted for accurate calculation of radiation heat flux. It was found that the flame propagation velocity become higher with the decrease of coal activation energy and the increase of coal volatile. Also, according to the increase of gas temperature and $O_2$ concentration, flame propagation velocity increased.

• Advances in environmental research
• /
• 제6권1호
• /
• pp.1-14
• /
• 2017

New technologies or improvement of the existing technologies are required to enhance the efficiency of removal of pollutants from wastewater. In this study we attempted to produce and test the activated carbon produced from the refused tea waste for the removal of dyes from wastewater. The objectives of this investigation were to produce activated carbon from refused tea waste by chemical activation, evaluate its performance for the removal of color produced from Acid Yellow 36, and the modeling of its dye removal with the kinetic study. The activation was performed in two steps namely carbonization at $375{\pm}25^{\circ}C$ and chemical activation with HCl at $800^{\circ}C$ under the absence of Oxygen. Adsorption isotherms and kinetic studies were performed with a textile dye, Acid Yellow 36, at different concentrations (20-80 mg/L). The maximum dye removal (~90%) observed at 80 mg/L dye concentration and it reduced at low dye concentrations. Maximum adsorption (71.97 mg/g) was recorded at 96 h at $29{\pm}1^{\circ}C$. Low pH increased the dye adsorption (pH=2; 78.27 mg/g) while adsorption reduced at high pH levels indicating that the competition occurs in between OH- ions and AY36 molecules for the adsorption sites in RTAC. The Langmuir isotherm model clearly explained the dye adsorption, favorably, by RTAC. Moreover, kinetic studied performed showed that the pseudo second order kinetic model clearly describes the dye adsorption. Based on the results obtained in this study, it can be concluded that RTAC can be used for the removal of textile dyes.

• 대한의생명과학회지
• /
• 제27권3호
• /
• pp.142-153
• /
• 2021

Liver fibrosis is a wound-healing response to chronic liver injury, which is caused by the continuous and excess deposition of extracellular matrix (ECM). The aim of this study is to investigate whether Uncaria rhynchophylla water extract (UR) can ameliorate thioacetamide (TAA)-induced liver fibrosis. The liver fibrosis model was induced on C57BL/6 mice by intraperitoneal injection with TAA three times a week for 8 weeks. UR (200 mg/kg) or silymarin (50 mg/kg) was administered orally daily for 8 weeks. Biochemical analyses including AST, ALT, MPO, and Ammonia levels were measured in serum. In the mice liver tissues, western blot and histological staining were analyzed. As a result, UR dramatically reduced the levels in serum AST, ALT, MPO, and Ammonia levels. UR treatment regulated NADPH oxidase factors expression, and antioxidant enzymes except for GPx-1/2 were significantly increased via Nrf2 activation. Furthermore, pro-inflammatory mediators, such as COX-2 and iNOS were markedly suppressed through the inhibition of NF-κB activation. Expressions of ECM-related protein including α-SMA and Collagen I were noticeably decreased. The additional histological evaluation confirmed that hepatocyte damage and collagenous fiber accumulation were attenuated. Taken together, these data suggest that UR possessed hepatoprotective effects in TAA-induced liver fibrosis via the NF-κB inactivation and Nrf2 activation. Therefore, UR may act as a potential therapeutic drug against liver fibrosis.

• 산업융합연구
• /
• 제19권6호
• /
• pp.177-186
• /
• 2021

본고는 인지적 과제를 수행하는 동안 우울 및 불안 환자의 정신병리적 과정과 이의 치료접근 방식에 대한 통합적 이해를 위해 최근 제시된 신경인지 연결망을 토대로 인지과정 및 정서조절의 비정상적 기능 연결성을 재해석 할 수 있는 모델을 제안하고자 하였다. 재구성된 우울과 불안장애 신경인지 연결망 모델을 통해, 우울증은 불이행방식 연결망(default mode network; DMN)의 과다 활성화에 기인하는 '자기참조적 사고로의 과몰입'으로, 불안장애는 불이행방식 연결망의 과소 활성화에 기인하는 '자기참조적 사고와의 단절'로 규정해 볼 수 있음을 확인하였다. 신경인지 연결망 중 자기의식 및 투사와 관련되는 자기참조 처리가 주요 기능인 DMN의 비정상적 활성화와 병리적 기능의 체계적 연결시도는 우울와 불안에 대한 통합적 해석과 치료적 접근에 시사점을 줄 수 있는 또 다른 출발점이 될 수 있을 것이다.

• 운동영양학회지
• /
• 제16권2호
• /
• pp.93-100
• /
• 2012

Alzheimer's disease (AD) is the most common cause of dementia in adults. Microtubule associated protein tau is abnormally phosphorylated in AD and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). NFTs are the most common intraneuronal inclusion in the brains of patients with AD and have been implicated in mediating neuronal cell death and cognitive deficit. Aberrant phosphorylation of tau is an early pathological event in AD, but the underlying mechanisms are unclear. MAP kinases are a family of Serine/Threonine (Ser/Thr) kinases that involved hyper - phosphorylation of tau in AD. The purpose of this study was to investigate the effect of treadmill exercise on phosphorylation of tau level and activation of MAPKs including JNK, ERK, p38-MAPK. To address this, Tg mouse model of AD, Tg-NSE/hTau 23, which expresses human tau 23 in the brain, was chosen. Animals were subjected to treadmill exercise for 12 weeks from 24 months of age. Treadmill exercise in Tg group improved cognitive function compared with Tg-SED group in watermaze test. In addition, treadmill exercised Tg mice significantly reduced the activation of JNK54/46, p38-MAPK and tau (Ser404, Ser202, Thr231), and increased activation of ERK44/42 in cerebral cortex. These results suggest that treadmill exercise may provide a therapeutic potential to alleviate the tau pathology like AD.