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http://dx.doi.org/10.14406/acu.2013.30.1.073

Acupuncture Stimulation at LI11 Suppresses Seizure and Apoptosis in Hippocampi on an Epilepsy Mouse Model  

Lee, Jong Boon (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Hwang, Kyoung Min (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Yoo, Tae-Won (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Bae, Chang-Hwan (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Kwon, Sunoh (Acupuncture & Meridian Science Research Center, Kyung Hee University)
Kim, Seung-Tae (Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Korean Journal of Acupuncture / v.30, no.1, 2013 , pp. 73-80 More about this Journal
Abstract
Objectives : LI11 has been known to suppress epileptic seizure. Using an mouse epilepsy model, we investigated whether acupuncture stimulation at LI11 can suppress kainic acid(KA)-induced epileptic seizure and apoptosis in the mouse hippocampus. Methods : Eight-week-old male C57/BL6 mice(20~25 g) were given acupuncture at LI11 or ST36 once a day for 3 days. After the last acupuncture stimulations, KA(30 mg/kg) was injected intraperitoneally and the degree of seizure was observed for 90 minutes. Twenty-four hours after KA administration, mice were sacrificed and the neural cell death, astrocyte activation and caspase-3 expression in their hippocampi were investigated. Results : Acupuncture stimulation at LI11 suppressed KA-induced epileptic seizure, neuronal cell death, astrocyte activation and caspase-3 expression. Conclusions : Acupuncture stimulation at LI11 decreases the KA-induced epileptic seizure and protects hippocampal cell death via regulating astrocyte activation and caspase-3 expression.
Keywords
acupuncture; LI11; epilepsy; kainic acid; astrocyte; caspase-3;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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