• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.04a
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• pp.728-729
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• 2014

• 한국초전도학회:학술대회논문집
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• 2008.08a
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• pp.34-34
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• 2008

• Korean Journal of Acupuncture
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• v.29 no.3
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• pp.396-405
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• 2012

Objectives : To confirm whether acupuncture can suppress the degree of seizure and the activation of astrocytes in hippocampi using kainic acid(KA)-induced epilepsy mouse model. Methods : 8 weeks C57BL/6 mice(20~25 g) were given acupuncture once a day at acupoint HT8(Shaofu) bilaterally during 2 days before KA injection. After an intraperitoneal injection of 30 mg/kg KA, acupuncture treatment was subsequently administered once more(total 3 times), and the degree of seizure was observed for 120 min. The neuronal cell death, pERK expression, and astrocyte activation confirmed 1 hour and 24 hours after KA injection. Results : Acupuncture treatment at HT8 suppressed KA-induced epileptic seizure. One hour after KA injection, the pERK expression was increased, which was reduced by the acupuncture treatment. Twenty four hours after injection, the treatment decreased the KA-induced neuronal cell death, the interleukin-$1{\beta}$ expression and the astrocyte activation in the CA3 region of the mouse hippocampus. Conclusions : Acupuncture treatment at HT8 decreases the KA-induced epileptic seizure, the neural cell inflammation and death.

• Journal of the Korean Institute of Gas
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• v.24 no.3
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• pp.40-46
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• 2020

Tertbutylperoxymaleate is the one of the organic peroxides used as a raw material of initiator formulations of artificial marble manufacturing. In this study, the thermal decomposition characteristic of TBPM was evaluated using the differential scanning calorimeter in the air and nitrogen circumstance. Regardless of the reaction atmosphere, TBPM showed the exothermic peak due to the drastic decomposition reaction below 130 ℃. The activation energy estimated by dynamic methods had a range of 203~217 kJ/mol and that estimated by model-free analysis method had a range of 118~232 kJ/mol with a thermal conversion. And the ADT₂₄, the temperature that lead to the maximum heating rate within 24 hours, was evaluated as (80~95) ℃ using the estimated activation energy.

• Korean Journal of Acupuncture
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• v.30 no.1
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• pp.73-80
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• 2013

Objectives : LI11 has been known to suppress epileptic seizure. Using an mouse epilepsy model, we investigated whether acupuncture stimulation at LI11 can suppress kainic acid(KA)-induced epileptic seizure and apoptosis in the mouse hippocampus. Methods : Eight-week-old male C57/BL6 mice(20~25 g) were given acupuncture at LI11 or ST36 once a day for 3 days. After the last acupuncture stimulations, KA(30 mg/kg) was injected intraperitoneally and the degree of seizure was observed for 90 minutes. Twenty-four hours after KA administration, mice were sacrificed and the neural cell death, astrocyte activation and caspase-3 expression in their hippocampi were investigated. Results : Acupuncture stimulation at LI11 suppressed KA-induced epileptic seizure, neuronal cell death, astrocyte activation and caspase-3 expression. Conclusions : Acupuncture stimulation at LI11 decreases the KA-induced epileptic seizure and protects hippocampal cell death via regulating astrocyte activation and caspase-3 expression.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.1
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• pp.38-45
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• 2009

Oxy-fuel combustion of pulverized coal is one of the promising new technologies to reduce $CO_2$ and NOx from coal combustion. However, the stability of pulverized coal flame is reduced in the oxy-fuel combustion. This flame stability is concerned with the flame propagation that is affected by surrounding gas and coal characteristics, such as gas temperature, gas composition, coal volatile, coal activation energy and coal size. In this paper, a study on the influence of surrounding gas and coal characteristics on the flame propagation velocity in oxy-fuel combustion of pulverized coal was preformed. One dimensional model was used to calculate the flame propagation velocity of pulverized coal clouds. In this model, the radiation is considered to be the main source of heat exchange, and Monte Carlo method was adopted for accurate calculation of radiation heat flux. It was found that the flame propagation velocity become higher with the decrease of coal activation energy and the increase of coal volatile. Also, according to the increase of gas temperature and $O_2$ concentration, flame propagation velocity increased.

• Advances in environmental research
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• v.6 no.1
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• pp.1-14
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• 2017

New technologies or improvement of the existing technologies are required to enhance the efficiency of removal of pollutants from wastewater. In this study we attempted to produce and test the activated carbon produced from the refused tea waste for the removal of dyes from wastewater. The objectives of this investigation were to produce activated carbon from refused tea waste by chemical activation, evaluate its performance for the removal of color produced from Acid Yellow 36, and the modeling of its dye removal with the kinetic study. The activation was performed in two steps namely carbonization at $375{\pm}25^{\circ}C$ and chemical activation with HCl at $800^{\circ}C$ under the absence of Oxygen. Adsorption isotherms and kinetic studies were performed with a textile dye, Acid Yellow 36, at different concentrations (20-80 mg/L). The maximum dye removal (~90%) observed at 80 mg/L dye concentration and it reduced at low dye concentrations. Maximum adsorption (71.97 mg/g) was recorded at 96 h at $29{\pm}1^{\circ}C$. Low pH increased the dye adsorption (pH=2; 78.27 mg/g) while adsorption reduced at high pH levels indicating that the competition occurs in between OH- ions and AY36 molecules for the adsorption sites in RTAC. The Langmuir isotherm model clearly explained the dye adsorption, favorably, by RTAC. Moreover, kinetic studied performed showed that the pseudo second order kinetic model clearly describes the dye adsorption. Based on the results obtained in this study, it can be concluded that RTAC can be used for the removal of textile dyes.

• Biomedical Science Letters
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• v.27 no.3
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• pp.142-153
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• 2021

Liver fibrosis is a wound-healing response to chronic liver injury, which is caused by the continuous and excess deposition of extracellular matrix (ECM). The aim of this study is to investigate whether Uncaria rhynchophylla water extract (UR) can ameliorate thioacetamide (TAA)-induced liver fibrosis. The liver fibrosis model was induced on C57BL/6 mice by intraperitoneal injection with TAA three times a week for 8 weeks. UR (200 mg/kg) or silymarin (50 mg/kg) was administered orally daily for 8 weeks. Biochemical analyses including AST, ALT, MPO, and Ammonia levels were measured in serum. In the mice liver tissues, western blot and histological staining were analyzed. As a result, UR dramatically reduced the levels in serum AST, ALT, MPO, and Ammonia levels. UR treatment regulated NADPH oxidase factors expression, and antioxidant enzymes except for GPx-1/2 were significantly increased via Nrf2 activation. Furthermore, pro-inflammatory mediators, such as COX-2 and iNOS were markedly suppressed through the inhibition of NF-κB activation. Expressions of ECM-related protein including α-SMA and Collagen I were noticeably decreased. The additional histological evaluation confirmed that hepatocyte damage and collagenous fiber accumulation were attenuated. Taken together, these data suggest that UR possessed hepatoprotective effects in TAA-induced liver fibrosis via the NF-κB inactivation and Nrf2 activation. Therefore, UR may act as a potential therapeutic drug against liver fibrosis.

• Journal of Industrial Convergence
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• v.19 no.6
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• pp.177-186
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• 2021

This review aims to propose a model that can reinterpret the abnormal and functional connections between cognitive processes and emotional regulations based on the neurocognitive networks for a comprehensive understanding of pathologic processes and treatment approach of depression and anxiety disorder. Through the processes of rebuilding the network model for depression and anxiety disorder, it was confirmed that depression can be said to be 'over-immersion in self-referencing' due to hyper-activation of default mode network (DMN), and anxiety disorders to be 'disconnection with self-referencing' due to hypo-activation of DMN. The attempts to link up between abnormal activation and pathological function of DMN which is thought to be involved in self-referential processing associated with self-consciousness and projection among neurocognitive networks may be another starting point that can afford to be suggestive in integrated interpretation and therapeutic approach to depression and anxiety disorder.

• Korean Journal of Exercise Nutrition
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• v.16 no.2
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• pp.93-100
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• 2012

Alzheimer's disease (AD) is the most common cause of dementia in adults. Microtubule associated protein tau is abnormally phosphorylated in AD and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). NFTs are the most common intraneuronal inclusion in the brains of patients with AD and have been implicated in mediating neuronal cell death and cognitive deficit. Aberrant phosphorylation of tau is an early pathological event in AD, but the underlying mechanisms are unclear. MAP kinases are a family of Serine/Threonine (Ser/Thr) kinases that involved hyper - phosphorylation of tau in AD. The purpose of this study was to investigate the effect of treadmill exercise on phosphorylation of tau level and activation of MAPKs including JNK, ERK, p38-MAPK. To address this, Tg mouse model of AD, Tg-NSE/hTau 23, which expresses human tau 23 in the brain, was chosen. Animals were subjected to treadmill exercise for 12 weeks from 24 months of age. Treadmill exercise in Tg group improved cognitive function compared with Tg-SED group in watermaze test. In addition, treadmill exercised Tg mice significantly reduced the activation of JNK54/46, p38-MAPK and tau (Ser404, Ser202, Thr231), and increased activation of ERK44/42 in cerebral cortex. These results suggest that treadmill exercise may provide a therapeutic potential to alleviate the tau pathology like AD.