• Title/Summary/Keyword: Action of the children

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Modulation of Inflammatory Pathways and Adipogenesis by the Action of Gentisic Acid in RAW 264.7 and 3T3-L1 Cell Lines

  • Kang, Min-jae;Choi, Woosuk;Yoo, Seung Hyun;Nam, Soo-Wan;Shin, Pyung-Gyun;Kim, Keun Ki;Kim, Gun-Do
    • Journal of Microbiology and Biotechnology
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    • v.31 no.8
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    • pp.1079-1087
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    • 2021
  • Gentisic acid (GA), a benzoic acid derivative present in various food ingredients, has been shown to have diverse pharmaceutical activities such as anti-carcinogenic, antioxidant, and hepatoprotective effects. In this study, we used a co-culture system to investigate the mechanisms of the anti-inflammatory and anti-adipogenic effects of GA on macrophages and adipocytes, respectively, as well as its effect on obesity-related chronic inflammation. We found that GA effectively suppressed lipopolysaccharide-stimulated inflammatory responses by controlling the production of nitric oxide and pro-inflammatory cytokines and modulating inflammation-related protein pathways. GA treatment also inhibited lipid accumulation in adipocytes by modulating the expression of major adipogenic transcription factors and their upstream protein pathways. Furthermore, in the macrophage-adipocyte co-culture system, GA decreased the production of obesity-related cytokines. These results indicate that GA possesses effective anti-inflammatory and anti-adipogenic activities and may be used in developing treatments for the management of obesity-related chronic inflammatory diseases.

A Study on the Development and Implementation of Refugee Education Programs for Early Childhood (유아 대상 난민교육 프로그램 개발 및 실행)

  • Sera Kim;Sungeun Yang
    • Korean Journal of Childcare and Education
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    • v.20 no.2
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    • pp.1-16
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    • 2024
  • Objective: The objective of this study was to develop a refugee education program for early childhood and apply it in daycare center settings to examine the reactions of children aged 5. Methods: Referring to Kemmis and McTaggart(1988) action research model, the refugee education program recommended by UNHCR, and linking it with the national Nuri-curriculum in Korea, a total of five sessions of a refugee education program for early childhood were developed and applied to 20 children aged 5. Results: The application of the preschool refugee education program resulted in positive changes in cognitive, emotional, and behavioral aspects. These changes provided opportunities for early childhood to practice respect towards others, fostering a broader understanding and appreciation of diverse cultures. Conclusion/Implications: This study holds significance in contributing to the discourse on the necessity and direction of refugee education through the development and application of a refugee education program for early childhood. It is anticipated that this research will stimulate in-depth discussions on educational approaches that foster early childhood interest in global issues and cultivate a sense of global citizenship and attitude in the future.

Urinary bladder rupture during voiding cystourethrography

  • Lee, Kyong-Ok;Park, Se-Jin;Shin, Jae-Il;Lee, Suk-Young;Kim, Kee-Hyuck
    • Clinical and Experimental Pediatrics
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    • v.55 no.5
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    • pp.181-184
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    • 2012
  • Voiding cystourethrography (VCUG) is a commonly performed diagnostic procedure for the evaluation of vesicoureteral reflux with urinary tract infection or congenital renal diseases in children. The procedure is relatively simple and cost-effective, and complications are very rare. The iatrogenic complication of VCUG range from discomfort, urinary tract infection to bacteremia, as well as bladder rupture. Bladder rupture is a rare complication of VCUG, and only a few cases were reported. Bladder rupture among healthy children during VCUG is an especially uncommon event. Bladder rupture associated with VCUG is usually more common in chronically unused bladders like chronic renal failure. Presented is a case of bladder rupture that occurred during a VCUG in a healthy 9-month-old infant, due to instilled action of dye by high pressure. This injury completely healed after 7 days of operation, and it was confirmed with a postoperative cystography. The patient's bladder volume, underlying disease, velocity of the contrast media instilled, catheter size, and styles of instillation are important factors to prevent bladder rupture during VCUG. Management of bladder rupture should be individualized, but the majority of infants are treated with the operation. In conclusion, bladder rupture is a rare complication, however, delicate attention is needed in order to prevent more dire situations.

Antidromic Electrically Compound Action Potential in Cochlear Implantees (인공와우 이식자의 역행성 청신경 복합활동전위)

  • Heo, Seung-Deok;Jung, Sung-Wook;Jung, Seung-Hyun
    • Phonetics and Speech Sciences
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    • v.1 no.4
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    • pp.203-207
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    • 2009
  • Electrically evoked compound action potentials (ECAP) have originated from the distal end of the auditory nerve. ECAP are characterized as the difference between the clearly large trough (N) and the following positive peak (P). N-wave occurs around $200-400\;{\mu}s$ after stimulus onset and P-wave at around $400-800\;{\mu}s$. Contrary to expectations, positive peaked ECAP (pp-ECAP) was dominated by a relatively large-amplitude positive following negative peak. pp-ECAP can be recorded from the sites on or near the surgically exposed nerve trunk in animal models and/or in cases of monophasic stimulation. This study will provide the causes of the appearance of pp-ECAP in cases of cochlear implant recipients using imaging studies and medical records and statistically analysis between N-P and P-N on the amplitude input-output function (amp-I/O) for the prediction of the possibilities of clinical tools. Thirteen children participated in the study and received a Cochlear CI-24RE (CA). ECAP was recorded using auto-NRT (Cochlear Ltd., Australia) at four to five weeks post surgery. pp-ECAP was measured from 36 electrodes and typical ECAP from 220 electrodes. There was no abnormality in the imaging study and operation finding in patients with typical ECAP. pp-ECAP was found at the inner ear anormaly and ossification in imaging study and gel-state inner ear fluid was observed in the operation finding. The amplitude of pp-ECAP increased depending on current intensities, but amp-I/O increase more gradually than in the case of typical ECAP (p=0.003). pp-ECAP is antidromic potential which can record from the inner ear anormaly and ossified cochlear. Amp-I/O also depends on current intensity as well typical ECAP. These results provide a useful tool for audiological evaluation for the spiral ganglion cell status to the value of pp-ECAP.

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Factors Associated Intention of Mothers regarding COVID-19 Vaccination for Elementary School Students based on the Health Belief Model (건강신념모델에 기반한 초등학생의 코로나19 예방접종에 대한 어머니의 접종의도에 영향을 미치는 요인)

  • Heo, Bang-Guel;Lee, Hyun-Ye;Kim, Jin-Ju;Jeong, Mi-Ui;Ha, Yeongmi
    • Journal of the Korean Society of School Health
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    • v.35 no.1
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    • pp.22-30
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    • 2022
  • Purpose: Based on the Health Belief Model, this study aimed to identify factors influencing on COVID-19 vaccination intention of mothers with elementary school children by examining the relationships between perceived susceptibility, perceived severity, perceived benefit, perceived barrier, cue to action, and perceived self-efficacy. Methods: Mothers with elementary school children were recruited from three elementary schools. An online survey was conducted of 130 mothers in November, 2021. Results: As a result, the factors influencing on vaccination intention were perceived self-efficacy (β=.33), perceived susceptibility (β=.18), perceived benefit (β=.16), and perceived barrier (β=-.17). Conclusion: Based on our findings, there is a need to develop a tailored nursing intervention that enhances perceived self-efficacy, perceived susceptibility and perceived benefit while decreasing perceived barrier in order to improve vaccination intention.

Improving Social Interaction Between Children With Autism Spectrum Disorder and Their Neurotypical Siblings Through a Cooperative Music Playing Intervention (자폐스펙트럼장애 아동과 비장애 형제간 상호작용 향상을 위한 협력적 악기연주 프로그램 적용 사례)

  • Jung, Jin Won
    • Journal of Music and Human Behavior
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    • v.20 no.2
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    • pp.61-88
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    • 2023
  • This case study examined whether a cooperative musical instrument playing could enhance interactions between children with autism spectrum disorder (ASD) and their neurotypical (NT) siblings. It involved three children with ASD aged 7-12 years and three NT siblings aged 6-11 years. Each group, comprising a child with ASD and their NT sibling, participated in a 40-minute sessions twice weekly for eight sessions over four weeks. The intervention included three stages: simultaneous action, complementary action, and achieving a joint goal. Evaluation criteria included the initiation and response behaviors of each child, and sequential interactive behaviors and cooperative behaviors between pairs were measured. Additionally, before and after the intervention, parents and NT sibling assessed their perceived sibling relationships. Results showed increased interactive and cooperative behaviors. Post-intervention, both parents and NT siblings rated the sibling relationship highly, despite little change in sibling conflict and competition consciousness. These findings indicate that interactive instrument playing can enhance perceptions of siblings as cooperative play partners and aid in teaching them how to collaborate during interactions.

The Development of Robot and Augmented Reality Based Contents and Instructional Model Supporting Childrens' Dramatic Play (로봇과 증강현실 기반의 유아 극놀이 콘텐츠 및 교수.학습 모형 개발)

  • Jo, Miheon;Han, Jeonghye;Hyun, Eunja
    • Journal of The Korean Association of Information Education
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    • v.17 no.4
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    • pp.421-432
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    • 2013
  • The purpose of this study is to develop contents and an instructional model that support children's dramatic play by integrating the robot and augmented reality technology. In order to support the dramatic play, the robot shows various facial expressions and actions, serves as a narrator and a sound manager, supports the simultaneous interaction by using the camera and recognizing the markers and children's motions, records children's activities as a photo and a video that can be used for further activities. The robot also uses a projector to allow children to directly interact with the video object. On the other hand, augmented reality offers a variety of character changes and props, and allows various effects of background and foreground. Also it allows natural interaction between the contents and children through the real-type interface, and provides the opportunities for the interaction between actors and audiences. Along with these, augmented reality provides an experience-based learning environment that induces a sensory immersion by allowing children to manipulate or choose the learning situation and experience the results. In addition, the instructional model supporting dramatic play consists of 4 stages(i.e., teachers' preparation, introducing and understanding a story, action plan and play, evaluation and wrapping up). At each stage, detailed activities to decide or proceed are suggested.

Inhalation of panaxadiol alleviates lung inflammation via inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells

  • Yifan Wang;Hao Wei;Zhen Song;Liqun Jiang;Mi Zhang;Xiao Lu;Wei Li;Yuqing Zhao;Lei Wu;Shuxian Li;Huijuan Shen;Qiang Shu;Yicheng Xie
    • Journal of Ginseng Research
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    • v.48 no.1
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    • pp.77-88
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    • 2024
  • Background: Lung inflammation occurs in many lung diseases, but has limited effective therapeutics. Ginseng and its derivatives have anti-inflammatory effects, but their unstable physicochemical and metabolic properties hinder their application in the treatment. Panaxadiol (PD) is a stable saponin among ginsenosides. Inhalation administration may solve these issues, and the specific mechanism of action needs to be studied. Methods: A mouse model of lung inflammation induced by lipopolysaccharide (LPS), an in vitro macrophage inflammation model, and a coculture model of epithelial cells and macrophages were used to study the effects and mechanisms of inhalation delivery of PD. Pathology and molecular assessments were used to evaluate efficacy. Transcriptome sequencing was used to screen the mechanism and target. Finally, the efficacy and mechanism were verified in a human BALF cell model. Results: Inhaled PD reduced LPS-induced lung inflammation in mice in a dose-dependent manner, including inflammatory cell infiltration, lung tissue pathology, and inflammatory factor expression. Meanwhile, the dose of inhalation was much lower than that of intragastric administration under the same therapeutic effect, which may be related to its higher bioavailability and superior pharmacokinetic parameters. Using transcriptome analysis and verification by a coculture model of macrophage and epithelial cells, we found that PD may act by inhibiting TNFA/TNFAR and IL7/IL7R signaling to reduce macrophage inflammatory factor-induced epithelial apoptosis and promote proliferation. Conclusion: PD inhalation alleviates lung inflammation and pathology by inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells. PD may be a novel drug for the clinical treatment of lung inflammation.

A Study on the Adaptation Process About Sexually Abused Children by Kin and Kith - With a Focus on the Children at the Shelter - (근친 성학대 피해 아동의 적응과정에 대한 연구 - 쉼터에서 생활하는 아동을 중심으로 -)

  • Han, In-young;Kim, Jin-sook;Park, Myung-sook;Yoo, Seo-koo
    • Korean Journal of Social Welfare Studies
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    • no.37
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    • pp.199-240
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    • 2008
  • This study set out to investigate the adaptation process and experiential structure of those children who went through sexual abuse by looking into their inner worlds in order to understand what kind of meaning sexual abuse had on them. For that, the investigator conducted in-depth interviews with 13 children aged 8~16 who lived at the shelter after experiencing sexual abuse. The methodology of Grounded Theory by Strauss and Corbin(1990) was used to analyze raw data. The analysis results indicate that the core theme of the adaptation process among the children living at the shelter after sexually abused by kin and kith was "hoping to appear the same as others." According to the results, the core phenomenon was "blaming the victims." The causal conditions include "broken families," "antihuman sexual abuse," "making sexual abuse a public issue," and "the trap of the family." The contextual conditions include "the chain named family," "family as the last fortress" and "structural enforcement of silence." The intervening strategies was "dual emotions toward the shelter." The action/interaction strategies include "aftermath of violence" and "trying to escape." The consequences were "preparation for the future" and "uncertain future." The identified stages include the confusion, keeping the secret, leaking the secret to others, intervention by others, social support and challenge and adjustment stage. The three identified types were "withdrawal and avoidance," "settling down in reality" and "overcoming and challenging." Based on the analysis results, discussions were made about the social welfare plans and intervention strategies in the conclusion.

Case Study Using Action Learning on Parent Education Program for Prospective Early Childhood Teachers (액션러닝 교수법을 적용한 예비유아교사의 부모교육 수업 사례연구)

  • Kim, Sook Ryung;Park, Jungwon
    • The Journal of the Korea Contents Association
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    • v.17 no.12
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    • pp.148-157
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    • 2017
  • This study provided an overview of how action learning runs in parents' education classes by analyzing the case of parent education program for prospective early childhood teachers. The subjects of this study were 32 pre - service teachers (30 students in early childhood education, 2 double major students) who were enrolled in the department of early childhood education at P university in Daejeon. The research was conducted theoretical and practical action learning program for 12 weeks. The data collection was organized by students preparing weekly diaries, group assignments, in-depth interview materials, colleagues and self-assessment, and analysed with the qualitative case study approach. The results of the qualitative analysis are as follows: Action learning teaching method provided opportunities to encounter diverse cases through student led and group activities. Students could experience a specific problem solving method between parents-children relationships as prospective parents. Students could have a chance to solve real-life situations that are difficult to experience in theoretical classroom situations between teachers-parents relationship as prospective teachers. Although the realization of practical knowledge of real-world conflict has been challenging, it has become a chance to have confidence with the role of parents and the role of teachers in the future.