• Advances in Traditional Medicine
• /
• 제1권2호
• /
• pp.36-44
• /
• 2000

The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities using the melanoma B-16-derived metastatic tumors were examined at dosages of 2, 5 and 10 mg/100 g. F-7 and F-8 showed the highest tumor metastatic inhibitory activities (inhibition ratio 60 and 80% in 2 mg/100 g), and in dose of 5 mg/100 g, the inhibitory ratios were 85 and 70%, respectively. Furthermore, 10 mg/100 g of intraperitoneal (i.p.) injection gave 90 and 95% of inhibition. When the effects of polysaccharides on hypersensitivity were examined, the inhibitory activities were not markedly observed in oral administration, indicating that the polysaccharides are directly acting to immune system. Also, the polysaccharides increased the number of circulating blood leukocytes and total peritoneal exudate cells. Although implantation of tumor cells greatly decreased the productivity of antibody (antibody-mediated) and T lymphocyte reactivity (delayed-type) as 6.3 from 9.3 and 5.9 from 7.7, represented by the increase of footpad thickness, respectively. the polysaccharides elevated the reactivity of T lymphocyte in tumor-bearing mice, which were rapidly recovered by discontinuance of sample treatments. Especially, F-2, F-5, F-7 and F-8 remarkably recovered the decreased sensitivity. These results clearly indicated that the i.p. injection is much effective to suppress tumor growth than oral administration.

• Molecules and Cells
• /
• 제20권1호
• /
• pp.83-89
• /
• 2005

HtrA2/Omi is a mammalian mitochondrial serine protease homologous to the E. coli HtrA/DegP gene products. Recently, HtrA2/Omi was found to have a dual role in mammalian cells, acting as an apoptosis-inducing protein and being involved in maintenance of mitochondrial homeostasis. By screening a human brain cDNA library with $A{\beta}$ peptide as bait in a yeast two-hybrid system, we identified HtrA2/Omi as a binding partner of $A{\beta}$ peptide. The interaction between $A{\beta}$ peptide and HtrA2/Omi was confirmed by an immunoblot binding assay. The possible involvement of HtrA2/Omi in $A{\beta}$ peptide metabolism was investigated. In vitro peptide cleavage assays showed that HtrA2/Omi did not directly promote the production of $A{\beta}$ peptide at the ${\beta}/{\gamma}$-secretase level, or the degradation of $A{\beta}$ peptide. However, overexpression of HtrA2/Omi in K269 cells decreased the production of $A{\beta}40$ and $A{\beta}42$ by up to 30%. These results rule out the involvement of HtrA2/Omi in the etiology of Alzheimer's disease. However, the fact that overexpression of HtrA2/Omi reduces the generation of $A{\beta}40$ and $A{\beta}42$ suggests that it may play some positive role in mammalian cells.

• 한국추진공학회지
• /
• 제13권3호
• /
• pp.41-49
• /
• 2009

본 논문은 공기흡입식 추진기관의 고체 로켓 부스터 분리에 관한 수학적 모델링과 시뮬레이션 기법을 기술하였다. 비행체 및 부스터는 하나의 다물체(multi-body)로 고려하였고 부스터는 단지 비행체의 축 방향으로 움직이는 것으로 가정하였다. 비행체 및 부스터의 동적 운동은 Kane 방법에 의해 모델링 되었다. 다양한 부스터 위치에 따라 전체 시스템에 작용하는 공력은 DATCOM 소프트웨어를 사용하여 산출되었으며 부스터 분리 유효 작용면에 작용하는 내부 분리 압력은 일반적인 기체역학 및 Taylor-MacColl 관계식에 의해 산출되었다. 수치적 해석은 Mathworks사의 Matlab이 사용되었다. 해석 결과에 의하면 부스터 분리 동안 마하수 및 받음각 변화 등은 크지 않는 것으로 나타났으며, 실제 시험 장치를 이용한 부스터 분리 시험이 진행될 경우 자세 각 변화, 흡입 유동 특성 등은 무시할 만한 수치임을 확인할 수 있었다.

• 한국항공우주학회지
• /
• 제41권1호
• /
• pp.25-30
• /
• 2013

집적형 하이브리드 구동장치는 적층형 압전재료(압전스택)를 이용한 마이크로 펌프에서 토출되는 유체로 피스톤을 구동시키는데 크기는 작으면서도 큰 구동력과 높은 속도를 동시에 출력할 수 있는 새로운 개념의 통합 구동장치로서 현재 소형화 및 고출력을 요구하는 항공 우주, 유도무기 등 다양한 분야에서 광범위하게 연구되고 있다. 본 연구에서는 이러한 하이브리드 구동장치의 구동원리 및 성능 시험에 대해 소개하였다. 우선 구동장치의 주 동력인 압전 스택의 성능 시험을 수행함으로써 압전 스택의 구동전력과 구동시간에 따른 성능 변화를 관찰하였고 다음 구동장치의 성능 시험을 통해 구동장치의 최대 이송속도와 최대 구동력을 측정하였다. 구동장치의 최대 이송속도는 53.3 mm/s로, 최대 구동력은 240.7 N으로, 최대 일률은 3.2 W로 측정되었다.

• 자원환경지질
• /
• 제9권2호
• /
• pp.85-106
• /
• 1976

The Bulgugsa acidic igneous rocks of the late Cretaceous age are largely distributed in Busan area, which is located in the southeastern corner of the Korean Peninsula. These igneous rocks comprise in ascending order, felsite, dacitic-rhyolitic welded tuffs, granite porphyry and granitic rocks. The former three members represent the early phase of volcanic activities, so that they are named as Jangsan volcanic rocks. The granitic rocks consist of granodiorite, hornblende biotite granite, Kumjongsan granite, fine grained granite, and Daebyen granite, represent the late phase of igneous activities. The Kumjongsan grainte, the largest pluton of the granitic mass, emplaced between two great vertical faults trending NNE. New chemical analyses of 33 rock samples of these acidic rocks are given. Their chemical compositions are generally similar to those of the late Mesozoic acidic igneous rocks of the northern Ashio mountains, and C-Zone granite group of the Ogcheon geosyncline, with their characteristic variation trends of several oxides. Their chemical compositions also show that $Al_2O_3$ is high value, and differentiation index is high, too. Systematically developing joints in Kumjungsan granite are divisible into two types at least. One is the NS-N $20^{\circ}E$ trendirig, $85^{\circ}{\sim}90^{\circ}$ dipping type of joint system which coincides with the trends of distribution of the granite mass and the dikes intruding this granite. Joints of this type may be cooling joints generated as tension cracks. The other is the $N60^{\circ}{\sim}70^{\circ}W$ or $N40^{\circ}{\sim}60^{\circ}E$ trending type of joint systems. It is considered that. joints belonging to this type may be shear joint occurring under the state of south-north tectonic couple acting at the east and west side of the granite mass. Igneous activities of the the Bulgugsa acidic igneous rocks in Busan area was taken place as. follows, formation of the magma reservoir, eruption and intrusion of felsite, consolidation of vents. and increasing vapor pressure in magma reservoir, eruption of pyroclastic flows, caldera collapse, intrusion of granite porphyry, and intrusion of granitic rocks at the latest stage.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2003년도 ICCAS
• /
• pp.1625-1628
• /
• 2003

Recently the VR technique has evolved into a mixed reality (MR) technique, in which a user can observe a real world in front of him/her as well as virtual objects displayed. This has been realized by the employment of a see-through type HMD (S-HMD). We have been developing a mixed reality space employing the MR technique. The objective of our study is to realize a virtual human that acts as a man-machine interface in the real space. It is important in the study to create a virtual human acting naturally in front of a user. In order to give natural motions to the virtual human, we employ a developed motion capture technique. We have already created various 3-D human motion models by the motion capture technique. In this paper, we present a technique for creating a virtual human using a human model provided by a computer graphics software, 3D Studio Max(C). The main difficulty of this issue is that 3D Studio Max(C) claims 28 feature points for describing a human motion, but the used motion capture system assumes less number of feature points. Therefore a technique is proposed in the paper for producing motion data of 28 feature points from the motion data of less number of feature points or from incomplete motion data. Performance of the proposed technique was examined by observing visually the demonstration of some motions of a created virtual human and overall natural motions were realized.

• Steel and Composite Structures
• /
• 제37권3호
• /
• pp.291-306
• /
• 2020

The noise from the elevated lines of rail transit has become a growing problem. This paper presents a new method for the rapid prediction of the structure-borne noise from steel or composite bridges, based on the receptance and Statistical Energy Analysis (SEA), which is essential to the study of the generation mechanism and the design of a low-noise bridge. First, the vertical track-bridge coupled vibration equations in the frequency domain are constructed by simplifying the rail and the bridge as an infinite Timoshenko beam and a finite Euler-Bernoulli beam respectively. Second, all wheel/rail forces acting upon the track are computed by taking a moving wheel-rail roughness spectrum as the excitation to the train-track-bridge system. The displacements of rail and bridge are obtained by substituting wheel/rail forces into the track-bridge coupled vibration equations, and all spring forces on the bridge are calculated by multiplying the stiffness by the deformation of each spring. Then, the input power to the bridge in the SEA model is derived from spring forces and the bridge receptance. The vibration response of the bridge is derived from the solution to the power balance equations of the bridge, and then the structure-borne noise from the bridge is obtained. Finally, a tri-span continuous steel-concrete composite bridge is taken as a numerical example, and the theoretical calculations in terms of the vibration and noise induced by a passing train agree well with the field measurements, verifying the method. The influence of various factors on wheel/rail and spring forces is investigated to simplify the train-track-bridge interaction calculation for predicting the vibration and noise from steel or composite bridges.

• Wind and Structures
• /
• 제10권4호
• /
• pp.301-314
• /
• 2007

The lever-type active multiple tuned mass dampers (LT-AMTMD), consisting of several lever-type active tuned mass dampers (LT-ATMD), is proposed in this paper to attenuate the vibrations of long-span bridges under the excitation directly acting on the structure, rather than through the base. With resorting to the derived analytical-expressions for the dynamic magnification factors of the LT-AMTMD structure system, the performance assessment then is conducted on the LT-AMTMD with the identical stiffness and damping coefficient but unequal mass. Numerical results indicate that the LT-AMTMD with the actuator set at the mass block can provide better effectiveness in reducing the vibrations of long-span bridges compared to the LT-AMTMD with the actuator set at other locations. An appealing feature of the LT-AMTMD with the actuator set at the mass block is that the static stretching of the spring may be freely adjusted in accordance with the practical requirements through changing the location of the support within the viable range while maintaining the same performance (including the same stroke displacement). Likewise, it is shown that the LT-AMTMD with the actuator set at the mass block can further ameliorate the performance of the lever-type multiple tuned mass dampers (LT-MTMD) and has higher effectiveness than a single lever-type active tuned mass damper (LT-ATMD). Therefore, the LT-AMTMD with the actuator set at the mass block may be a better means of suppressing the vibrations of long-span bridges with the consequence of not requiring the large static stretching of the spring and possessing a desirable robustness.

• The Korean Journal of Physiology and Pharmacology
• /
• 제5권4호
• /
• pp.333-342
• /
• 2001

Adriamycin is a commonly used chemotherapeutic agent for cancer, including acute leukemia, lymphoma, and a number of solid human tumors. However, recent studies have recognized severe cardiotoxicity after an acute dose, which are likely the result of generation of free radicals and lipid peroxidation. Therefore, the clinical uses of adriamycin have been limited. Melatonin, the pineal gland hormone known for its ability to modulate circardian rhythm, has recently been studied in its several functions, including cancer growth inhibition, stimulating the immune system, and acting as an antioxidant and radical scavenging effects. In the present study, we evaluated the effect of melatonin administration on adriamycin-induced cardiotoxicity in rat. Heart slices were prepared using a Stadie-Riggs microtome for the measurement of malondialdehyde (MDA) content used as an index of lipid peroxidation and lactate dehydrogenase (LDH) release as an indicator of lethal cell injury. Serious adriamycin-induced lethality was observed in rat by a single intraperitoneal injection in a dose-dependent manner. A single injection of adriamycin (25 mg/kg, i.p.) induced a lethality rate of 86%, with melatonin (10 mg/kg s.c. for 6 days) treatment reducing the adriamycin-induced lethality rate to 20%. The severe body weight loss caused by adriamycin was also significantly attenuated by melatonin treatment. Treatment of melatonin marked reduced adriamycin-induced the levels of MDA formation and LDH release. A cell damage indicated by the loss of myofibrils, swelling of the mitochondria as well as cytoplasmic vacuolization was seen in adriamycin-treated group. Melatonin attenuated the adriamycin-induced structural alterations. These data provide evidence that melatonin prevents adriamycin-induced cardiotoxicity and might serve as a combination with adriamycin to limit free radical-mediated cardiotoxicity.

• 복식
• /
• 제58권8호
• /
• pp.91-105
• /
• 2008

Spatial multiplication phenomenon, expressed through de-constructive trend since the late of 20C, have got changed existing fixed and dis-variable space to smooth, fluid, and changeable space. Ex-form and fluidity of new spatial paradigm have been focused through lots of scientific theories studied between digital thought and indeterminacy and rankless nature phenomena. In 21C fashion, indeterminate and irregular form and space have been crested continuously, which could not explain simply according as the fluidity theory Different from the space crested for multi-function and multipurpose, this is revealed the characteristics of chaosmos that communizes the order and the disorder, deconstruction and creation. Ex-formal space of fashion have shown the relationship of de-centerizing, de-territorial, and do-structural phenomenon among different fashion elements. This paper intends to understand the concept of ex-form, and study expressive manners of ex-formal space of 21C fashion, and conclusion as follows. 1) Overlap changes single space of fashion to multi-layered space through the repeat system of pleats, origami, and folding. 2) Ex-gravity expressed in deviation of the gravity acting vertical direction, for example, twisting, curve, winding, portion. 3) Morphing is shown the change process from single fixed form to different complex form. 4) Blurring is expressed in re-combination and re-arrangement among elements of fashion. 5) Blob shows hybrid fashion space through the liberal compounding and separation of a lot of different elements.