HtrA2 Interacts with Aβ Peptide but Does Not Directly Alter Its Production or Degradation
![]() |
Liu, Meng-Lu
(Department of Microbiology and Research Center for Industrial Development of Biofood Materials, Chonbuk National University Medical School)
Liu, Ming-Jie (Department of Microbiology and Research Center for Industrial Development of Biofood Materials, Chonbuk National University Medical School) Kim, Jin-Man (Department of Microbiology and Research Center for Industrial Development of Biofood Materials, Chonbuk National University Medical School) Kim, Hyeon-Jin (Jinis Biopharmaceuticals Company) Kim, Jeong-Hak (Jinis Biopharmaceuticals Company) Hong, Seong-Tshool (Department of Microbiology and Research Center for Industrial Development of Biofood Materials, Chonbuk National University Medical School) |
1 | Faccio, L., Fusco, C., Chen, A., Martinotti, S., Bonventre, J. V., et al. (2000) Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J. Biol. Chem. 275, 2581-2588 DOI ScienceOn |
2 | Fraering, P. C., Ye, W., Strub, J. M., Dolios, G., LaVoie, M. J., et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43, 9774-9789 DOI ScienceOn |
3 | Kim, H. J., Kim, H. J., Lim, S. C., Kim, S. H., and Kim, T. Y. (2003) Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells. Mol. Cells 16, 331-337 |
4 | Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., et al. (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. USA 96, 3922-3927 |
5 | Martins, L. M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N. F., et al. (2002) The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaperlike motif. J. Biol. Chem. 277, 439-444 DOI ScienceOn |
6 | Park, H. J., Seong, Y. M., Choi, J. Y., Kang, S., and Rhim, H. (2004) Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi. Neurosci. Lett. 357, 63-67 DOI ScienceOn |
7 | Selkoe, D. J. (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 (Suppl. 6738), A23-31 DOI ScienceOn |
8 | Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., et al. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540 DOI ScienceOn |
9 | Yang, Q. H., Church-Hajduk, R., Ren, J., Newton, M. L., and Du, C. (2003) Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev. 17, 1487-1496 DOI ScienceOn |
10 | Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K., et al. (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8, 613-621 DOI ScienceOn |
11 | Spiess, C., Beil, A., and Ehrmann, M. (1999) A temperaturedependent switch from chaperone to protease in a widely conserved heat shock protein. Cell 97, 339-347 DOI ScienceOn |
12 | Gong, Y. S., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., et al. (2003) Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. USA 100, 10417-11422 |
13 | Hansson, C. A., Frykman, S., Farmery, M. R., Tjernberg, L. O., Nilsberth, C., et al. (2004) Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J. Biol. Chem. 279, 51654-51660 DOI ScienceOn |
14 | Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., et al. (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14, 419-427 DOI ScienceOn |
15 | Vaux, D. L. and Silke, J. (2003) HtrA2/Omi, a sheep in Wolf's clothing. Cell 115, 251-253 DOI ScienceOn |
16 | Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533- 537 DOI ScienceOn |
17 | Martins, L. M., Turk, B. E., Cowling, V., Borg, A., Jarrell, E. T., et al. (2003) Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. J. Biol. Chem. 278, 49417-49427 DOI ScienceOn |
18 | van Loo, G., van Gurp, M., Depuydt, B., Srinivasula, S. M., Rodriguez, I., et al. (2002) The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 9, 20-26 DOI |
19 | Cilenti, L., Lee, Y., Hess, S., Srinivasula, S., Park, K. M., et al. (2003) Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J. Biol. Chem. 278, 11489-11494 DOI ScienceOn |
20 | De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., et al. (1999) A presenilin-1-dependent gamma-secretaselike protease mediates release of Notch intracellular domain. Nature 398, 518-522 DOI ScienceOn |
21 | Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407, 48-54 DOI ScienceOn |
22 | Gray, C. W., Ward, R. V., Karran, E., Turconi, S., Rowles, A., et al. (2000) Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur. J. Biochem. 267, 5699-5710 DOI ScienceOn |
23 | Hooper, N. M. and Turner, A. J. (2002) The search for alphasecretase and its potential as a therapeutic approach to Alzheimer's disease. Curr. Med. Chem. 9, 1107-1119 ScienceOn |
24 | Savopoulos, J. W., Carter, P. S., Turconi, S., Pettman, G. R., Karran, E. H., et al. (2000) Expression, purification, and functional analysis of the human serine protease HtrA2. Protein Exp. Purif. 19, 227-234 DOI ScienceOn |
25 | Gupta, S., Singh, R., Datta, P., Zhang, Z., Orr, C., et al. (2004) The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity. J. Biol. Chem. 279, 45844-45854 DOI ScienceOn |
26 | Hegde, R., Srinivasula, S. M., Zhang, Z., Wassell, R., Mukattash, R., et al. (2002) Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277, 432-438 DOI ScienceOn |
27 | Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., et al. (2003) The role of presenilin cofactors in the gammasecretase complex. Nature 422, 438-441 DOI ScienceOn |
28 | Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24, 9848-9862 DOI ScienceOn |
29 | Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 DOI ScienceOn |
30 | Verhagen, A. M., Silke, J., Ekert, P. G., Pakusch, M., Kaufmann, H., et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277, 445-454 DOI ScienceOn |
31 | Yan, S. D., Fu, J., Soto, C., Chen, X., Zhu, H., et al. (1997) An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature 389, 689-695 DOI ScienceOn |
32 | Jones, J. M., Datta, P., Srinivasula, S. M., Ji, W., Gupta, S., et al. (2003) Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425, 721–727 DOI ScienceOn |
![]() |