• Korean Journal of Pharmacognosy
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• v.18 no.2
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• pp.103-106
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• 1987

Two diterpene alkaloids were isolated from Aconitum napiforme which is a native plant in Korea, and identified as hypaconitine and mesaconitine by UV, IR, MS and NMR data.

• Korean Journal of Pharmacognosy
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• v.33 no.3 s.130
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• pp.157-168
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• 2002

Aconites distribute widely in northern hemispere of the earth reaching to arctic zone from warm and temperate one. Chinese crude drug 'Cho O'(草烏) has been used as a remedy for apoplexy, dyspepsia, neuralgia, chronic rheumatis etc. Though the botanical origin of the crude drug has been considered to be Aconitum species of Ranunculaceae, there has been no confirmation on it. To clarify the botanical origin of Cho O, the morphological and anatomical characteristics of the roots of Aconitum species growing in Korea, i.e. A. chiisanense, A. ciliare, A. jaluense, A. napiforme, A. proliferum, A. pseudoproliferum and A. triphyllum were studied. As the result, Cho O was proved to be the roots of Aconitum triphyllum, A. jaluense, A. chiisanense and A. napiforme.

• Korean Journal of Pharmacognosy
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• v.25 no.4 s.99
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• pp.395-398
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• 1994

A diterpene alkaloid in addition to hypaconitine and mesaconitine was isolated from the tubers of Aconitum napiforme (Ranunculaceae), which is an indigenous plant in Korea. Its structure was elucidated as 8-methoxy 14-benzoyl hypaconine by Physicochemical and spectroscopic data. This compound was isolated from this plant for the first time.

• Korean Journal of Plant Taxonomy
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• v.41 no.3
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• pp.215-222
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• 2011

Various aneuploidy and polyploidy have been reported in the genus Aconitum L. (ca. 300 species worldwide, Ranunculaceae), and there is a demonstrated association between major lineage diversification and polyploidy. This study reports chromosome counts of eight Aconitum from Korea, including the first counts for A. japonicum Thunb. subsp. napiforme ($H. L{\acute{e}}v.$ & Vaniot) Kadota (2n = 32) and A. longecassidatum Nakai (2n = 16). The study also includes chromosome numbers for two taxa on the Critically Endangered species list in Korea. Among Korean native species, chromosome numbers in Aconitum subgenus Aconitum range from 2n = 16 to 2n = 64 with diverse levels of polyploidy (2x, 4x, and 8x), whereas Aconitum subg. Lycoctonum exhibits only diploids (2n = 16). Greater chromosome number diversity in subg. Aconitum than subg. Lycoctonum might explain higher species diversity within the former subgenus (more than 250 species worldwide). Investigating chromosome number diversity of Aconitum in a phylogenetic framework will be a critical step to understand species richness of the genus.

• Korean Journal of Plant Taxonomy
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• v.31 no.4
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• pp.343-358
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• 2001

We have examined the pedicel pubescence and other major morphological characters of 11 putative hybrid populations of Aconitum subgn. Aconitum at Mt. Sobaek to understand their origin. These populations show very complicated patterns of variation in pedicel pubescence ; they contain individuals having pedicels (1) completely glabrous, (2) with few micropapillate curved hairs near the receptacle, (3) moderately pubescent with micropapillate curved hairs from middle to upper portion, (4) sparsely pubescent with a mixture of micropapillate curved hairs and smooth-surfaced spreading glandular hairs near the receptacle, and (5) moderately pubescent with both types of hairs but from middle to upper portion. All five types of individuals co-occur in most populations with varying proportions. These results, in conjunction with evidence from the analysis of other major morphological characters, suggest that the populations at Mt. Sobaek were derived from the multiple hybridization events involving A. kusnezoffii, A. japonicum subsup. napiforme, and A. jaluense subsp. jaluense. In addition, the absence of "typical" forms of these putative parental taxa in Mt. Sobaek area suggests that repeated introgression has probably occurred in these populations.

• Journal of Plant Biology
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• v.25 no.4
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• pp.175-180
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• 1982

This paper is proposed to describe three new species and four varieties from Cheju Island to central part of Korea in Southern Korea. The new plant taxa are as follows: clematis taeguensis Y. Lee, sp. nov.; Prunus linearipetalus Y. Lee, sp. nov.; Vicia linearifolia Y. Lee, sp. nov.; Clematis brachyura Maxim. var. hexasepala Y. Lee, var. nov.; Ranunculus quelpaertensis(Lev.) Nakai var. albiflorus Y. Lee, var. nov.; Aconitum napiforme Lev. et Vaniot var. albiflorum Y. Lee, var. nov.; Ajuga decumbens Thunb. var. rosa Y. Lee, var. nov.

• Korean Journal of Environment and Ecology
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• v.26 no.5
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• pp.635-653
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• 2012

Vascular plants of Oruem in region of Jeju-City were investigated 454 taxa totally; 116 families, 301 genera, 359 species, 3 subspecies, 78 varieties and 14 forms. In the studied Oruems in region of Jeju-City within altitude 800m, evergreen tree forests does not range and a lot of Pines thunbergii forest and Cryptomeria japonica and Chamaecyparis obtusa plantation forest were. The endemic species of Oruem in region of Jeju-City were 14 taxa such as Asarum maculatum, Hepatica insularis, Cardamine glechomifolia etc. The floristics degree categorized by the specific distribution of plant species were total 116 Taxa, that is, V grade species Magnolia kobus, Aconitum japonicum subsp. napiforme, Ligularia taquetii etc, 6 kinds be, IV grade species Rubus ribisoideus, Ligustrum salicinum, Carex macrandrolepis etc, 16 kinds be, III grade species Illicium anisatum, Hydrangea petiolaris, Rubus schizostylus etc, 37 kinds be, II grade species Pseudostellaria coreana, potentilla dickinsii, Euonymus pauciflorus etc, 6 kinds and I grade species Sphenomeris chinensis, Pteris multifida, Machilus thunbergii etc, be. 51 kinds were confirmed. Rare and Endemic Plant Species of Korea Forest Service were 11 taxa such as Asarum maculatum, Aconitum japonicum subsp. napiforme and Magnolia kobus etc. Naturalized plant were confirmed 31 taxons with Rumex acetosella, Hypochaeris radicata and Sisyrinchium atlanticum etc.

• Korean Journal of Medicinal Crop Science
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• v.25 no.4
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• pp.231-237
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• 2017

Background: Cisplatin is one of the most extensively used chemotherapeutic agents for the treatment of cancer, including bladder, and ovarian cancers. However, it has been shown to induce nephrotoxicity, despite being an outstanding anti-cancer drug. In this study, we investigated the protective effect of dopaol ${\beta}$-D-glucoside (dopaol) on cisplatin-induced nephrotoxicity. Methods and Results: To confirm the protective effect of dopaol on cisplatin-induced nephrotoxicity, HK-2 cells were treated with $20{\mu}M$ cisplatin and $80{\mu}M$ dopaol. Cisplatin increased apoptosis, caspase-3 activity and mitochondrial dysfunction; however pretreatment with $80{\mu}M$ dopaol successfully attenuated apoptosis, caspase-3 activity and mitochondrial dysfunction. To evaluate the protective effect dopaol on cisplatin-induced nephrotoxicity in vivo, we used an animal model (balb/c mice, 20 mg/kg, i.p. once/day for 3 day). The results were similar to those obtained using HK-2 cells; renal tubular damage and neutrophilia induced by cisplatin reduced following dopaol injection (10 mg/kg, i.p. once/day for 3 day). Conclusions: These results indicate that dopaol treatment reduced cisplatin-induced nephrotoxicity in vitro and in vivo, and can be used to treat cisplatin-induced nephrotoxicity. However, further studies are required to determine the toxicity high dose dopaol and the signal pathways involved in its mechanism of action in animal models.