• 한방안이비인후피부과학회지
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• 제21권1호
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• pp.113-120
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• 2008

Objective : The purpose of this study was to explore the correlation between efficacy and various factors of the acne patients. Method : We reviewed 30 acne patients who visited Allergy/Derma-cosmetic Clinic at Kyung Hee Neo Medical Center from June, 2006 to December, 2007 and were treated with herbal medicine and acupuncture for 4 weeks. We investigated premenstrual aggravation of acne, facial burning sensation, constipation, Heart Rate Variability(HRV) results and regional distribution of acne. And we evaluated inflammatory acnes according to the Korean Acne Grading System(KAGS). Results & Conclusions : 1. The average age of total patients was 23.0 years old. The most frequent age group was 21-25 years old. Patients evaluated as KAGS Grade 2 were most common. 2. In total patients, inflammatory acne were reduced significantly after 4 weeks of treatment. 3. The result of analysis on premenstrual aggravation of acne, facial burning sensation and constipation, there weren't any difference of treatment results on statistical meaning. 4. The results show that there were significant correlations between the Low Frequency at HRV and the rate of acne reduction. (Pearson correlation = -0.565) 5. If the distribution of acne did not involve the T-zone of the face, chest, or back of the body, inflammatory acne were significantly decreased after 4 weeks of treatment.

• 산업진흥연구
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• 제8권1호
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• pp.1-10
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• 2023

본 연구는 밀배아 추출물을 이용하여 여드름성 피부 개선용 원료를 개발하고자 포뮬라 (EJ-F101)를 제작하여 이를 이용하여 임상시험용 크림을 제조하였으며 임상실험 진행하였다. 분석 결과, 제품 사용 전·후 비교 시제품 사용 4주 후 시점에서 시험군과 대조군 모두 안면 부위의 병변 개방면포, 폐쇄면포 구진 피지 및 유분량 항목에 대해 유의한 개선 효과를 보였고, 대조군에 비해 시험군에서 좀 더 유의한 개선 효과를 보였다. 제품의 효능에 대한 설문 결과, 대부분 항목에서 제품 사용 4주 후 시점에서 대조 제품에 비해 시험제품에서 긍정적인 답변이 높게 나타났으며, '개방 면포' 항목을 제외하고 시험제품은 약 43~81%의 연구대상자가 긍정적으로 답변하였다. 또한, 제품의 사용성에 관한 모든 항목에 대해 제품 사용 4주 후 시점에서 시험군은 약 14~86%, 대조군은 약 38~90%의 연구 대상자가 긍정적으로 답변하였다. 피부 안전성 평가 결과, 본 모든 연구대상자에게서 피부 이상반응은 관찰되지 않았다. 위와 같은 결과를 근거로 밀배아 추출물을 이용한 크림은 여드름성 피부에 사용하기 적합(non comedogenicity) 한 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.251-268
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• 1998

125 Cases of Acne were treated by Acupuncture and Herb-med treatment during a three months duration from April 1996 to February 1998 in Kyung Hee Univ. Department of Ophthal, Otolaryngology. College of Oriental Medicine. We have observed the cases and the results as follows: 1. The age of average was 24.55 age : 21.91 in males, 24.55 in females. and in these, the gulf between males and females were showed statically significant diference. In the age of onset, averag was 16.96 age and mode was 18 age and male's average was 16.96 age, minimun was 11 age, maximum 40 age and female's average was 20.14 age, minimun was 10 age, maximum 40 age. and these were showed statically significant diference between males and females. 2. In the distribution of season, winter was the most with $37.8\%$ of out patients, the rest was similar to difference of each other. but there was clear difference between males and females. 3. In the duration of history, the average was 5.10 years and male's average was 5.13 years. on the other hand female's was 5.09 years but there is no any significant difference have a resemblance with each other. 4. In blood type, O type was the most with $35.20\%$ and there was in the order of A type was $26.40\%\;B\;type\;was\;23.20\%,\;AB\;type\;was\;15.20\%$ but these were not significant difference by the chi-tend and analysis of variance with total cases, males and females. 5. In select of the preference food, patients of the prefer worm food was $42.40\%\;and\;cool\;food\;was\;38.40\%,\;tepid\;food\;was\;24\%$ but these were no significant difference by the chi-test and ANOVA of each other. 6. the state of pulse classified into 11 type and average was 7.2 times, maximum was 29 times with Hyun Sae, at the same time, the female's average was 6.73 times, maximum was 27 times and male's average was 1.5 times. The result of test with each other, these were showed statically significant difference as compared total cases with males but there were not females ones. 7. In the frequency of the major cause, oversensitiveness was the most with $34.93\%$. secondly there was in order of indigestion $30.82\%$ and menstrual irregularity and menstruation pain $23.28\%$. constipation $10.96\%$ and these showed statically significant difference as compared the females with males on the result of test for difference with each other. 8. In frequency of the symptoms, itching was the most with $31.97\%$ and there was in order of nodule $20.49\%$, pustule $18.85\%,\;papule\;15.58\%,\;flare\;13.12\%$ and also these showed statically significant difference as compared the females with males 9. for the Distribution of acne region, face was the most with $64.06\%$ and there was in order of back $14.29\%,\;upper-chest\;11.69\%,\;neck\;7.79\%$ and there was no significant difference as compared total cases with males and females. 10. Acne applied 30 prescription to 4 weeks and over and 20 weeks and over was $23.3\%$, 30 weeks and over was $16.67\%$ and average of administration duration were 4.2 weeks(male's average 5.78, maximum 96 weeks and female's average 3.85, maximum 23 weeks) maximum was 96 weeks, minimum was 1 week. 11. In the acupuncture treatment, $96.6\%$ applied to acupuncture and average was 5.44 times, maximum 46 times, minimum 1 time(male's average 4.64, female's 5.62) but these were not any significant differeence. 12. for the medication, author made a investigation and comparison between control group with treated group in order to observe for the therapeutic effect during the 1 month and 2, 3. From these results, we can see that acne was improved by the oriental treatment. in the 1 month, average of control group was 13.24 and treated group was 11.78. these showed statically significant decrease in P<0.02 as compared the treated group with control group. In the 2 months, average of control group was 13.43 and treated group was 9.03. these showed statically significant decrease in P<0.003 as compared the treated group with control group. In the 3 months, average of control group was 13.78 and treated group was 8.06. these showed statically significant decrease in P<0.008 as compared the treated group with control group.

• International Journal of Industrial Entomology and Biomaterials
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• 제31권1호
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• pp.14-19
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• 2015

In a previous report, we identified several candidate antimicrobial peptides through de novo RNA sequencing of the centipede Scolopendra subspinipes mutilans. Here, we identify and characterize one of these peptides, Scolopendrasin I. We identified the centipede antimicrobial peptide Cecropin from the centipede transcriptome using an SVM algorithm, and subsequently analyzed the amino acid sequence for predicted secondary structure using a GOR algorithm. We identified an alpha helical region of Cecropin and named it Scolopendrasin I. We then assessed antimicrobial and hemolytic activity of Scolopendrasin I. Scolopendrasin I showed antimicrobial activity against various microbes, including antibiotic-resistant Gram-negative bacteria, in a radial diffusion assay. Scolopendrasin I had potent antibacterial activity against acne-associated microbes in a colony count assay and showed no hemolytic activity in a hemolysis assay. In addition, we confirmed that Scolopendrasin I bound to the surface of bacteria via a specific interaction with lipoteichoic acid and lipopolysaccharide, two components of bacterial cell membranes. In conclusion, the results presented here provide evidence that this is an efficient strategy for antimicrobial peptide candidate identification and that Scolopendrasin I has potential for successful antibiotic development.

• Archives of Plastic Surgery
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• 제39권1호
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• pp.63-66
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• 2012

Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a $12.5{\times}10cm$ lobulated mass on the posterior neck and upper back. The patient had a widespread presence of nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

• 한방안이비인후피부과학회지
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• 제13권1호
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• pp.280-290
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• 2000

We analyzed statistics study in 1695 patients, who had visited to the Dept. of surgery, ophthalmology & otolaryngology Hospital of Downtown Orirental Medicine Kyung Hee University from March, 1996 to July, 1998. The results were as follows. 1. Distribution of ophthalmology, otolaryngology and dermatology classification was $43.48\%\;in\;ophthalmology,\;16.70\%\;in\;rhinology,\;5.72\%\;in\;laryngology,\;17.94\%\;in\;dermatology\;and\;16.17\%$ in otiatrics. 2. Ophthalmology group were $31.93\%$ males and $47.90\%$ females in 10 years old within. In treatment term, opthalmology patients who had treated for 1 month within was $59.70\%$. Strabismus and visual disorder was the most common ophthalmo-disease. 3. Rhinology group were $30.00\%$ males in 10 years old within and $21.56\%$ females in 21-30years old. In treatmentm, rhinology patients who had treated for 1 month within was $53.71\%$. Rhinitis and sinusitis was the most common rhinio-disease. 4. Otiatrics group were $30.54\%$ males in 41-50 years old and $31.78\%$ females in 51-60 years old. In treatment term, otiatries patients who had treated for 1 month within was $53.28\%$. Tinnitus, hearing loss and otitis media was the most common otiatrics-disease. 5. Laryngology group were $29.27\%$ males in 31-40 years old and $28.57\%$ females in 51-60 years old. In treatment term. Laryngology patients who had treated for 1 month within was $91.75\%$ Epipharyngitis and abnormal sensation pharyngolarylgeal region was the most common laryngo-disease. 6. Dermatology group were $39.82\%$ males and $39.79\%$ females in 21-30 years old. In treatment term, dematology patients who had treated for 1 month within was $83.55\%$. Acne and Pruritus was the most common ophthalmo-disease.

• Journal of Korean Biological Nursing Science
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• 제2권2호
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• pp.20-37
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• 2000

The purpose of this study was to investigate the relationships between the differentials in life styles and their effect on the epidermal facial tissue in order to provide a basis for health professionals so that they might better be able to maintain and promote healthy skin care and further delay the premature ageing of the epidermal facial tissue. The subjects consisted of 145 females of various ages who visited skin care room in cerming health promoting behaviors(Park In sook's Profile) and questions on their behavioral practices pertaining to personal skin care were used. The investigation also ess of the four parts of the epidermal facial tissue studied. All data collected wee entered into the SAS program and analyzed for frequency, percentages, the utilized Pusan. The study dates ranged from May 1, 1998 to May 30, 1998. The methods used for this investigation were a questionnaire survey consisting of general objective questions. The questions con a "skin analyzer" to measured levels of moisturizing hydrated, facial oils, and roughnmean, t-test, ANOVA, and Pearson Correlation Coefficients. The results of this study were as follows ; 1. Epidermal facial oil was at its highest levels in the chin area with additional decreasing levels in the forehead and nose regions. The least regions were those of the cheeks. The highest levels of hydration on the other hand started with the forehead followed by the area of the chin, the cheeks and the lowest level of epidermal facial hydration was in the region of the nose. 2. The average score of the performance in the health promoting behaviors variable was 139.51. The variables with the highest degree of the performance were rest and sleeping(35.71). The lowest degree was hiegenic life(23.44). 3. The relationship health promoting behaviors and epidermal condition was not correlated with oil, hydration and roughness of the skin surface. 4. Skin care behavioral characteristics related to epidermal condition were washing style and temperature of washing water. 5. General characteristics related to epidermal condition were occupation, education level, acne and melasma. In conclusion, this study showed that several factors were significant in the behavior of skin care. Clear knowledge of both internal and external factors which affect the epidermal condition will help women to pursue active and appropriate practices in their health behaviors and skin care.

• 한방안이비인후피부과학회지
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• 제18권2호
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• pp.51-61
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• 2005

We analyzed statistics study in 1394 patients, who had visited to the Dept. of dermatology, ophthalmology & otorhinolaryngology Hospital of Oriental Medicine Sangji University from July, 2003 to December, 2004. The results were as follows. 1. Distribution of ophthalmology, otorhinolaryngology and dermatology classification was 14.23% in ophthalmology, 13.92% in rhinology, 4.79% in laryngology, 23.05% in dermatology, 8.25% in otology, 2.14% in stomatology and 33.63% in other. 2. Ophthalmology group were 12.39% males and 14.16% females in 61years old over. In treatment term, opthalmology patients who had treated for 2 weeks within were 85.84%. Blepharism and asthenopia were the most common ophthalmologic disease. 3. Rhinology group were 18.10% males in 11-20 years old and 14.48% females in 10 years old within. In treatment term, rhinology patients who had treated for 2 weeks within were 70.59%. Rhinitis and sinusitis were the most common rhiniologic disease. 4. Otology group were 19.08% males and 16.80% females in 61years old over. In treatment term, otologic patients who had treated for 2 weeks within were 64.89%. Tinnitus and vertigo were the most common otologic disease. 5. Laryngology group were 10.53% males and 17.11% females 41-50 years old. In treatment term, laryngology patients who had treated for 2 weeks within were 85.53%. pharyngitis and abnormal pharyngolarylgeal region sensation were the most common laryngologic disease. 6. Stomatology group were 11.76% males in 31-40, 41-50 years old and 17.65% females in 61 years old over. In treatment term, stomatology patients who had treated for 2 weeks within were 82.35%. Stomatitis and labium spasm were the most common stomatologic disease. 7. Dermatology group were 11.75% males and 15.30% females in 21-30 years old. In treatment term, dermatology patients who had treated for 2 weeks within were 72.95%. Acne and urticaria were the most common dermatologic disease. 8. Other group were 8.99% males in 41-50 years old and 14.04% female in 61 years old over. In treatment term, other group patients who had treated for 2 weeks within were 69.29%. Bell's palsy and common cold were the most common other disease.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.26-27
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• 2018

유전 자원에 대한 접근 및 이용에 따른 이익의 공정한 공유를 표방하는 나고야 의정서가 발효되면서, 최근 국내 천연자원을 이용한 바이오 소재 및 제품 개발 연구에 많은 지원이 이뤄지고 있다. 국내 화장품 연구 및 개발 동향은 기존의 합성 화합물 중심에서 벗어나 안전성이 확보된 천연 바이오 소재 중심으로 변화하고 있다. 또한 기능성화장품의 범위가 기존에 크게 미백, 주름개선, 자외선 차단 3가지에서 염모, 탈모 완화, 여드름 완화, 아토피성 피부의 보습 등으로 세분화 및 추가됨으로써 화장품 연구 개발의 범위가 확대되었다. 이러한 기능성 화장품 범위 확대, 화장품 소재에 대한 안전성 규제 강화, 동물실험 금지 등 화장품 연구 환경 변화로 인해 다양한 천연물 기반의 생물학적 활성을 갖는 유효 성분들이 기능성 화장품 소재로 연구되는 사례가 점차 증가하고 있다. 충북은 바이오산업을 지역 특화산업으로 선정하여 바이오산업 육성을 위한 중부권의 오송생명과학단지/오창과학산업단지와 북부권 제천 바이오벨리 조성, 충주기업도시 등을 통해 바이오 제약 및 화장품 기업 유치 와 바이오 산업클러스터를 완성해 가고 있다. 이와 더불어 오송생명과학단지 내에 위치한 오송화장품임상연구지원센터는 충북 지역 중소 화장품 기업들의 글로벌 시장 진출 및 동남아 수출 지원을 위해 임상시험, 효능평가, 해외 인증, 해외시장 박람회 등의 지원을 중점적으로 수행하고 있다. 이러한 하드웨어 인프라 조성과 함께 충북의 천연 소재를 이용한 다양한 국책 연구 개발 사업을 추진하여 충북 특화자원인 황기, 오미자 뿐 아니라 두충, 익지인, 소목 등을 이용한 화장품 소재 개발 연구를 수행하고 있다. 충북지역 기업체 및 연구기관을 중심으로 천연물의 지표 및 유효 물질 원료 확보와 이를 활용한 기능성 화장품 제품화가 본격적으로 추진되고 있어 향후 충북 천연물 산업은 화장품 산업을 중심으로 더욱 성장해 나갈 것으로 기대된다.