• Neonatal Medicine
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• v.17 no.2
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• pp.155-160
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• 2010

Metabolic acidosis is commonly encountered issues in the management of critically ill neonates and especially of preterm infants during early neonatal days. In extremely premature infants, low glomerular filtration rate and immaturity of renal tubules to produce new bicarbonate causes renal bicarbonate loss. Higher intake of amino acids, relatively greater contribution of protein to the energy metabolism and mineralization process in growing bones are also responsible for higher acid load in premature infant than in adult. Despite widespread use of sodium bicarbonate in the management of severe metabolic acidosis, use of sodium bicarbonate in premature infants should be restricted to a reasonable but unproven exception such as ongoing renal loss. Despite concern about the low pH value (<7.2) which can compromise cellular metabolic function, no treatment guideline has been established regarding the management of metabolic acidosis in premature infants. Appropriately powered randomized controlled trials of base therapy to treat metabolic acidosis in critically ill newborn infants are demanding.

• Korean Journal of Veterinary Research
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• v.60 no.3
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• pp.133-137
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• 2020

Diarrhea is the most common cause of death in calves, and remains a major health challenge. Although there are many studies on the related pathogens, the understanding of the clinicopathological changes is limited. This study aimed to identify the pathogens and observe the clinicopathological changes in electrolytes and acute phase proteins (APPs) associated with diarrhea. Blood samples and fecal samples were collected from 141 calves for the determination of APPs, electrolyte and acid-base status and identification of enteropathogens, respectively. Single or co-infections with enteropathogens, including virus (bovine viral diarrhea virus, coronavirus, and rotavirus), Eimeria, Cryptosporidium, and Escherichia coli K99 were detected in both non-diarrheic and diarrheic calves. Levels of APPs such as serum amyloid A, haptoglobin and fibrinogen were comparable between diarrheic and non-diarrheic calves. Hypoglycemia, high blood urea, electrolytes and acid-base imbalance (hyponatremia, hypochloremia, and decreased bicarbonate), and strong ion difference (SID) acidosis showed a significant association in diarrheic calves (p < 0.01). Particularly, significant hyponatremia, bicarbonate loss, SID acidosis, hypoglycemia, and elevated blood urea nitrogen were found in rotavirus-infected calves. Monitoring the clinicopathological parameters of APPs and electrolyte levels could be vital in the clinical management of diarrheic calves.

• Journal of the Korea Safety Management & Science
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• v.18 no.1
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• pp.203-208
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• 2016

Bioinformatics service is very new and emerging in market that provides information such as whether or not occurrence of a particular disease through the base of DNA(Deoxyribonucleic Acid) & RNA(Ribo Nucleic Acid) sequence analysis. Recently, interest growing rapidly in utilization of the industrial purpose, but provision of commercialization like pricing and service packaging is not enough to go to market. For go-to-market, firstly refine the services and perform cost calculation of services in cost-plus method then estimate consumer utility by conducting conjoint analysis. Collectively, with cost and consumer utility result, optimal service price can be calculated.

• Korean Journal of Adult Nursing
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• v.21 no.3
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• pp.349-354
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• 2009

Purpose: The purpose of this study was to determine core nursing intervention in nursing records and to compare perceived nursing intervention priority and nursing intervention frequency of general surgery department. Methods: Subjects were 70 nurses who work in the general surgery department. Data was collected using a nursing intervention classification and analyzed by frequency and mean. Results: The most frequent nursing interventions of nursing records were orderly risk management, coping assistance, tissue perfusion management, skin/wound management and nutrition support. Important nursing interventions were tissue perfusion management, respiratory management, electrolyte acid-base management, elimination, peri-operative care. The most frequent nursing interventions were drug management, peri-operative care, risk management, tissue perfusion management, patient education. Conclusion: This study found that nursing records were different from intervention priority and nursing frequency. So further study is needed for finding focused intervention of specific subjects and differences with priority of nursing and frequency of nursing.

• Computational Structural Engineering
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• v.11 no.1
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• pp.27-37
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• 1998

본 고에서는 지진해석과 관련하여 가장 중요한 원칙과 해석법에 대한 개략을 제시하여 철근콘크리트 구조물의 지진해석과 관련된 용어 및 특수과제를 언급하고자 한다. 이 해석의 위력이나 매력적인 점에도 불구하고 지진응답에 대한 해석은 항상 많은 불확실성에 부닥칠 수 있다는 것을 강조하고자 한다. 해석은 설계과정의 한 단계에 불과하여 수많은 컴퓨터 출력 페이지가 빈틈없는(sound) 기술적 판단을 대신하여서는 안된다. 구조물에 있어서의 지진력은 외부에서 가해진 하중으로부터 발생하는 것이 아니다. 구조물에 압력 및 흡입력으로 작용하는 풍하중과는 달리, 구조물의 기저(base)에서의 주기적 운동에 의한 응답으로서 상부구조물은 가속도를 받게 되고 따라서 관성력으로서 지진력이 얻어지게 된다. 지진응답은 기본적으로 동적인 성질을 가지며 고유주기와 감쇠와 같은 동적 특성은 이 응답을 결정하는데 결정적인 역할을 한다. 만약 지진해석이 실제적인 것이 되자면, 단순화된 방식으로라도 이러한 동적 특성을 고려할 수 있는 것이어야 한다. 이러한 동적 성질이 복잡성의 한 요인이며, 다른 요인으로서 해석적 장애가 존재한다. 대부분의 구조물은 최대지진에 대하여 상당한 항복현상을 나타냄으로써 저항하도록 설계하고 있다. 따라서 설계자는 최대지진에 대한 구조물의 비선형 동적 거동에 대하여 어느 정도 이해를 하고 있어야 한다. 원칙적으로 이것은 매우 복잡하고 어려운 해석적 문제를 제기하게 된다. 실제로는 매우 단순화된 해석법, 적절한 설계 및 상세의 조합만으로도 만족스러운 거동을 얻는 것에 부족함이 없다. 어쨌든 이러한 해석기법의 바탕과 한계를 이해하는 것은 필수적이다.tidyl ethanolamine$(20.9{\sim}29.7%)$, phosphatidyl inositol$(18.4{\sim}26.1%)$ 순으로 많았다. 각 구성지질의 지방산조성은 4종의 버섯 공히 linoleic acid와 palmitic acid가 주요 지방산이었으나 싸리버섯은 중성지질에서 oleic acid의 함량이 높았다.n the part of special landscape management area, it is necessary to introduce landscape impact assessment system to more effective landscape management.ch served as supporting organizations. The control of the construction and management of the royal garden and landscape was held by decision makers, executors of works and management. 2) The general process of the construction and management of the royal garden and landscape included Sangji and Kyuho다 as the first step; In case of buildings and facilities, according to former examples and drawings, the most of the planning and design was already fixed.

• Journal of the Korean Society of Safety
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• v.32 no.2
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• pp.52-58
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• 2017

One of the most important elements of the management of chemical accident is threat zone estimation of fires, explosions and toxic gas dispersion based on chemical releases. The threat zone estimation is going to be standard of emergency response for the first defender and base line data of off-site risk assesment (hereinafter referred to as "ORA") and risk management plan (hereinafter referred to as "RMP"). Generally, ALOHA form EPA(U.S.) and Kora(from KOREA MINISTRY OF ENVIRONMENT) has been used for the off-site consequence analysis in Korea. However it is hard to predict accurate consequences rapidly in case of emergency. Hydrochloric acid is a multipurpose raw material used in many industrial applications such as chemical, metal and food industries. It is usually treated in concentrations from 10 ~ 35 %, and release accident have occurred frequently. In this study, we have developed a simplified estimating method and equation to calculate threat zone easily in case of emergency due to release accident of hydrochloric acid.

• Clinical and Experimental Pediatrics
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• v.52 no.10
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• pp.1061-1068
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• 2009

The treatment of pediatric patients with chronic renal disease comprises management of nutritional imbalance, fluid, electrolyte, and acid-base disturbances, mineral bone disease, anemia, hypertension, and growth retardation. The treatment also includes administration of appropriate renal replacement therapy, if required. Adequate dietary intake of carbohydrates, fats, and proteins and caloric intake must be encouraged in such patients to ensure proper growth and development. In addition, fluid, electrolyte, and acid-base status must be regularly monitored and should be well maintained. Serum calcium, phosphorus, and parathyroid hormone levels must be maintained at their target range, which are determined on the basis of the glomerular filtration rate, to avoid the development of mineral bone disease. This can be achieved by using phosphorus binders and vitamin D analogues. An erythropoiesis-stimulating agent must be administered along with iron supplementation to maintain the hemoglobin level of the patients between 11-12 g/dL. Hypertension must be controlled with adequate water and sodium balance and appropriate antihypertensive agents. Administration of recombinant human growth hormone is recommended to improve the final adult heights.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.6
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• pp.543-547
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• 2015

We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a $Corneometer^{(R)}$. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62~1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.

• Journal of the Korean Applied Science and Technology
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• v.31 no.4
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• pp.711-718
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• 2014

In this paper, the mechanical property change was investigated by adding 1,4-butanediol as chain extender of polyurethane dispersion for leather coating. Reagents for the synthesis were polypropylene glycol(PPG), isoporon diisocyanate(IPDI), dimethylolpropionic acid(DMPA) and 1,4-BD. All samples showed good solvent resistance and flexibility by different content of the 1,4-BD. As results, samples which contains a lot of 1,4-BD showed good properties whth strength of $1.80kg_f/mm^2$ and abrasion test measurement of 49.54 mg.loss. According to elongation test, the sample which contains low amount of 1,4-BD was good property as 364 %.

• Tribology and Lubricants
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• v.25 no.6
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• pp.432-437
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• 2009

The effect of oxidation in SAE 5W30 engine oils on friction and wear characteristics was investigated using reciprocating bench tester and shell 4-ball tester. Commercial engine oils were collected and oxidized using the KS M 2021 method modifying the oxidation time. Kinematic viscosity, total acid number(TAN), FT-IR spectrum and total base number(TBN) also measured to examine the chemical change of oils with oxidation. The results showed that TAN was slightly changed and Kinematic viscosity was suddenly increased during the oxidation stage. however, TBN results keep a constant slope after TBN linearly decreased with oxidation time. Spectroscopy results showed that spectrums were orderly increased at $1710cm^{-1}$ during the oxidation time. Friction test results showed that oxidation of oils formed unstable friction layers causing higher fluctuating friction. however, the wear resistance was independent of oxidized time due to the different friction characteristics by oxidation. We found several factors in relation to lubrication properties with oxidation time. This factors were Viscosity, TBN, change of FT-IR spectrum, friction coefficient using reciprocating bench tester and wear scar.