• Progress in Medical Physics
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• v.23 no.3
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• pp.169-176
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• 2012

Frameless method in brain radiosurgery has advantages relative to rigid head-frame method in terms of patient friendly and flexible application of multi-fractionation. However, it has also disadvantages and the most negative point is that it cannot control the patient motion during treatment as lowly as the level of the frame-based radiosurgery, which could affect to the treatment accuracy. In the present study, we analyzed the geometric uncertainty of the intra-fraction motion using the actual treatment records of 294-CyberKnife treatments for brain tumors. Based on the analysis, we statistically presented the magnitude of intra-fraction motion in frameless radiosurgy. The result could provide the quantitative information to determine the adequate treatment margins to compensate the intra-fraction movements.

• Journal of Korean Society of Transportation
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• v.34 no.5
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• pp.465-475
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• 2016

Since inaccurate demand estimation for recent urban rail construction may result in financial burden to cities, precise prediction for operating cost as well as construction costs is necessary to avoid or reduce budget loss of the local or central government. The operating cost is directly related to the public fare and affect a policy to determine the rate system. Therefore, there is a pressing need to develop an estimating model for reliable operating cost of urban railway. This study introduces a new model to estimate the operating cost with new variables. It provides a better prediction in accuracy and reliability compared to the existing model, considering the feature of urban railway. For verification of our model, railway operation data from a few cities for the last five years were comprehensively examined to determine variables that affect the operating cost. The operating cost was estimated in a dummy regression model using five independent variables, which were average distance between stations, daily trains distance, total passenger capacity of a train in a train, driving mode(manned/unmanned), and investment type(financial/private).

• Economic and Environmental Geology
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• v.45 no.4
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• pp.377-384
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• 2012

The main field component of the Earth's magnetic field was modeled from the tri-axial magnetometer onboard KOrean MultiPurpose SATellite-II (KOMPSAT-II) for the purpose of satellite attitude control. The model computed by the KOMPSAT-II magnetometer measurement data is compared with the International Geomagnetic Reference Field (IGRF) model of a degree of up to 13 in spherical harmonic coefficients. The previous study with KOMPSAT-I (Kim et al. 2004) indicated a good correlation of power spectrum of spherical harmonic coefficients with respect to the degree up to 5. This study, however, showed an agreement of the degree up to 8-9 of the coefficient power spectrum and a discrepancy between degrees 10 and 13. We have concluded that relevant data selection process, removal of the external field from the data in the high latitude region, an accuracy of the magnetometer all play an important role in finding a coherence with the IGRF model. This study will be extended to the secular variation model of geomagnetism if longer-period data become available.

• Journal of Pharmaceutical Investigation
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• v.35 no.2
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• pp.123-127
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• 2005

An HPLC method was employed for the determination of ethambutol in human plasma. After addition of internal standard (IS, octylamine, $2\;{\mu}g/mL$) and alkalinization of the plasma with 5 M sodium hydroxide, the drug and IS were extracted into the mixture of chloroform and diethyl ether (40:60, v/v). Following a 15-min vortex-mixing and a 10min centrifugation, the organic phase was spiked with $100{\mu}L$ of phenylethylisocyanate $(2000{\mu}g/mL)$ for chemical derivatization, mixed for 5 min and evaporated to dryness under a stream of nitrogen. The residue was reconstituted with $100{\mu}L$ of mobile phase and $20{\mu}L$ was injected into C18 column with a mobile phase consisting of methanol:water (70:30, v/v). The samples were detected utilizing an ultraviolet detector at 200 nm. The method was specific and validated with a limit of $0.15\;{\mu}g/mL$. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of this method was demonstrated by analysis of human plasma after oral administration of a single 1200-mg dose to 20 healthy subjects. From the plasma ethambutol concentration vs. time curves, the mean AUC was $9.61{\pm}1.64\;{\mu}g{\cdot}hr/mL$ and Cmax of $2.68\;{\mu}g/mL$ reached 2.73 hr after administration. The mean biological half-life of ethambutol was $3.46{\pm}1.21$ hr. Based on the results, this simple and validated assay could readily be used in any pharmacokinetic studies using humans.

• Applied Biological Chemistry
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• v.30 no.1
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• pp.65-70
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• 1987

In Girder to measure the pressure and weight decrease of drying sample during the vacuum drying process of food, sensing devices were designed and constructed with strain gauge. Microcomputer based vacuum drying system was made up of these devices interfaced to apple II microcomputer. The electrical output signal from vacuum sensor which constituted with Bourdon tube whereon strain gauge attached were digitalized and input to microcomputer through the MC 6821 interface I.C. chip. The relationship between read-out digital value (D) from microcomputer and readings of vacuum gauge (P, mmHg) was P=-146.136+3.620D'(r=0.9994) The pressure control of vacuum dryer was successfully conducted in the range of $400{\sim}600\;mmHg$ accuracy. The digitalized load cell output (D) could be correlated with the real weight (W, g) as W=-14,000+0.585D (r=0.9998) Drying curves of green red pepper under $64^{\circ}C$, $400{\sim}600\;mmHg$ was similar to those of red pepper and differently affected by the degree of vacuum pressure but was varied according to their shape (cut or whole). Moisture movement of green red pepper during the vacuum drying process was fitted to Page model. The empirical equations obtained were $M-M_e/M_o-M_e={\exp}\;(-0.0673{\theta}^{1.177})$ and $M-M_e/M_o-M_e={\exp}\;(-0.0655\;{\theta}^{1.477})$ for whole and cut green red pepper, respectively.

• The Journal of Engineering Geology
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• v.20 no.3
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• pp.281-295
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• 2010

A new, automated apparatus is proposed for calculating the Soil-Water Characteristic Curve (SWCC), representing a simple and easily applied testing device for continuous measurements of the volumetric water content and suction of unsaturated soils. The use of this apparatus helps to avoid the errors that arise when performing experiments. Consequently, the apparatus provides greater accuracy in calculating the SWCC of unsaturated soils. The apparatus is composed of a pressure panel, flow cell, water reservoir, air bubble trap, balance, sample-preparation accessories, and measurement system, among other components. The air pressure can attain 300 kPa, and a general test can be completed in a short time. The apparatus can simply control the drying process and wetting process. The changes in volumetric water content that occur during the drying and wetting processes are shown directly in the SWRC program, in real time. As a case study, we performed an SWCC test of Joomunjin sand (75% relative density) to measure matric suction and volumetric water content during both the drying and wetting processes. The test revealed hysteresis behavior, whereby the water content on the wetting curve is always lower than that on the drying curve for a specific matric suction, during the wetting and drying processes. Based on the test results, SWCCs were estimated using the Brooks and Corey, van Genuchten, and Fredlund and Xing models. The van Genuchten model performed best for the given soil conditions, as it yielded the highest coefficient of determination.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.3
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• pp.291-297
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• 2016

Direct georeferencing has become widespread in the field of digital aerial photogrammetry; as a result, the boresight calibration has become an essential component of the procedure to calculating exterior orientation parameters of aerial photographs accurately. During this procedure, a reference is used for the height of the geoid model, and the calibration results can appear different depending on the geoid model. The exterior orientation parameters calculated through direct georeferencing during boresight calibration may have varied values according to the corresponding geoid model. With that in mind, the effects of the geoid model on the boresight calibration were analyzed through three different cases. The geoid models used in the experiments were EGM96, EGM08, and KNGeoid14, and, through boresight calibration, the datum shift and boresight angle for each model was computed. After calculating the exterior orientation of each case, the GCP (Ground Control Point) was verified using the DPW (Digital Photogrammetry Workstation). In each case, results in the boresight calibration acquired through the geoid model demonstrated a difference in the Z datum, the exterior orientation heights Z, and the rotation Ω and Φ. After utilizing the DPW in each case and comparing it to the GCP, the difference in accuracy in accordance with the geoid model was found to be within 3cm, and it was concluded that the geoid model did not have a significant impact on boresight calibration.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.8
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• pp.260-267
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• 2018

Surface electromyography (sEMG) is mainly used as an on/off switch in the early stage of the study and was then expanded to navigational control of powered-wheelchairs and recognition of sign language or finger gestures. There are difficulties in communication between people who know and do not know sign language; therefore, many efforts have been made to recognize sign language or finger gestures. Recently, use of sEMG signals to recognize sign language signals have been investigated; however, most studies of this topic conducted to date have focused on Chinese finger number gestures. Since sign language and finger gestures vary among regions, Korean- and Chinese-finger number gestures differ from each other. Accordingly, the recognition performance of Korean finger number gestures based on sEMG signals can be severely degraded if the same muscles are specified as for Chinese finger number gestures. However, few studies of Korean finger number gestures based on sEMG signals have been conducted. Thus, this study was conducted to identify potential forearm muscles from which to collect sEMG signals for Korean finger number gestures. To accomplish this, six Korean finger number gestures from number zero to five were investigated to determine the usefulness of the proposed muscles and electrode placements by showing that CNN technique based on sEMG signal after sufficient learning recognizes six Korean finger number gestures in accuracy of 100%.

• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.644-653
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• 2018

Landslides occur frequently due to the effects of heavy rainfall and typhoons caused by climate change. Erosion control measures are needed to effectively prevent landslide damage. In order to improve their efficiency, it is necessary to quantitatively measure the sediment discharge from the mountain stream. In this study, a load cell sensor was installed in a mountain stream and the measured values were compared according to the applicability and load test type in the mountain stream. The result of the load test showed that the effect of the loading type (load test 1, 2) was low at average (loadings) of 0.4kgf and 0.6kgf at sites 1 and 2, respectively. The load factor was also derived by regression analysis to increase the accuracy of the measured values. According to the results of the load factor (normalized) to the load-cell measurement value, the output value increased by 14.8% and 24.6% in sites 1 and 2, respectively, and was calculated to be similar to the reference value. The load cell sensor enabled us to quantitatively estimate the amount of sediment discharge in the mountain stream through time series analysis with the water level and rainfall information. If the monitoring is carried out for a long time, it can be used to find the sediment discharge mechanism for the mountain stream. In addition, applying sensors such as load-cells to a mountain stream is expected to contribute to the development of related industries, such as the manufacturing of measurement sensors.