• Food Science and Biotechnology
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• 제18권5호
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• pp.1124-1131
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• 2009

Acanthopanax senticosus has been used in East Asia as a traditional medicine. The purpose of this study is the investigation of an extraction method for A. senticosus var subinermis (ASvS) leaves to improve their antioxidant and anti-inflammatory activities. Six extracts were prepared: extracted with water (W), ethanol (Eth), water or ethanol after ultra high pressure (WP, EthP), and water or ethanol after an extrusion process (WEx, EthEx). Diphenylpicrylhydrazyl (DPPH) radical scavenging activity and ferric reducing ability showed that all extracts had a significant antioxidant activity. In anti-inflammatory activities, Eth and EthEx significantly inhibited the release of lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$, and interleukin (IL)-$1{\beta}$ independent of cell viability in RAW 264.7 macrophage cells. Inducible NO synthase (iNOS) protein was significantly decreased by EthEx. These findings present that Eth and EthEx extracts of ASvS leaves have anti-inflammatory activities, and EthEx extract suppresses LPS-induced NO through the down-regulation of iNOS and pro-inflammatory cytokines.

• 생약학회지
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• 제48권1호
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• pp.5-9
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• 2017

This study was carried out to obtain the basic information that can be used to index Acanthopanax in eleven species of China and Korea. The phytochemical components from the berry of Acanthopanax species, were measured by the HPLC analysis. Protocatechuic acid, eleutheroside B, eleutheroside E, scopolin, rutin, hyperoside, chiisanoside, oleanolic acid were found in ethanol extracts from the berry of Acanthopanax species. Total phenolic compound of Acanthopanax sessiliflorum f. chungbuensis berry (0.682%) was about seven times higher than those of Acanthopanax divaricatus f. distigmatis berry (0.091%). As a result, the order of the eleutheroside E content was 1) Acanthopanax sessiliflorum f. chungbuensis (0.554%), 2) A. divaricatus var. albeofructus (0.501%), 3) A. divaricatus f. flavi-flos (0.452%). And also, the order of the chiisanoside content was 1) Acanthopanax senticosus var. subinermis (8.434%), 2) A. seoulense (0.94%), 3) A. divaricatus f. flavi-flos (0.798%).

• 한국약용작물학회지
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• 제6권2호
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• pp.114-120
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• 1998

가시 오갈피의 지상부 수확량과 유용성분을 증대시키기 위하여 생육이 양호한 품종을 대목으로 접목재배를 하였다. 접목재배한 가시오갈피의 유용성분의 변화를 규명하는 일환으로 정유성분의 변화를 측정한 결과를 요약하면 다음과 같다. 1. 가시오갈피 잎의 고유 성분 중에서 접목재배로 인하여 함량이 증가한 것은 calarene, ${\alpha}-beramotene$, spathulenol 등이고, 감소한 것은 cis-caryophyllene, epizomarene, M204 $(t_R=2.07)$이었으며, ${\beta}-pinene$, ${\beta}-myrcene$, 2,5,5,-trimethyl- 1,3,6-heptatriene, ${\beta}-elemene$ 등은 전혀 나타나지 않았다. 2. 줄기의 고유 성분은 접목재배와 일반재배 사이에 큰 차이가 없었으며, 접목 1년생보다 3년생에서 함량이 높게 검출되었다. 가장 많이 함유한 성분은 ${\alpha}-bergamotene$으로 27% 정도이었다. 3. 뿌리에서는 좀가시오갈피 고유 성분인 ethylbenzene, 2-furancarboxaldehyde, M134 $(t_R=2.11)$, M205 $(t_R=3.16)$ 등이 측정되지 않았고, 가시오갈피 고유 성분인 6,6-dimethyl-3-methylenbicycloheptane, M166 $(t_R=1.82)$, (+) -aromadendrene, ${\beta}-bisabolene$, M204 $(t_R=3.01)$ 등이 대목에 새롭게 생성 축적되었다.