• Archives of Pharmacal Research
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• 제27권8호
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• pp.825-828
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• 2004

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-［(${\alpha}-L-rhamnopyranosyl(1{\rightarrow}4)-{\beta}-D-glucopyrano-syl(1{\rightarrow}6)]-{\beta}-D-glucopyranosyl]$ ester (3), and ursolic acid (4) by physicochemical and spectro-scopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor ($IC_{50}:{\;}12.65{\;}{\mu\textrm{m}}$).

• 동의생리병리학회지
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• 제20권6호
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• pp.1625-1628
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• 2006

The (-)-pimara-9 (11), 15-dien-19-oic acid, acanthoic acid was extracted from the roots of Acanthopanax koreanum using bioassay-guided isolation of a MeOH extract. Acanthoic acid was assayed against Streptococcus mutans and Staphylococcus epidermidis causing dental caries and opportunistic pathogen. The minimum inhibitory concentration (MIC) of acanthoic acid against Streptococcus mutans and Staphylococcus epidermidis was 2 and 4 ${\mu}g/mL$, respectively, which was much lower than those of other natural antimicrobial agents such as 8 ${\mu}g/mL$ of tanshinone IIA. Acanthoic acid also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Streptococcus grodenii in the MIC range of 4${\sim}$32 ${\mu}g/mL$. Our findings suggest that acanthoic acid could be employed as a potential antibacterial agent for preventing dental caries and skin infections.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.183-183
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• 2002

Many polysaccharides isolated from plants have been shown to enhance various immune responses in vivo and in vitro. Here we demonstrate that polysaccharide isolated from the root of Acanthopanax koreanum (AK) has a unique mode of immunostimulation with regard to its cell-type specificity.(omitted)

• 한국생태학회:학술대회논문집
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• 한국생태학회 1999년도 국제 Symposium 및 '99 춘계 공동 학술 발표대회
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• pp.101-101
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• 1999

• Journal of Microbiology and Biotechnology
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• 제26권7호
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• pp.1224-1233
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• 2016

The present study assessed the effects of an aqueous extract of Acanthopanax koreanum root (AE) and of AE following fermentation by lactic acid bacteria (Lactobacillus plantarum and Bifidobacterium bifidum) (AEF) on human skin fibroblast HS68 cells exposed to ultraviolet B (UVB) irradiation and oxidative stress. AEF effectively antagonized the senescence-associated β-galactosidase staining and upregulation of p53 and p21^Cip1/WAF1 induced by UVB or H₂O₂ treatment in HS68 cells. It also exhibited excellent antioxidant activities in radical scavenging assays and reduced the intracellular level of reactive oxygen species induced by UVB or H₂O₂ treatment. The antioxidant and antisenescent activities of AEF were greater than those of nonfermented A. koreanum extract. AEF significantly repressed the UVB- or H₂O₂-induced activities of matrix metalloproteinase (MMP)-1 and -3, overexpression of MMP-1, and nuclear factor κB (NF-κB) activation. This repression of NF-κB activation and MMP-1 overexpression was attenuated by a mitogen-activated protein kinase activator, suggesting that this AEF activity was dependent on this signaling pathway. Taken together, these data indicated that AEF-mediated antioxidant and anti-photoaging activities may produce anti-wrinkle effects on human skin.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.297.2-297.2
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• 2003

The roots and rhizome of Acanthopanax koreanum are used as folk medicine to ameliorate hepatitis in Korea. The ability of A. koreanum to protect mice from fulminant hepatitis induced in mice by D-galactosamine and lipopolysaccharide was evaluated. Preparations of A. koreanum used were an ethanol extract, and the ethanol-soluble and ethanol-insoluble components of the water extract. (omitted)

• 한국식품영양과학회지
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• 제42권12호
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• pp.2082-2087
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• 2013

오가피의 주요 성분으로 알려져 있는 eleutheroside B와 E 그리고 식물의 세포벽을 구성하는 ${\beta}$-glucan 함량을 강원도(A. senticosus), 충남(A. senticosus), 제주도(A. koreanum) 산지별 오가피의 뿌리, 줄기, 잎, 열매 부위별로 각각 분석한 결과, 충남 오가피는 eleutheroside B가 검출되지 않는 것에 반해 특이적으로 높은 eleutheroside E를 함유하고 있었으며, 제주도 산지 오가피는 뿌리, 줄기, 잎, 열매모든 부위에서 eleutheroside B와 E가 함께 검출되는 것으로 확인되었다. 서로 다른 산지에서 재배되었지만 지역과 품종에 상관없이 줄기 부위에 가장 많은 eleutheroside B와 E가 함유되어 있었으며, ${\beta}$-glucan 또한 강원도(7.46%), 충남(3.41%), 제주도(5.05%) 산지 오가피 모두 줄기 부위에 가장 많았다. 오가피는 같은 품종이더라도 재배지역에 따라 eleutheroside B와 E 그리고 ${\beta}$-glucan 함량에 차이를 보여주었고 산지와 품종에 상관없이 줄기 부위에 가장 많이 함유되어 있었다. 따라서 본 연구결과를 기초로 오가피 소재 제품을 만들기 위해서는 제품의 목적에 따라 산지 및 부위의 선택이 필요할 것으로 사료되며, 산지에 따른 유효성분 차이에 있어서 탐라오가피는 제주도 특산식물로 오가피를 이용한 제품개발 시 지표성분을 표준화하는데 있어서 용이할 것으로 판단된다.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.183-183
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• 2002

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.408-409
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• 2010

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.435-436
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• 2010