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Triterpenoids from Acanthopanax koreanum Root and Their Inhibitory Activities on NFAT Transcription  

Cai, Xing-Fu (College of Pharmacy, Chungnam National University)
Lee, Im-Seon (College of Pharmacy, Chungnam National University)
Shen, Guanghai (College of Pharmacy, Chungnam National University)
Dat, Nguyen-Tien (College of Pharmacy, Chungnam National University)
Lee, Jung-Joon (College of Pharmacy, Chungnam National University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.27, no.8, 2004 , pp. 825-828 More about this Journal
Abstract
Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-［(${\alpha}-L-rhamnopyranosyl(1{\rightarrow}4)-{\beta}-D-glucopyrano-syl(1{\rightarrow}6)]-{\beta}-D-glucopyranosyl]$ ester (3), and ursolic acid (4) by physicochemical and spectro-scopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor ($IC_{50}:{\;}12.65{\;}{\mu\textrm{m}}$).
Keywords
Acanthopanax koreanum; Araliaceae; Triterpenoid; NFAT transcription factor; Inhibitory effect;
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Times Cited By Web Of Science : 14  (Related Records In Web of Science)
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