• Journal of Radiation Protection and Research
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• v.32 no.1
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• pp.1-8
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• 2007

A model for radiological dose assessment in an urban environment, METRO-K has been developed. Characteristics of the model are as follows ; 1) mathematical structures are simple (i.e. simplified input parameters) and easy to understand due to get the results by analytical methods using experimental and empirical data, 2) complex urban environment can easily be made up using only 5 types of basic surfaces, 3) various remediation measures can be applied to different surfaces by evaluating the exposure doses contributing from each contamination surface. Exposure doses contributing from each contamination surface at a particular location of a receptor were evaluated using the data library of kerma values as a function of gamma energy and contamination surface. A kerma data library was prepared fur 7 representative types of Korean urban buildings by extending those data given for 4 representative types of European urban buildings. Initial input data are daily radionuclide concentration in air and precipitation, and fraction of chemical type. Final outputs are absorbed dose rate in air contributing from the basic surfaces as a function of time following a radionuclide deposition, and exposure dose rate contributing from various surfaces constituting the urban environment at a particular location of a receptor. As the result of a contaminative scenario for an apartment built-up area, exposure dose rates show a distinct difference for surrounding environment as well as locations of a receptor.

• Journal of Radiation Protection and Research
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• v.21 no.1
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• pp.41-50
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• 1996

In this study, the theoretical calculation of the air kerma-to-dose equivalent conversion factors was performed with a Monte Carlo N-Particle transport code for the two types of extremity phantom of the ANSI and the KAERI, respectively. Considering the distribution of absorbed dose due to the interaction of homogeneous Parallel broad beam of monoenergetic primary photons in the range between 15keV and 1.5MeV, the air kerma-to-dose equivalent conversion factors based on the kerma approximation were calculated. It is showed that all the theoretical conversion factors of the two types of the extremity phantom for the ANSI and the KAERI agree well with the experimental values of the ANSI N13.32 draft(1995) for each energy within 5.7%, maximum difference ratio, except for 13.6%, difference ratio in the case for the energy of less than 40keV. It is due to uncertainties of experiment occurred in the low X-ray energy range and geometry considered in the MCNP code.

• Toxicological Research
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• v.26 no.4
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• pp.275-283
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• 2010

Placenta transfer study in non-human primate (NHP) is one of the crucial components in the assessment of developmental toxicity because of the similarity between NHP and humans. To establish the method to determine placenta transfer in non-human primate, toxicokinetics of valproic acid (VPA), a drug used to treat epilepsy in pregnant women, were determined in pregnant cynomolgus monkeys. After mating, pregnancy-proven females were daily administered with VPA at dose levels of 0, 20, 60 and 180 mg/kg by oral route during the organogenesis period from gestation day (GD) 20 to 50. Concentrations of VPA and its metabolite, 4-ene-VPA, in maternal plasma on GDs 20 and 50, and concentrations of VPA and 4-ene-VPA in placenta, amniotic fluid and fetus on GD 50 were analyzed using LC/MS/MS. Following single oral administration of VPA to pregnant monkeys, concentrations of VPA and 4-ene-VPA were generally quantifiable in the plasma from all treatment groups up to 4-24 hours post-dose, demonstrating that VPA was absorbed and the monkeys were systemically exposed to VPA and 4-ene-VPA. After repeated administration of VPA to the monkeys, VPA was detected in amniotic fluid, placenta and fetus from all treatment groups, demonstrating that VPA was transferred via placenta and the fetus was exposed to VPA, and the exposures were increased with increasing dose. Concentrations of 4-ene-VPA in amniotic fluid and fetus were below the limit of quantification, but small amount of 4-ene-VPA was detected in placenta. In conclusion, pregnant monkeys were exposed to VPA and 4-ene-VPA after oral administration of VPA at dose levels of 20, 60 and 180 mg/kg during the organogenesis period. VPA was transferred via placenta and the fetus was exposed to VPA with dose-dependent exposure. The metabolite, 4-ene VPA, was not detected in both amniotic fluid and fetus, but small amount of 4-ene-VPA was detected in placenta. These results demonstrated that proper procedures to investigate placenta transfer in NHP, such as mating and diagnosis of pregnancy via examining gestational sac with ultrasonography, collection of amniotic fluid, placenta and fetus after Caesarean section followed by adequate bioanalysis and toxicokinetic analysis, were established in this study using cynomolugus monkeys.

• Food Science of Animal Resources
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• v.26 no.4
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• pp.471-477
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• 2006

This study was conducted to evaluate the application of high dose irradiation for ensuring shelf stability of marinated and precooked pork rib steak in the severe environments such as desert or space, etc. Marinated and precooked pork rib steak was manufactured, vacuum-packaged and gamma-irradiated with the absorbed doses of 10, 20, 30, 40 and 50 kGy, and used for the tests of the growth of microorganisms and lipid oxidation during storage at 35t of acceleration condition. Any growth of microorganisms was not observed in irradiated samples after irradiation immediately. However, the growths were observed in 10, 20 and 30 kGy samples at 4, 7 and 14 day storage, respectively. High dose (40 and 50 kGy) gamma irradiation retarded the growth of aerobic microorganisms by the analysis of kinetic parameter. The content of malondialdehyde increased in all samples during storage periods, and gamma irradiation accelerated the increase of lipid oxidation. Therefore, the application of combination of the various food processing technology should be considered for the sterilization of marinated and precooked pork rib steak without any deterioration of the quality occurred by high dose irradiation.

• The Korean Journal of Nuclear Medicine
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• v.33 no.2
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• pp.163-171
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• 1999

Purpose: Liquid beta emitter filled in angioplasty balloon could be used to perform endovascular balloon brachytherapy to prevent coronary artery restenosis. We investigated the dosimetry for Re-188-DTPA liquid-filled balloon and medical internal radiation dosimetry in case of balloon leakage. Materials and Methods: We estimated radiation dose from an angioplasty balloon (20 mm length, 3 mm diameter cylinder) to the adjacent vessel wall using Monte Carlo EGS4 code. We obtained time-activity curves of kidneys in normal dog and calculated $T_{max},\;T_{1/2}$. Using MIRDOSE3 program, we estimated absorbed doses to the major organs (kidneys, bladder) and the whole body when we assumed that balloon leaked all the isotope contained. Results: The radiation dose was 17.5 Gy at the balloon surface when we applied 3,700 MBq/ml of Re-188 for 100 seconds, Fifty percent of the energy deposited within 1 mm from the balloon surface. The estimated internal dose to the whole body was 0.005 mGy/MBq and 18.5 mGy for the spillage of 3,700 MBq of Re-188. Conclusion: We suggest that Re-188-DTPA can be used for endovascular balloon brachytherapy to inhibit coronary artery restenosis after angioplasty with tolerable whole body radiation dose in case of balloon rupture.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3117-3122
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• 2011

Skull A-P projections are the bi-product where the ESD (Entrance Surface Dose) for digital radiography is much higher than that conventional screen-film radiography. Therefore, the aim of this study was to reduce radiation doses to patients by using an added filter. This research focuses on the identification of the reduction of exposure to radiation based on the thickness of an added filter when applying the 'Skull A-P Projection' by using the 'Skull Phantom'. Also, an experiment was conducted to evaluate the qualitative decline of images through filtration. The measurement of one's exposed dose to radiation was executed by locating the 'Skull Phantom' on the position of the 'Skull AP,' while changing 16 kinds of added filters from 0.1 mmAl to 0.5 mmCu + 2.0 mmAl in terms of incident and penetrating doses. For the qualitative evaluation of images, a total number of 17 images have been acquired in the 'Skull Phantom' under the same conditions as those for the measurement of one's exposed dose. The acquired images have been evaluated by a radiological specialist. As a result, the images with a diagnostic value have been obtained by using such added filters as the compound filter of 0.2 mmCu +1.0 mmAl. The exposed dose absorbed on the 'Skull Phantom' is about 0.6 mGy. The value is only 12% of 5 mGy, the ESD value acquired on the 'Skull P-A Projection', which is recommended by the International Atomic Energy Agency (IAEA). As a result, depending on the parts of inspection, it is possible to reduce the patient's exposed dosage of radiation considerably by using an appropriate added filter.

• Journal of the Korean Society of Radiology
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• v.12 no.7
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• pp.845-852
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• 2018

This study aimed to investigate the difference of X-ray exposure by comparing and analyzing absorbed dose according to changes in the number of frames in coronary angiography, also depending whether the zoom mode is FOV enlargement or Zoom Live. Moreover, for appropriate frame selection measures for examination, including the effect of frame change on the image quality, were sought by measuring the noise strength expressed by the standard deviation (SD), the signal to noise ratio (SNR) and contrast to noise ratio (CNR). The study was conducted with an anthropomorphic phantom on an angio-system. The linear relationship between the frame rate and the radiation dose was evident. On the contrary, the indices of image quality (SD, SNR, and CNR) were almost constant irrespective of the number of frames. The difference depending on the zoom mode was not statistically significant for DAP, air kerma, and SD (p > 0.05). However, SNR and CNR were statistically different between FOV enlargement and Zoom Live. In conclusion, since the image quality was not degraded significantly with the decreasing frame rate from 30, 15, to 7.5 f/s and the radiation dose evidently decreases in almost exactly linear proportion to the decreasing frame rate, the number of frames per second needs to be maintained as low as reasonably achievable. As for the dependence on the zooming mode, the Live Zoom mode showed statistically significant improvement in the image quality indices of SNR and CNR and it justifies active use of the Live Zoom mode which enables real-time image enlargment without additional radiation dose.

• Journal of the Korean Society of Radiology
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• v.13 no.3
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• pp.459-464
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• 2019

In order to minimize the radiation exposure dose of the thyroid site at dental cone-beam computer tomography, a protector using a Bolus was prepared, and the radiation shielding effect and the appropriateness of the image were evaluated. Using a dental cone-beam computed tomography (CBCT), a glass dosimeter was attached to the left and right sides of the thyroid for a dental radiation phantom, and the radiation dose was measured. The absorbed dose for each shield was measured by another method to 10 mm, 20 mm, and 30 mm-thickness, respectively. Eight evaluators evaluated whether or not the medical image is appropriate. When using a 30 mm Bolus shield at the left thyroid site, the resulting value is reduced by an average of $342.67{\mu}Gy$ by 20.7% from the average value of $431.22{\mu}Gy$ measured without using a Bolus shield, the right thyroid site In the case of using 30 mm Bolus shield, it showed a dose reduction effect of 21.9% with an average of $424.56{\mu}Gy$. The adequacy of the medical image was judged to be usable by both evaluators. In conclusion, the dental cone-beam computerized tomography can be used as a useful shielding material because it has a radiation shielding effect and it is possible to treat the diagnosis of the bolus protector in the thyroid without any obstruction shade in order to minimize the radiation dose.

• Analytical Science and Technology
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• v.20 no.6
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• pp.460-467
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• 2007

Dose rate conversion factor was calculated to estimate the absorbed effective annual doses for soils for the beta-rays and gamma-rays, which were emitted from $^{238,235}U$, $^{232}Th$, and $^{40}K$ isotopes. The most recent data of the emitted energies per decay, half-lifes, and branching ratios, which were obtained from National Nuclear Data Center, were used. When this factor and the effective annual doses for the beta-rays and the gamma-rays of natural radioisotopes were compared with those of Aitken, these of $^{238}U$, $^{232}Th$ and $^{40}K$ are estimated to have good agreements but a large difference is shown in this for $^{235}U$. Through the calculations of effective annual doses by using these factor and the measurements of gamma-ray spectra for soils, which were extracted from prehistoric remains (Mansuri) on Osong, Chungchengbuk-do, The annual effective doses were obtained to be 3.8~5.9 mGy/yr. Also, when these doses including decay elements upper Rn were compared with those on all isotopes, the differences within 9~30 % were obtained. The analysis method of the annual effective doses for the beta-rays and the gamma-rays of the natural isotopes of soils was established by this dose rate conversion factor.

• Journal of radiological science and technology
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• v.30 no.3
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• pp.213-219
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• 2007

The purpose of this study is to evaluate shielding effect of radiation protector for interventional radiologists in procedures by measuring inside and outside of radiation protector. In this study, we measured the radiation dose of 4 interventional radiologists during TACE and PTBD procedure for 4 month(2005.05-2005.09). Absorbed dose were measured by TLD placed underneath and over radiation protector such as Goggle, Thyroid protector, Apron and placed on the 4th finger of Hand. In addition, we measured background radiation dose in the control room using TLD. During TACE procedure, using 0.07 mmPb Goggle decreased average 53.8% of radiation dose rate in continuous fluoroscopic mode and decreased average 77.6% of radiation dose rate in pulse fluoroscopic mode. Using 0.5 mmPb Thyroid protector decreased average 88.9% of radiation dose rate in continuous fluoroscopic mode and decreased average 92.8% in pulse fluoroscopic mode. During PTBD procedure, using 0.07 mmPb Goggle decreased radiation dose rate average 62.7%, 87.9% by 0.5 mmPb Thyroid protector, 90.5% by 0.5 mmPb Apron. The average fluoroscopic time of PTBD was 6.14 min. shorter than TACE procedure, but radiation exposure dose rate of PTBD was 3 times higher in total body dose, and 40 times higher in hand dose rate than TACE. Interventional radiologists must wear thicker protector recommended over 0.5 mmPb. Also, they must use lead Goggle during interventional procedure. Abdomen dose decreased average 38.4% by drawing a lead curtain under the patient's table, therefore, they must draw a lead curtain to shield scattering ray. Radiation exposure dose decreased average 59.0% by using pulse fluoroscopic mode. So radiologists would better use pulse fluoroscopic mode than continuous fluoroscopic mode to decrease exposure dose.