• Korean Journal of Pharmacognosy
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• v.48 no.2
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• pp.97-107
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• 2017

There is no doubt that the effect of ginseng on blood pressure could be different depending upon the type of ginseng employed for the experiment and methodology, thereby can exert bilateral modulatory activity on blood pressure. It has been reported that ginseng induced no significant change in blood pressure in those subjects with normal blood pressure, but had a normalizing effect on the subjects with abnormal blood pressure. Especially, experimental evidence indicates that ginsenoside Rg3, a major component of red ginseng, has been found to lower blood pressure, which is mediated by release of endothelium-derived NO, enhancing the accumulation of cGMP in the rat aorta. This clinical results further support the beneficial effect of Korean ginseng on blood pressure elucidated by animal experiment. As expected, a multicentric non-controlled clinical study shows that the effect of ginseng consumption has been found to normalize blood pressure in hypertensive or hypotensive individuals as compared to virtually no effect in normotensives. In addition, ginseng has been known to exhibit blood pressure decreased with no significant side effect and deteriorated QOL during the combination therapy of ginseng and anti-hypertensive drugs. This review provides a comprehensive overview on the effects of Korean ginseng on blood pressure.

• The Journal of Internal Korean Medicine
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• v.41 no.3
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• pp.531-541
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• 2020

From January 2014 to December 2016, 38 out of 153 inpatients admitted to the Korean Medicine Hospital for more than one month underwent follow-up blood tests to evaluate their liver function levels, and one drug-induced liver injury (DILI) patient was observed. 1. At the time of admission, six (15.8%) of the 38 patients had abnormal alanine aminotransferase (ALT) levels and five of them recovered after hospitalization. 2. At follow-up, two (5.3%) patients had a Council for International Organizations of Medical Science (CIOMS)-based liver injury. One was identified as a liver injury accompanied by pneumonia, and one was judged as a liver injury caused by the drug. 3. The patient had a suspected DILI and completely recovered after 13 days while discontinuing the herbal medication and by using Sanggangunbi-tang (生肝健脾湯).

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.4
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• pp.49-60
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• 2008

The current VIPS are not effective in safety point of view, because they are originally developed for mimicking loop detectors. Therefore, it is important to identify vehicle trajectories in real time, because recognizing vehicle movements over a detection zone enables to identify which situations are hazardous, and what causes them to be hazardous. In order to improve limited safety functions of the current VIPS, this research has developed a computer vision system of monitoring individual vehicle trajectories based on image processing, and offer the detailed information, for example, incident detection and conflict as well as traffic information via tracking image detectors. This system is capable of recognizing individual vehicle maneuvers and increasing the effectiveness of various traffic situations. Experiments were conducted for measuring the cases of incident detection and abnormal vehicle trajectory with rapid lane change.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.2
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• pp.20-37
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• 2012

Objectives : The primary purpose of present study is to evaluate the effect of a supplement of Bee Larva on tinnitus. the second is to comparatively evaluate safety of this supplement. Methods : Among those patients who visited Semyung Oriental Medical Center from January 11st, 2010 to February 20th, 2010, we screened 45 patients considered suitable for this study after some examinations and consent of the patients. they were devided into 2 groups. Group A took 5 tablets of this supplement everyday for 4 weeks, group B, placebo, in the same way. for 4 weeks, we checked changes in intensity, duration, extent of tinnitus on daily life and sleep and THI(Tinnitus Handicap Inventory) score. to evaluate safety of this supplement, adverse events, assessment of vital sign, hematologic examination were recorded. Result : Through 4 weeks of the clinical trial, we found that this supplement is effective on tinnitus and it improves intensity, duration and extent (its influence on daily life) of tinnitus, influence of tinnitus on sleep and THI score more effectively than the placebo drug. Also, in the assessment of the safety of the study the supplement of bee Larva and placebo drug, there were no adverse events and side effects over the average which need treatment for it. Moreover, there were not any abnormal findings in change of blood pressure and hematologic examination. Conclusion : According to this experiment, we confirmed that the supplement of bee Larva can be used effectively and safely on tinnitus.

• Journal of the Korea Institute of Building Construction
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• v.21 no.2
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• pp.149-156
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• 2021

This study empirically verified whether aggressive order intake affect occurrence of defects of Korean construction companies. In order to compensate for the shortage of construction costs due to aggressive low-cost orders of contractors, self-response measures such as design changes are followed, and construction defects may be induced in this process. It aims to verify relevance between aggressive order intake and defect in construction empirically using financial accounting data. As a result, it was confirmed that an abnormal increase in order volume and a deterioration in profitability such as operating margin due to aggressive order taking behavior leads to a decrease in construction quality and occurrence of defects. In addition, it was also confirmed that low construction ability and intentional changes in construction design or contract conditions after construction commences were a direct causes of defects. The results of this study can serve as an opportunity to come up with measures to prevent defects by confirming the relationship between defects in construction and deterioration of profitability due to aggressive low-cost order takings.

• Journal of Veterinary Science
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• v.22 no.1
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• pp.7.1-7.13
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• 2021

Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive disease is characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. Recently, the application of induced neural stem cells (iNSCs), converted from fibroblasts using specific transcription factors, to repair degenerated lesions has been considered a novel therapy. Objectives: The therapeutic effects on NPC by human iNSCs generated by our research group have not yet been studied in vivo; in this study, we investigate those effects. Methods: We used an NPC mouse model to efficiently evaluate the therapeutic effect of iNSCs, because neurodegeneration progress is rapid in NPC. In addition, application of human iNSCs from NPC patient-derived fibroblasts in an NPC model in vivo can give insight into the clinical usefulness of iNSC treatment. The iNSCs, generated from NPC patientderived fibroblasts using the SOX2 and HMGA2 reprogramming factors, were transplanted by intracerebral injection into NPC mice. Results: Transplantation of iNSCs showed positive results in survival and body weight change in vivo. Additionally, iNSC-treated mice showed improved learning and memory in behavior test results. Furthermore, through magnetic resonance imaging and histopathological assessments, we observed delayed neurodegeneration in NPC mouse brains. Conclusions: iNSCs converted from patient-derived fibroblasts can become another choice of treatment for neurodegenerative diseases such as NPC.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.3
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• pp.559-572
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• 2019

In the southeast sea of Korea, the cold water is concentrated in every summer, showing in abnormal oceanic conditions. Cold water occurred in the southeast sea is dominantly influenced by wind, which occurs when the south wind is continuously blowing for 3 to 7 days more. In this study, water temperature, wind speed and direction data of KMA, KHOA and KHNP, Chlorophyll-a of COMS/GOCI, GHRSST Level 4 SST of NASA, and red tide alert data of the National Institute of Fisheries Science were used to analyze the correlation between occurrence and change of the cold water and the red tide of Cochlodinium polykrikoides. The upwelling cold water mass showed a characteristic of moving northward along the current and occurrence a high concentration of chlorophyll along the water mass. Also, when the warm current were strong, the characteristic of red tide showed a northward moving.

• Journal of Korea Society of Industrial Information Systems
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• v.25 no.6
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• pp.15-23
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• 2020

While research activities in the agricultural field for climate change are being actively carried out, smart agriculture using information and communication technology has become a new trend in line with the Fourth Industrial Revolution. Accordingly, research is being conducted to identify and respond to signs of abnormal growth in advance by monitoring the stress of crops in various outdoor environments and soil conditions. There are also attempts to analyze data collected in real time through various sensors using artificial intelligence techniques or big data technologies. In this paper, we propose a big data model that is effective in analyzing the growth environment informations and biometric information of crops by using the existing relational database for big data analysis. The performance of the model was measured by the response time to a query according to the amount of data. As a result, it was confirmed that there is a maximum time reduction effect of 23.8%.

• Korean Journal of Metals and Materials
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• v.50 no.4
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• pp.324-330
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• 2012

The microstructural changes of three pieces from an ancient iron pot were studied in order to identify present the material degradation due to repeated heating for one-thousand years. The microstructures of the pieces were divided into the areas of ferrite/graphite, ferrite/pearlite, and corroded oxidation. The area of ferrite/graphite was undergone by severe Galvanic corrosion, but that of ferrite/pearlite was not even during a thousand years' using. The shape of the graphites was coexisted with types of A, B, and C of as modern graphite classification. In the ferrite/pearlite area, abnormal acicula precipitates with a high aspect ratio of $0.2{\mu}m$ thickness and several hundreds ${\mu}m$ length were presented. They might be a kind of carbide in the ferrite matrix with its special precipitate plane.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.3
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• pp.545-552
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• 2012

The rapid development of information technology is making large changes in our lives today. Also the infrastructure and services are combinding with information technology which predicts another huge change in our environment. However, the development of information technology brings various types of side effects and these side effects not only cause financial loss but also can develop into a nationwide crisis. Therefore, the detection and quick reaction towards these side effects is critical and much research is being done. Intrusion detection systems can be an example of such research. However, intrusion detection systems mostly tend to focus on judging whether particular traffic or files are malicious or not. Also it is difficult for intrusion detection systems to detect newly developed malicious codes. Therefore, this paper proposes a method which determines whether the present network model is normal or abnormal by comparing it with past network situations.