• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.321-330
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• 2021

Oxidative stress plays a crucial role in the development of neuronal disorders including brain ischemic injury. Thioredoxin 1 (Trx1), a 12 kDa oxidoreductase, has anti-oxidant and anti-apoptotic functions in various cells. It has been highly implicated in brain ischemic injury. However, the protective mechanism of Trx1 against hippocampal neuronal cell death is not identified yet. Using a cell permeable Tat-Trx1 protein, protective mechanism of Trx1 against hydrogen peroxide-induced cell death was examined using HT-22 cells and an ischemic animal model. Transduced Tat-Trx1 markedly inhibited intracellular ROS levels, DNA fragmentation, and cell death in H2O2-treatment HT-22 cells. Tat-Trx1 also significantly inhibited phosphorylation of ASK1 and MAPKs in signaling pathways of HT-22 cells. In addition, Tat-Trx1 regulated expression levels of Akt, NF-κB, and apoptosis related proteins. In an ischemia animal model, Tat-Trx1 markedly protected hippocampal neuronal cell death and reduced astrocytes and microglia activation. These findings indicate that transduced Tat-Trx1 might be a potential therapeutic agent for treating ischemic injury.

• Journal of Arbitration Studies
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• v.27 no.1
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• pp.131-160
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• 2017

When any investment dispute arises, the investor has to exhaust the local remedies available in the host state, and according to the agreement between the parties, the investor is filed to the ICSID arbitral tribunal to seek arbitral awards. At this time, if the arbitral tribunal decides that the investment agreement has been violated, it normally demands the host state to provide financial compensations to the investor for economic loss. According to the rules of the investment agreement, the host state is supposed to fulfill the arbitral awards voluntarily. If it is unwilling to provide financial compensations according to the arbitral awards, however, the investor may ask the domestic court of the host state for the recognition and enforcement of arbitral awards. In addition, if the host state is unwilling to fulfill arbitral awards on account of state immunity, the investor may ask his own country (state of nationality) for diplomatic protection and urge it to demand the fulfillment of arbitral awards. Effectiveness for pecuniary damages, a means to solve problems arising in the enforcement of investment arbitral awards, is found to be rather ineffective. For such cases, this study suggests an alternative to demand either a restitution of property or a corrections of violated measures subject to arbitral awards.

• Korean Medical Education Review
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• v.22 no.1
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• pp.28-31
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• 2020

For the past 20 years, the medical education accreditation program of Korean Institute of Medical Education and Evaluation (KIMEE) has contributed greatly to the standardization and improvement of the quality of basic medical education in Korea. Now, it contributes to establishing and promoting the future of medical education. Since its inception in 2019, Accreditation Standard of KIMEE 2019 (ASK2019) aims to achieve world-class medical education through the application of learner-centered curriculum using a continuum framework for the three phases of formal medical education: basic medical education, post-graduate medical education, and continuing professional development. ASK2019 also promotes medical education which meets community needs and employs systematic assessments throughout the education process. These are important changes that can be used to gauge the future of the medical education accreditation system. Furthermore, internationalization, interprofessional education, health systems science, and on-going, permanent self-assessment systems in every medical school are emerging as important topics for the future of medical education. It's time for the medical education accreditation system in Korea to observe and adopt new trends in global medical education.

• Journal of Ginseng Research
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• v.40 no.4
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• pp.423-430
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• 2016

Background: The induction of cellular defensive genes such as phase II detoxifying and antioxidant enzymes is a highly effective strategy for protection against carcinogenesis as well as slowing cancer development. Transcription factor Nrf2 (nuclear factor E2-related factor 2) is responsible for activation of phase II enzymes induced by natural chemopreventive compounds. Methods: Red ginseng oil (RGO) was extracted using a supercritical $CO_2$ extraction system and chemical profile of RGO was investigated by GC/MS. Effects of RGO on regulation of the Nrf2/antioxidant response element (ARE) pathway were determined by ARE-luciferase assay, western blotting, and confocal microscopy. Results: The predominant components of RGO were 9,12-octadecadienoic acid (31.48%), bicyclo[10.1.0] tridec-1-ene (22.54%), and 22,23-dihydrostigmasterol (16.90%). RGO treatment significantly increased nuclear translocation of Nrf2 as well as ARE reporter gene activity, leading to upregulation of heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1. Phosphorylation of the upstream kinases such as apoptosis signal-regulating kinase (ASK)1, mitogen-activated protein kinase (MAPK) kinase (MKK)4/7, c-Jun N-terminal kinase (JNK), and p38 MAPK were enhanced by treatment with RGO. In addition, RGO-mediated Nrf2 expression and nuclear translocation was attenuated by JNK inhibitor SP600125 and p38 MAPK inhibitor SB202190. Conclusion: RGO could be used as a potential chemopreventive agent, possibly by induction of Nrf2/ARE-mediated phase II enzymes via ASK1-MKK4/7-JNK and p38 MAPK signaling pathways.

• Communications of the Korean Mathematical Society
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• v.22 no.2
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• pp.183-194
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• 2007

For an irreducible binomial polynomial $f(x)=x^n-b{\in}K[x]$ with a field K, we ask when does the mth iteration $f_m$ is irreducible but $m+1th\;f_{m+1}$ is reducible over K. Let S(n, m) be the set of b's such that $f_m$ is irreducible but $f_{m+1}$ is reducible over K. We investigate the set S(n, m) by taking K as the rational number field.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.2
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• pp.1-6
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• 2011

In this paper, an 1.5Gbit/s wireless data transmission system using the carrier frequency of 300 GHz band was implemented. The RF front-end was composed of schottky diode sub-harmonic mixer, frequency tripler, and horn antennas for transmitter and receiver, respectively. The LO frequencies of sub-harmonic mixer are 150GHz for transmit chain and 156GHz for receive chain. The ASK(Amplitude Shift Keying) modulation was used in the transmitter and the envelope detection method was used in the heterodyne receiver. The conversion loss of sub-harmonic mixer and implementation system loss were measured to be 9.8dB and 1.2dB, respectively. The 1.5Gbit/s video signal with HD-SDI format was transmitted over wireless distance of 40cm without optical lens(4.2m with optical lens) and displayed on HDTV at the transmitted average output power of $20{\mu}W$.

• ETRI Journal
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• v.34 no.6
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• pp.800-806
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• 2012

Transmission performances of direct detection-based 100-Gb/s modulation formats are investigated and compared for metro area optical networks. The effects of optical signal-to-noise ratio sensitivity, chromatic dispersion, cross-channel nonlinearity, and transmission distance on the performance of differential 8-ary phase-shift keying (D8PSK), differential phase-shift keying plus three-level amplitude-shift keying (DPSK+3ASK), and dual-carrier differential quaternary phase-shift keying (DC-DQPSK) are evaluated. The performance of coherent dual-polarization quadrature phase-shift keying (DP-QPSK) with block phase estimation and coherent DP-QPSK with digital differential detection are also presented for reference. According to our analysis, all three direct detection modulation formats could transmit a 100-Gb/s signal over several hundred kilometers of a single-mode fiber link. The results also show that DC-DQPSK outperforms D8PSK and DPSK+3ASK, and the performance of DC-DQPSK is comparable to that of coherent DP-QPSK with digital differential detection. The maximum transmission distance of DC-DQPSK is over 1,000 km, which is enough distance for metro applications.

• The Transactions of the Korean Institute of Power Electronics
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• v.21 no.3
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• pp.275-281
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• 2016

A novel bidirectional magnetic wireless communication system is proposed in this study. This system provides the communication capability between the source and load sides by high-frequency signal while wireless power is transferred. Contrary to the conventional wireless communication systems using complex IC circuit and active components, the proposed system is simply composed of passive components. It is practical and beneficial for environmental robustness, cost effectiveness, and simple implementation. The detailed static analysis of the proposed system for power and communication lines is established. The proposed system is experimentally verified, and results show that a 0.1 voltage gain for communication line is obtained while a 2.0 voltage gain for the power line is achieved. The proposed system is adequate for practical applications as it allows the inductive power transfer system to wirelessly and easily communicate between the source and load sides.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.1A
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• pp.58-64
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• 2006

A 900-MHz band transceiver has been developed for RFID reader applications. In the transmitter, a GaAs SPST switch is used for high speed switching and low power consumption. In the receiver, a double balanced mixer is used to compress even-harmonic products. The ASK demodulator which consists of an active filter and comparator is used to reject the unwanted in band interferers. The transceiver produces a maximum transmitting power of 30 dBm and exhibits an 5 m communication range with a 6-dBi gain antenna.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.542-545
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• 2006

In recent years, RFID is widely used in Industrial applications including factory, material flow, logistics and defense areas. In this paper, we developed a RFID baseband system with ASK modulation and convolutional channel code. A commercial ASK RF module is used and its frequency range in $350\sim351MHz$ and power is 10mW and the convolution code is constraint length k=3 and rate R=1/2. The performance is measured by frame error rate and the convolutional code is very useful in performance improvement and, also we implemented the binary search algorithm as anti-collision method and we show the wave shapes whit collision occurrence. This RFID system is designed by FPGA therefore it produces result of speed-up and improvement of reliability.